| Gene Symbol | SMNDC1 |
| Entrez Gene ID | 10285 |
| Full Name | survival motor neuron domain containing 1 |
| Synonyms | SMNR,SPF30,TDRD16C |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a constituent of the spliceosome complex. This gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
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SMNDC1 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following SMNDC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SMNDC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu43918 Clone ID Related Accession (Same CDS sequence) XM_005269382.3 Accession Version XM_005269382.3 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 600bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1575475200000 Organism Homo sapiens(human) Product survival of motor neuron-related-splicing factor 30 isoform X1 Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005269382.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##
1
61
121
181
241
301
361
421
481
541ATGGAAGTTA TAGAACTAAC CAAAGACCTT CTGTCAACTC AACCTTCTGA GACGCTTGCA
AGTTCAGACA GTTTTGCTTC TACTCAACCT ACTCATTCAT GGAAAGTAGG AGACAAGTGT
ATGGCAGTCT GGAGTGAAGA TGGACAGTGT TATGAAGCGG AGATTGAGGA GATAGATGAA
GAAAATGGCA CCGCTGCAAT CACCTTTGCT GGTTATGGCA ATGCTGAAGT GACTCCACTG
TTGAACCTCA AGCCTGTAGA AGAAGGAAGG AAGGCAAAGG AGGACAGTGG CAACAAACCC
ATGTCAAAAA AAGAAATGAT TGCCCAGCAG CGTGAATATA AAAAGAAGAA AGCTTTGAAA
AAAGCTCAGA GAATAAAAGA ACTTGAGCAG GAAAGAGAGG ACCAGAAAGT GAAATGGCAA
CAATTCAACA ACAGAGCCTA TTCTAAAAAC AAAAAAGGCC AGGTAAAGAG GAGTATTTTT
GCTTCACCTG AGAGTGTGAC TGGTAAAGTT GGAGTAGGAA CCTGTGGAAT TGCTGATAAA
CCTATGACAC AATATCAAGA TACCTCTAAA TACAATGTCA GGCATTTGAT GCCTCAATAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq XP_005269439.1 CDS 530..1129 Translation 
Target ORF information:
RefSeq Version XM_005269382.3 Organism Homo sapiens(human) Definition Homo sapiens survival motor neuron domain containing 1 (SMNDC1), transcript variant X1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
XM_005269382.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541ATGGAAGTTA TAGAACTAAC CAAAGACCTT CTGTCAACTC AACCTTCTGA GACGCTTGCA
AGTTCAGACA GTTTTGCTTC TACTCAACCT ACTCATTCAT GGAAAGTAGG AGACAAGTGT
ATGGCAGTCT GGAGTGAAGA TGGACAGTGT TATGAAGCGG AGATTGAGGA GATAGATGAA
GAAAATGGCA CCGCTGCAAT CACCTTTGCT GGTTATGGCA ATGCTGAAGT GACTCCACTG
TTGAACCTCA AGCCTGTAGA AGAAGGAAGG AAGGCAAAGG AGGACAGTGG CAACAAACCC
ATGTCAAAAA AAGAAATGAT TGCCCAGCAG CGTGAATATA AAAAGAAGAA AGCTTTGAAA
AAAGCTCAGA GAATAAAAGA ACTTGAGCAG GAAAGAGAGG ACCAGAAAGT GAAATGGCAA
CAATTCAACA ACAGAGCCTA TTCTAAAAAC AAAAAAGGCC AGGTAAAGAG GAGTATTTTT
GCTTCACCTG AGAGTGTGAC TGGTAAAGTT GGAGTAGGAA CCTGTGGAAT TGCTGATAAA
CCTATGACAC AATATCAAGA TACCTCTAAA TACAATGTCA GGCATTTGAT GCCTCAATAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu19036 Clone ID Related Accession (Same CDS sequence) NM_005871.3 , NM_005871.4 Accession Version NM_005871.3 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 717bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1550332800000 Organism Homo sapiens(human) Product survival of motor neuron-related-splicing factor 30 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ694303.1 and BC011234.1. This sequence is a reference standard in the RefSeqGene project. On Jun 27, 2008 this sequence version replaced NM_005871.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC011234.1, SRR1163655.469350.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661ATGTCAGAGG ATTTAGCAAA GCAGCTGGCA AGCTACAAAG CTCAGCTCCA GCAAGTTGAA
GCTGCATTAT CTGGAAATGG AGAAAATGAA GATTTGCTAA AATTGAAGAA AGATTTACAA
GAAGTTATAG AACTAACCAA AGACCTTCTG TCAACTCAAC CTTCTGAGAC GCTTGCAAGT
TCAGACAGTT TTGCTTCTAC TCAACCTACT CATTCATGGA AAGTAGGAGA CAAGTGTATG
GCAGTCTGGA GTGAAGATGG ACAGTGTTAT GAAGCGGAGA TTGAGGAGAT AGATGAAGAA
AATGGCACCG CTGCAATCAC CTTTGCTGGT TATGGCAATG CTGAAGTGAC TCCACTGTTG
AACCTCAAGC CTGTAGAAGA AGGAAGGAAG GCAAAGGAGG ACAGTGGCAA CAAACCCATG
TCAAAAAAAG AAATGATTGC CCAGCAGCGT GAATATAAAA AGAAGAAAGC TTTGAAAAAA
GCTCAGAGAA TAAAAGAACT TGAGCAGGAA AGAGAGGACC AGAAAGTGAA ATGGCAACAA
TTCAACAACA GAGCCTATTC TAAAAACAAA AAAGGCCAGG TAAAGAGGAG TATTTTTGCT
TCACCTGAGA GTGTGACTGG TAAAGTTGGA GTAGGAACCT GTGGAATTGC TGATAAACCT
ATGACACAAT ATCAAGATAC CTCTAAATAC AATGTCAGGC ATTTGATGCC TCAATAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_005862.1 CDS 203..919 Translation
Target ORF information:
RefSeq Version NM_005871.3 Organism Homo sapiens(human) Definition Homo sapiens survival motor neuron domain containing 1 (SMNDC1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_005871.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661ATGTCAGAGG ATTTAGCAAA GCAGCTGGCA AGCTACAAAG CTCAGCTCCA GCAAGTTGAA
GCTGCATTAT CTGGAAATGG AGAAAATGAA GATTTGCTAA AATTGAAGAA AGATTTACAA
GAAGTTATAG AACTAACCAA AGACCTTCTG TCAACTCAAC CTTCTGAGAC GCTTGCAAGT
TCAGACAGTT TTGCTTCTAC TCAACCTACT CATTCATGGA AAGTAGGAGA CAAGTGTATG
GCAGTCTGGA GTGAAGATGG ACAGTGTTAT GAAGCGGAGA TTGAGGAGAT AGATGAAGAA
AATGGCACCG CTGCAATCAC CTTTGCTGGT TATGGCAATG CTGAAGTGAC TCCACTGTTG
AACCTCAAGC CTGTAGAAGA AGGAAGGAAG GCAAAGGAGG ACAGTGGCAA CAAACCCATG
TCAAAAAAAG AAATGATTGC CCAGCAGCGT GAATATAAAA AGAAGAAAGC TTTGAAAAAA
GCTCAGAGAA TAAAAGAACT TGAGCAGGAA AGAGAGGACC AGAAAGTGAA ATGGCAACAA
TTCAACAACA GAGCCTATTC TAAAAACAAA AAAGGCCAGG TAAAGAGGAG TATTTTTGCT
TCACCTGAGA GTGTGACTGG TAAAGTTGGA GTAGGAACCT GTGGAATTGC TGATAAACCT
ATGACACAAT ATCAAGATAC CTCTAAATAC AATGTCAGGC ATTTGATGCC TCAATAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu19036 Clone ID Related Accession (Same CDS sequence) NM_005871.3 , NM_005871.4 Accession Version NM_005871.4 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 717bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1571932800000 Organism Homo sapiens(human) Product survival of motor neuron-related-splicing factor 30 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ694303.1, BC011234.1 and AL360182.15. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_005871.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.162975.1, SRR1803613.40257.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000369603.10/ ENSP00000358616.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661ATGTCAGAGG ATTTAGCAAA GCAGCTGGCA AGCTACAAAG CTCAGCTCCA GCAAGTTGAA
GCTGCATTAT CTGGAAATGG AGAAAATGAA GATTTGCTAA AATTGAAGAA AGATTTACAA
GAAGTTATAG AACTAACCAA AGACCTTCTG TCAACTCAAC CTTCTGAGAC GCTTGCAAGT
TCAGACAGTT TTGCTTCTAC TCAACCTACT CATTCATGGA AAGTAGGAGA CAAGTGTATG
GCAGTCTGGA GTGAAGATGG ACAGTGTTAT GAAGCGGAGA TTGAGGAGAT AGATGAAGAA
AATGGCACCG CTGCAATCAC CTTTGCTGGT TATGGCAATG CTGAAGTGAC TCCACTGTTG
AACCTCAAGC CTGTAGAAGA AGGAAGGAAG GCAAAGGAGG ACAGTGGCAA CAAACCCATG
TCAAAAAAAG AAATGATTGC CCAGCAGCGT GAATATAAAA AGAAGAAAGC TTTGAAAAAA
GCTCAGAGAA TAAAAGAACT TGAGCAGGAA AGAGAGGACC AGAAAGTGAA ATGGCAACAA
TTCAACAACA GAGCCTATTC TAAAAACAAA AAAGGCCAGG TAAAGAGGAG TATTTTTGCT
TCACCTGAGA GTGTGACTGG TAAAGTTGGA GTAGGAACCT GTGGAATTGC TGATAAACCT
ATGACACAAT ATCAAGATAC CTCTAAATAC AATGTCAGGC ATTTGATGCC TCAATAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_005862.1 CDS 174..890 Translation
Target ORF information:
RefSeq Version NM_005871.4 Organism Homo sapiens(human) Definition Homo sapiens survival motor neuron domain containing 1 (SMNDC1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_005871.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661ATGTCAGAGG ATTTAGCAAA GCAGCTGGCA AGCTACAAAG CTCAGCTCCA GCAAGTTGAA
GCTGCATTAT CTGGAAATGG AGAAAATGAA GATTTGCTAA AATTGAAGAA AGATTTACAA
GAAGTTATAG AACTAACCAA AGACCTTCTG TCAACTCAAC CTTCTGAGAC GCTTGCAAGT
TCAGACAGTT TTGCTTCTAC TCAACCTACT CATTCATGGA AAGTAGGAGA CAAGTGTATG
GCAGTCTGGA GTGAAGATGG ACAGTGTTAT GAAGCGGAGA TTGAGGAGAT AGATGAAGAA
AATGGCACCG CTGCAATCAC CTTTGCTGGT TATGGCAATG CTGAAGTGAC TCCACTGTTG
AACCTCAAGC CTGTAGAAGA AGGAAGGAAG GCAAAGGAGG ACAGTGGCAA CAAACCCATG
TCAAAAAAAG AAATGATTGC CCAGCAGCGT GAATATAAAA AGAAGAAAGC TTTGAAAAAA
GCTCAGAGAA TAAAAGAACT TGAGCAGGAA AGAGAGGACC AGAAAGTGAA ATGGCAACAA
TTCAACAACA GAGCCTATTC TAAAAACAAA AAAGGCCAGG TAAAGAGGAG TATTTTTGCT
TCACCTGAGA GTGTGACTGG TAAAGTTGGA GTAGGAACCT GTGGAATTGC TGATAAACCT
ATGACACAAT ATCAAGATAC CTCTAAATAC AATGTCAGGC ATTTGATGCC TCAATAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
-
PubMed
Fragile X mental retardation protein recognizes a G quadruplex structure within the survival motor neuron domain containing 1 mRNA 5'-UTR.
Molecular bioSystems13(8)1448-1457(2017 Jul)
McAninch DS,Heinaman AM,Lang CN,Moss KR,Bassell GJ,Rita Mihailescu M,Evans TL
Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
Gut63(1)80-7(2014 Jan)
Yang SK,Hong M,Zhao W,Jung Y,Baek J,Tayebi N,Kim KM,Ye BD,Kim KJ,Park SH,Lee I,Lee EJ,Kim WH,Cheon JH,Kim YH,Jang BI,Kim HS,Choi JH,Koo JS,Lee JH,Jung SA,Lee YJ,Jang JY,Shin HD,Kang D,Youn HS,Liu J,Song K
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW
Dynamic protein-protein interaction wiring of the human spliceosome.
Molecular cell45(4)567-80(2012 Feb)
Hegele A,Kamburov A,Grossmann A,Sourlis C,Wowro S,Weimann M,Will CL,Pena V,Lührmann R,Stelzl U
Crystal structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30.
PloS one7(2)e30375(2012)
Liu K,Guo Y,Liu H,Bian C,Lam R,Liu Y,Mackenzie F,Rojas LA,Reinberg D,Bedford MT,Xu RM,Min J
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