| Gene Symbol | SRSF8 |
| Entrez Gene ID | 10929 |
| Full Name | serine and arginine rich splicing factor 8 |
| Synonyms | DSM-1,SFRS2B,SRP46 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a member of a family of proteins containing a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal arginine-serine-rich (RS) domain. The encoded protein functions as a pre-mRNA splicing factor. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]. |
| Disorder MIM: |
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SRSF8 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following SRSF8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SRSF8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu09269 Clone ID Related Accession (Same CDS sequence) XM_017017142.1 , NM_032102.3 Accession Version NM_032102.3 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 849bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1564934400000 Organism Homo sapiens(human) Product serine/arginine-rich splicing factor 8 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA723253.1, AF031166.1, BC057783.1, AK023379.1, AP001264.4 and KF510392.1. On Jun 19, 2013 this sequence version replaced NM_032102.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841ATGAGCTGCG GCCGCCCCCC TCCCGACGTG GACGGCATGA TCACCCTCAA GGTGGACAAC
CTGACCTACC GCACCTCTCC CGACAGCTTG AGGCGCGTGT TCGAGAAGTA CGGGCGCGTG
GGCGACGTGT ACATCCCGCG GGAGCCCCAC ACCAAGGCGC CCCGGGGCTT CGCTTTCGTC
CGCTTTCACG ACCGGCGCGA CGCCCAAGAC GCCGAGGCCG CCATGGACGG GGCGGAGCTG
GACGGACGCG AGCTGCGGGT GCAGGTGGCG CGCTATGGCC GCCGGGACCT GCCCCGCAGC
CGCCAGGGAG AGCCACGCGG CAGGTCCAGA GGCGGCGGCT ACGGACGGCG GAGCCGCAGC
TACGGGCGGC GGAGCCGCAG CCCCAGGCGG CGACACCGCA GCCGATCCCG GGGTCCCAGC
TGCTCCAGGT CCCGCAGCCG ATCTCGCTAT AGGGGTTCTC GCTATAGCCG GTCTCCCTAC
AGCCGATCTC CTTACAGCCG GTCGCGCTAC AGCCGCTCTC CCTACAGCAG ATCTCGCTAC
AGGGAATCTC GCTACGGCGG ATCTCACTAC AGCTCATCTG GTTACAGTAA CTCTCGCTAC
AGCCGATATC ACAGCAGCCG GTCTCACTCG AAGTCTGGGT CCTCCACTAG CTCTCGCTCT
GCATCAACCT CCAAATCGAG CTCTGCGCGA CGATCCAAGT CCTCCTCGGT CTCCAGGTCT
CGCTCGCGGT CCAGGTCTTC ATCTATGACC AGGAGTCCTC CCCGGGTATC CAAGAGGAAA
TCCAAGTCAA GGTCGCGATC CAAGAGGCCC CCCAAGTCTC CTGAAGAGGA AGGACAGATG
TCCTCTTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_115285.1 CDS 351..1199 Translation 
Target ORF information:
RefSeq Version NM_032102.3 Organism Homo sapiens(human) Definition Homo sapiens serine and arginine rich splicing factor 8 (SRSF8), transcript variant 1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_032102.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841ATGAGCTGCG GCCGCCCCCC TCCCGACGTG GACGGCATGA TCACCCTCAA GGTGGACAAC
CTGACCTACC GCACCTCTCC CGACAGCTTG AGGCGCGTGT TCGAGAAGTA CGGGCGCGTG
GGCGACGTGT ACATCCCGCG GGAGCCCCAC ACCAAGGCGC CCCGGGGCTT CGCTTTCGTC
CGCTTTCACG ACCGGCGCGA CGCCCAAGAC GCCGAGGCCG CCATGGACGG GGCGGAGCTG
GACGGACGCG AGCTGCGGGT GCAGGTGGCG CGCTATGGCC GCCGGGACCT GCCCCGCAGC
CGCCAGGGAG AGCCACGCGG CAGGTCCAGA GGCGGCGGCT ACGGACGGCG GAGCCGCAGC
TACGGGCGGC GGAGCCGCAG CCCCAGGCGG CGACACCGCA GCCGATCCCG GGGTCCCAGC
TGCTCCAGGT CCCGCAGCCG ATCTCGCTAT AGGGGTTCTC GCTATAGCCG GTCTCCCTAC
AGCCGATCTC CTTACAGCCG GTCGCGCTAC AGCCGCTCTC CCTACAGCAG ATCTCGCTAC
AGGGAATCTC GCTACGGCGG ATCTCACTAC AGCTCATCTG GTTACAGTAA CTCTCGCTAC
AGCCGATATC ACAGCAGCCG GTCTCACTCG AAGTCTGGGT CCTCCACTAG CTCTCGCTCT
GCATCAACCT CCAAATCGAG CTCTGCGCGA CGATCCAAGT CCTCCTCGGT CTCCAGGTCT
CGCTCGCGGT CCAGGTCTTC ATCTATGACC AGGAGTCCTC CCCGGGTATC CAAGAGGAAA
TCCAAGTCAA GGTCGCGATC CAAGAGGCCC CCCAAGTCTC CTGAAGAGGA AGGACAGATG
TCCTCTTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu09269 Clone ID Related Accession (Same CDS sequence) XM_017017142.1 , NM_032102.3 Accession Version XM_017017142.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 849bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1575475200000 Organism Homo sapiens(human) Product serine/arginine-rich splicing factor 8 isoform X1 Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841ATGAGCTGCG GCCGCCCCCC TCCCGACGTG GACGGCATGA TCACCCTCAA GGTGGACAAC
CTGACCTACC GCACCTCTCC CGACAGCTTG AGGCGCGTGT TCGAGAAGTA CGGGCGCGTG
GGCGACGTGT ACATCCCGCG GGAGCCCCAC ACCAAGGCGC CCCGGGGCTT CGCTTTCGTC
CGCTTTCACG ACCGGCGCGA CGCCCAAGAC GCCGAGGCCG CCATGGACGG GGCGGAGCTG
GACGGACGCG AGCTGCGGGT GCAGGTGGCG CGCTATGGCC GCCGGGACCT GCCCCGCAGC
CGCCAGGGAG AGCCACGCGG CAGGTCCAGA GGCGGCGGCT ACGGACGGCG GAGCCGCAGC
TACGGGCGGC GGAGCCGCAG CCCCAGGCGG CGACACCGCA GCCGATCCCG GGGTCCCAGC
TGCTCCAGGT CCCGCAGCCG ATCTCGCTAT AGGGGTTCTC GCTATAGCCG GTCTCCCTAC
AGCCGATCTC CTTACAGCCG GTCGCGCTAC AGCCGCTCTC CCTACAGCAG ATCTCGCTAC
AGGGAATCTC GCTACGGCGG ATCTCACTAC AGCTCATCTG GTTACAGTAA CTCTCGCTAC
AGCCGATATC ACAGCAGCCG GTCTCACTCG AAGTCTGGGT CCTCCACTAG CTCTCGCTCT
GCATCAACCT CCAAATCGAG CTCTGCGCGA CGATCCAAGT CCTCCTCGGT CTCCAGGTCT
CGCTCGCGGT CCAGGTCTTC ATCTATGACC AGGAGTCCTC CCCGGGTATC CAAGAGGAAA
TCCAAGTCAA GGTCGCGATC CAAGAGGCCC CCCAAGTCTC CTGAAGAGGA AGGACAGATG
TCCTCTTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq XP_016872631.1 CDS 313..1161 Translation
Target ORF information:
RefSeq Version XM_017017142.1 Organism Homo sapiens(human) Definition Homo sapiens serine and arginine rich splicing factor 8 (SRSF8), transcript variant X1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK XM_017017142.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841ATGAGCTGCG GCCGCCCCCC TCCCGACGTG GACGGCATGA TCACCCTCAA GGTGGACAAC
CTGACCTACC GCACCTCTCC CGACAGCTTG AGGCGCGTGT TCGAGAAGTA CGGGCGCGTG
GGCGACGTGT ACATCCCGCG GGAGCCCCAC ACCAAGGCGC CCCGGGGCTT CGCTTTCGTC
CGCTTTCACG ACCGGCGCGA CGCCCAAGAC GCCGAGGCCG CCATGGACGG GGCGGAGCTG
GACGGACGCG AGCTGCGGGT GCAGGTGGCG CGCTATGGCC GCCGGGACCT GCCCCGCAGC
CGCCAGGGAG AGCCACGCGG CAGGTCCAGA GGCGGCGGCT ACGGACGGCG GAGCCGCAGC
TACGGGCGGC GGAGCCGCAG CCCCAGGCGG CGACACCGCA GCCGATCCCG GGGTCCCAGC
TGCTCCAGGT CCCGCAGCCG ATCTCGCTAT AGGGGTTCTC GCTATAGCCG GTCTCCCTAC
AGCCGATCTC CTTACAGCCG GTCGCGCTAC AGCCGCTCTC CCTACAGCAG ATCTCGCTAC
AGGGAATCTC GCTACGGCGG ATCTCACTAC AGCTCATCTG GTTACAGTAA CTCTCGCTAC
AGCCGATATC ACAGCAGCCG GTCTCACTCG AAGTCTGGGT CCTCCACTAG CTCTCGCTCT
GCATCAACCT CCAAATCGAG CTCTGCGCGA CGATCCAAGT CCTCCTCGGT CTCCAGGTCT
CGCTCGCGGT CCAGGTCTTC ATCTATGACC AGGAGTCCTC CCCGGGTATC CAAGAGGAAA
TCCAAGTCAA GGTCGCGATC CAAGAGGCCC CCCAAGTCTC CTGAAGAGGA AGGACAGATG
TCCTCTTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
The protein interaction landscape of the human CMGC kinase group.
Cell reports3(4)1306-20(2013 Apr)
Varjosalo M,Keskitalo S,Van Drogen A,Nurkkala H,Vichalkovski A,Aebersold R,Gstaiger M
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanhäusser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M
A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins).
Genes & development24(11)1073-4(2010 Jun)
Manley JL,Krainer AR
Increased expression of splicing factor SRp20 mRNA in bipolar disorder patients.
Journal of affective disorders110(1-2)62-9(2008 Sep)
Watanuki T,Funato H,Uchida S,Matsubara T,Kobayashi A,Wakabayashi Y,Otsuki K,Nishida A,Watanabe Y
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