GABARAPL2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GABARAPL2
Entrez Gene ID	11345
Full Name	GABA type A receptor associated protein like 2
Synonyms	ATG8,ATG8C,GATE-16,GATE16,GEF-2,GEF2
General protein information	Preferred Names GABA type A receptor associated protein like 2 Names gamma-aminobutyric acid receptor-associated protein-like 2 GABA(A) receptor-associated protein-like 2 MAP1 light chain 3 related protein ganglioside expression factor 2 general protein transport factor p16 golgi-associated ATPase enhancer of 16 kDa
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q23.1
Disorder MIM:	607452

mRNA and Protein(s)

mRNA	Protein	Name
NM_007285.7	NP_009216.1	gamma-aminobutyric acid receptor-associated protein-like 2
NM_007285.6	NP_009216.1	gamma-aminobutyric acid receptor-associated protein-like 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	GABARAPL2	NP_009216.1
Pan troglodytes (chimpanzee)	GABARAPL2	XP_511114.4
Gallus gallus (chicken)	GABARAPL2	XP_001232689.1
Xenopus tropicalis (tropical clawed frog)	gabarapl2	NP_001096511.1
Canis lupus familiaris (dog)	GABARAPL2	XP_005620731.1
Bos taurus (cattle)	GABARAPL2	NP_777100.1
Rattus norvegicus (Norway rat)	Gabarapl2	NP_073197.1
Arabidopsis thaliana (thale cress)	APG8A	NP_001078424.1
Danio rerio (zebrafish)	gabarapl2	NP_991286.1
Arabidopsis thaliana (thale cress)	ATG8B	NP_849298.1
Macaca mulatta (Rhesus monkey)	GABARAPL2	XP_001104154.2
Mus musculus (house mouse)	Gabarapl2	NP_080969.2

Gene Ontology
Bibliography

Related articles in PubMed

TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress.
An H, Ordureau A, Paulo JA, Shoemaker CJ, Denic V, Harper JW
Molecular cell74(5)891-908.e10(2019 06)

A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5α and mammalian autophagy-related ATG8 proteins.
Keown JR, Black MM, Ferron A, Yap M, Barnett MJ, Pearce FG, Stoye JP, Goldstone DC
The Journal of biological chemistry293(47)18378-18386(2018 11)

Autophagy differentially regulates TNF receptor Fn14 by distinct mammalian Atg8 proteins.
Winer H, Fraiberg M, Abada A, Dadosh T, Tamim-Yecheskel BC, Elazar Z
Nature communications9(1)3744(2018 09)

A novel modelling mechanism of PAEL receptor and GABARAPL2 interaction involved in Parkinson's disease.
Dutta P, Dargahi L, O'Connell KE, Bolia A, Ozkan B, Sailer AW, Dev KK
Neuroscience letters67312-18(2018 04)

Stress-associated endoplasmic reticulum protein 1 (SERP1) and Atg8 synergistically regulate unfolded protein response (UPR) that is independent on autophagy in Candida albicans.
Li J, Yu Q, Zhang B, Xiao C, Ma T, Yi X, Liang C, Li M
International journal of medical microbiology : IJMM308(3)378-386(2018 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GABARAPL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GABARAPL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23415	NM_007285.7 Latest version!	Homo sapiens GABA type A receptor associated protein like 2 (GABARAPL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$104.30 $149.00
View Old Accession Versions >>
OHu23415	NM_007285.6	Homo sapiens GABA type A receptor associated protein like 2 (GABARAPL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$104.30 $149.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GABARAPL2 ( NM_007285.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_009216.1 Homo sapiens GABA type A receptor associated protein like 2 (GABARAPL2), mRNA.

Price & Availability↑

CloneID	OHu23415
Clone ID Related Accession (Same CDS sequence)	NM_007285.7 , NM_007285.6
Accession Version	NM_007285.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1572105600000
Organism	Homo sapiens(human)
Product	gamma-aminobutyric acid receptor-associated protein-like 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB030710.1. On Nov 23, 2018 this sequence version replaced NM_007285.6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.178644.1, BC029601.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000037243.7/ ENSP00000037243.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGTGGA TGTTCAAGGA GGACCACTCG CTGGAACACA GATGCGTGGA GTCCGCGAAG 
ATTCGAGCGA AATATCCCGA CAGGGTTCCG GTGATTGTGG AAAAGGTCTC AGGCTCTCAG 
ATTGTTGACA TTGACAAACG GAAGTACTTG GTTCCATCTG ATATCACTGT GGCTCAGTTC 
ATGTGGATCA TCAGGAAAAG GATCCAGCTT CCTTCTGAAA AGGCGATCTT CCTGTTTGTG 
GATAAGACAG TCCCACAGTC CAGCCTAACT ATGGGACAGC TTTACGAGAA GGAAAAAGAT 
GAAGATGGAT TCTTATATGT GGCCTACAGC GGAGAGAACA CTTTTGGCTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009216.1
CDS	109..462
Translation	MKWMFKEDHSLEHRCVESAKIRAKYPDRVPVIVEKVSGSQIVDIDKRKYLVPSDITVAQFMWIIRKRIQLPSEKAIFLFVDKTVPQSSLTMGQLYEKEKDEDGFLYVAYSGENTFGF

Target ORF information:

RefSeq Version	NM_007285.7
Organism	Homo sapiens(human)
Definition	Homo sapiens GABA type A receptor associated protein like 2 (GABARAPL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007285.7

ORF Insert Sequence:

ATGAAGTGGA TGTTCAAGGA GGACCACTCG CTGGAACACA GATGCGTGGA GTCCGCGAAG 
ATTCGAGCGA AATATCCCGA CAGGGTTCCG GTGATTGTGG AAAAGGTCTC AGGCTCTCAG 
ATTGTTGACA TTGACAAACG GAAGTACTTG GTTCCATCTG ATATCACTGT GGCTCAGTTC 
ATGTGGATCA TCAGGAAAAG GATCCAGCTT CCTTCTGAAA AGGCGATCTT CCTGTTTGTG 
GATAAGACAG TCCCACAGTC CAGCCTAACT ATGGGACAGC TTTACGAGAA GGAAAAAGAT 
GAAGATGGAT TCTTATATGT GGCCTACAGC GGAGAGAACA CTTTTGGCTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GABARAPL2 ( NM_007285.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_009216.1 Homo sapiens GABA type A receptor associated protein like 2 (GABARAPL2), mRNA.

Price & Availability↑

CloneID	OHu23415
Clone ID Related Accession (Same CDS sequence)	NM_007285.7 , NM_007285.6
Accession Version	NM_007285.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514217600000
Organism	Homo sapiens(human)
Product	gamma-aminobutyric acid receptor-associated protein-like 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB030710.1. On or before Mar 7, 2003 this sequence version replaced NM_173722.1, NM_007285.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB030710.1, SRR1163657.169106.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGTGGA TGTTCAAGGA GGACCACTCG CTGGAACACA GATGCGTGGA GTCCGCGAAG 
ATTCGAGCGA AATATCCCGA CAGGGTTCCG GTGATTGTGG AAAAGGTCTC AGGCTCTCAG 
ATTGTTGACA TTGACAAACG GAAGTACTTG GTTCCATCTG ATATCACTGT GGCTCAGTTC 
ATGTGGATCA TCAGGAAAAG GATCCAGCTT CCTTCTGAAA AGGCGATCTT CCTGTTTGTG 
GATAAGACAG TCCCACAGTC CAGCCTAACT ATGGGACAGC TTTACGAGAA GGAAAAAGAT 
GAAGATGGAT TCTTATATGT GGCCTACAGC GGAGAGAACA CTTTTGGCTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009216.1
CDS	137..490
Translation	MKWMFKEDHSLEHRCVESAKIRAKYPDRVPVIVEKVSGSQIVDIDKRKYLVPSDITVAQFMWIIRKRIQLPSEKAIFLFVDKTVPQSSLTMGQLYEKEKDEDGFLYVAYSGENTFGF

Target ORF information:

RefSeq Version	NM_007285.6
Organism	Homo sapiens(human)
Definition	Homo sapiens GABA type A receptor associated protein like 2 (GABARAPL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007285.6

ORF Insert Sequence:

ATGAAGTGGA TGTTCAAGGA GGACCACTCG CTGGAACACA GATGCGTGGA GTCCGCGAAG 
ATTCGAGCGA AATATCCCGA CAGGGTTCCG GTGATTGTGG AAAAGGTCTC AGGCTCTCAG 
ATTGTTGACA TTGACAAACG GAAGTACTTG GTTCCATCTG ATATCACTGT GGCTCAGTTC 
ATGTGGATCA TCAGGAAAAG GATCCAGCTT CCTTCTGAAA AGGCGATCTT CCTGTTTGTG 
GATAAGACAG TCCCACAGTC CAGCCTAACT ATGGGACAGC TTTACGAGAA GGAAAAAGAT 
GAAGATGGAT TCTTATATGT GGCCTACAGC GGAGAGAACA CTTTTGGCTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress.
Molecular cell74(5)891-908.e10(2019 06)
An H,Ordureau A,Paulo JA,Shoemaker CJ,Denic V,Harper JW

A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5α and mammalian autophagy-related ATG8 proteins.
The Journal of biological chemistry293(47)18378-18386(2018 11)
Keown JR,Black MM,Ferron A,Yap M,Barnett MJ,Pearce FG,Stoye JP,Goldstone DC

Autophagy differentially regulates TNF receptor Fn14 by distinct mammalian Atg8 proteins.
Nature communications9(1)3744(2018 09)
Winer H,Fraiberg M,Abada A,Dadosh T,Tamim-Yecheskel BC,Elazar Z

A novel modelling mechanism of PAEL receptor and GABARAPL2 interaction involved in Parkinson's disease.
Neuroscience letters67312-18(2018 04)
Dutta P,Dargahi L,O'Connell KE,Bolia A,Ozkan B,Sailer AW,Dev KK

Stress-associated endoplasmic reticulum protein 1 (SERP1) and Atg8 synergistically regulate unfolded protein response (UPR) that is independent on autophagy in Candida albicans.
International journal of medical microbiology : IJMM308(3)378-386(2018 Apr)
Li J,Yu Q,Zhang B,Xiao C,Ma T,Yi X,Liang C,Li M