CLCN6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLCN6
Entrez Gene ID	1185
Full Name	chloride voltage-gated channel 6
Synonyms	CLC-6
General protein information	Preferred Names chloride voltage-gated channel 6 Names chloride transport protein 6 chloride channel, voltage-sensitive 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.22
Summary	This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012].
Disorder MIM:	602726

mRNA and Protein(s)

mRNA	Protein	Name
NM_001256959.1	NP_001243888.1	chloride transport protein 6 isoform 2
NM_001286.4	NP_001277.1	chloride transport protein 6 isoform 1
NM_001286.3	NP_001277.1	chloride transport protein 6 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CLCN6	NP_001277.1
Pan troglodytes (chimpanzee)	CLCN6	XP_001140805.1
Mus musculus (house mouse)	Clcn6	NP_036059.1
Danio rerio (zebrafish)	clcn6	XP_696527.3
Rattus norvegicus (Norway rat)	Clcn6	NP_001099949.1
Macaca mulatta (Rhesus monkey)	CLCN6	XP_001104721.1
Bos taurus (cattle)	CLCN6	NP_001192799.1
Gallus gallus (chicken)	CLCN6	XP_417644.2
Xenopus tropicalis (tropical clawed frog)	clcn6	XP_002937575.2
Canis lupus familiaris (dog)	CLCN6	XP_005618051.1
Arabidopsis thaliana (thale cress)	CLC-D	NP_197996.1

Gene Ontology
Bibliography

Related articles in PubMed

Rare Exome Sequence Variants in CLCN6 Reduce Blood Pressure Levels and Hypertension Risk.
Yu B, Pulit SL, Hwang SJ, Brody JA, Amin N, Auer PL, Bis JC, Boerwinkle E, Burke GL, Chakravarti A, Correa A, Dreisbach AW, Franco OH, Ehret GB, Franceschini N, Hofman A, Lin DY, Metcalf GA, Musani SK, Muzny D, Palmas W, Raffel L, Reiner A, Rice K, Rotter JI, Veeraraghavan N, Fox E, Guo X, North KE, Gibbs RA, van Duijn CM, Psaty BM, Levy D, Newton-Cheh C, Morrison AC,
Circulation. Cardiovascular genetics9(1)64-70(2016 Feb)

Single nucleotide variations in CLCN6 identified in patients with benign partial epilepsies in infancy and/or febrile seizures.
Yamamoto T, Shimojima K, Sangu N, Komoike Y, Ishii A, Abe S, Yamashita S, Imai K, Kubota T, Fukasawa T, Okanishi T, Enoki H, Tanabe T, Saito A, Furukawa T, Shimizu T, Milligan CJ, Petrou S, Heron SE, Dibbens LM, Hirose S, Okumura A
PloS one10(3)e0118946(2015)

Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster.
Del Greco M F, Pattaro C, Luchner A, Pichler I, Winkler T, Hicks AA, Fuchsberger C, Franke A, Melville SA, Peters A, Wichmann HE, Schreiber S, Heid IM, Krawczak M, Minelli C, Wiedermann CJ, Pramstaller PP
Human molecular genetics20(8)1660-71(2011 Apr)

The late endosomal ClC-6 mediates proton/chloride countertransport in heterologous plasma membrane expression.
Neagoe I, Stauber T, Fidzinski P, Bergsdorf EY, Jentsch TJ
The Journal of biological chemistry285(28)21689-97(2010 Jul)

Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium.
Lamb FS, Graeff RW, Clayton GH, Smith RL, Schutte BC, McCray PB Jr
American journal of respiratory cell and molecular biology24(4)376-81(2001 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CLCN6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLCN6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11598	NM_001256959.1 Latest version!	Homo sapiens chloride voltage-gated channel 6 (CLCN6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
OHu23036	NM_001286.4 Latest version!	Homo sapiens chloride voltage-gated channel 6 (CLCN6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$300.30 $429.00
View Old Accession Versions >>
OHu23036	NM_001286.3	Homo sapiens chloride voltage-gated channel 6 (CLCN6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$300.30 $429.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLCN6 ( NM_001256959.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243888.1 Homo sapiens chloride voltage-gated channel 6 (CLCN6), transcript variant 2, mRNA.

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CloneID	OHu11598
Clone ID Related Accession (Same CDS sequence)	NM_001256959.1
Accession Version	NM_001256959.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2544bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1564934400000
Organism	Homo sapiens(human)
Product	chloride transport protein 6 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA229615.1, AK294764.1, AL021155.1 and R20538.1. Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK294764.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01820687 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGGGT GCAGGGGGTC TCTGTGCTGC TGCTGCAGGT GGTGCTGCTG CTGCGGTGAG 
CGTGAGACCC GCACCCCCGA GGAGCTGACC ATCCTTGGAG AAACACAGGA GGAGGAGGAT 
GAGATTCTTC CAAGGAAAGA CTATGAGAAA GGTCGAAGAT ATGAGGCGGT GAAGTGGATG 
GTGGTGTTTG CCATTGGAGT CTGCACTGGC CTGGTGGGTC TCTTTGTGGA CTTTTTTGTG 
CGACTCTTCA CCCAACTCAA GTTCGGAGTG GTACAGACAT CGGTGGAGGA GTGCAGCCAG 
AAAGGCTGCC TCGCTCTGTC TCTCCTTGAA CTCCTGGGTT TTAACCTCAC CTTTGTCTTC 
CTGGCAAGCC TCCTTGTTCT CATTGAGCCG GTGGCAGCAG GTTCCGGGAT ACCCGAGGTC 
AAATGCTATC TGAATGGCGT AAAGGTGCCA GGAATCGTCC GTCTCCGGAC CCTGCTCTGC 
AAGGTCCTTG GAGTGCTGTT CAGTGTGGCT GGAGGGCTCT TCGTGGGGAA GGAAGGCCCC 
ATGATCCACA GTGGTTCGGT GGTGGGAGCT GGCCTCCCTC AGTTTCAGAG CATCTCCTTA 
CGGAAGATCC AGTTTAACTT CCCCTATTTC CGAAGCGACA GAGACAAGAG AGACTTTGTA 
TCAGCAGGAG CGGCTGCTGG AGTTGCTGCA GCTTTCGGGG CGCCAATCGG GGGTACCTTG 
TTCAGTCTAG AGGAGGGTTC GTCCTTCTGG AACCAAGGGC TCACGTGGAA AGTGCTCTTT 
TGTTCCATGT CTGCCACCTT CACCCTCAAC TTCTTCCGTT CTGGGATTCA GTTTGGAAGC 
TGGGGTTCCT TCCAGCTCCC TGGATTGCTG AACTTTGGCG AGTTTAAGTG CTCTGACTCT 
GATAAAAAAT GTCATCTCTG GACAGCTATG GATTTGGGTT TCTTCGTCGT GATGGGGGTC 
ATTGGGGGCC TCCTGGGAGC CACATTCAAC TGTCTGAACA AGAGGCTTGC AAAGTACCGT 
ATGCGAAACG TGCACCCGAA ACCTAAGCTC GTCAGAGTCT TAGAGAGCCT CCTTGTGTCT 
CTGGTAACCA CCGTGGTGGT GTTTGTGGCC TCGATGGTGT TAGGAGAATG CCGACAGATG 
TCCTCTTCGA GTCAAATCGG TAATGACTCA TTCCAGCTCC AGGTCACAGA AGATGTGAAT 
TCAAGTATCA AGACATTTTT TTGTCCCAAT GATACCTACA ATGACATGGC CACACTCTTC 
TTCAACCCGC AGGAGTCTGC CATCCTCCAG CTCTTCCACC AGGATGGTAC TTTCAGCCCC 
GTCACTCTGG CCTTGTTCTT CGTTCTCTAT TTCTTGCTTG CATGTTGGAC TTACGGCATT 
TCTGTTCCAA GTGGCCTTTT TGTGCCTTCT CTGCTGTGTG GAGCTGCTTT TGGACGTTTA 
GTTGCCAATG TCCTAAAAAG CTACATTGGA TTGGGCCACA TCTATTCGGG GACCTTTGCC 
CTGATTGGTG CAGCGGCTTT CTTGGGCGGG GTGGTCCGCA TGACCATCAG CCTCACGGTC 
ATCCTGATCG AGTCCACCAA TGAGATCACC TACGGGCTCC CCATCATGGT CACACTGATG 
GTGGCCAAAT GGACAGGGGA CTTTTTCAAT AAGGGCATTT ATGATATCCA CGTGGGCCTG 
CGAGGCGTGC CGCTTCTGGA ATGGGAGACA GAGGTGGAAA TGGACAAGCT GAGAGCCAGC 
GACATCATGG AGCCCAACCT GACCTACGTC TACCCGCACA CCCGCATCCA GTCTCTGGTG 
AGCATCCTGC GCACCACGGT CCACCATGCC TTCCCGGTGG TCACAGAGAA CCGCGGTAAC 
GAGAAGGAGT TCATGAAGGG CAACCAGCTC ATCAGCAACA ACATCAAGTT CAAGAAATCC 
AGCATCCTCA CCCGGGCTGG CGAGCAGCGC AAACGGAGCC AGTCCATGAA GTCCTACCCA 
TCCAGCGAGC TACGGAACAT GTGTGATGAG CACATCGCCT CTGAGGAGCC AGCCGAGAAG 
GAGGACCTCC TGCAGCAGAT GCTGGAAAGG AGATACACTC CCTACCCCAA CCTATACCCT 
GACCAGTCCC CAAGTGAAGA CTGGACCATG GAGGAGCGGT TCCGCCCTCT GACCTTCCAC 
GGCCTGATCC TTCGGTCGCA GCTTGTCACC CTGCTTGTCC GAGGAGTTTG TTACTCTGAA 
AGCCAGTCGA GCGCCAGCCA GCCGCGCCTC TCCTATGCCG AGATGGCCGA GGACTACCCG 
CGGTACCCCG ACATCCACGA CCTGGACCTG ACGCTGCTCA ACCCGCGCAT GATCGTGGAT 
GTCACCCCAT ACATGAACCC TTCGCCTTTC ACCGTCTCGC CCAACACCCA CGTCTCCCAA 
GTCTTCAACC TGTTCAGAAC GATGGGCCTG CGCCACCTGC CCGTGGTGAA CGCTGTGGGA 
GAGATCGTGG GGATCATCAC ACGGCACAAC CTCACCTATG AATTTCTGCA GGCCCGGCTG 
AGGCAGCACT ACCAGACCAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243888.1
CDS	168..2711
Translation	MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYEKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQLFHQDGTFSPVTLALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLGHIYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLEWETEVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQLISNNIKFKKSSILTRAGEQRKRSQSMKSYPSSELRNMCDEHIASEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYEFLQARLRQHYQTI

Target ORF information:

RefSeq Version	NM_001256959.1
Organism	Homo sapiens(human)
Definition	Homo sapiens chloride voltage-gated channel 6 (CLCN6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256959.1

ORF Insert Sequence:

ATGGCGGGGT GCAGGGGGTC TCTGTGCTGC TGCTGCAGGT GGTGCTGCTG CTGCGGTGAG 
CGTGAGACCC GCACCCCCGA GGAGCTGACC ATCCTTGGAG AAACACAGGA GGAGGAGGAT 
GAGATTCTTC CAAGGAAAGA CTATGAGAAA GGTCGAAGAT ATGAGGCGGT GAAGTGGATG 
GTGGTGTTTG CCATTGGAGT CTGCACTGGC CTGGTGGGTC TCTTTGTGGA CTTTTTTGTG 
CGACTCTTCA CCCAACTCAA GTTCGGAGTG GTACAGACAT CGGTGGAGGA GTGCAGCCAG 
AAAGGCTGCC TCGCTCTGTC TCTCCTTGAA CTCCTGGGTT TTAACCTCAC CTTTGTCTTC 
CTGGCAAGCC TCCTTGTTCT CATTGAGCCG GTGGCAGCAG GTTCCGGGAT ACCCGAGGTC 
AAATGCTATC TGAATGGCGT AAAGGTGCCA GGAATCGTCC GTCTCCGGAC CCTGCTCTGC 
AAGGTCCTTG GAGTGCTGTT CAGTGTGGCT GGAGGGCTCT TCGTGGGGAA GGAAGGCCCC 
ATGATCCACA GTGGTTCGGT GGTGGGAGCT GGCCTCCCTC AGTTTCAGAG CATCTCCTTA 
CGGAAGATCC AGTTTAACTT CCCCTATTTC CGAAGCGACA GAGACAAGAG AGACTTTGTA 
TCAGCAGGAG CGGCTGCTGG AGTTGCTGCA GCTTTCGGGG CGCCAATCGG GGGTACCTTG 
TTCAGTCTAG AGGAGGGTTC GTCCTTCTGG AACCAAGGGC TCACGTGGAA AGTGCTCTTT 
TGTTCCATGT CTGCCACCTT CACCCTCAAC TTCTTCCGTT CTGGGATTCA GTTTGGAAGC 
TGGGGTTCCT TCCAGCTCCC TGGATTGCTG AACTTTGGCG AGTTTAAGTG CTCTGACTCT 
GATAAAAAAT GTCATCTCTG GACAGCTATG GATTTGGGTT TCTTCGTCGT GATGGGGGTC 
ATTGGGGGCC TCCTGGGAGC CACATTCAAC TGTCTGAACA AGAGGCTTGC AAAGTACCGT 
ATGCGAAACG TGCACCCGAA ACCTAAGCTC GTCAGAGTCT TAGAGAGCCT CCTTGTGTCT 
CTGGTAACCA CCGTGGTGGT GTTTGTGGCC TCGATGGTGT TAGGAGAATG CCGACAGATG 
TCCTCTTCGA GTCAAATCGG TAATGACTCA TTCCAGCTCC AGGTCACAGA AGATGTGAAT 
TCAAGTATCA AGACATTTTT TTGTCCCAAT GATACCTACA ATGACATGGC CACACTCTTC 
TTCAACCCGC AGGAGTCTGC CATCCTCCAG CTCTTCCACC AGGATGGTAC TTTCAGCCCC 
GTCACTCTGG CCTTGTTCTT CGTTCTCTAT TTCTTGCTTG CATGTTGGAC TTACGGCATT 
TCTGTTCCAA GTGGCCTTTT TGTGCCTTCT CTGCTGTGTG GAGCTGCTTT TGGACGTTTA 
GTTGCCAATG TCCTAAAAAG CTACATTGGA TTGGGCCACA TCTATTCGGG GACCTTTGCC 
CTGATTGGTG CAGCGGCTTT CTTGGGCGGG GTGGTCCGCA TGACCATCAG CCTCACGGTC 
ATCCTGATCG AGTCCACCAA TGAGATCACC TACGGGCTCC CCATCATGGT CACACTGATG 
GTGGCCAAAT GGACAGGGGA CTTTTTCAAT AAGGGCATTT ATGATATCCA CGTGGGCCTG 
CGAGGCGTGC CGCTTCTGGA ATGGGAGACA GAGGTGGAAA TGGACAAGCT GAGAGCCAGC 
GACATCATGG AGCCCAACCT GACCTACGTC TACCCGCACA CCCGCATCCA GTCTCTGGTG 
AGCATCCTGC GCACCACGGT CCACCATGCC TTCCCGGTGG TCACAGAGAA CCGCGGTAAC 
GAGAAGGAGT TCATGAAGGG CAACCAGCTC ATCAGCAACA ACATCAAGTT CAAGAAATCC 
AGCATCCTCA CCCGGGCTGG CGAGCAGCGC AAACGGAGCC AGTCCATGAA GTCCTACCCA 
TCCAGCGAGC TACGGAACAT GTGTGATGAG CACATCGCCT CTGAGGAGCC AGCCGAGAAG 
GAGGACCTCC TGCAGCAGAT GCTGGAAAGG AGATACACTC CCTACCCCAA CCTATACCCT 
GACCAGTCCC CAAGTGAAGA CTGGACCATG GAGGAGCGGT TCCGCCCTCT GACCTTCCAC 
GGCCTGATCC TTCGGTCGCA GCTTGTCACC CTGCTTGTCC GAGGAGTTTG TTACTCTGAA 
AGCCAGTCGA GCGCCAGCCA GCCGCGCCTC TCCTATGCCG AGATGGCCGA GGACTACCCG 
CGGTACCCCG ACATCCACGA CCTGGACCTG ACGCTGCTCA ACCCGCGCAT GATCGTGGAT 
GTCACCCCAT ACATGAACCC TTCGCCTTTC ACCGTCTCGC CCAACACCCA CGTCTCCCAA 
GTCTTCAACC TGTTCAGAAC GATGGGCCTG CGCCACCTGC CCGTGGTGAA CGCTGTGGGA 
GAGATCGTGG GGATCATCAC ACGGCACAAC CTCACCTATG AATTTCTGCA GGCCCGGCTG 
AGGCAGCACT ACCAGACCAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLCN6 ( NM_001286.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001277.1 Homo sapiens chloride voltage-gated channel 6 (CLCN6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23036
Clone ID Related Accession (Same CDS sequence)	NM_001286.4 , NM_001286.3
Accession Version	NM_001286.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2610bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1564934400000
Organism	Homo sapiens(human)
Product	chloride transport protein 6 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA229615.1, D28475.2, AL021155.1 and R20538.1. On Nov 23, 2018 this sequence version replaced NM_001286.3. Transcript Variant: This variant (1) is the longest transcript and encodes the longer isoform (1). This isoform is also known as CLC-6a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.67387.1, SRR1803613.95142.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGGGT GCAGGGGGTC TCTGTGCTGC TGCTGCAGGT GGTGCTGCTG CTGCGGTGAG 
CGTGAGACCC GCACCCCCGA GGAGCTGACC ATCCTTGGAG AAACACAGGA GGAGGAGGAT 
GAGATTCTTC CAAGGAAAGA CTATGAGAGT TTGGATTATG ATCGCTGTAT CAATGACCCT 
TACCTGGAAG TTTTGGAGAC CATGGATAAT AAGAAAGGTC GAAGATATGA GGCGGTGAAG 
TGGATGGTGG TGTTTGCCAT TGGAGTCTGC ACTGGCCTGG TGGGTCTCTT TGTGGACTTT 
TTTGTGCGAC TCTTCACCCA ACTCAAGTTC GGAGTGGTAC AGACATCGGT GGAGGAGTGC 
AGCCAGAAAG GCTGCCTCGC TCTGTCTCTC CTTGAACTCC TGGGTTTTAA CCTCACCTTT 
GTCTTCCTGG CAAGCCTCCT TGTTCTCATT GAGCCGGTGG CAGCAGGTTC CGGGATACCC 
GAGGTCAAAT GCTATCTGAA TGGCGTAAAG GTGCCAGGAA TCGTCCGTCT CCGGACCCTG 
CTCTGCAAGG TCCTTGGAGT GCTGTTCAGT GTGGCTGGAG GGCTCTTCGT GGGGAAGGAA 
GGCCCCATGA TCCACAGTGG TTCGGTGGTG GGAGCTGGCC TCCCTCAGTT TCAGAGCATC 
TCCTTACGGA AGATCCAGTT TAACTTCCCC TATTTCCGAA GCGACAGAGA CAAGAGAGAC 
TTTGTATCAG CAGGAGCGGC TGCTGGAGTT GCTGCAGCTT TCGGGGCGCC AATCGGGGGT 
ACCTTGTTCA GTCTAGAGGA GGGTTCGTCC TTCTGGAACC AAGGGCTCAC GTGGAAAGTG 
CTCTTTTGTT CCATGTCTGC CACCTTCACC CTCAACTTCT TCCGTTCTGG GATTCAGTTT 
GGAAGCTGGG GTTCCTTCCA GCTCCCTGGA TTGCTGAACT TTGGCGAGTT TAAGTGCTCT 
GACTCTGATA AAAAATGTCA TCTCTGGACA GCTATGGATT TGGGTTTCTT CGTCGTGATG 
GGGGTCATTG GGGGCCTCCT GGGAGCCACA TTCAACTGTC TGAACAAGAG GCTTGCAAAG 
TACCGTATGC GAAACGTGCA CCCGAAACCT AAGCTCGTCA GAGTCTTAGA GAGCCTCCTT 
GTGTCTCTGG TAACCACCGT GGTGGTGTTT GTGGCCTCGA TGGTGTTAGG AGAATGCCGA 
CAGATGTCCT CTTCGAGTCA AATCGGTAAT GACTCATTCC AGCTCCAGGT CACAGAAGAT 
GTGAATTCAA GTATCAAGAC ATTTTTTTGT CCCAATGATA CCTACAATGA CATGGCCACA 
CTCTTCTTCA ACCCGCAGGA GTCTGCCATC CTCCAGCTCT TCCACCAGGA TGGTACTTTC 
AGCCCCGTCA CTCTGGCCTT GTTCTTCGTT CTCTATTTCT TGCTTGCATG TTGGACTTAC 
GGCATTTCTG TTCCAAGTGG CCTTTTTGTG CCTTCTCTGC TGTGTGGAGC TGCTTTTGGA 
CGTTTAGTTG CCAATGTCCT AAAAAGCTAC ATTGGATTGG GCCACATCTA TTCGGGGACC 
TTTGCCCTGA TTGGTGCAGC GGCTTTCTTG GGCGGGGTGG TCCGCATGAC CATCAGCCTC 
ACGGTCATCC TGATCGAGTC CACCAATGAG ATCACCTACG GGCTCCCCAT CATGGTCACA 
CTGATGGTGG CCAAATGGAC AGGGGACTTT TTCAATAAGG GCATTTATGA TATCCACGTG 
GGCCTGCGAG GCGTGCCGCT TCTGGAATGG GAGACAGAGG TGGAAATGGA CAAGCTGAGA 
GCCAGCGACA TCATGGAGCC CAACCTGACC TACGTCTACC CGCACACCCG CATCCAGTCT 
CTGGTGAGCA TCCTGCGCAC CACGGTCCAC CATGCCTTCC CGGTGGTCAC AGAGAACCGC 
GGTAACGAGA AGGAGTTCAT GAAGGGCAAC CAGCTCATCA GCAACAACAT CAAGTTCAAG 
AAATCCAGCA TCCTCACCCG GGCTGGCGAG CAGCGCAAAC GGAGCCAGTC CATGAAGTCC 
TACCCATCCA GCGAGCTACG GAACATGTGT GATGAGCACA TCGCCTCTGA GGAGCCAGCC 
GAGAAGGAGG ACCTCCTGCA GCAGATGCTG GAAAGGAGAT ACACTCCCTA CCCCAACCTA 
TACCCTGACC AGTCCCCAAG TGAAGACTGG ACCATGGAGG AGCGGTTCCG CCCTCTGACC 
TTCCACGGCC TGATCCTTCG GTCGCAGCTT GTCACCCTGC TTGTCCGAGG AGTTTGTTAC 
TCTGAAAGCC AGTCGAGCGC CAGCCAGCCG CGCCTCTCCT ATGCCGAGAT GGCCGAGGAC 
TACCCGCGGT ACCCCGACAT CCACGACCTG GACCTGACGC TGCTCAACCC GCGCATGATC 
GTGGATGTCA CCCCATACAT GAACCCTTCG CCTTTCACCG TCTCGCCCAA CACCCACGTC 
TCCCAAGTCT TCAACCTGTT CAGAACGATG GGCCTGCGCC ACCTGCCCGT GGTGAACGCT 
GTGGGAGAGA TCGTGGGGAT CATCACACGG CACAACCTCA CCTATGAATT TCTGCAGGCC 
CGGCTGAGGC AGCACTACCA GACCATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001277.1
CDS	73..2682
Translation	MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQLFHQDGTFSPVTLALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLGHIYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLEWETEVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQLISNNIKFKKSSILTRAGEQRKRSQSMKSYPSSELRNMCDEHIASEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYEFLQARLRQHYQTI

Target ORF information:

RefSeq Version	NM_001286.4
Organism	Homo sapiens(human)
Definition	Homo sapiens chloride voltage-gated channel 6 (CLCN6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001286.4

ORF Insert Sequence:

ATGGCGGGGT GCAGGGGGTC TCTGTGCTGC TGCTGCAGGT GGTGCTGCTG CTGCGGTGAG 
CGTGAGACCC GCACCCCCGA GGAGCTGACC ATCCTTGGAG AAACACAGGA GGAGGAGGAT 
GAGATTCTTC CAAGGAAAGA CTATGAGAGT TTGGATTATG ATCGCTGTAT CAATGACCCT 
TACCTGGAAG TTTTGGAGAC CATGGATAAT AAGAAAGGTC GAAGATATGA GGCGGTGAAG 
TGGATGGTGG TGTTTGCCAT TGGAGTCTGC ACTGGCCTGG TGGGTCTCTT TGTGGACTTT 
TTTGTGCGAC TCTTCACCCA ACTCAAGTTC GGAGTGGTAC AGACATCGGT GGAGGAGTGC 
AGCCAGAAAG GCTGCCTCGC TCTGTCTCTC CTTGAACTCC TGGGTTTTAA CCTCACCTTT 
GTCTTCCTGG CAAGCCTCCT TGTTCTCATT GAGCCGGTGG CAGCAGGTTC CGGGATACCC 
GAGGTCAAAT GCTATCTGAA TGGCGTAAAG GTGCCAGGAA TCGTCCGTCT CCGGACCCTG 
CTCTGCAAGG TCCTTGGAGT GCTGTTCAGT GTGGCTGGAG GGCTCTTCGT GGGGAAGGAA 
GGCCCCATGA TCCACAGTGG TTCGGTGGTG GGAGCTGGCC TCCCTCAGTT TCAGAGCATC 
TCCTTACGGA AGATCCAGTT TAACTTCCCC TATTTCCGAA GCGACAGAGA CAAGAGAGAC 
TTTGTATCAG CAGGAGCGGC TGCTGGAGTT GCTGCAGCTT TCGGGGCGCC AATCGGGGGT 
ACCTTGTTCA GTCTAGAGGA GGGTTCGTCC TTCTGGAACC AAGGGCTCAC GTGGAAAGTG 
CTCTTTTGTT CCATGTCTGC CACCTTCACC CTCAACTTCT TCCGTTCTGG GATTCAGTTT 
GGAAGCTGGG GTTCCTTCCA GCTCCCTGGA TTGCTGAACT TTGGCGAGTT TAAGTGCTCT 
GACTCTGATA AAAAATGTCA TCTCTGGACA GCTATGGATT TGGGTTTCTT CGTCGTGATG 
GGGGTCATTG GGGGCCTCCT GGGAGCCACA TTCAACTGTC TGAACAAGAG GCTTGCAAAG 
TACCGTATGC GAAACGTGCA CCCGAAACCT AAGCTCGTCA GAGTCTTAGA GAGCCTCCTT 
GTGTCTCTGG TAACCACCGT GGTGGTGTTT GTGGCCTCGA TGGTGTTAGG AGAATGCCGA 
CAGATGTCCT CTTCGAGTCA AATCGGTAAT GACTCATTCC AGCTCCAGGT CACAGAAGAT 
GTGAATTCAA GTATCAAGAC ATTTTTTTGT CCCAATGATA CCTACAATGA CATGGCCACA 
CTCTTCTTCA ACCCGCAGGA GTCTGCCATC CTCCAGCTCT TCCACCAGGA TGGTACTTTC 
AGCCCCGTCA CTCTGGCCTT GTTCTTCGTT CTCTATTTCT TGCTTGCATG TTGGACTTAC 
GGCATTTCTG TTCCAAGTGG CCTTTTTGTG CCTTCTCTGC TGTGTGGAGC TGCTTTTGGA 
CGTTTAGTTG CCAATGTCCT AAAAAGCTAC ATTGGATTGG GCCACATCTA TTCGGGGACC 
TTTGCCCTGA TTGGTGCAGC GGCTTTCTTG GGCGGGGTGG TCCGCATGAC CATCAGCCTC 
ACGGTCATCC TGATCGAGTC CACCAATGAG ATCACCTACG GGCTCCCCAT CATGGTCACA 
CTGATGGTGG CCAAATGGAC AGGGGACTTT TTCAATAAGG GCATTTATGA TATCCACGTG 
GGCCTGCGAG GCGTGCCGCT TCTGGAATGG GAGACAGAGG TGGAAATGGA CAAGCTGAGA 
GCCAGCGACA TCATGGAGCC CAACCTGACC TACGTCTACC CGCACACCCG CATCCAGTCT 
CTGGTGAGCA TCCTGCGCAC CACGGTCCAC CATGCCTTCC CGGTGGTCAC AGAGAACCGC 
GGTAACGAGA AGGAGTTCAT GAAGGGCAAC CAGCTCATCA GCAACAACAT CAAGTTCAAG 
AAATCCAGCA TCCTCACCCG GGCTGGCGAG CAGCGCAAAC GGAGCCAGTC CATGAAGTCC 
TACCCATCCA GCGAGCTACG GAACATGTGT GATGAGCACA TCGCCTCTGA GGAGCCAGCC 
GAGAAGGAGG ACCTCCTGCA GCAGATGCTG GAAAGGAGAT ACACTCCCTA CCCCAACCTA 
TACCCTGACC AGTCCCCAAG TGAAGACTGG ACCATGGAGG AGCGGTTCCG CCCTCTGACC 
TTCCACGGCC TGATCCTTCG GTCGCAGCTT GTCACCCTGC TTGTCCGAGG AGTTTGTTAC 
TCTGAAAGCC AGTCGAGCGC CAGCCAGCCG CGCCTCTCCT ATGCCGAGAT GGCCGAGGAC 
TACCCGCGGT ACCCCGACAT CCACGACCTG GACCTGACGC TGCTCAACCC GCGCATGATC 
GTGGATGTCA CCCCATACAT GAACCCTTCG CCTTTCACCG TCTCGCCCAA CACCCACGTC 
TCCCAAGTCT TCAACCTGTT CAGAACGATG GGCCTGCGCC ACCTGCCCGT GGTGAACGCT 
GTGGGAGAGA TCGTGGGGAT CATCACACGG CACAACCTCA CCTATGAATT TCTGCAGGCC 
CGGCTGAGGC AGCACTACCA GACCATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLCN6 ( NM_001286.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001277.1 Homo sapiens chloride voltage-gated channel 6 (CLCN6), transcript variant 1, mRNA.

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CloneID	OHu23036
Clone ID Related Accession (Same CDS sequence)	NM_001286.4 , NM_001286.3
Accession Version	NM_001286.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2610bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506787200000
Organism	Homo sapiens(human)
Product	chloride transport protein 6 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA229615.1, D28475.2, AL021155.1 and R20538.1. This sequence is a reference standard in the RefSeqGene project. On Mar 9, 2012 this sequence version replaced NM_001286.2. Transcript Variant: This variant (1) is the longest transcript and encodes the longer isoform (1). This isoform is also known as CLC-6a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.11076.1, SRR1803611.28111.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGGGT GCAGGGGGTC TCTGTGCTGC TGCTGCAGGT GGTGCTGCTG CTGCGGTGAG 
CGTGAGACCC GCACCCCCGA GGAGCTGACC ATCCTTGGAG AAACACAGGA GGAGGAGGAT 
GAGATTCTTC CAAGGAAAGA CTATGAGAGT TTGGATTATG ATCGCTGTAT CAATGACCCT 
TACCTGGAAG TTTTGGAGAC CATGGATAAT AAGAAAGGTC GAAGATATGA GGCGGTGAAG 
TGGATGGTGG TGTTTGCCAT TGGAGTCTGC ACTGGCCTGG TGGGTCTCTT TGTGGACTTT 
TTTGTGCGAC TCTTCACCCA ACTCAAGTTC GGAGTGGTAC AGACATCGGT GGAGGAGTGC 
AGCCAGAAAG GCTGCCTCGC TCTGTCTCTC CTTGAACTCC TGGGTTTTAA CCTCACCTTT 
GTCTTCCTGG CAAGCCTCCT TGTTCTCATT GAGCCGGTGG CAGCAGGTTC CGGGATACCC 
GAGGTCAAAT GCTATCTGAA TGGCGTAAAG GTGCCAGGAA TCGTCCGTCT CCGGACCCTG 
CTCTGCAAGG TCCTTGGAGT GCTGTTCAGT GTGGCTGGAG GGCTCTTCGT GGGGAAGGAA 
GGCCCCATGA TCCACAGTGG TTCGGTGGTG GGAGCTGGCC TCCCTCAGTT TCAGAGCATC 
TCCTTACGGA AGATCCAGTT TAACTTCCCC TATTTCCGAA GCGACAGAGA CAAGAGAGAC 
TTTGTATCAG CAGGAGCGGC TGCTGGAGTT GCTGCAGCTT TCGGGGCGCC AATCGGGGGT 
ACCTTGTTCA GTCTAGAGGA GGGTTCGTCC TTCTGGAACC AAGGGCTCAC GTGGAAAGTG 
CTCTTTTGTT CCATGTCTGC CACCTTCACC CTCAACTTCT TCCGTTCTGG GATTCAGTTT 
GGAAGCTGGG GTTCCTTCCA GCTCCCTGGA TTGCTGAACT TTGGCGAGTT TAAGTGCTCT 
GACTCTGATA AAAAATGTCA TCTCTGGACA GCTATGGATT TGGGTTTCTT CGTCGTGATG 
GGGGTCATTG GGGGCCTCCT GGGAGCCACA TTCAACTGTC TGAACAAGAG GCTTGCAAAG 
TACCGTATGC GAAACGTGCA CCCGAAACCT AAGCTCGTCA GAGTCTTAGA GAGCCTCCTT 
GTGTCTCTGG TAACCACCGT GGTGGTGTTT GTGGCCTCGA TGGTGTTAGG AGAATGCCGA 
CAGATGTCCT CTTCGAGTCA AATCGGTAAT GACTCATTCC AGCTCCAGGT CACAGAAGAT 
GTGAATTCAA GTATCAAGAC ATTTTTTTGT CCCAATGATA CCTACAATGA CATGGCCACA 
CTCTTCTTCA ACCCGCAGGA GTCTGCCATC CTCCAGCTCT TCCACCAGGA TGGTACTTTC 
AGCCCCGTCA CTCTGGCCTT GTTCTTCGTT CTCTATTTCT TGCTTGCATG TTGGACTTAC 
GGCATTTCTG TTCCAAGTGG CCTTTTTGTG CCTTCTCTGC TGTGTGGAGC TGCTTTTGGA 
CGTTTAGTTG CCAATGTCCT AAAAAGCTAC ATTGGATTGG GCCACATCTA TTCGGGGACC 
TTTGCCCTGA TTGGTGCAGC GGCTTTCTTG GGCGGGGTGG TCCGCATGAC CATCAGCCTC 
ACGGTCATCC TGATCGAGTC CACCAATGAG ATCACCTACG GGCTCCCCAT CATGGTCACA 
CTGATGGTGG CCAAATGGAC AGGGGACTTT TTCAATAAGG GCATTTATGA TATCCACGTG 
GGCCTGCGAG GCGTGCCGCT TCTGGAATGG GAGACAGAGG TGGAAATGGA CAAGCTGAGA 
GCCAGCGACA TCATGGAGCC CAACCTGACC TACGTCTACC CGCACACCCG CATCCAGTCT 
CTGGTGAGCA TCCTGCGCAC CACGGTCCAC CATGCCTTCC CGGTGGTCAC AGAGAACCGC 
GGTAACGAGA AGGAGTTCAT GAAGGGCAAC CAGCTCATCA GCAACAACAT CAAGTTCAAG 
AAATCCAGCA TCCTCACCCG GGCTGGCGAG CAGCGCAAAC GGAGCCAGTC CATGAAGTCC 
TACCCATCCA GCGAGCTACG GAACATGTGT GATGAGCACA TCGCCTCTGA GGAGCCAGCC 
GAGAAGGAGG ACCTCCTGCA GCAGATGCTG GAAAGGAGAT ACACTCCCTA CCCCAACCTA 
TACCCTGACC AGTCCCCAAG TGAAGACTGG ACCATGGAGG AGCGGTTCCG CCCTCTGACC 
TTCCACGGCC TGATCCTTCG GTCGCAGCTT GTCACCCTGC TTGTCCGAGG AGTTTGTTAC 
TCTGAAAGCC AGTCGAGCGC CAGCCAGCCG CGCCTCTCCT ATGCCGAGAT GGCCGAGGAC 
TACCCGCGGT ACCCCGACAT CCACGACCTG GACCTGACGC TGCTCAACCC GCGCATGATC 
GTGGATGTCA CCCCATACAT GAACCCTTCG CCTTTCACCG TCTCGCCCAA CACCCACGTC 
TCCCAAGTCT TCAACCTGTT CAGAACGATG GGCCTGCGCC ACCTGCCCGT GGTGAACGCT 
GTGGGAGAGA TCGTGGGGAT CATCACACGG CACAACCTCA CCTATGAATT TCTGCAGGCC 
CGGCTGAGGC AGCACTACCA GACCATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001277.1
CDS	168..2777
Translation	MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQLFHQDGTFSPVTLALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLGHIYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLEWETEVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQLISNNIKFKKSSILTRAGEQRKRSQSMKSYPSSELRNMCDEHIASEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYEFLQARLRQHYQTI

Target ORF information:

RefSeq Version	NM_001286.3
Organism	Homo sapiens(human)
Definition	Homo sapiens chloride voltage-gated channel 6 (CLCN6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001286.3

ORF Insert Sequence:

ATGGCGGGGT GCAGGGGGTC TCTGTGCTGC TGCTGCAGGT GGTGCTGCTG CTGCGGTGAG 
CGTGAGACCC GCACCCCCGA GGAGCTGACC ATCCTTGGAG AAACACAGGA GGAGGAGGAT 
GAGATTCTTC CAAGGAAAGA CTATGAGAGT TTGGATTATG ATCGCTGTAT CAATGACCCT 
TACCTGGAAG TTTTGGAGAC CATGGATAAT AAGAAAGGTC GAAGATATGA GGCGGTGAAG 
TGGATGGTGG TGTTTGCCAT TGGAGTCTGC ACTGGCCTGG TGGGTCTCTT TGTGGACTTT 
TTTGTGCGAC TCTTCACCCA ACTCAAGTTC GGAGTGGTAC AGACATCGGT GGAGGAGTGC 
AGCCAGAAAG GCTGCCTCGC TCTGTCTCTC CTTGAACTCC TGGGTTTTAA CCTCACCTTT 
GTCTTCCTGG CAAGCCTCCT TGTTCTCATT GAGCCGGTGG CAGCAGGTTC CGGGATACCC 
GAGGTCAAAT GCTATCTGAA TGGCGTAAAG GTGCCAGGAA TCGTCCGTCT CCGGACCCTG 
CTCTGCAAGG TCCTTGGAGT GCTGTTCAGT GTGGCTGGAG GGCTCTTCGT GGGGAAGGAA 
GGCCCCATGA TCCACAGTGG TTCGGTGGTG GGAGCTGGCC TCCCTCAGTT TCAGAGCATC 
TCCTTACGGA AGATCCAGTT TAACTTCCCC TATTTCCGAA GCGACAGAGA CAAGAGAGAC 
TTTGTATCAG CAGGAGCGGC TGCTGGAGTT GCTGCAGCTT TCGGGGCGCC AATCGGGGGT 
ACCTTGTTCA GTCTAGAGGA GGGTTCGTCC TTCTGGAACC AAGGGCTCAC GTGGAAAGTG 
CTCTTTTGTT CCATGTCTGC CACCTTCACC CTCAACTTCT TCCGTTCTGG GATTCAGTTT 
GGAAGCTGGG GTTCCTTCCA GCTCCCTGGA TTGCTGAACT TTGGCGAGTT TAAGTGCTCT 
GACTCTGATA AAAAATGTCA TCTCTGGACA GCTATGGATT TGGGTTTCTT CGTCGTGATG 
GGGGTCATTG GGGGCCTCCT GGGAGCCACA TTCAACTGTC TGAACAAGAG GCTTGCAAAG 
TACCGTATGC GAAACGTGCA CCCGAAACCT AAGCTCGTCA GAGTCTTAGA GAGCCTCCTT 
GTGTCTCTGG TAACCACCGT GGTGGTGTTT GTGGCCTCGA TGGTGTTAGG AGAATGCCGA 
CAGATGTCCT CTTCGAGTCA AATCGGTAAT GACTCATTCC AGCTCCAGGT CACAGAAGAT 
GTGAATTCAA GTATCAAGAC ATTTTTTTGT CCCAATGATA CCTACAATGA CATGGCCACA 
CTCTTCTTCA ACCCGCAGGA GTCTGCCATC CTCCAGCTCT TCCACCAGGA TGGTACTTTC 
AGCCCCGTCA CTCTGGCCTT GTTCTTCGTT CTCTATTTCT TGCTTGCATG TTGGACTTAC 
GGCATTTCTG TTCCAAGTGG CCTTTTTGTG CCTTCTCTGC TGTGTGGAGC TGCTTTTGGA 
CGTTTAGTTG CCAATGTCCT AAAAAGCTAC ATTGGATTGG GCCACATCTA TTCGGGGACC 
TTTGCCCTGA TTGGTGCAGC GGCTTTCTTG GGCGGGGTGG TCCGCATGAC CATCAGCCTC 
ACGGTCATCC TGATCGAGTC CACCAATGAG ATCACCTACG GGCTCCCCAT CATGGTCACA 
CTGATGGTGG CCAAATGGAC AGGGGACTTT TTCAATAAGG GCATTTATGA TATCCACGTG 
GGCCTGCGAG GCGTGCCGCT TCTGGAATGG GAGACAGAGG TGGAAATGGA CAAGCTGAGA 
GCCAGCGACA TCATGGAGCC CAACCTGACC TACGTCTACC CGCACACCCG CATCCAGTCT 
CTGGTGAGCA TCCTGCGCAC CACGGTCCAC CATGCCTTCC CGGTGGTCAC AGAGAACCGC 
GGTAACGAGA AGGAGTTCAT GAAGGGCAAC CAGCTCATCA GCAACAACAT CAAGTTCAAG 
AAATCCAGCA TCCTCACCCG GGCTGGCGAG CAGCGCAAAC GGAGCCAGTC CATGAAGTCC 
TACCCATCCA GCGAGCTACG GAACATGTGT GATGAGCACA TCGCCTCTGA GGAGCCAGCC 
GAGAAGGAGG ACCTCCTGCA GCAGATGCTG GAAAGGAGAT ACACTCCCTA CCCCAACCTA 
TACCCTGACC AGTCCCCAAG TGAAGACTGG ACCATGGAGG AGCGGTTCCG CCCTCTGACC 
TTCCACGGCC TGATCCTTCG GTCGCAGCTT GTCACCCTGC TTGTCCGAGG AGTTTGTTAC 
TCTGAAAGCC AGTCGAGCGC CAGCCAGCCG CGCCTCTCCT ATGCCGAGAT GGCCGAGGAC 
TACCCGCGGT ACCCCGACAT CCACGACCTG GACCTGACGC TGCTCAACCC GCGCATGATC 
GTGGATGTCA CCCCATACAT GAACCCTTCG CCTTTCACCG TCTCGCCCAA CACCCACGTC 
TCCCAAGTCT TCAACCTGTT CAGAACGATG GGCCTGCGCC ACCTGCCCGT GGTGAACGCT 
GTGGGAGAGA TCGTGGGGAT CATCACACGG CACAACCTCA CCTATGAATT TCTGCAGGCC 
CGGCTGAGGC AGCACTACCA GACCATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Rare Exome Sequence Variants in CLCN6 Reduce Blood Pressure Levels and Hypertension Risk.
Circulation. Cardiovascular genetics9(1)64-70(2016 Feb)
Yu B,Pulit SL,Hwang SJ,Brody JA,Amin N,Auer PL,Bis JC,Boerwinkle E,Burke GL,Chakravarti A,Correa A,Dreisbach AW,Franco OH,Ehret GB,Franceschini N,Hofman A,Lin DY,Metcalf GA,Musani SK,Muzny D,Palmas W,Raffel L,Reiner A,Rice K,Rotter JI,Veeraraghavan N,Fox E,Guo X,North KE,Gibbs RA,van Duijn CM,Psaty BM,Levy D,Newton-Cheh C,Morrison AC,

Single nucleotide variations in CLCN6 identified in patients with benign partial epilepsies in infancy and/or febrile seizures.
PloS one10(3)e0118946(2015)
Yamamoto T,Shimojima K,Sangu N,Komoike Y,Ishii A,Abe S,Yamashita S,Imai K,Kubota T,Fukasawa T,Okanishi T,Enoki H,Tanabe T,Saito A,Furukawa T,Shimizu T,Milligan CJ,Petrou S,Heron SE,Dibbens LM,Hirose S,Okumura A

Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster.
Human molecular genetics20(8)1660-71(2011 Apr)
Del Greco M F,Pattaro C,Luchner A,Pichler I,Winkler T,Hicks AA,Fuchsberger C,Franke A,Melville SA,Peters A,Wichmann HE,Schreiber S,Heid IM,Krawczak M,Minelli C,Wiedermann CJ,Pramstaller PP

The late endosomal ClC-6 mediates proton/chloride countertransport in heterologous plasma membrane expression.
The Journal of biological chemistry285(28)21689-97(2010 Jul)
Neagoe I,Stauber T,Fidzinski P,Bergsdorf EY,Jentsch TJ

Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium.
American journal of respiratory cell and molecular biology24(4)376-81(2001 Apr)
Lamb FS,Graeff RW,Clayton GH,Smith RL,Schutte BC,McCray PB Jr

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CLCN6 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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