TOB1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TOB1
Entrez Gene ID	10140
Full Name	transducer of ERBB2, 1
Synonyms	APRO5,APRO6,PIG49,TOB,TROB,TROB1
General protein information	Preferred Names transducer of ERBB2, 1 Names protein Tob1 proliferation-inducing gene 49 transducer of erbB-2 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.33
Summary	This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].
Disorder MIM:	605523

mRNA and Protein(s)

mRNA	Protein	Name
NM_001243885.2	NP_001230814.1	protein Tob1 isoform 2
NM_005749.3	NP_005740.1	protein Tob1 isoform 1
NM_005749.4	NP_005740.1	protein Tob1 isoform 1
NM_001243877.1	NP_001230806.1	protein Tob1 isoform 1
NM_001243885.1	NP_001230814.1	protein Tob1 isoform 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tob1	NP_033453.2
Rattus norvegicus (Norway rat)	Tob1	NP_579851.2
Xenopus tropicalis (tropical clawed frog)	tob1	NP_001016611.1
Homo sapiens (human)	TOB1	NP_001230806.1
Danio rerio (zebrafish)	tob1b	NP_998139.1
Pan troglodytes (chimpanzee)	TOB1	XP_523795.3
Macaca mulatta (Rhesus monkey)	LOC706873	XP_001095282.1
Danio rerio (zebrafish)	tob1a	NP_938177.1
Canis lupus familiaris (dog)	TOB1	XP_005624733.1
Bos taurus (cattle)	TOB1	NP_001070543.2
Gallus gallus (chicken)	TOB1	NP_001001467.1

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNA-371a-3p promotes progression of gastric cancer by targeting TOB1.
Guo H, Ji F, Zhao X, Yang X, He J, Huang L, Zhang Y
Cancer letters443179-188(2019 02)

High expression of Tob1 indicates poor survival outcome and promotes tumour progression via a Wnt positive feedback loop in colon cancer.
Li D, Xiao L, Ge Y, Fu Y, Zhang W, Cao H, Chen B, Wang H, Zhan YY, Hu T
Molecular cancer17(1)159(2018 11)

MicroRNA-590 promotes pathogenic Th17 cell differentiation through targeting Tob1 and is associated with multiple sclerosis.
Liu Q, Gao Q, Zhang Y, Li Z, Mei X
Biochemical and biophysical research communications493(2)901-908(2017 11)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

The polymorphism in miR-25 attenuated the oncogenic function in gastric cancer.
Zhou J, Zhou J, Wang W, Li W, Wu L, Li G, Shi J, Zhou S
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(4)5515-20(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TOB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TOB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09551	NM_001243877.1 Latest version!	Homo sapiens transducer of ERBB2, 1 (TOB1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu09551	NM_005749.4 Latest version!	Homo sapiens transducer of ERBB2, 1 (TOB1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu10136	NM_001243885.2 Latest version!	Homo sapiens transducer of ERBB2, 1 (TOB1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu09551	NM_005749.3	Homo sapiens transducer of ERBB2, 1 (TOB1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu10136	NM_001243885.1	Homo sapiens transducer of ERBB2, 1 (TOB1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TOB1 ( NM_005749.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005740.1 Homo sapiens transducer of ERBB2, 1 (TOB1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09551
Clone ID Related Accession (Same CDS sequence)	NM_005749.3 , NM_005749.4 , NM_001243877.1
Accession Version	NM_005749.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1508688000000
Organism	Homo sapiens(human)
Product	protein Tob1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA039934.1, BC098415.1 and BC031406.1. On Sep 1, 2011 this sequence version replaced NM_005749.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DB198273.1, SRR1163657.225214.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGCTTG AAATCCAAGT AGCACTAAAT TTTATTATTT CGTATTTGTA CAATAAGCTT 
CCCAGGAGAC GTGTCAACAT TTTTGGTGAA GAACTTGAAA GACTTCTTAA GAAGAAATAT 
GAAGGGCACT GGTATCCTGA AAAGCCATAC AAAGGATCGG GGTTTAGATG TATACACATA 
GGGGAGAAAG TGGACCCAGT GATTGAACAA GCATCCAAAG AGAGTGGTTT GGACATTGAT 
GATGTTCGTG GCAATCTGCC ACAGGATCTT AGTGTTTGGA TCGACCCATT TGAGGTTTCT 
TACCAAATTG GTGAAAAGGG ACCAGTGAAG GTGCTTTACG TGGATGATAA TAATGAAAAT 
GGATGTGAGT TGGATAAGGA GATCAAAAAC AGCTTTAACC CAGAGGCCCA GGTTTTTATG 
CCCATAAGTG ACCCAGCCTC ATCAGTGTCC AGCTCTCCAT CGCCTCCTTT TGGTCACTCT 
GCTGCTGTAA GCCCTACCTT CATGCCCCGG TCCACTCAGC CTTTAACCTT TACCACTGCC 
ACTTTTGCTG CCACCAAGTT CGGCTCTACC AAAATGAAGA ATAGTGGCCG TAGCAACAAG 
GTTGCACGTA CTTCTCCCAT CAACCTCGGC TTGAATGTGA ATGACCTCTT GAAGCAGAAA 
GCCATCTCTT CCTCAATGCA CTCTCTGTAT GGGCTTGGCT TGGGTAGCCA GCAGCAGCCA 
CAGCAACAGC AGCAGCCAGC CCAGCCGCCA CCGCCACCAC CACCACCACA GCAGCAACAA 
CAGCAGAAAA CCTCTGCTCT TTCTCCTAAT GCCAAGGAAT TTATTTTTCC TAATATGCAG 
GGTCAAGGTA GTAGTACCAA TGGAATGTTC CCAGGTGACA GCCCCCTTAA CCTCAGTCCT 
CTCCAGTACA GTAATGCCTT TGATGTGTTT GCAGCCTATG GAGGCCTCAA TGAGAAATCT 
TTTGTAGATG GCTTGAATTT TAGCTTAAAT AACATGCAGT ATTCTAACCA GCAATTCCAG 
CCTGTTATGG CTAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005740.1
CDS	444..1481
Translation	MQLEIQVALNFIISYLYNKLPRRRVNIFGEELERLLKKKYEGHWYPEKPYKGSGFRCIHIGEKVDPVIEQASKESGLDIDDVRGNLPQDLSVWIDPFEVSYQIGEKGPVKVLYVDDNNENGCELDKEIKNSFNPEAQVFMPISDPASSVSSSPSPPFGHSAAVSPTFMPRSTQPLTFTTATFAATKFGSTKMKNSGRSNKVARTSPINLGLNVNDLLKQKAISSSMHSLYGLGLGSQQQPQQQQQPAQPPPPPPPPQQQQQQKTSALSPNAKEFIFPNMQGQGSSTNGMFPGDSPLNLSPLQYSNAFDVFAAYGGLNEKSFVDGLNFSLNNMQYSNQQFQPVMAN

Target ORF information:

RefSeq Version	NM_005749.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transducer of ERBB2, 1 (TOB1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005749.3

ORF Insert Sequence:

ATGCAGCTTG AAATCCAAGT AGCACTAAAT TTTATTATTT CGTATTTGTA CAATAAGCTT 
CCCAGGAGAC GTGTCAACAT TTTTGGTGAA GAACTTGAAA GACTTCTTAA GAAGAAATAT 
GAAGGGCACT GGTATCCTGA AAAGCCATAC AAAGGATCGG GGTTTAGATG TATACACATA 
GGGGAGAAAG TGGACCCAGT GATTGAACAA GCATCCAAAG AGAGTGGTTT GGACATTGAT 
GATGTTCGTG GCAATCTGCC ACAGGATCTT AGTGTTTGGA TCGACCCATT TGAGGTTTCT 
TACCAAATTG GTGAAAAGGG ACCAGTGAAG GTGCTTTACG TGGATGATAA TAATGAAAAT 
GGATGTGAGT TGGATAAGGA GATCAAAAAC AGCTTTAACC CAGAGGCCCA GGTTTTTATG 
CCCATAAGTG ACCCAGCCTC ATCAGTGTCC AGCTCTCCAT CGCCTCCTTT TGGTCACTCT 
GCTGCTGTAA GCCCTACCTT CATGCCCCGG TCCACTCAGC CTTTAACCTT TACCACTGCC 
ACTTTTGCTG CCACCAAGTT CGGCTCTACC AAAATGAAGA ATAGTGGCCG TAGCAACAAG 
GTTGCACGTA CTTCTCCCAT CAACCTCGGC TTGAATGTGA ATGACCTCTT GAAGCAGAAA 
GCCATCTCTT CCTCAATGCA CTCTCTGTAT GGGCTTGGCT TGGGTAGCCA GCAGCAGCCA 
CAGCAACAGC AGCAGCCAGC CCAGCCGCCA CCGCCACCAC CACCACCACA GCAGCAACAA 
CAGCAGAAAA CCTCTGCTCT TTCTCCTAAT GCCAAGGAAT TTATTTTTCC TAATATGCAG 
GGTCAAGGTA GTAGTACCAA TGGAATGTTC CCAGGTGACA GCCCCCTTAA CCTCAGTCCT 
CTCCAGTACA GTAATGCCTT TGATGTGTTT GCAGCCTATG GAGGCCTCAA TGAGAAATCT 
TTTGTAGATG GCTTGAATTT TAGCTTAAAT AACATGCAGT ATTCTAACCA GCAATTCCAG 
CCTGTTATGG CTAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TOB1 ( NM_005749.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005740.1 Homo sapiens transducer of ERBB2, 1 (TOB1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09551
Clone ID Related Accession (Same CDS sequence)	NM_005749.3 , NM_005749.4 , NM_001243877.1
Accession Version	NM_005749.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573315200000
Organism	Homo sapiens(human)
Product	protein Tob1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA039934.1, BC098415.1 and BC031406.1. On Nov 22, 2018 this sequence version replaced NM_005749.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.256920.1, SRR1163657.225214.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000499247.3/ ENSP00000427695.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGCTTG AAATCCAAGT AGCACTAAAT TTTATTATTT CGTATTTGTA CAATAAGCTT 
CCCAGGAGAC GTGTCAACAT TTTTGGTGAA GAACTTGAAA GACTTCTTAA GAAGAAATAT 
GAAGGGCACT GGTATCCTGA AAAGCCATAC AAAGGATCGG GGTTTAGATG TATACACATA 
GGGGAGAAAG TGGACCCAGT GATTGAACAA GCATCCAAAG AGAGTGGTTT GGACATTGAT 
GATGTTCGTG GCAATCTGCC ACAGGATCTT AGTGTTTGGA TCGACCCATT TGAGGTTTCT 
TACCAAATTG GTGAAAAGGG ACCAGTGAAG GTGCTTTACG TGGATGATAA TAATGAAAAT 
GGATGTGAGT TGGATAAGGA GATCAAAAAC AGCTTTAACC CAGAGGCCCA GGTTTTTATG 
CCCATAAGTG ACCCAGCCTC ATCAGTGTCC AGCTCTCCAT CGCCTCCTTT TGGTCACTCT 
GCTGCTGTAA GCCCTACCTT CATGCCCCGG TCCACTCAGC CTTTAACCTT TACCACTGCC 
ACTTTTGCTG CCACCAAGTT CGGCTCTACC AAAATGAAGA ATAGTGGCCG TAGCAACAAG 
GTTGCACGTA CTTCTCCCAT CAACCTCGGC TTGAATGTGA ATGACCTCTT GAAGCAGAAA 
GCCATCTCTT CCTCAATGCA CTCTCTGTAT GGGCTTGGCT TGGGTAGCCA GCAGCAGCCA 
CAGCAACAGC AGCAGCCAGC CCAGCCGCCA CCGCCACCAC CACCACCACA GCAGCAACAA 
CAGCAGAAAA CCTCTGCTCT TTCTCCTAAT GCCAAGGAAT TTATTTTTCC TAATATGCAG 
GGTCAAGGTA GTAGTACCAA TGGAATGTTC CCAGGTGACA GCCCCCTTAA CCTCAGTCCT 
CTCCAGTACA GTAATGCCTT TGATGTGTTT GCAGCCTATG GAGGCCTCAA TGAGAAATCT 
TTTGTAGATG GCTTGAATTT TAGCTTAAAT AACATGCAGT ATTCTAACCA GCAATTCCAG 
CCTGTTATGG CTAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005740.1
CDS	444..1481
Translation	MQLEIQVALNFIISYLYNKLPRRRVNIFGEELERLLKKKYEGHWYPEKPYKGSGFRCIHIGEKVDPVIEQASKESGLDIDDVRGNLPQDLSVWIDPFEVSYQIGEKGPVKVLYVDDNNENGCELDKEIKNSFNPEAQVFMPISDPASSVSSSPSPPFGHSAAVSPTFMPRSTQPLTFTTATFAATKFGSTKMKNSGRSNKVARTSPINLGLNVNDLLKQKAISSSMHSLYGLGLGSQQQPQQQQQPAQPPPPPPPPQQQQQQKTSALSPNAKEFIFPNMQGQGSSTNGMFPGDSPLNLSPLQYSNAFDVFAAYGGLNEKSFVDGLNFSLNNMQYSNQQFQPVMAN

Target ORF information:

RefSeq Version	NM_005749.4
Organism	Homo sapiens(human)
Definition	Homo sapiens transducer of ERBB2, 1 (TOB1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005749.4

ORF Insert Sequence:

ATGCAGCTTG AAATCCAAGT AGCACTAAAT TTTATTATTT CGTATTTGTA CAATAAGCTT 
CCCAGGAGAC GTGTCAACAT TTTTGGTGAA GAACTTGAAA GACTTCTTAA GAAGAAATAT 
GAAGGGCACT GGTATCCTGA AAAGCCATAC AAAGGATCGG GGTTTAGATG TATACACATA 
GGGGAGAAAG TGGACCCAGT GATTGAACAA GCATCCAAAG AGAGTGGTTT GGACATTGAT 
GATGTTCGTG GCAATCTGCC ACAGGATCTT AGTGTTTGGA TCGACCCATT TGAGGTTTCT 
TACCAAATTG GTGAAAAGGG ACCAGTGAAG GTGCTTTACG TGGATGATAA TAATGAAAAT 
GGATGTGAGT TGGATAAGGA GATCAAAAAC AGCTTTAACC CAGAGGCCCA GGTTTTTATG 
CCCATAAGTG ACCCAGCCTC ATCAGTGTCC AGCTCTCCAT CGCCTCCTTT TGGTCACTCT 
GCTGCTGTAA GCCCTACCTT CATGCCCCGG TCCACTCAGC CTTTAACCTT TACCACTGCC 
ACTTTTGCTG CCACCAAGTT CGGCTCTACC AAAATGAAGA ATAGTGGCCG TAGCAACAAG 
GTTGCACGTA CTTCTCCCAT CAACCTCGGC TTGAATGTGA ATGACCTCTT GAAGCAGAAA 
GCCATCTCTT CCTCAATGCA CTCTCTGTAT GGGCTTGGCT TGGGTAGCCA GCAGCAGCCA 
CAGCAACAGC AGCAGCCAGC CCAGCCGCCA CCGCCACCAC CACCACCACA GCAGCAACAA 
CAGCAGAAAA CCTCTGCTCT TTCTCCTAAT GCCAAGGAAT TTATTTTTCC TAATATGCAG 
GGTCAAGGTA GTAGTACCAA TGGAATGTTC CCAGGTGACA GCCCCCTTAA CCTCAGTCCT 
CTCCAGTACA GTAATGCCTT TGATGTGTTT GCAGCCTATG GAGGCCTCAA TGAGAAATCT 
TTTGTAGATG GCTTGAATTT TAGCTTAAAT AACATGCAGT ATTCTAACCA GCAATTCCAG 
CCTGTTATGG CTAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TOB1 ( NM_001243877.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001230806.1 Homo sapiens transducer of ERBB2, 1 (TOB1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09551
Clone ID Related Accession (Same CDS sequence)	NM_005749.3 , NM_005749.4 , NM_001243877.1
Accession Version	NM_001243877.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573315200000
Organism	Homo sapiens(human)
Product	protein Tob1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313904.1 and BC031406.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK313904.1, DA251060.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162841 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGCTTG AAATCCAAGT AGCACTAAAT TTTATTATTT CGTATTTGTA CAATAAGCTT 
CCCAGGAGAC GTGTCAACAT TTTTGGTGAA GAACTTGAAA GACTTCTTAA GAAGAAATAT 
GAAGGGCACT GGTATCCTGA AAAGCCATAC AAAGGATCGG GGTTTAGATG TATACACATA 
GGGGAGAAAG TGGACCCAGT GATTGAACAA GCATCCAAAG AGAGTGGTTT GGACATTGAT 
GATGTTCGTG GCAATCTGCC ACAGGATCTT AGTGTTTGGA TCGACCCATT TGAGGTTTCT 
TACCAAATTG GTGAAAAGGG ACCAGTGAAG GTGCTTTACG TGGATGATAA TAATGAAAAT 
GGATGTGAGT TGGATAAGGA GATCAAAAAC AGCTTTAACC CAGAGGCCCA GGTTTTTATG 
CCCATAAGTG ACCCAGCCTC ATCAGTGTCC AGCTCTCCAT CGCCTCCTTT TGGTCACTCT 
GCTGCTGTAA GCCCTACCTT CATGCCCCGG TCCACTCAGC CTTTAACCTT TACCACTGCC 
ACTTTTGCTG CCACCAAGTT CGGCTCTACC AAAATGAAGA ATAGTGGCCG TAGCAACAAG 
GTTGCACGTA CTTCTCCCAT CAACCTCGGC TTGAATGTGA ATGACCTCTT GAAGCAGAAA 
GCCATCTCTT CCTCAATGCA CTCTCTGTAT GGGCTTGGCT TGGGTAGCCA GCAGCAGCCA 
CAGCAACAGC AGCAGCCAGC CCAGCCGCCA CCGCCACCAC CACCACCACA GCAGCAACAA 
CAGCAGAAAA CCTCTGCTCT TTCTCCTAAT GCCAAGGAAT TTATTTTTCC TAATATGCAG 
GGTCAAGGTA GTAGTACCAA TGGAATGTTC CCAGGTGACA GCCCCCTTAA CCTCAGTCCT 
CTCCAGTACA GTAATGCCTT TGATGTGTTT GCAGCCTATG GAGGCCTCAA TGAGAAATCT 
TTTGTAGATG GCTTGAATTT TAGCTTAAAT AACATGCAGT ATTCTAACCA GCAATTCCAG 
CCTGTTATGG CTAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001230806.1
CDS	430..1467
Translation	MQLEIQVALNFIISYLYNKLPRRRVNIFGEELERLLKKKYEGHWYPEKPYKGSGFRCIHIGEKVDPVIEQASKESGLDIDDVRGNLPQDLSVWIDPFEVSYQIGEKGPVKVLYVDDNNENGCELDKEIKNSFNPEAQVFMPISDPASSVSSSPSPPFGHSAAVSPTFMPRSTQPLTFTTATFAATKFGSTKMKNSGRSNKVARTSPINLGLNVNDLLKQKAISSSMHSLYGLGLGSQQQPQQQQQPAQPPPPPPPPQQQQQQKTSALSPNAKEFIFPNMQGQGSSTNGMFPGDSPLNLSPLQYSNAFDVFAAYGGLNEKSFVDGLNFSLNNMQYSNQQFQPVMAN

Target ORF information:

RefSeq Version	NM_001243877.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transducer of ERBB2, 1 (TOB1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001243877.1

ORF Insert Sequence:

ATGCAGCTTG AAATCCAAGT AGCACTAAAT TTTATTATTT CGTATTTGTA CAATAAGCTT 
CCCAGGAGAC GTGTCAACAT TTTTGGTGAA GAACTTGAAA GACTTCTTAA GAAGAAATAT 
GAAGGGCACT GGTATCCTGA AAAGCCATAC AAAGGATCGG GGTTTAGATG TATACACATA 
GGGGAGAAAG TGGACCCAGT GATTGAACAA GCATCCAAAG AGAGTGGTTT GGACATTGAT 
GATGTTCGTG GCAATCTGCC ACAGGATCTT AGTGTTTGGA TCGACCCATT TGAGGTTTCT 
TACCAAATTG GTGAAAAGGG ACCAGTGAAG GTGCTTTACG TGGATGATAA TAATGAAAAT 
GGATGTGAGT TGGATAAGGA GATCAAAAAC AGCTTTAACC CAGAGGCCCA GGTTTTTATG 
CCCATAAGTG ACCCAGCCTC ATCAGTGTCC AGCTCTCCAT CGCCTCCTTT TGGTCACTCT 
GCTGCTGTAA GCCCTACCTT CATGCCCCGG TCCACTCAGC CTTTAACCTT TACCACTGCC 
ACTTTTGCTG CCACCAAGTT CGGCTCTACC AAAATGAAGA ATAGTGGCCG TAGCAACAAG 
GTTGCACGTA CTTCTCCCAT CAACCTCGGC TTGAATGTGA ATGACCTCTT GAAGCAGAAA 
GCCATCTCTT CCTCAATGCA CTCTCTGTAT GGGCTTGGCT TGGGTAGCCA GCAGCAGCCA 
CAGCAACAGC AGCAGCCAGC CCAGCCGCCA CCGCCACCAC CACCACCACA GCAGCAACAA 
CAGCAGAAAA CCTCTGCTCT TTCTCCTAAT GCCAAGGAAT TTATTTTTCC TAATATGCAG 
GGTCAAGGTA GTAGTACCAA TGGAATGTTC CCAGGTGACA GCCCCCTTAA CCTCAGTCCT 
CTCCAGTACA GTAATGCCTT TGATGTGTTT GCAGCCTATG GAGGCCTCAA TGAGAAATCT 
TTTGTAGATG GCTTGAATTT TAGCTTAAAT AACATGCAGT ATTCTAACCA GCAATTCCAG 
CCTGTTATGG CTAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TOB1 ( NM_001243885.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001230814.1 Homo sapiens transducer of ERBB2, 1 (TOB1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu10136
Clone ID Related Accession (Same CDS sequence)	NM_001243885.2 , NM_001243885.1
Accession Version	NM_001243885.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573315200000
Organism	Homo sapiens(human)
Product	protein Tob1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA039934.1, AA675891.1, AK313904.1 and BC031406.1. On May 31, 2019 this sequence version replaced NM_001243885.1. Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.1184659.1, SRR3476690.98684.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCATAA GTGACCCAGC CTCATCAGTG TCCAGCTCTC CATCGCCTCC TTTTGGTCAC 
TCTGCTGCTG TAAGCCCTAC CTTCATGCCC CGGTCCACTC AGCCTTTAAC CTTTACCACT 
GCCACTTTTG CTGCCACCAA GTTCGGCTCT ACCAAAATGA AGAATAGTGG CCGTAGCAAC 
AAGGTTGCAC GTACTTCTCC CATCAACCTC GGCTTGAATG TGAATGACCT CTTGAAGCAG 
AAAGCCATCT CTTCCTCAAT GCACTCTCTG TATGGGCTTG GCTTGGGTAG CCAGCAGCAG 
CCACAGCAAC AGCAGCAGCC AGCCCAGCCG CCACCGCCAC CACCACCACC ACAGCAGCAA 
CAACAGCAGA AAACCTCTGC TCTTTCTCCT AATGCCAAGG AATTTATTTT TCCTAATATG 
CAGGGTCAAG GTAGTAGTAC CAATGGAATG TTCCCAGGTG ACAGCCCCCT TAACCTCAGT 
CCTCTCCAGT ACAGTAATGC CTTTGATGTG TTTGCAGCCT ATGGAGGCCT CAATGAGAAA 
TCTTTTGTAG ATGGCTTGAA TTTTAGCTTA AATAACATGC AGTATTCTAA CCAGCAATTC 
CAGCCTGTTA TGGCTAACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001230814.1
CDS	658..1278
Translation	MPISDPASSVSSSPSPPFGHSAAVSPTFMPRSTQPLTFTTATFAATKFGSTKMKNSGRSNKVARTSPINLGLNVNDLLKQKAISSSMHSLYGLGLGSQQQPQQQQQPAQPPPPPPPPQQQQQQKTSALSPNAKEFIFPNMQGQGSSTNGMFPGDSPLNLSPLQYSNAFDVFAAYGGLNEKSFVDGLNFSLNNMQYSNQQFQPVMAN

Target ORF information:

RefSeq Version	NM_001243885.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transducer of ERBB2, 1 (TOB1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001243885.2

ORF Insert Sequence:

ATGCCCATAA GTGACCCAGC CTCATCAGTG TCCAGCTCTC CATCGCCTCC TTTTGGTCAC 
TCTGCTGCTG TAAGCCCTAC CTTCATGCCC CGGTCCACTC AGCCTTTAAC CTTTACCACT 
GCCACTTTTG CTGCCACCAA GTTCGGCTCT ACCAAAATGA AGAATAGTGG CCGTAGCAAC 
AAGGTTGCAC GTACTTCTCC CATCAACCTC GGCTTGAATG TGAATGACCT CTTGAAGCAG 
AAAGCCATCT CTTCCTCAAT GCACTCTCTG TATGGGCTTG GCTTGGGTAG CCAGCAGCAG 
CCACAGCAAC AGCAGCAGCC AGCCCAGCCG CCACCGCCAC CACCACCACC ACAGCAGCAA 
CAACAGCAGA AAACCTCTGC TCTTTCTCCT AATGCCAAGG AATTTATTTT TCCTAATATG 
CAGGGTCAAG GTAGTAGTAC CAATGGAATG TTCCCAGGTG ACAGCCCCCT TAACCTCAGT 
CCTCTCCAGT ACAGTAATGC CTTTGATGTG TTTGCAGCCT ATGGAGGCCT CAATGAGAAA 
TCTTTTGTAG ATGGCTTGAA TTTTAGCTTA AATAACATGC AGTATTCTAA CCAGCAATTC 
CAGCCTGTTA TGGCTAACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TOB1 ( NM_001243885.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001230814.1 Homo sapiens transducer of ERBB2, 1 (TOB1), transcript variant 3, mRNA.

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CloneID	OHu10136
Clone ID Related Accession (Same CDS sequence)	NM_001243885.2 , NM_001243885.1
Accession Version	NM_001243885.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1529769600000
Organism	Homo sapiens(human)
Product	protein Tob1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA039934.1, AA675891.1, AK313904.1 and BC031406.1. Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA907335.1, AA675891.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCATAA GTGACCCAGC CTCATCAGTG TCCAGCTCTC CATCGCCTCC TTTTGGTCAC 
TCTGCTGCTG TAAGCCCTAC CTTCATGCCC CGGTCCACTC AGCCTTTAAC CTTTACCACT 
GCCACTTTTG CTGCCACCAA GTTCGGCTCT ACCAAAATGA AGAATAGTGG CCGTAGCAAC 
AAGGTTGCAC GTACTTCTCC CATCAACCTC GGCTTGAATG TGAATGACCT CTTGAAGCAG 
AAAGCCATCT CTTCCTCAAT GCACTCTCTG TATGGGCTTG GCTTGGGTAG CCAGCAGCAG 
CCACAGCAAC AGCAGCAGCC AGCCCAGCCG CCACCGCCAC CACCACCACC ACAGCAGCAA 
CAACAGCAGA AAACCTCTGC TCTTTCTCCT AATGCCAAGG AATTTATTTT TCCTAATATG 
CAGGGTCAAG GTAGTAGTAC CAATGGAATG TTCCCAGGTG ACAGCCCCCT TAACCTCAGT 
CCTCTCCAGT ACAGTAATGC CTTTGATGTG TTTGCAGCCT ATGGAGGCCT CAATGAGAAA 
TCTTTTGTAG ATGGCTTGAA TTTTAGCTTA AATAACATGC AGTATTCTAA CCAGCAATTC 
CAGCCTGTTA TGGCTAACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001230814.1
CDS	658..1278
Translation	MPISDPASSVSSSPSPPFGHSAAVSPTFMPRSTQPLTFTTATFAATKFGSTKMKNSGRSNKVARTSPINLGLNVNDLLKQKAISSSMHSLYGLGLGSQQQPQQQQQPAQPPPPPPPPQQQQQQKTSALSPNAKEFIFPNMQGQGSSTNGMFPGDSPLNLSPLQYSNAFDVFAAYGGLNEKSFVDGLNFSLNNMQYSNQQFQPVMAN

Target ORF information:

RefSeq Version	NM_001243885.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transducer of ERBB2, 1 (TOB1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001243885.1

ORF Insert Sequence:

ATGCCCATAA GTGACCCAGC CTCATCAGTG TCCAGCTCTC CATCGCCTCC TTTTGGTCAC 
TCTGCTGCTG TAAGCCCTAC CTTCATGCCC CGGTCCACTC AGCCTTTAAC CTTTACCACT 
GCCACTTTTG CTGCCACCAA GTTCGGCTCT ACCAAAATGA AGAATAGTGG CCGTAGCAAC 
AAGGTTGCAC GTACTTCTCC CATCAACCTC GGCTTGAATG TGAATGACCT CTTGAAGCAG 
AAAGCCATCT CTTCCTCAAT GCACTCTCTG TATGGGCTTG GCTTGGGTAG CCAGCAGCAG 
CCACAGCAAC AGCAGCAGCC AGCCCAGCCG CCACCGCCAC CACCACCACC ACAGCAGCAA 
CAACAGCAGA AAACCTCTGC TCTTTCTCCT AATGCCAAGG AATTTATTTT TCCTAATATG 
CAGGGTCAAG GTAGTAGTAC CAATGGAATG TTCCCAGGTG ACAGCCCCCT TAACCTCAGT 
CCTCTCCAGT ACAGTAATGC CTTTGATGTG TTTGCAGCCT ATGGAGGCCT CAATGAGAAA 
TCTTTTGTAG ATGGCTTGAA TTTTAGCTTA AATAACATGC AGTATTCTAA CCAGCAATTC 
CAGCCTGTTA TGGCTAACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNA-371a-3p promotes progression of gastric cancer by targeting TOB1.
Cancer letters443179-188(2019 02)
Guo H,Ji F,Zhao X,Yang X,He J,Huang L,Zhang Y

High expression of Tob1 indicates poor survival outcome and promotes tumour progression via a Wnt positive feedback loop in colon cancer.
Molecular cancer17(1)159(2018 11)
Li D,Xiao L,Ge Y,Fu Y,Zhang W,Cao H,Chen B,Wang H,Zhan YY,Hu T

MicroRNA-590 promotes pathogenic Th17 cell differentiation through targeting Tob1 and is associated with multiple sclerosis.
Biochemical and biophysical research communications493(2)901-908(2017 11)
Liu Q,Gao Q,Zhang Y,Li Z,Mei X

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

The polymorphism in miR-25 attenuated the oncogenic function in gastric cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(4)5515-20(2016 Apr)
Zhou J,Zhou J,Wang W,Li W,Wu L,Li G,Shi J,Zhou S

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TOB1 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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