YWHAQ cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	YWHAQ
Entrez Gene ID	10971
Full Name	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
Synonyms	14-3-3,1C5,HS1
General protein information	Preferred Names tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta Names 14-3-3 protein theta 14-3-3 protein T-cell 14-3-3 protein tau protein, theta tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p25.1
Summary	This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008].
Disorder MIM:	609009

mRNA and Protein(s)

mRNA	Protein	Name
NM_006826.3	NP_006817.1	14-3-3 protein theta
NM_006826.4	NP_006817.1	14-3-3 protein theta

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	YWHAQ	XP_003949798.1
Macaca mulatta (Rhesus monkey)	YWHAQ	XP_001097635.1
Gallus gallus (chicken)	YWHAQ	NP_001006415.1
Mus musculus (house mouse)	LOC102634437	XP_006538470.1
Homo sapiens (human)	YWHAQ	NP_006817.1
Bos taurus (cattle)	YWHAQ	NP_001071595.1
Mus musculus (house mouse)	Ywhaq	NP_035869.1
Rattus norvegicus (Norway rat)	Ywhaq	NP_037185.1
Xenopus tropicalis (tropical clawed frog)	ywhaq	NP_001025570.1
Canis lupus familiaris (dog)	YWHAQ	XP_532871.1
Danio rerio (zebrafish)	ywhaqb	NP_958892.1

Gene Ontology
Bibliography

Related articles in PubMed

Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes.
Lee JH, Han JH, Kim H, Park SM, Joe EH, Jou I
Acta neuropathologica communications7(1)68(2019 05)

Mechanism of IRSp53 inhibition by 14-3-3.
Kast DJ, Dominguez R
Nature communications10(1)483(2019 01)

Chk1 and 14-3-3 proteins inhibit atypical E2Fs to prevent a permanent cell cycle arrest.
Yuan R, Vos HR, van Es RM, Chen J, Burgering BM, Westendorp B, de Bruin A
The EMBO journal37(5)(2018 03)

Upregulation of MUC1 by its novel activator 14-3-3ζ promotes tumor invasion and indicates poor prognosis in lung adenocarcinoma.
Xue M, Tao W
Oncology reports38(5)2637-2646(2017 Nov)

Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners.
Sluchanko NN, Tugaeva KV, Greive SJ, Antson AA
Scientific reports7(1)12014(2017 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following YWHAQ gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the YWHAQ cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16909	NM_006826.4 Latest version!	Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta (YWHAQ), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu16909	NM_006826.3	Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta (YWHAQ), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

YWHAQ ( NM_006826.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006817.1 Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta (YWHAQ), mRNA.

Price & Availability↑

CloneID	OHu16909
Clone ID Related Accession (Same CDS sequence)	NM_006826.3 , NM_006826.4
Accession Version	NM_006826.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 738bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1513440000000
Organism	Homo sapiens(human)
Product	14-3-3 protein theta
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY044745.1, BC093019.1, BC050601.1 and AA729400.1. On Jun 21, 2013 this sequence version replaced NM_006826.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.10376.1, SRR1803613.255954.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAAGA CTGAGCTGAT CCAGAAGGCC AAGCTGGCCG AGCAGGCCGA GCGCTACGAC 
GACATGGCCA CCTGCATGAA GGCAGTGACC GAGCAGGGCG CCGAGCTGTC CAACGAGGAG 
CGCAACCTGC TCTCCGTGGC CTACAAGAAC GTGGTCGGGG GCCGCAGGTC CGCCTGGAGG 
GTCATCTCTA GCATCGAGCA GAAGACCGAC ACCTCCGACA AGAAGTTGCA GCTGATTAAG 
GACTATCGGG AGAAAGTGGA GTCCGAGCTG AGATCCATCT GCACCACGGT GCTGGAATTG 
TTGGATAAAT ATTTAATAGC CAATGCAACT AATCCAGAGA GTAAGGTCTT CTATCTGAAA 
ATGAAGGGTG ATTACTTCCG GTACCTTGCT GAAGTTGCGT GTGGTGATGA TCGAAAACAA 
ACGATAGATA ATTCCCAAGG AGCTTACCAA GAGGCATTTG ATATAAGCAA GAAAGAGATG 
CAACCCACAC ACCCAATCCG CCTGGGGCTT GCTCTTAACT TTTCTGTATT TTACTATGAG 
ATTCTTAATA ACCCAGAGCT TGCCTGCACG CTGGCTAAAA CGGCTTTTGA TGAGGCCATT 
GCTGAACTTG ATACACTGAA TGAAGACTCA TACAAAGACA GCACCCTCAT CATGCAGTTG 
CTTAGAGACA ACCTAACACT TTGGACATCA GACAGTGCAG GAGAAGAATG TGATGCGGCA 
GAAGGGGCTG AAAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006817.1
CDS	198..935
Translation	MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIDNSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDSAGEECDAAEGAEN

Target ORF information:

RefSeq Version	NM_006826.3
Organism	Homo sapiens(human)
Definition	Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta (YWHAQ), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006826.3

ORF Insert Sequence:

ATGGAGAAGA CTGAGCTGAT CCAGAAGGCC AAGCTGGCCG AGCAGGCCGA GCGCTACGAC 
GACATGGCCA CCTGCATGAA GGCAGTGACC GAGCAGGGCG CCGAGCTGTC CAACGAGGAG 
CGCAACCTGC TCTCCGTGGC CTACAAGAAC GTGGTCGGGG GCCGCAGGTC CGCCTGGAGG 
GTCATCTCTA GCATCGAGCA GAAGACCGAC ACCTCCGACA AGAAGTTGCA GCTGATTAAG 
GACTATCGGG AGAAAGTGGA GTCCGAGCTG AGATCCATCT GCACCACGGT GCTGGAATTG 
TTGGATAAAT ATTTAATAGC CAATGCAACT AATCCAGAGA GTAAGGTCTT CTATCTGAAA 
ATGAAGGGTG ATTACTTCCG GTACCTTGCT GAAGTTGCGT GTGGTGATGA TCGAAAACAA 
ACGATAGATA ATTCCCAAGG AGCTTACCAA GAGGCATTTG ATATAAGCAA GAAAGAGATG 
CAACCCACAC ACCCAATCCG CCTGGGGCTT GCTCTTAACT TTTCTGTATT TTACTATGAG 
ATTCTTAATA ACCCAGAGCT TGCCTGCACG CTGGCTAAAA CGGCTTTTGA TGAGGCCATT 
GCTGAACTTG ATACACTGAA TGAAGACTCA TACAAAGACA GCACCCTCAT CATGCAGTTG 
CTTAGAGACA ACCTAACACT TTGGACATCA GACAGTGCAG GAGAAGAATG TGATGCGGCA 
GAAGGGGCTG AAAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

YWHAQ ( NM_006826.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006817.1 Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta (YWHAQ), mRNA.

Price & Availability↑

CloneID	OHu16909
Clone ID Related Accession (Same CDS sequence)	NM_006826.3 , NM_006826.4
Accession Version	NM_006826.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 738bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577721600000
Organism	Homo sapiens(human)
Product	14-3-3 protein theta
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC093019.1, BC050601.1 and AA729400.1. On Nov 24, 2018 this sequence version replaced NM_006826.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.172956.1, SRR1803611.223311.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000238081.8/ ENSP00000238081.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGAAGA CTGAGCTGAT CCAGAAGGCC AAGCTGGCCG AGCAGGCCGA GCGCTACGAC 
GACATGGCCA CCTGCATGAA GGCAGTGACC GAGCAGGGCG CCGAGCTGTC CAACGAGGAG 
CGCAACCTGC TCTCCGTGGC CTACAAGAAC GTGGTCGGGG GCCGCAGGTC CGCCTGGAGG 
GTCATCTCTA GCATCGAGCA GAAGACCGAC ACCTCCGACA AGAAGTTGCA GCTGATTAAG 
GACTATCGGG AGAAAGTGGA GTCCGAGCTG AGATCCATCT GCACCACGGT GCTGGAATTG 
TTGGATAAAT ATTTAATAGC CAATGCAACT AATCCAGAGA GTAAGGTCTT CTATCTGAAA 
ATGAAGGGTG ATTACTTCCG GTACCTTGCT GAAGTTGCGT GTGGTGATGA TCGAAAACAA 
ACGATAGATA ATTCCCAAGG AGCTTACCAA GAGGCATTTG ATATAAGCAA GAAAGAGATG 
CAACCCACAC ACCCAATCCG CCTGGGGCTT GCTCTTAACT TTTCTGTATT TTACTATGAG 
ATTCTTAATA ACCCAGAGCT TGCCTGCACG CTGGCTAAAA CGGCTTTTGA TGAGGCCATT 
GCTGAACTTG ATACACTGAA TGAAGACTCA TACAAAGACA GCACCCTCAT CATGCAGTTG 
CTTAGAGACA ACCTAACACT TTGGACATCA GACAGTGCAG GAGAAGAATG TGATGCGGCA 
GAAGGGGCTG AAAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006817.1
CDS	140..877
Translation	MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIDNSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDSAGEECDAAEGAEN

Target ORF information:

RefSeq Version	NM_006826.4
Organism	Homo sapiens(human)
Definition	Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta (YWHAQ), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006826.4

ORF Insert Sequence:

ATGGAGAAGA CTGAGCTGAT CCAGAAGGCC AAGCTGGCCG AGCAGGCCGA GCGCTACGAC 
GACATGGCCA CCTGCATGAA GGCAGTGACC GAGCAGGGCG CCGAGCTGTC CAACGAGGAG 
CGCAACCTGC TCTCCGTGGC CTACAAGAAC GTGGTCGGGG GCCGCAGGTC CGCCTGGAGG 
GTCATCTCTA GCATCGAGCA GAAGACCGAC ACCTCCGACA AGAAGTTGCA GCTGATTAAG 
GACTATCGGG AGAAAGTGGA GTCCGAGCTG AGATCCATCT GCACCACGGT GCTGGAATTG 
TTGGATAAAT ATTTAATAGC CAATGCAACT AATCCAGAGA GTAAGGTCTT CTATCTGAAA 
ATGAAGGGTG ATTACTTCCG GTACCTTGCT GAAGTTGCGT GTGGTGATGA TCGAAAACAA 
ACGATAGATA ATTCCCAAGG AGCTTACCAA GAGGCATTTG ATATAAGCAA GAAAGAGATG 
CAACCCACAC ACCCAATCCG CCTGGGGCTT GCTCTTAACT TTTCTGTATT TTACTATGAG 
ATTCTTAATA ACCCAGAGCT TGCCTGCACG CTGGCTAAAA CGGCTTTTGA TGAGGCCATT 
GCTGAACTTG ATACACTGAA TGAAGACTCA TACAAAGACA GCACCCTCAT CATGCAGTTG 
CTTAGAGACA ACCTAACACT TTGGACATCA GACAGTGCAG GAGAAGAATG TGATGCGGCA 
GAAGGGGCTG AAAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes.
Acta neuropathologica communications7(1)68(2019 05)
Lee JH,Han JH,Kim H,Park SM,Joe EH,Jou I

Mechanism of IRSp53 inhibition by 14-3-3.
Nature communications10(1)483(2019 01)
Kast DJ,Dominguez R

Chk1 and 14-3-3 proteins inhibit atypical E2Fs to prevent a permanent cell cycle arrest.
The EMBO journal37(5)(2018 03)
Yuan R,Vos HR,van Es RM,Chen J,Burgering BM,Westendorp B,de Bruin A

Upregulation of MUC1 by its novel activator 14-3-3ζ promotes tumor invasion and indicates poor prognosis in lung adenocarcinoma.
Oncology reports38(5)2637-2646(2017 Nov)
Xue M,Tao W

Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners.
Scientific reports7(1)12014(2017 09)
Sluchanko NN,Tugaeva KV,Greive SJ,Antson AA

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YWHAQ cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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