| Gene Symbol | SF3B4 |
| Entrez Gene ID | 10262 |
| Full Name | splicing factor 3b subunit 4 |
| Synonyms | AFD1,Hsh49,SAP49,SF3b49 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: | |
| Disorder Html: | Acrofacial dysostosis 1, Nager type, 154400 (3) |
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SF3B4 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following SF3B4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SF3B4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu26484 
Clone ID Related Accession (Same CDS sequence) NM_005850.4 , NM_005850.5 Accession Version NM_005850.4 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1275bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1508601600000 Organism Homo sapiens(human) Product splicing factor 3B subunit 4 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK097315.1, DA535996.1, BC004273.1 and AI925089.1. This sequence is a reference standard in the RefSeqGene project. On Mar 10, 2011 this sequence version replaced NM_005850.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.1548.1, AK097315.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261ATGGCTGCCG GGCCGATCTC CGAGCGGAAT CAGGATGCCA CTGTGTACGT GGGGGGCCTG
GATGAGAAGG TTAGTGAACC GCTGCTGTGG GAACTGTTTC TCCAGGCTGG ACCAGTAGTC
AACACCCACA TGCCAAAGGA TAGAGTCACT GGCCAGCACC AAGGCTATGG CTTTGTGGAA
TTCTTGAGTG AGGAAGATGC TGACTATGCC ATTAAGATCA TGAACATGAT CAAACTCTAT
GGGAAGCCAA TACGGGTGAA CAAAGCATCA GCTCACAACA AAAACCTGGA TGTAGGGGCC
AACATTTTCA TTGGGAACCT GGACCCTGAG ATTGATGAGA AGTTGCTTTA TGATACTTTC
AGCGCCTTTG GGGTCATCTT ACAAACCCCC AAAATTATGC GGGACCCTGA CACAGGCAAC
TCCAAAGGTT ATGCCTTTAT TAATTTTGCT TCATTTGATG CTTCGGATGC AGCAATTGAA
GCCATGAATG GGCAGTACCT CTGTAACCGT CCTATCACCG TATCTTATGC CTTCAAGAAG
GACTCCAAGG GTGAGCGCCA TGGCTCAGCA GCCGAACGAC TTCTGGCAGC TCAGAACCCG
CTCTCCCAGG CTGATCGCCC TCATCAGCTG TTTGCAGATG CACCTCCTCC ACCCTCTGCT
CCCAATCCTG TGGTATCATC ATTGGGGTCT GGGCTTCCTC CACCAGGCAT GCCTCCTCCT
GGCTCCTTCC CACCCCCAGT GCCACCTCCT GGAGCCCTCC CACCTGGGAT ACCCCCAGCC
ATGCCCCCAC CACCTATGCC TCCTGGGGCT GCAGGACATG GCCCCCCATC GGCAGGAACC
CCAGGGGCAG GACATCCTGG TCATGGACAC TCACATCCTC ACCCATTCCC ACCGGGTGGG
ATGCCCCATC CAGGGATGTC TCAGATGCAG CTTGCACACC ATGGCCCTCA TGGCTTAGGA
CATCCCCACG CTGGACCCCC AGGCTCTGGG GGCCAGCCAC CGCCCCGACC ACCACCTGGA
ATGCCTCATC CTGGACCTCC TCCAATGGGC ATGCCCCCCC GAGGGCCTCC ATTCGGATCT
CCCATGGGTC ACCCAGGTCC TATGCCTCCG CATGGTATGC GTGGACCTCC TCCACTGATG
CCCCCCCATG GATACACTGG CCCTCCACGA CCCCCACCCT ATGGCTACCA GCGGGGGCCT
CTCCCTCCAC CCAGACCCAC TCCCCGGCCA CCAGTTCCCC CTCGAGGCCC ACTTCGAGGC
CCTCTCCCTC AGTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_005841.1 CDS 494..1768 Translation 
Target ORF information:
RefSeq Version NM_005850.4 Organism Homo sapiens(human) Definition Homo sapiens splicing factor 3b subunit 4 (SF3B4), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_005850.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261ATGGCTGCCG GGCCGATCTC CGAGCGGAAT CAGGATGCCA CTGTGTACGT GGGGGGCCTG
GATGAGAAGG TTAGTGAACC GCTGCTGTGG GAACTGTTTC TCCAGGCTGG ACCAGTAGTC
AACACCCACA TGCCAAAGGA TAGAGTCACT GGCCAGCACC AAGGCTATGG CTTTGTGGAA
TTCTTGAGTG AGGAAGATGC TGACTATGCC ATTAAGATCA TGAACATGAT CAAACTCTAT
GGGAAGCCAA TACGGGTGAA CAAAGCATCA GCTCACAACA AAAACCTGGA TGTAGGGGCC
AACATTTTCA TTGGGAACCT GGACCCTGAG ATTGATGAGA AGTTGCTTTA TGATACTTTC
AGCGCCTTTG GGGTCATCTT ACAAACCCCC AAAATTATGC GGGACCCTGA CACAGGCAAC
TCCAAAGGTT ATGCCTTTAT TAATTTTGCT TCATTTGATG CTTCGGATGC AGCAATTGAA
GCCATGAATG GGCAGTACCT CTGTAACCGT CCTATCACCG TATCTTATGC CTTCAAGAAG
GACTCCAAGG GTGAGCGCCA TGGCTCAGCA GCCGAACGAC TTCTGGCAGC TCAGAACCCG
CTCTCCCAGG CTGATCGCCC TCATCAGCTG TTTGCAGATG CACCTCCTCC ACCCTCTGCT
CCCAATCCTG TGGTATCATC ATTGGGGTCT GGGCTTCCTC CACCAGGCAT GCCTCCTCCT
GGCTCCTTCC CACCCCCAGT GCCACCTCCT GGAGCCCTCC CACCTGGGAT ACCCCCAGCC
ATGCCCCCAC CACCTATGCC TCCTGGGGCT GCAGGACATG GCCCCCCATC GGCAGGAACC
CCAGGGGCAG GACATCCTGG TCATGGACAC TCACATCCTC ACCCATTCCC ACCGGGTGGG
ATGCCCCATC CAGGGATGTC TCAGATGCAG CTTGCACACC ATGGCCCTCA TGGCTTAGGA
CATCCCCACG CTGGACCCCC AGGCTCTGGG GGCCAGCCAC CGCCCCGACC ACCACCTGGA
ATGCCTCATC CTGGACCTCC TCCAATGGGC ATGCCCCCCC GAGGGCCTCC ATTCGGATCT
CCCATGGGTC ACCCAGGTCC TATGCCTCCG CATGGTATGC GTGGACCTCC TCCACTGATG
CCCCCCCATG GATACACTGG CCCTCCACGA CCCCCACCCT ATGGCTACCA GCGGGGGCCT
CTCCCTCCAC CCAGACCCAC TCCCCGGCCA CCAGTTCCCC CTCGAGGCCC ACTTCGAGGC
CCTCTCCCTC AGTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu26484 Clone ID Related Accession (Same CDS sequence) NM_005850.4 , NM_005850.5 Accession Version NM_005850.5 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1275bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1570636800000 Organism Homo sapiens(human) Product splicing factor 3B subunit 4 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA535996.1, BC004273.1 and AI925089.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_005850.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.596165.1, AK097315.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000271628.9/ ENSP00000271628.8 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261ATGGCTGCCG GGCCGATCTC CGAGCGGAAT CAGGATGCCA CTGTGTACGT GGGGGGCCTG
GATGAGAAGG TTAGTGAACC GCTGCTGTGG GAACTGTTTC TCCAGGCTGG ACCAGTAGTC
AACACCCACA TGCCAAAGGA TAGAGTCACT GGCCAGCACC AAGGCTATGG CTTTGTGGAA
TTCTTGAGTG AGGAAGATGC TGACTATGCC ATTAAGATCA TGAACATGAT CAAACTCTAT
GGGAAGCCAA TACGGGTGAA CAAAGCATCA GCTCACAACA AAAACCTGGA TGTAGGGGCC
AACATTTTCA TTGGGAACCT GGACCCTGAG ATTGATGAGA AGTTGCTTTA TGATACTTTC
AGCGCCTTTG GGGTCATCTT ACAAACCCCC AAAATTATGC GGGACCCTGA CACAGGCAAC
TCCAAAGGTT ATGCCTTTAT TAATTTTGCT TCATTTGATG CTTCGGATGC AGCAATTGAA
GCCATGAATG GGCAGTACCT CTGTAACCGT CCTATCACCG TATCTTATGC CTTCAAGAAG
GACTCCAAGG GTGAGCGCCA TGGCTCAGCA GCCGAACGAC TTCTGGCAGC TCAGAACCCG
CTCTCCCAGG CTGATCGCCC TCATCAGCTG TTTGCAGATG CACCTCCTCC ACCCTCTGCT
CCCAATCCTG TGGTATCATC ATTGGGGTCT GGGCTTCCTC CACCAGGCAT GCCTCCTCCT
GGCTCCTTCC CACCCCCAGT GCCACCTCCT GGAGCCCTCC CACCTGGGAT ACCCCCAGCC
ATGCCCCCAC CACCTATGCC TCCTGGGGCT GCAGGACATG GCCCCCCATC GGCAGGAACC
CCAGGGGCAG GACATCCTGG TCATGGACAC TCACATCCTC ACCCATTCCC ACCGGGTGGG
ATGCCCCATC CAGGGATGTC TCAGATGCAG CTTGCACACC ATGGCCCTCA TGGCTTAGGA
CATCCCCACG CTGGACCCCC AGGCTCTGGG GGCCAGCCAC CGCCCCGACC ACCACCTGGA
ATGCCTCATC CTGGACCTCC TCCAATGGGC ATGCCCCCCC GAGGGCCTCC ATTCGGATCT
CCCATGGGTC ACCCAGGTCC TATGCCTCCG CATGGTATGC GTGGACCTCC TCCACTGATG
CCCCCCCATG GATACACTGG CCCTCCACGA CCCCCACCCT ATGGCTACCA GCGGGGGCCT
CTCCCTCCAC CCAGACCCAC TCCCCGGCCA CCAGTTCCCC CTCGAGGCCC ACTTCGAGGC
CCTCTCCCTC AGTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_005841.1 CDS 45..1319 Translation
Target ORF information:
RefSeq Version NM_005850.5 Organism Homo sapiens(human) Definition Homo sapiens splicing factor 3b subunit 4 (SF3B4), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_005850.5
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261ATGGCTGCCG GGCCGATCTC CGAGCGGAAT CAGGATGCCA CTGTGTACGT GGGGGGCCTG
GATGAGAAGG TTAGTGAACC GCTGCTGTGG GAACTGTTTC TCCAGGCTGG ACCAGTAGTC
AACACCCACA TGCCAAAGGA TAGAGTCACT GGCCAGCACC AAGGCTATGG CTTTGTGGAA
TTCTTGAGTG AGGAAGATGC TGACTATGCC ATTAAGATCA TGAACATGAT CAAACTCTAT
GGGAAGCCAA TACGGGTGAA CAAAGCATCA GCTCACAACA AAAACCTGGA TGTAGGGGCC
AACATTTTCA TTGGGAACCT GGACCCTGAG ATTGATGAGA AGTTGCTTTA TGATACTTTC
AGCGCCTTTG GGGTCATCTT ACAAACCCCC AAAATTATGC GGGACCCTGA CACAGGCAAC
TCCAAAGGTT ATGCCTTTAT TAATTTTGCT TCATTTGATG CTTCGGATGC AGCAATTGAA
GCCATGAATG GGCAGTACCT CTGTAACCGT CCTATCACCG TATCTTATGC CTTCAAGAAG
GACTCCAAGG GTGAGCGCCA TGGCTCAGCA GCCGAACGAC TTCTGGCAGC TCAGAACCCG
CTCTCCCAGG CTGATCGCCC TCATCAGCTG TTTGCAGATG CACCTCCTCC ACCCTCTGCT
CCCAATCCTG TGGTATCATC ATTGGGGTCT GGGCTTCCTC CACCAGGCAT GCCTCCTCCT
GGCTCCTTCC CACCCCCAGT GCCACCTCCT GGAGCCCTCC CACCTGGGAT ACCCCCAGCC
ATGCCCCCAC CACCTATGCC TCCTGGGGCT GCAGGACATG GCCCCCCATC GGCAGGAACC
CCAGGGGCAG GACATCCTGG TCATGGACAC TCACATCCTC ACCCATTCCC ACCGGGTGGG
ATGCCCCATC CAGGGATGTC TCAGATGCAG CTTGCACACC ATGGCCCTCA TGGCTTAGGA
CATCCCCACG CTGGACCCCC AGGCTCTGGG GGCCAGCCAC CGCCCCGACC ACCACCTGGA
ATGCCTCATC CTGGACCTCC TCCAATGGGC ATGCCCCCCC GAGGGCCTCC ATTCGGATCT
CCCATGGGTC ACCCAGGTCC TATGCCTCCG CATGGTATGC GTGGACCTCC TCCACTGATG
CCCCCCCATG GATACACTGG CCCTCCACGA CCCCCACCCT ATGGCTACCA GCGGGGGCCT
CTCCCTCCAC CCAGACCCAC TCCCCGGCCA CCAGTTCCCC CTCGAGGCCC ACTTCGAGGC
CCTCTCCCTC AGTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
SF3B4 is regulated by microRNA-133b and promotes cell proliferation and metastasis in hepatocellular carcinoma.
EBioMedicine3857-68(2018 Dec)
Liu Z,Li W,Pang Y,Zhou Z,Liu S,Cheng K,Qin Q,Jia Y,Liu S
Structure of the human activated spliceosome in three conformational states.
Cell research28(3)307-322(2018 Mar)
Zhang X,Yan C,Zhan X,Li L,Lei J,Shi Y
SF3B4 as an early-stage diagnostic marker and driver of hepatocellular carcinoma.
BMB reports51(2)57-58(2018 Feb)
Shen Q,Nam SW
Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.
Nature communications815522(2017 05)
Teng T,Tsai JH,Puyang X,Seiler M,Peng S,Prajapati S,Aird D,Buonamici S,Caleb B,Chan B,Corson L,Feala J,Fekkes P,Gerard B,Karr C,Korpal M,Liu X,T Lowe J,Mizui Y,Palacino J,Park E,Smith PG,Subramanian V,Wu ZJ,Zou J,Yu L,Chicas A,Warmuth M,Larsen N,Zhu P
SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(3)1010428317695913(2017 Mar)
Zhou W,Ma N,Jiang H,Rong Y,Deng Y,Feng Y,Zhu H,Kuang T,Lou W,Xie D,Wang D
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