SGK2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SGK2
Entrez Gene ID	10110
Full Name	SGK2, serine/threonine kinase 2
Synonyms	H-SGK2,dJ138B7.2
General protein information	Preferred Names SGK2, serine/threonine kinase 2 Names serine/threonine-protein kinase Sgk2 serum/glucocorticoid regulated kinase 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.12
Summary	This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010].
Disorder MIM:	607589

mRNA and Protein(s)

mRNA	Protein	Name
NM_001199264.1	NP_001186193.1	serine/threonine-protein kinase Sgk2 isoform alpha
NM_170693.3	NP_733794.1	serine/threonine-protein kinase Sgk2 isoform alpha
NM_170693.2	NP_733794.1	serine/threonine-protein kinase Sgk2 isoform alpha
NM_016276.3	NP_057360.2	serine/threonine-protein kinase Sgk2 isoform beta

Pathways from BioSystems

Homologies

Magnaporthe oryzae (rice blast fungus)	MGG_06599	XP_003716929.1
Homo sapiens (human)	SGK2	NP_057360.2
Danio rerio (zebrafish)	sgk2a	NP_001107094.1
Kluyveromyces lactis	KLLA0B12716g	XP_452097.1
Macaca mulatta (Rhesus monkey)	SGK2	XP_001083986.2
Mus musculus (house mouse)	Sgk2	NP_038759.1
Gallus gallus (chicken)	SGK2	XP_004947056.1
Saccharomyces cerevisiae (baker's yeast)	YPK2	NP_013822.1
Eremothecium gossypii	AGOS_ABL028W	NP_982919.2
Rattus norvegicus (Norway rat)	Sgk2	NP_604458.1
Xenopus tropicalis (tropical clawed frog)	sgk2	XP_002932914.2
Schizosaccharomyces pombe (fission yeast)	gad8	NP_588010.1
Neurospora crassa	NCU07280	XP_962134.2
Pan troglodytes (chimpanzee)	SGK2	XP_001142856.2
Canis lupus familiaris (dog)	SGK2	XP_005635135.1
Bos taurus (cattle)	SGK2	NP_001069228.1
Saccharomyces cerevisiae (baker's yeast)	YPK1	NP_012796.1

Gene Ontology
Bibliography

Related articles in PubMed

SGK2 promotes hepatocellular carcinoma progression and mediates GSK-3β/β-catenin signaling in HCC cells.
Liu J, Zhang G, Lv Y, Zhang X, Ying C, Yang S, Kong X, Yu Y
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(6)1010428317700408(2017 Jun)

Parental origin of the deletion del(20q) in Shwachman-Diamond patients and loss of the paternally derived allele of the imprinted L3MBTL1 gene.
Nacci L, Valli R, Maria Pinto R, Zecca M, Cipolli M, Morini J, Cesaro S, Boveri E, Rosti V, Corti P, Ambroni M, Pasquali F, Danesino C, Maserati E, Minelli A
Genes, chromosomes & cancer56(1)51-58(2017 01)

Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2.
Wang H, Xu D, Toh MF, Pao AC, You G
Biochemical pharmacology102120-129(2016 Feb)

Statin-activated nuclear receptor PXR promotes SGK2 dephosphorylation by scaffolding PP2C to induce hepatic gluconeogenesis.
Gotoh S, Negishi M
Scientific reports514076(2015 Sep)

Serum- and glucocorticoid-regulated kinase 2 determines drug-activated pregnane X receptor to induce gluconeogenesis in human liver cells.
Gotoh S, Negishi M
The Journal of pharmacology and experimental therapeutics348(1)131-40(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SGK2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SGK2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07137	NM_016276.3 Latest version!	Homo sapiens serum/glucocorticoid regulated kinase 2 (SGK2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu01025	NM_001199264.1 Latest version!	Homo sapiens serum/glucocorticoid regulated kinase 2 (SGK2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
OHu01025	NM_170693.3 Latest version!	Homo sapiens serum/glucocorticoid regulated kinase 2 (SGK2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
View Old Accession Versions >>
OHu01025	NM_170693.2	Homo sapiens serum/glucocorticoid regulated kinase 2 (SGK2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SGK2 ( NM_016276.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057360.2 Homo sapiens serum/glucocorticoid regulated kinase 2 (SGK2), transcript variant 2, mRNA.

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CloneID	OHu07137
Clone ID Related Accession (Same CDS sequence)	NM_016276.3
Accession Version	NM_016276.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1284bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550160000000
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase Sgk2 isoform beta
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF186470.1, CD627734.1 and BC065511.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2002 this sequence version replaced NM_016276.2. Transcript Variant: This variant (2) encodes the longer isoform (beta). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF186470.1, SRR1803611.131136.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGGGGT TGCTTACCTC GGGTAGGAAA CCCTCAGGCG GTGGCAGGTG CACAGGTAGG 
GGAGGATGGA GAGGGCAGTG GTGCCTGAAG CCCTGGATGG GCGGAGCTGA CCCCCCAACA 
CCAACTCTCT CATGCCTGCT CCTCCCTGTC CCCCCAGAGC TGCCTGATCA TTGCTACAGA 
ATGAACTCTA GCCCAGCTGG GACCCCAAGT CCACAGCCCT CCAGGGCCAA TGGGAACATC 
AACCTGGGGC CTTCAGCCAA CCCAAATGCC CAGCCCACGG ACTTCGACTT CCTCAAAGTC 
ATCGGCAAAG GGAACTACGG GAAGGTCCTA CTGGCCAAGC GCAAGTCTGA TGGGGCGTTC 
TATGCAGTGA AGGTACTACA GAAAAAGTCC ATCTTAAAGA AGAAAGAGCA GAGCCACATC 
ATGGCAGAGC GCAGTGTGCT TCTGAAGAAC GTGCGGCACC CCTTCCTCGT GGGCCTGCGC 
TACTCCTTCC AGACACCTGA GAAGCTCTAC TTCGTGCTCG ACTATGTCAA CGGGGGAGAG 
CTCTTCTTCC ACCTGCAGCG GGAGCGCCGG TTCCTGGAGC CCCGGGCCAG GTTCTACGCT 
GCTGAGGTGG CCAGCGCCAT TGGCTACCTG CACTCCCTCA ACATCATTTA CAGGGATCTG 
AAACCAGAGA ACATTCTCTT GGACTGCCAG GGACACGTGG TGCTGACGGA TTTTGGCCTC 
TGCAAGGAAG GTGTAGAGCC TGAAGACACC ACATCCACAT TCTGTGGTAC CCCTGAGTAC 
TTGGCACCTG AAGTGCTTCG GAAAGAGCCT TATGATCGAG CAGTGGACTG GTGGTGCTTG 
GGGGCAGTCC TCTACGAGAT GCTCCATGGC CTGCCGCCCT TCTACAGCCA AGATGTATCC 
CAGATGTATG AGAACATTCT GCACCAGCCG CTACAGATCC CCGGAGGCCG GACAGTGGCC 
GCCTGTGACC TCCTGCAAAG CCTTCTCCAC AAGGACCAGA GGCAGCGGCT GGGCTCCAAA 
GCAGACTTTC TTGAGATTAA GAACCATGTA TTCTTCAGCC CCATAAACTG GGATGACCTG 
TACCACAAGA GGCTAACTCC ACCCTTCAAC CCAAATGTGA CAGGACCTGC TGACTTGAAG 
CATTTTGACC CAGAGTTCAC CCAGGAAGCT GTGTCCAAGT CCATTGGCTG TACCCCTGAC 
ACTGTGGCCA GCAGCTCTGG GGCCTCAAGT GCATTCCTGG GATTTTCTTA TGCGCCAGAG 
GATGATGACA TCTTGGATTG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057360.2
CDS	220..1503
Translation	MQGLLTSGRKPSGGGRCTGRGGWRGQWCLKPWMGGADPPTPTLSCLLLPVPPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPEDDDILDC

Target ORF information:

RefSeq Version	NM_016276.3
Organism	Homo sapiens(human)
Definition	Homo sapiens serum/glucocorticoid regulated kinase 2 (SGK2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016276.3

ORF Insert Sequence:

ATGCAGGGGT TGCTTACCTC GGGTAGGAAA CCCTCAGGCG GTGGCAGGTG CACAGGTAGG 
GGAGGATGGA GAGGGCAGTG GTGCCTGAAG CCCTGGATGG GCGGAGCTGA CCCCCCAACA 
CCAACTCTCT CATGCCTGCT CCTCCCTGTC CCCCCAGAGC TGCCTGATCA TTGCTACAGA 
ATGAACTCTA GCCCAGCTGG GACCCCAAGT CCACAGCCCT CCAGGGCCAA TGGGAACATC 
AACCTGGGGC CTTCAGCCAA CCCAAATGCC CAGCCCACGG ACTTCGACTT CCTCAAAGTC 
ATCGGCAAAG GGAACTACGG GAAGGTCCTA CTGGCCAAGC GCAAGTCTGA TGGGGCGTTC 
TATGCAGTGA AGGTACTACA GAAAAAGTCC ATCTTAAAGA AGAAAGAGCA GAGCCACATC 
ATGGCAGAGC GCAGTGTGCT TCTGAAGAAC GTGCGGCACC CCTTCCTCGT GGGCCTGCGC 
TACTCCTTCC AGACACCTGA GAAGCTCTAC TTCGTGCTCG ACTATGTCAA CGGGGGAGAG 
CTCTTCTTCC ACCTGCAGCG GGAGCGCCGG TTCCTGGAGC CCCGGGCCAG GTTCTACGCT 
GCTGAGGTGG CCAGCGCCAT TGGCTACCTG CACTCCCTCA ACATCATTTA CAGGGATCTG 
AAACCAGAGA ACATTCTCTT GGACTGCCAG GGACACGTGG TGCTGACGGA TTTTGGCCTC 
TGCAAGGAAG GTGTAGAGCC TGAAGACACC ACATCCACAT TCTGTGGTAC CCCTGAGTAC 
TTGGCACCTG AAGTGCTTCG GAAAGAGCCT TATGATCGAG CAGTGGACTG GTGGTGCTTG 
GGGGCAGTCC TCTACGAGAT GCTCCATGGC CTGCCGCCCT TCTACAGCCA AGATGTATCC 
CAGATGTATG AGAACATTCT GCACCAGCCG CTACAGATCC CCGGAGGCCG GACAGTGGCC 
GCCTGTGACC TCCTGCAAAG CCTTCTCCAC AAGGACCAGA GGCAGCGGCT GGGCTCCAAA 
GCAGACTTTC TTGAGATTAA GAACCATGTA TTCTTCAGCC CCATAAACTG GGATGACCTG 
TACCACAAGA GGCTAACTCC ACCCTTCAAC CCAAATGTGA CAGGACCTGC TGACTTGAAG 
CATTTTGACC CAGAGTTCAC CCAGGAAGCT GTGTCCAAGT CCATTGGCTG TACCCCTGAC 
ACTGTGGCCA GCAGCTCTGG GGCCTCAAGT GCATTCCTGG GATTTTCTTA TGCGCCAGAG 
GATGATGACA TCTTGGATTG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SGK2 ( NM_001199264.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001186193.1 Homo sapiens serum/glucocorticoid regulated kinase 2 (SGK2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu01025
Clone ID Related Accession (Same CDS sequence)	NM_001199264.1 , NM_170693.3 , NM_170693.2
Accession Version	NM_001199264.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1104bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1548691200000
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase Sgk2 isoform alpha
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC385330.1, BC065511.1, DA244897.1 and AF186470.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (3) contains an alternate in-frame exon in the 5' coding region, compared to variant 2. Variants 1 and 3 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.188134.1, SRR1660803.219110.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END##

ATGAACTCTA GCCCAGCTGG GACCCCAAGT CCACAGCCCT CCAGGGCCAA TGGGAACATC 
AACCTGGGGC CTTCAGCCAA CCCAAATGCC CAGCCCACGG ACTTCGACTT CCTCAAAGTC 
ATCGGCAAAG GGAACTACGG GAAGGTCCTA CTGGCCAAGC GCAAGTCTGA TGGGGCGTTC 
TATGCAGTGA AGGTACTACA GAAAAAGTCC ATCTTAAAGA AGAAAGAGCA GAGCCACATC 
ATGGCAGAGC GCAGTGTGCT TCTGAAGAAC GTGCGGCACC CCTTCCTCGT GGGCCTGCGC 
TACTCCTTCC AGACACCTGA GAAGCTCTAC TTCGTGCTCG ACTATGTCAA CGGGGGAGAG 
CTCTTCTTCC ACCTGCAGCG GGAGCGCCGG TTCCTGGAGC CCCGGGCCAG GTTCTACGCT 
GCTGAGGTGG CCAGCGCCAT TGGCTACCTG CACTCCCTCA ACATCATTTA CAGGGATCTG 
AAACCAGAGA ACATTCTCTT GGACTGCCAG GGACACGTGG TGCTGACGGA TTTTGGCCTC 
TGCAAGGAAG GTGTAGAGCC TGAAGACACC ACATCCACAT TCTGTGGTAC CCCTGAGTAC 
TTGGCACCTG AAGTGCTTCG GAAAGAGCCT TATGATCGAG CAGTGGACTG GTGGTGCTTG 
GGGGCAGTCC TCTACGAGAT GCTCCATGGC CTGCCGCCCT TCTACAGCCA AGATGTATCC 
CAGATGTATG AGAACATTCT GCACCAGCCG CTACAGATCC CCGGAGGCCG GACAGTGGCC 
GCCTGTGACC TCCTGCAAAG CCTTCTCCAC AAGGACCAGA GGCAGCGGCT GGGCTCCAAA 
GCAGACTTTC TTGAGATTAA GAACCATGTA TTCTTCAGCC CCATAAACTG GGATGACCTG 
TACCACAAGA GGCTAACTCC ACCCTTCAAC CCAAATGTGA CAGGACCTGC TGACTTGAAG 
CATTTTGACC CAGAGTTCAC CCAGGAAGCT GTGTCCAAGT CCATTGGCTG TACCCCTGAC 
ACTGTGGCCA GCAGCTCTGG GGCCTCAAGT GCATTCCTGG GATTTTCTTA TGCGCCAGAG 
GATGATGACA TCTTGGATTG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186193.1
CDS	196..1299
Translation	MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPEDDDILDC

Target ORF information:

RefSeq Version	NM_001199264.1
Organism	Homo sapiens(human)
Definition	Homo sapiens serum/glucocorticoid regulated kinase 2 (SGK2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199264.1

ORF Insert Sequence:

ATGAACTCTA GCCCAGCTGG GACCCCAAGT CCACAGCCCT CCAGGGCCAA TGGGAACATC 
AACCTGGGGC CTTCAGCCAA CCCAAATGCC CAGCCCACGG ACTTCGACTT CCTCAAAGTC 
ATCGGCAAAG GGAACTACGG GAAGGTCCTA CTGGCCAAGC GCAAGTCTGA TGGGGCGTTC 
TATGCAGTGA AGGTACTACA GAAAAAGTCC ATCTTAAAGA AGAAAGAGCA GAGCCACATC 
ATGGCAGAGC GCAGTGTGCT TCTGAAGAAC GTGCGGCACC CCTTCCTCGT GGGCCTGCGC 
TACTCCTTCC AGACACCTGA GAAGCTCTAC TTCGTGCTCG ACTATGTCAA CGGGGGAGAG 
CTCTTCTTCC ACCTGCAGCG GGAGCGCCGG TTCCTGGAGC CCCGGGCCAG GTTCTACGCT 
GCTGAGGTGG CCAGCGCCAT TGGCTACCTG CACTCCCTCA ACATCATTTA CAGGGATCTG 
AAACCAGAGA ACATTCTCTT GGACTGCCAG GGACACGTGG TGCTGACGGA TTTTGGCCTC 
TGCAAGGAAG GTGTAGAGCC TGAAGACACC ACATCCACAT TCTGTGGTAC CCCTGAGTAC 
TTGGCACCTG AAGTGCTTCG GAAAGAGCCT TATGATCGAG CAGTGGACTG GTGGTGCTTG 
GGGGCAGTCC TCTACGAGAT GCTCCATGGC CTGCCGCCCT TCTACAGCCA AGATGTATCC 
CAGATGTATG AGAACATTCT GCACCAGCCG CTACAGATCC CCGGAGGCCG GACAGTGGCC 
GCCTGTGACC TCCTGCAAAG CCTTCTCCAC AAGGACCAGA GGCAGCGGCT GGGCTCCAAA 
GCAGACTTTC TTGAGATTAA GAACCATGTA TTCTTCAGCC CCATAAACTG GGATGACCTG 
TACCACAAGA GGCTAACTCC ACCCTTCAAC CCAAATGTGA CAGGACCTGC TGACTTGAAG 
CATTTTGACC CAGAGTTCAC CCAGGAAGCT GTGTCCAAGT CCATTGGCTG TACCCCTGAC 
ACTGTGGCCA GCAGCTCTGG GGCCTCAAGT GCATTCCTGG GATTTTCTTA TGCGCCAGAG 
GATGATGACA TCTTGGATTG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SGK2 ( NM_170693.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_733794.1 Homo sapiens serum/glucocorticoid regulated kinase 2 (SGK2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu01025
Clone ID Related Accession (Same CDS sequence)	NM_001199264.1 , NM_170693.3 , NM_170693.2
Accession Version	NM_170693.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1104bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571500800000
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase Sgk2 isoform alpha
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB183229.1, AF169034.2 and BC065511.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_170693.2. Transcript Variant: This variant (1) contains an alternate in-frame exon in the 5' coding region, compared to variant 2. Variants 1 and 3 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189664.131813.1, SRR5189664.60084.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000373100.7/ ENSP00000362192.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAACTCTA GCCCAGCTGG GACCCCAAGT CCACAGCCCT CCAGGGCCAA TGGGAACATC 
AACCTGGGGC CTTCAGCCAA CCCAAATGCC CAGCCCACGG ACTTCGACTT CCTCAAAGTC 
ATCGGCAAAG GGAACTACGG GAAGGTCCTA CTGGCCAAGC GCAAGTCTGA TGGGGCGTTC 
TATGCAGTGA AGGTACTACA GAAAAAGTCC ATCTTAAAGA AGAAAGAGCA GAGCCACATC 
ATGGCAGAGC GCAGTGTGCT TCTGAAGAAC GTGCGGCACC CCTTCCTCGT GGGCCTGCGC 
TACTCCTTCC AGACACCTGA GAAGCTCTAC TTCGTGCTCG ACTATGTCAA CGGGGGAGAG 
CTCTTCTTCC ACCTGCAGCG GGAGCGCCGG TTCCTGGAGC CCCGGGCCAG GTTCTACGCT 
GCTGAGGTGG CCAGCGCCAT TGGCTACCTG CACTCCCTCA ACATCATTTA CAGGGATCTG 
AAACCAGAGA ACATTCTCTT GGACTGCCAG GGACACGTGG TGCTGACGGA TTTTGGCCTC 
TGCAAGGAAG GTGTAGAGCC TGAAGACACC ACATCCACAT TCTGTGGTAC CCCTGAGTAC 
TTGGCACCTG AAGTGCTTCG GAAAGAGCCT TATGATCGAG CAGTGGACTG GTGGTGCTTG 
GGGGCAGTCC TCTACGAGAT GCTCCATGGC CTGCCGCCCT TCTACAGCCA AGATGTATCC 
CAGATGTATG AGAACATTCT GCACCAGCCG CTACAGATCC CCGGAGGCCG GACAGTGGCC 
GCCTGTGACC TCCTGCAAAG CCTTCTCCAC AAGGACCAGA GGCAGCGGCT GGGCTCCAAA 
GCAGACTTTC TTGAGATTAA GAACCATGTA TTCTTCAGCC CCATAAACTG GGATGACCTG 
TACCACAAGA GGCTAACTCC ACCCTTCAAC CCAAATGTGA CAGGACCTGC TGACTTGAAG 
CATTTTGACC CAGAGTTCAC CCAGGAAGCT GTGTCCAAGT CCATTGGCTG TACCCCTGAC 
ACTGTGGCCA GCAGCTCTGG GGCCTCAAGT GCATTCCTGG GATTTTCTTA TGCGCCAGAG 
GATGATGACA TCTTGGATTG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_733794.1
CDS	157..1260
Translation	MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPEDDDILDC

Target ORF information:

RefSeq Version	NM_170693.3
Organism	Homo sapiens(human)
Definition	Homo sapiens serum/glucocorticoid regulated kinase 2 (SGK2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_170693.3

ORF Insert Sequence:

ATGAACTCTA GCCCAGCTGG GACCCCAAGT CCACAGCCCT CCAGGGCCAA TGGGAACATC 
AACCTGGGGC CTTCAGCCAA CCCAAATGCC CAGCCCACGG ACTTCGACTT CCTCAAAGTC 
ATCGGCAAAG GGAACTACGG GAAGGTCCTA CTGGCCAAGC GCAAGTCTGA TGGGGCGTTC 
TATGCAGTGA AGGTACTACA GAAAAAGTCC ATCTTAAAGA AGAAAGAGCA GAGCCACATC 
ATGGCAGAGC GCAGTGTGCT TCTGAAGAAC GTGCGGCACC CCTTCCTCGT GGGCCTGCGC 
TACTCCTTCC AGACACCTGA GAAGCTCTAC TTCGTGCTCG ACTATGTCAA CGGGGGAGAG 
CTCTTCTTCC ACCTGCAGCG GGAGCGCCGG TTCCTGGAGC CCCGGGCCAG GTTCTACGCT 
GCTGAGGTGG CCAGCGCCAT TGGCTACCTG CACTCCCTCA ACATCATTTA CAGGGATCTG 
AAACCAGAGA ACATTCTCTT GGACTGCCAG GGACACGTGG TGCTGACGGA TTTTGGCCTC 
TGCAAGGAAG GTGTAGAGCC TGAAGACACC ACATCCACAT TCTGTGGTAC CCCTGAGTAC 
TTGGCACCTG AAGTGCTTCG GAAAGAGCCT TATGATCGAG CAGTGGACTG GTGGTGCTTG 
GGGGCAGTCC TCTACGAGAT GCTCCATGGC CTGCCGCCCT TCTACAGCCA AGATGTATCC 
CAGATGTATG AGAACATTCT GCACCAGCCG CTACAGATCC CCGGAGGCCG GACAGTGGCC 
GCCTGTGACC TCCTGCAAAG CCTTCTCCAC AAGGACCAGA GGCAGCGGCT GGGCTCCAAA 
GCAGACTTTC TTGAGATTAA GAACCATGTA TTCTTCAGCC CCATAAACTG GGATGACCTG 
TACCACAAGA GGCTAACTCC ACCCTTCAAC CCAAATGTGA CAGGACCTGC TGACTTGAAG 
CATTTTGACC CAGAGTTCAC CCAGGAAGCT GTGTCCAAGT CCATTGGCTG TACCCCTGAC 
ACTGTGGCCA GCAGCTCTGG GGCCTCAAGT GCATTCCTGG GATTTTCTTA TGCGCCAGAG 
GATGATGACA TCTTGGATTG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SGK2 ( NM_170693.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_733794.1 Homo sapiens serum/glucocorticoid regulated kinase 2 (SGK2), transcript variant 1, mRNA.

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CloneID	OHu01025
Clone ID Related Accession (Same CDS sequence)	NM_001199264.1 , NM_170693.3 , NM_170693.2
Accession Version	NM_170693.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1104bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1548691200000
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase Sgk2 isoform alpha
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB183229.1, AF169034.2 and BC065511.1. This sequence is a reference standard in the RefSeqGene project. On Nov 30, 2010 this sequence version replaced NM_170693.1. Transcript Variant: This variant (1) contains an alternate in-frame exon in the 5' coding region, compared to variant 2. Variants 1 and 3 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF169034.2, BC014037.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACTCTA GCCCAGCTGG GACCCCAAGT CCACAGCCCT CCAGGGCCAA TGGGAACATC 
AACCTGGGGC CTTCAGCCAA CCCAAATGCC CAGCCCACGG ACTTCGACTT CCTCAAAGTC 
ATCGGCAAAG GGAACTACGG GAAGGTCCTA CTGGCCAAGC GCAAGTCTGA TGGGGCGTTC 
TATGCAGTGA AGGTACTACA GAAAAAGTCC ATCTTAAAGA AGAAAGAGCA GAGCCACATC 
ATGGCAGAGC GCAGTGTGCT TCTGAAGAAC GTGCGGCACC CCTTCCTCGT GGGCCTGCGC 
TACTCCTTCC AGACACCTGA GAAGCTCTAC TTCGTGCTCG ACTATGTCAA CGGGGGAGAG 
CTCTTCTTCC ACCTGCAGCG GGAGCGCCGG TTCCTGGAGC CCCGGGCCAG GTTCTACGCT 
GCTGAGGTGG CCAGCGCCAT TGGCTACCTG CACTCCCTCA ACATCATTTA CAGGGATCTG 
AAACCAGAGA ACATTCTCTT GGACTGCCAG GGACACGTGG TGCTGACGGA TTTTGGCCTC 
TGCAAGGAAG GTGTAGAGCC TGAAGACACC ACATCCACAT TCTGTGGTAC CCCTGAGTAC 
TTGGCACCTG AAGTGCTTCG GAAAGAGCCT TATGATCGAG CAGTGGACTG GTGGTGCTTG 
GGGGCAGTCC TCTACGAGAT GCTCCATGGC CTGCCGCCCT TCTACAGCCA AGATGTATCC 
CAGATGTATG AGAACATTCT GCACCAGCCG CTACAGATCC CCGGAGGCCG GACAGTGGCC 
GCCTGTGACC TCCTGCAAAG CCTTCTCCAC AAGGACCAGA GGCAGCGGCT GGGCTCCAAA 
GCAGACTTTC TTGAGATTAA GAACCATGTA TTCTTCAGCC CCATAAACTG GGATGACCTG 
TACCACAAGA GGCTAACTCC ACCCTTCAAC CCAAATGTGA CAGGACCTGC TGACTTGAAG 
CATTTTGACC CAGAGTTCAC CCAGGAAGCT GTGTCCAAGT CCATTGGCTG TACCCCTGAC 
ACTGTGGCCA GCAGCTCTGG GGCCTCAAGT GCATTCCTGG GATTTTCTTA TGCGCCAGAG 
GATGATGACA TCTTGGATTG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_733794.1
CDS	189..1292
Translation	MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPEDDDILDC

Target ORF information:

RefSeq Version	NM_170693.2
Organism	Homo sapiens(human)
Definition	Homo sapiens serum/glucocorticoid regulated kinase 2 (SGK2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_170693.2

ORF Insert Sequence:

ATGAACTCTA GCCCAGCTGG GACCCCAAGT CCACAGCCCT CCAGGGCCAA TGGGAACATC 
AACCTGGGGC CTTCAGCCAA CCCAAATGCC CAGCCCACGG ACTTCGACTT CCTCAAAGTC 
ATCGGCAAAG GGAACTACGG GAAGGTCCTA CTGGCCAAGC GCAAGTCTGA TGGGGCGTTC 
TATGCAGTGA AGGTACTACA GAAAAAGTCC ATCTTAAAGA AGAAAGAGCA GAGCCACATC 
ATGGCAGAGC GCAGTGTGCT TCTGAAGAAC GTGCGGCACC CCTTCCTCGT GGGCCTGCGC 
TACTCCTTCC AGACACCTGA GAAGCTCTAC TTCGTGCTCG ACTATGTCAA CGGGGGAGAG 
CTCTTCTTCC ACCTGCAGCG GGAGCGCCGG TTCCTGGAGC CCCGGGCCAG GTTCTACGCT 
GCTGAGGTGG CCAGCGCCAT TGGCTACCTG CACTCCCTCA ACATCATTTA CAGGGATCTG 
AAACCAGAGA ACATTCTCTT GGACTGCCAG GGACACGTGG TGCTGACGGA TTTTGGCCTC 
TGCAAGGAAG GTGTAGAGCC TGAAGACACC ACATCCACAT TCTGTGGTAC CCCTGAGTAC 
TTGGCACCTG AAGTGCTTCG GAAAGAGCCT TATGATCGAG CAGTGGACTG GTGGTGCTTG 
GGGGCAGTCC TCTACGAGAT GCTCCATGGC CTGCCGCCCT TCTACAGCCA AGATGTATCC 
CAGATGTATG AGAACATTCT GCACCAGCCG CTACAGATCC CCGGAGGCCG GACAGTGGCC 
GCCTGTGACC TCCTGCAAAG CCTTCTCCAC AAGGACCAGA GGCAGCGGCT GGGCTCCAAA 
GCAGACTTTC TTGAGATTAA GAACCATGTA TTCTTCAGCC CCATAAACTG GGATGACCTG 
TACCACAAGA GGCTAACTCC ACCCTTCAAC CCAAATGTGA CAGGACCTGC TGACTTGAAG 
CATTTTGACC CAGAGTTCAC CCAGGAAGCT GTGTCCAAGT CCATTGGCTG TACCCCTGAC 
ACTGTGGCCA GCAGCTCTGG GGCCTCAAGT GCATTCCTGG GATTTTCTTA TGCGCCAGAG 
GATGATGACA TCTTGGATTG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SGK2 promotes hepatocellular carcinoma progression and mediates GSK-3β/β-catenin signaling in HCC cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(6)1010428317700408(2017 Jun)
Liu J,Zhang G,Lv Y,Zhang X,Ying C,Yang S,Kong X,Yu Y

Parental origin of the deletion del(20q) in Shwachman-Diamond patients and loss of the paternally derived allele of the imprinted L3MBTL1 gene.
Genes, chromosomes & cancer56(1)51-58(2017 01)
Nacci L,Valli R,Maria Pinto R,Zecca M,Cipolli M,Morini J,Cesaro S,Boveri E,Rosti V,Corti P,Ambroni M,Pasquali F,Danesino C,Maserati E,Minelli A

Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2.
Biochemical pharmacology102120-129(2016 Feb)
Wang H,Xu D,Toh MF,Pao AC,You G

Statin-activated nuclear receptor PXR promotes SGK2 dephosphorylation by scaffolding PP2C to induce hepatic gluconeogenesis.
Scientific reports514076(2015 Sep)
Gotoh S,Negishi M

Serum- and glucocorticoid-regulated kinase 2 determines drug-activated pregnane X receptor to induce gluconeogenesis in human liver cells.
The Journal of pharmacology and experimental therapeutics348(1)131-40(2014 Jan)
Gotoh S,Negishi M

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SGK2 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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