PIM2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PIM2
Entrez Gene ID	11040
Full Name	Pim-2 proto-oncogene, serine/threonine kinase
General protein information	Preferred Names Pim-2 proto-oncogene, serine/threonine kinase Names serine/threonine-protein kinase pim-2 pim-2 oncogene pim-2h proto-oncogene Pim-2 (serine threonine kinase)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp11.23
Summary	This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009].
Disorder MIM:	300295

mRNA and Protein(s)

mRNA	Protein	Name
NM_006875.3	NP_006866.2	serine/threonine-protein kinase pim-2
NM_006875.4	NP_006866.2	serine/threonine-protein kinase pim-2

Pathways from BioSystems

Homologies

Homo sapiens (human)	PIM2	NP_006866.2
Rattus norvegicus (Norway rat)	Pim2	NP_001165574.1
Macaca mulatta (Rhesus monkey)	PIM2	XP_001104389.1
Bos taurus (cattle)	PIM2	NP_001193307.1
Pan troglodytes (chimpanzee)	PIM2	XP_528972.3
Canis lupus familiaris (dog)	PIM2	XP_548990.3
Danio rerio (zebrafish)	pim1	NP_571614.1
Mus musculus (house mouse)	Pim2	NP_613072.1

Gene Ontology
Bibliography

Related articles in PubMed

Proviral insertion in murine lymphomas 2 promotes stomach cancer progression by regulating apoptosis via reactive oxygen species-triggered endoplasmic reticulum stress.
Xin H, Deng Y, Cao J
Biochemical and biophysical research communications506(1)145-152(2018 11)

PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer.
Yang T, Ren C, Qiao P, Han X, Wang L, Lv S, Sun Y, Liu Z, Du Y, Yu Z
Oncogene37(45)5997-6009(2018 11)

PIM2 survival kinase is upregulated in a p53-dependent manner in cells treated with camptothecin or co-treated with actinomycin D and nutlin-3a.
Zajkowicz A, Krześniak M, Gdowicz-Kłosok A, Łasut B, Rusin M
Archives of biochemistry and biophysics65526-36(2018 10)

Microenvironment-induced PIM kinases promote CXCR4-triggered mTOR pathway required for chronic lymphocytic leukaemia cell migration.
Białopiotrowicz E, Górniak P, Noyszewska-Kania M, Puła B, Makuch-Łasica H, Nowak G, Bluszcz A, Szydłowski M, Jabłonska E, Piechna K, Sewastianik T, Polak A, Lech-Marańda E, Budziszewska BK, Wasylecka-Juszczyńska M, Borg K, Warzocha K, Czardybon W, Gałęzowski M, Windak R, Brzózka K, Juszczyński P
Journal of cellular and molecular medicine22(7)3548-3559(2018 07)

PIM2 interacts with tristetraprolin and promotes breast cancer tumorigenesis.
Ren C, Yang T, Qiao P, Wang L, Han X, Lv S, Sun Y, Liu Z, Du Y, Yu Z
Molecular oncology12(5)690-704(2018 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PIM2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PIM2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28504	NM_006875.4 Latest version!	Homo sapiens Pim-2 proto-oncogene, serine/threonine kinase (PIM2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00
View Old Accession Versions >>
OHu28504	NM_006875.3	Homo sapiens Pim-2 proto-oncogene, serine/threonine kinase (PIM2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PIM2 ( NM_006875.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006866.2 Homo sapiens Pim-2 proto-oncogene, serine/threonine kinase (PIM2), mRNA.

Price & Availability↑

CloneID	OHu28504
Clone ID Related Accession (Same CDS sequence)	NM_006875.3 , NM_006875.4
Accession Version	NM_006875.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 936bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1511020800000
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase pim-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC378253.1, AK290931.1, BC018111.1 and AC233300.2. This sequence is a reference standard in the RefSeqGene project. On Oct 21, 2008 this sequence version replaced NM_006875.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.54631.1, SRR1803615.16995.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154405, SAMEA2155628 [ECO:0000348] ##Evidence-Data-END##

ATGTTGACCA AGCCTCTACA GGGGCCTCCC GCGCCCCCCG GGACCCCCAC GCCGCCGCCA 
GGAGGCAAGG ATCGGGAAGC GTTCGAGGCC GAGTATCGAC TCGGCCCCCT CCTGGGTAAG 
GGGGGCTTTG GCACCGTCTT CGCAGGACAC CGCCTCACAG ATCGACTCCA GGTGGCCATC 
AAAGTGATTC CCCGGAATCG TGTGCTGGGC TGGTCCCCCT TGTCAGACTC AGTCACATGC 
CCACTCGAAG TCGCACTGCT ATGGAAAGTG GGTGCAGGTG GTGGGCACCC TGGCGTGATC 
CGCCTGCTTG ACTGGTTTGA GACACAGGAG GGCTTCATGC TGGTCCTCGA GCGGCCTTTG 
CCCGCCCAGG ATCTCTTTGA CTATATCACA GAGAAGGGCC CACTGGGTGA AGGCCCAAGC 
CGCTGCTTCT TTGGCCAAGT AGTGGCAGCC ATCCAGCACT GCCATTCCCG TGGAGTTGTC 
CATCGTGACA TCAAGGATGA GAACATCCTG ATAGACCTAC GCCGTGGCTG TGCCAAACTC 
ATTGATTTTG GTTCTGGTGC CCTGCTTCAT GATGAACCCT ACACTGACTT TGATGGGACA 
AGGGTGTACA GCCCCCCAGA GTGGATCTCT CGACACCAGT ACCATGCACT CCCGGCCACT 
GTCTGGTCAC TGGGCATCCT CCTCTATGAC ATGGTGTGTG GGGACATTCC CTTTGAGAGG 
GACCAGGAGA TTCTGGAAGC TGAGCTCCAC TTCCCAGCCC ATGTCTCCCC AGACTGCTGT 
GCCCTAATCC GCCGGTGCCT GGCCCCCAAA CCTTCTTCCC GACCCTCACT GGAAGAGATC 
CTGCTGGACC CCTGGATGCA AACACCAGCC GAGGATGTAC CCCTCAACCC CTCCAAAGGA 
GGCCCTGCCC CTTTGGCCTG GTCCTTGCTA CCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006866.2
CDS	303..1238
Translation	MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP

Target ORF information:

RefSeq Version	NM_006875.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Pim-2 proto-oncogene, serine/threonine kinase (PIM2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006875.3

ORF Insert Sequence:

ATGTTGACCA AGCCTCTACA GGGGCCTCCC GCGCCCCCCG GGACCCCCAC GCCGCCGCCA 
GGAGGCAAGG ATCGGGAAGC GTTCGAGGCC GAGTATCGAC TCGGCCCCCT CCTGGGTAAG 
GGGGGCTTTG GCACCGTCTT CGCAGGACAC CGCCTCACAG ATCGACTCCA GGTGGCCATC 
AAAGTGATTC CCCGGAATCG TGTGCTGGGC TGGTCCCCCT TGTCAGACTC AGTCACATGC 
CCACTCGAAG TCGCACTGCT ATGGAAAGTG GGTGCAGGTG GTGGGCACCC TGGCGTGATC 
CGCCTGCTTG ACTGGTTTGA GACACAGGAG GGCTTCATGC TGGTCCTCGA GCGGCCTTTG 
CCCGCCCAGG ATCTCTTTGA CTATATCACA GAGAAGGGCC CACTGGGTGA AGGCCCAAGC 
CGCTGCTTCT TTGGCCAAGT AGTGGCAGCC ATCCAGCACT GCCATTCCCG TGGAGTTGTC 
CATCGTGACA TCAAGGATGA GAACATCCTG ATAGACCTAC GCCGTGGCTG TGCCAAACTC 
ATTGATTTTG GTTCTGGTGC CCTGCTTCAT GATGAACCCT ACACTGACTT TGATGGGACA 
AGGGTGTACA GCCCCCCAGA GTGGATCTCT CGACACCAGT ACCATGCACT CCCGGCCACT 
GTCTGGTCAC TGGGCATCCT CCTCTATGAC ATGGTGTGTG GGGACATTCC CTTTGAGAGG 
GACCAGGAGA TTCTGGAAGC TGAGCTCCAC TTCCCAGCCC ATGTCTCCCC AGACTGCTGT 
GCCCTAATCC GCCGGTGCCT GGCCCCCAAA CCTTCTTCCC GACCCTCACT GGAAGAGATC 
CTGCTGGACC CCTGGATGCA AACACCAGCC GAGGATGTAC CCCTCAACCC CTCCAAAGGA 
GGCCCTGCCC CTTTGGCCTG GTCCTTGCTA CCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PIM2 ( NM_006875.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006866.2 Homo sapiens Pim-2 proto-oncogene, serine/threonine kinase (PIM2), mRNA.

Price & Availability↑

CloneID	OHu28504
Clone ID Related Accession (Same CDS sequence)	NM_006875.3 , NM_006875.4
Accession Version	NM_006875.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 936bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase pim-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK290931.1, BC018111.1 and AC233300.2. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_006875.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.498291.1, SRR3476690.126295.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154405 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000376509.4/ ENSP00000365692.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTGACCA AGCCTCTACA GGGGCCTCCC GCGCCCCCCG GGACCCCCAC GCCGCCGCCA 
GGAGGCAAGG ATCGGGAAGC GTTCGAGGCC GAGTATCGAC TCGGCCCCCT CCTGGGTAAG 
GGGGGCTTTG GCACCGTCTT CGCAGGACAC CGCCTCACAG ATCGACTCCA GGTGGCCATC 
AAAGTGATTC CCCGGAATCG TGTGCTGGGC TGGTCCCCCT TGTCAGACTC AGTCACATGC 
CCACTCGAAG TCGCACTGCT ATGGAAAGTG GGTGCAGGTG GTGGGCACCC TGGCGTGATC 
CGCCTGCTTG ACTGGTTTGA GACACAGGAG GGCTTCATGC TGGTCCTCGA GCGGCCTTTG 
CCCGCCCAGG ATCTCTTTGA CTATATCACA GAGAAGGGCC CACTGGGTGA AGGCCCAAGC 
CGCTGCTTCT TTGGCCAAGT AGTGGCAGCC ATCCAGCACT GCCATTCCCG TGGAGTTGTC 
CATCGTGACA TCAAGGATGA GAACATCCTG ATAGACCTAC GCCGTGGCTG TGCCAAACTC 
ATTGATTTTG GTTCTGGTGC CCTGCTTCAT GATGAACCCT ACACTGACTT TGATGGGACA 
AGGGTGTACA GCCCCCCAGA GTGGATCTCT CGACACCAGT ACCATGCACT CCCGGCCACT 
GTCTGGTCAC TGGGCATCCT CCTCTATGAC ATGGTGTGTG GGGACATTCC CTTTGAGAGG 
GACCAGGAGA TTCTGGAAGC TGAGCTCCAC TTCCCAGCCC ATGTCTCCCC AGACTGCTGT 
GCCCTAATCC GCCGGTGCCT GGCCCCCAAA CCTTCTTCCC GACCCTCACT GGAAGAGATC 
CTGCTGGACC CCTGGATGCA AACACCAGCC GAGGATGTAC CCCTCAACCC CTCCAAAGGA 
GGCCCTGCCC CTTTGGCCTG GTCCTTGCTA CCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006866.2
CDS	191..1126
Translation	MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP

Target ORF information:

RefSeq Version	NM_006875.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Pim-2 proto-oncogene, serine/threonine kinase (PIM2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006875.4

ORF Insert Sequence:

ATGTTGACCA AGCCTCTACA GGGGCCTCCC GCGCCCCCCG GGACCCCCAC GCCGCCGCCA 
GGAGGCAAGG ATCGGGAAGC GTTCGAGGCC GAGTATCGAC TCGGCCCCCT CCTGGGTAAG 
GGGGGCTTTG GCACCGTCTT CGCAGGACAC CGCCTCACAG ATCGACTCCA GGTGGCCATC 
AAAGTGATTC CCCGGAATCG TGTGCTGGGC TGGTCCCCCT TGTCAGACTC AGTCACATGC 
CCACTCGAAG TCGCACTGCT ATGGAAAGTG GGTGCAGGTG GTGGGCACCC TGGCGTGATC 
CGCCTGCTTG ACTGGTTTGA GACACAGGAG GGCTTCATGC TGGTCCTCGA GCGGCCTTTG 
CCCGCCCAGG ATCTCTTTGA CTATATCACA GAGAAGGGCC CACTGGGTGA AGGCCCAAGC 
CGCTGCTTCT TTGGCCAAGT AGTGGCAGCC ATCCAGCACT GCCATTCCCG TGGAGTTGTC 
CATCGTGACA TCAAGGATGA GAACATCCTG ATAGACCTAC GCCGTGGCTG TGCCAAACTC 
ATTGATTTTG GTTCTGGTGC CCTGCTTCAT GATGAACCCT ACACTGACTT TGATGGGACA 
AGGGTGTACA GCCCCCCAGA GTGGATCTCT CGACACCAGT ACCATGCACT CCCGGCCACT 
GTCTGGTCAC TGGGCATCCT CCTCTATGAC ATGGTGTGTG GGGACATTCC CTTTGAGAGG 
GACCAGGAGA TTCTGGAAGC TGAGCTCCAC TTCCCAGCCC ATGTCTCCCC AGACTGCTGT 
GCCCTAATCC GCCGGTGCCT GGCCCCCAAA CCTTCTTCCC GACCCTCACT GGAAGAGATC 
CTGCTGGACC CCTGGATGCA AACACCAGCC GAGGATGTAC CCCTCAACCC CTCCAAAGGA 
GGCCCTGCCC CTTTGGCCTG GTCCTTGCTA CCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Proviral insertion in murine lymphomas 2 promotes stomach cancer progression by regulating apoptosis via reactive oxygen species-triggered endoplasmic reticulum stress.
Biochemical and biophysical research communications506(1)145-152(2018 11)
Xin H,Deng Y,Cao J

PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer.
Oncogene37(45)5997-6009(2018 11)
Yang T,Ren C,Qiao P,Han X,Wang L,Lv S,Sun Y,Liu Z,Du Y,Yu Z

PIM2 survival kinase is upregulated in a p53-dependent manner in cells treated with camptothecin or co-treated with actinomycin D and nutlin-3a.
Archives of biochemistry and biophysics65526-36(2018 10)
Zajkowicz A,Krześniak M,Gdowicz-Kłosok A,Łasut B,Rusin M

Microenvironment-induced PIM kinases promote CXCR4-triggered mTOR pathway required for chronic lymphocytic leukaemia cell migration.
Journal of cellular and molecular medicine22(7)3548-3559(2018 07)
Białopiotrowicz E,Górniak P,Noyszewska-Kania M,Puła B,Makuch-Łasica H,Nowak G,Bluszcz A,Szydłowski M,Jabłonska E,Piechna K,Sewastianik T,Polak A,Lech-Marańda E,Budziszewska BK,Wasylecka-Juszczyńska M,Borg K,Warzocha K,Czardybon W,Gałęzowski M,Windak R,Brzózka K,Juszczyński P

PIM2 interacts with tristetraprolin and promotes breast cancer tumorigenesis.
Molecular oncology12(5)690-704(2018 05)
Ren C,Yang T,Qiao P,Wang L,Han X,Lv S,Sun Y,Liu Z,Du Y,Yu Z

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PIM2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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