SIX2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SIX2
Entrez Gene ID	10736
Full Name	SIX homeobox 2
General protein information	Preferred Names SIX homeobox 2 Names homeobox protein SIX2 sine oculis homeobox homolog 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p21
Summary	This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis' homeobox protein. The encoded protein is a transcription factor which, like other members of this gene family, may be involved in limb or eye development. [provided by RefSeq, Dec 2008].
Disorder MIM:	604994

mRNA and Protein(s)

mRNA	Protein	Name
NM_016932.5	NP_058628.3	homeobox protein SIX2
XM_005264100.3	XP_005264157.1	homeobox protein SIX2 isoform X1
NM_016932.4	NP_058628.3	homeobox protein SIX2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Six2	NP_001178837.1
Gallus gallus (chicken)	SIX2	NP_001038160.1
Homo sapiens (human)	SIX2	NP_058628.3
Canis lupus familiaris (dog)	SIX2	XP_005626134.1
Bos taurus (cattle)	SIX2	NP_001192607.1
Mus musculus (house mouse)	Six2	NP_035510.1
Macaca mulatta (Rhesus monkey)	LOC717242	XP_001108575.2
Pan troglodytes (chimpanzee)	SIX2	XP_515444.3
Danio rerio (zebrafish)	six2a	NP_571858.1
Xenopus tropicalis (tropical clawed frog)	six2	NP_001093745.1

Gene Ontology
Bibliography

Related articles in PubMed

Wu Y, Song T, Liu M, He Q, Chen L, Liu Y, Ni D, Liu J, Hu Y, Gu Y, Li Q, Zhou Q, Xie Y
DNA and cell biology38(7)700-707(2019 Jul)

A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB.
Liu Z, Mar KB, Hanners NW, Perelman SS, Kanchwala M, Xing C, Schoggins JW, Alto NM
Nature568(7751)249-253(2019 04)

SIX2 Mediates Late-Stage Metastasis via Direct Regulation of
Oliphant MUJ, Vincent MY, Galbraith MD, Pandey A, Zaberezhnyy V, Rudra P, Johnson KR, Costello JC, Ghosh D, DeGregori J, Espinosa JM, Ford HL
Cancer research79(4)720-734(2019 02)

Six2 is negatively correlated with good prognosis and decreases 5-FU sensitivity via suppressing E-cadherin expression in hepatocellular carcinoma cells.
Li JW, Huang CZ, Li JH, Yuan JH, Chen QH, Zhang WF, Xu ZS, Liu YP, Li Y, Zhan MX, Lu LG
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie104204-210(2018 Aug)

SIX2 gene haploinsufficiency leads to a recognizable phenotype with ptosis, frontonasal dysplasia, and conductive hearing loss.
Henn A, Weng H, Novak S, Rettenberger G, Gerhardinger A, Rossier E, Zirn B
Clinical dysmorphology27(2)27-30(2018 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SIX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SIX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu35256	XM_005264100.3 Latest version!	Homo sapiens SIX homeobox 2 (SIX2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu18170	NM_016932.5 Latest version!	Homo sapiens SIX homeobox 2 (SIX2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00
View Old Accession Versions >>
OHu18170	NM_016932.4	Homo sapiens SIX homeobox 2 (SIX2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SIX2 ( NM_016932.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_058628.3 Homo sapiens SIX homeobox 2 (SIX2), mRNA.

Price & Availability↑

CloneID	OHu18170
Clone ID Related Accession (Same CDS sequence)	NM_016932.5 , NM_016932.4
Accession Version	NM_016932.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1512403200000
Organism	Homo sapiens(human)
Product	homeobox protein SIX2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF332197.1, BC024033.2, AI697804.1 and AI299144.1. This sequence is a reference standard in the RefSeqGene project. On Jan 1, 2009 this sequence version replaced NM_016932.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF332197.1, BC024033.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCATGC TGCCCACCTT CGGCTTCACG CAGGAGCAAG TGGCGTGCGT GTGCGAGGTG 
CTGCAGCAGG GCGGCAACAT CGAGCGGCTG GGCCGCTTCC TGTGGTCGCT GCCCGCCTGC 
GAGCACCTTC ACAAGAATGA AAGCGTGCTC AAGGCCAAGG CCGTGGTGGC CTTCCACCGC 
GGCAACTTCC GCGAGCTCTA CAAGATCCTG GAGAGCCACC AGTTCTCGCC GCACAACCAC 
GCCAAGCTGC AGCAGCTGTG GCTCAAGGCA CACTACATCG AGGCGGAGAA GCTGCGCGGC 
CGACCCCTGG GCGCCGTGGG CAAATACCGC GTGCGCCGCA AATTCCCGCT GCCGCGCTCC 
ATCTGGGACG GCGAGGAGAC CAGCTACTGC TTCAAGGAAA AGAGTCGCAG CGTGCTGCGC 
GAGTGGTACG CGCACAACCC CTACCCTTCA CCCCGCGAGA AGCGTGAGCT GGCGGAGGCC 
ACGGGCCTCA CCACCACACA GGTCAGCAAC TGGTTCAAGA ACCGGCGGCA GCGCGACCGG 
GCGGCCGAGG CCAAGGAAAG GGAGAACAAC GAGAACTCCA ATTCTAACAG CCACAACCCG 
CTGAATGGCA GCGGCAAGTC GGTGTTAGGC AGCTCGGAGG ATGAGAAGAC TCCATCGGGG 
ACGCCAGACC ACTCATCATC CAGCCCCGCA CTGCTCCTCA GCCCGCCGCC CCCTGGGCTG 
CCGTCCCTGC ACAGCCTGGG CCACCCTCCG GGCCCCAGCG CAGTGCCAGT GCCGGTGCCA 
GGCGGAGGTG GAGCGGACCC ACTGCAACAC CACCATGGCC TGCAGGACTC CATCCTCAAC 
CCCATGTCAG CCAACCTCGT GGACCTGGGC TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058628.3
CDS	294..1169
Translation	MSMLPTFGFTQEQVACVCEVLQQGGNIERLGRFLWSLPACEHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENNENSNSNSHNPLNGSGKSVLGSSEDEKTPSGTPDHSSSSPALLLSPPPPGLPSLHSLGHPPGPSAVPVPVPGGGGADPLQHHHGLQDSILNPMSANLVDLGS

Target ORF information:

RefSeq Version	NM_016932.4
Organism	Homo sapiens(human)
Definition	Homo sapiens SIX homeobox 2 (SIX2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016932.4

ORF Insert Sequence:

ATGTCCATGC TGCCCACCTT CGGCTTCACG CAGGAGCAAG TGGCGTGCGT GTGCGAGGTG 
CTGCAGCAGG GCGGCAACAT CGAGCGGCTG GGCCGCTTCC TGTGGTCGCT GCCCGCCTGC 
GAGCACCTTC ACAAGAATGA AAGCGTGCTC AAGGCCAAGG CCGTGGTGGC CTTCCACCGC 
GGCAACTTCC GCGAGCTCTA CAAGATCCTG GAGAGCCACC AGTTCTCGCC GCACAACCAC 
GCCAAGCTGC AGCAGCTGTG GCTCAAGGCA CACTACATCG AGGCGGAGAA GCTGCGCGGC 
CGACCCCTGG GCGCCGTGGG CAAATACCGC GTGCGCCGCA AATTCCCGCT GCCGCGCTCC 
ATCTGGGACG GCGAGGAGAC CAGCTACTGC TTCAAGGAAA AGAGTCGCAG CGTGCTGCGC 
GAGTGGTACG CGCACAACCC CTACCCTTCA CCCCGCGAGA AGCGTGAGCT GGCGGAGGCC 
ACGGGCCTCA CCACCACACA GGTCAGCAAC TGGTTCAAGA ACCGGCGGCA GCGCGACCGG 
GCGGCCGAGG CCAAGGAAAG GGAGAACAAC GAGAACTCCA ATTCTAACAG CCACAACCCG 
CTGAATGGCA GCGGCAAGTC GGTGTTAGGC AGCTCGGAGG ATGAGAAGAC TCCATCGGGG 
ACGCCAGACC ACTCATCATC CAGCCCCGCA CTGCTCCTCA GCCCGCCGCC CCCTGGGCTG 
CCGTCCCTGC ACAGCCTGGG CCACCCTCCG GGCCCCAGCG CAGTGCCAGT GCCGGTGCCA 
GGCGGAGGTG GAGCGGACCC ACTGCAACAC CACCATGGCC TGCAGGACTC CATCCTCAAC 
CCCATGTCAG CCAACCTCGT GGACCTGGGC TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIX2 ( XM_005264100.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005264157.1 Homo sapiens SIX homeobox 2 (SIX2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu35256
Clone ID Related Accession (Same CDS sequence)	XM_005264100.3
Accession Version	XM_005264100.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 882bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	homeobox protein SIX2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005264100.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCATGC TGCCCACCTT CGGCTTCACG CAGGAGCAAG TGGCGTGCGT GTGCGAGGTG 
CTGCAGCAGG GCGGCAACAT CGAGCGGCTG GGCCGCTTCC TGTGGTCGCT GCCCGCCTGC 
GAGCACCTTC ACAAGAATGA AAGCGTGCTC AAGGCCAAGG CCGTGGTGGC CTTCCACCGC 
GGCAACTTCC GCGAGCTCTA CAAGATCCTG GAGAGCCACC AGTTCTCGCC GCACAACCAC 
GCCAAGCTGC AGCAGCTGTG GCTCAAGGCA CACTACATCG AGGCGGAGAA GCTGCGCGGC 
CGACCCCTGG GCGCCGTGGG CAAATACCGC GTGCGCCGCA AATTCCCGCT GCCGCGCTCC 
ATCTGGGACG GCGAGGAGAC CAGCTACTGC TTCAAGGAAA AGAGTCGCAG CGTGCTGCGC 
GAGTGGTACG CGCACAACCC CTACCCTTCA CCCCGCGAGA AGCGTGAGCT GGCGGAGGCC 
ACGGGCCTCA CCACCACACA GGTCAGCAAC TGGTTCAAGA ACCGGCGGCA GCGCGACCGG 
GCGGCCGAGG CCAAGGAAAG GTACGAGGAG AACAACGAGA ACTCCAATTC TAACAGCCAC 
AACCCGCTGA ATGGCAGCGG CAAGTCGGTG TTAGGCAGCT CGGAGGATGA GAAGACTCCA 
TCGGGGACGC CAGACCACTC ATCATCCAGC CCCGCACTGC TCCTCAGCCC GCCGCCCCCT 
GGGCTGCCGT CCCTGCACAG CCTGGGCCAC CCTCCGGGCC CCAGCGCAGT GCCAGTGCCG 
GTGCCAGGCG GAGGTGGAGC GGACCCACTG CAACACCACC ATGGCCTGCA GGACTCCATC 
CTCAACCCCA TGTCAGCCAA CCTCGTGGAC CTGGGCTCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005264157.1
CDS	536..1417
Translation	MSMLPTFGFTQEQVACVCEVLQQGGNIERLGRFLWSLPACEHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERYEENNENSNSNSHNPLNGSGKSVLGSSEDEKTPSGTPDHSSSSPALLLSPPPPGLPSLHSLGHPPGPSAVPVPVPGGGGADPLQHHHGLQDSILNPMSANLVDLGS

Target ORF information:

RefSeq Version	XM_005264100.3
Organism	Homo sapiens(human)
Definition	Homo sapiens SIX homeobox 2 (SIX2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005264100.3

ORF Insert Sequence:

ATGTCCATGC TGCCCACCTT CGGCTTCACG CAGGAGCAAG TGGCGTGCGT GTGCGAGGTG 
CTGCAGCAGG GCGGCAACAT CGAGCGGCTG GGCCGCTTCC TGTGGTCGCT GCCCGCCTGC 
GAGCACCTTC ACAAGAATGA AAGCGTGCTC AAGGCCAAGG CCGTGGTGGC CTTCCACCGC 
GGCAACTTCC GCGAGCTCTA CAAGATCCTG GAGAGCCACC AGTTCTCGCC GCACAACCAC 
GCCAAGCTGC AGCAGCTGTG GCTCAAGGCA CACTACATCG AGGCGGAGAA GCTGCGCGGC 
CGACCCCTGG GCGCCGTGGG CAAATACCGC GTGCGCCGCA AATTCCCGCT GCCGCGCTCC 
ATCTGGGACG GCGAGGAGAC CAGCTACTGC TTCAAGGAAA AGAGTCGCAG CGTGCTGCGC 
GAGTGGTACG CGCACAACCC CTACCCTTCA CCCCGCGAGA AGCGTGAGCT GGCGGAGGCC 
ACGGGCCTCA CCACCACACA GGTCAGCAAC TGGTTCAAGA ACCGGCGGCA GCGCGACCGG 
GCGGCCGAGG CCAAGGAAAG GTACGAGGAG AACAACGAGA ACTCCAATTC TAACAGCCAC 
AACCCGCTGA ATGGCAGCGG CAAGTCGGTG TTAGGCAGCT CGGAGGATGA GAAGACTCCA 
TCGGGGACGC CAGACCACTC ATCATCCAGC CCCGCACTGC TCCTCAGCCC GCCGCCCCCT 
GGGCTGCCGT CCCTGCACAG CCTGGGCCAC CCTCCGGGCC CCAGCGCAGT GCCAGTGCCG 
GTGCCAGGCG GAGGTGGAGC GGACCCACTG CAACACCACC ATGGCCTGCA GGACTCCATC 
CTCAACCCCA TGTCAGCCAA CCTCGTGGAC CTGGGCTCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIX2 ( NM_016932.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_058628.3 Homo sapiens SIX homeobox 2 (SIX2), mRNA.

Price & Availability↑

CloneID	OHu18170
Clone ID Related Accession (Same CDS sequence)	NM_016932.5 , NM_016932.4
Accession Version	NM_016932.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1576339200000
Organism	Homo sapiens(human)
Product	homeobox protein SIX2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC012354.11, AF332197.1, BC024033.2, AI697804.1 and AI299144.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_016932.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF332197.1, BC024033.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000303077.7/ ENSP00000304502.6 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCATGC TGCCCACCTT CGGCTTCACG CAGGAGCAAG TGGCGTGCGT GTGCGAGGTG 
CTGCAGCAGG GCGGCAACAT CGAGCGGCTG GGCCGCTTCC TGTGGTCGCT GCCCGCCTGC 
GAGCACCTTC ACAAGAATGA AAGCGTGCTC AAGGCCAAGG CCGTGGTGGC CTTCCACCGC 
GGCAACTTCC GCGAGCTCTA CAAGATCCTG GAGAGCCACC AGTTCTCGCC GCACAACCAC 
GCCAAGCTGC AGCAGCTGTG GCTCAAGGCA CACTACATCG AGGCGGAGAA GCTGCGCGGC 
CGACCCCTGG GCGCCGTGGG CAAATACCGC GTGCGCCGCA AATTCCCGCT GCCGCGCTCC 
ATCTGGGACG GCGAGGAGAC CAGCTACTGC TTCAAGGAAA AGAGTCGCAG CGTGCTGCGC 
GAGTGGTACG CGCACAACCC CTACCCTTCA CCCCGCGAGA AGCGTGAGCT GGCGGAGGCC 
ACGGGCCTCA CCACCACACA GGTCAGCAAC TGGTTCAAGA ACCGGCGGCA GCGCGACCGG 
GCGGCCGAGG CCAAGGAAAG GGAGAACAAC GAGAACTCCA ATTCTAACAG CCACAACCCG 
CTGAATGGCA GCGGCAAGTC GGTGTTAGGC AGCTCGGAGG ATGAGAAGAC TCCATCGGGG 
ACGCCAGACC ACTCATCATC CAGCCCCGCA CTGCTCCTCA GCCCGCCGCC CCCTGGGCTG 
CCGTCCCTGC ACAGCCTGGG CCACCCTCCG GGCCCCAGCG CAGTGCCAGT GCCGGTGCCA 
GGCGGAGGTG GAGCGGACCC ACTGCAACAC CACCATGGCC TGCAGGACTC CATCCTCAAC 
CCCATGTCAG CCAACCTCGT GGACCTGGGC TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058628.3
CDS	343..1218
Translation	MSMLPTFGFTQEQVACVCEVLQQGGNIERLGRFLWSLPACEHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENNENSNSNSHNPLNGSGKSVLGSSEDEKTPSGTPDHSSSSPALLLSPPPPGLPSLHSLGHPPGPSAVPVPVPGGGGADPLQHHHGLQDSILNPMSANLVDLGS

Target ORF information:

RefSeq Version	NM_016932.5
Organism	Homo sapiens(human)
Definition	Homo sapiens SIX homeobox 2 (SIX2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016932.5

ORF Insert Sequence:

ATGTCCATGC TGCCCACCTT CGGCTTCACG CAGGAGCAAG TGGCGTGCGT GTGCGAGGTG 
CTGCAGCAGG GCGGCAACAT CGAGCGGCTG GGCCGCTTCC TGTGGTCGCT GCCCGCCTGC 
GAGCACCTTC ACAAGAATGA AAGCGTGCTC AAGGCCAAGG CCGTGGTGGC CTTCCACCGC 
GGCAACTTCC GCGAGCTCTA CAAGATCCTG GAGAGCCACC AGTTCTCGCC GCACAACCAC 
GCCAAGCTGC AGCAGCTGTG GCTCAAGGCA CACTACATCG AGGCGGAGAA GCTGCGCGGC 
CGACCCCTGG GCGCCGTGGG CAAATACCGC GTGCGCCGCA AATTCCCGCT GCCGCGCTCC 
ATCTGGGACG GCGAGGAGAC CAGCTACTGC TTCAAGGAAA AGAGTCGCAG CGTGCTGCGC 
GAGTGGTACG CGCACAACCC CTACCCTTCA CCCCGCGAGA AGCGTGAGCT GGCGGAGGCC 
ACGGGCCTCA CCACCACACA GGTCAGCAAC TGGTTCAAGA ACCGGCGGCA GCGCGACCGG 
GCGGCCGAGG CCAAGGAAAG GGAGAACAAC GAGAACTCCA ATTCTAACAG CCACAACCCG 
CTGAATGGCA GCGGCAAGTC GGTGTTAGGC AGCTCGGAGG ATGAGAAGAC TCCATCGGGG 
ACGCCAGACC ACTCATCATC CAGCCCCGCA CTGCTCCTCA GCCCGCCGCC CCCTGGGCTG 
CCGTCCCTGC ACAGCCTGGG CCACCCTCCG GGCCCCAGCG CAGTGCCAGT GCCGGTGCCA 
GGCGGAGGTG GAGCGGACCC ACTGCAACAC CACCATGGCC TGCAGGACTC CATCCTCAAC 
CCCATGTCAG CCAACCTCGT GGACCTGGGC TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DNA and cell biology38(7)700-707(2019 Jul)
Wu Y,Song T,Liu M,He Q,Chen L,Liu Y,Ni D,Liu J,Hu Y,Gu Y,Li Q,Zhou Q,Xie Y

A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB.
Nature568(7751)249-253(2019 04)
Liu Z,Mar KB,Hanners NW,Perelman SS,Kanchwala M,Xing C,Schoggins JW,Alto NM

SIX2 Mediates Late-Stage Metastasis via Direct Regulation of
Cancer research79(4)720-734(2019 02)
Oliphant MUJ,Vincent MY,Galbraith MD,Pandey A,Zaberezhnyy V,Rudra P,Johnson KR,Costello JC,Ghosh D,DeGregori J,Espinosa JM,Ford HL

Six2 is negatively correlated with good prognosis and decreases 5-FU sensitivity via suppressing E-cadherin expression in hepatocellular carcinoma cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie104204-210(2018 Aug)
Li JW,Huang CZ,Li JH,Yuan JH,Chen QH,Zhang WF,Xu ZS,Liu YP,Li Y,Zhan MX,Lu LG

SIX2 gene haploinsufficiency leads to a recognizable phenotype with ptosis, frontonasal dysplasia, and conductive hearing loss.
Clinical dysmorphology27(2)27-30(2018 Apr)
Henn A,Weng H,Novak S,Rettenberger G,Gerhardinger A,Rossier E,Zirn B

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SIX2 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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