Trpml cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Trpml
Entrez Gene ID	40152
Full Name	Transient receptor potential cation channel, mucolipin
Synonyms	CG8743,CT25240,DmTRPML,Dmel\CG8743,TRPML,l(3)76BDi,trpml
General protein information	Preferred Names Transient receptor potential cation channel, mucolipin Names CG8743 gene product from transcript CG8743-RA CG8743-PA TRP mucolipin Trpml-PA l(3)76BDi transient receptor potential cation channel, mucolipin transient receptor potential cation channel, mucolipin ortholog transient receptor potential mucolipin
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3L Map Location: 76C2-76C2

mRNA and Protein(s)

mRNA	Protein	Name
NM_140888.4	NP_649145.1	transient receptor potential cation channel, mucolipin

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	CG42638	NP_001163472.1
Homo sapiens (human)	MCOLN3	NP_060768.8
Pan troglodytes (chimpanzee)	MCOLN3	XP_001140802.1
Canis lupus familiaris (dog)	MCOLN3	XP_005622047.1
Gallus gallus (chicken)	MCOLN3	XP_004936700.1
Caenorhabditis elegans (roundworm)	cup-5	NP_498664.3
Danio rerio (zebrafish)	LOC100001113	XP_001341182.5
Bos taurus (cattle)	MCOLN3	NP_001179296.1
Xenopus tropicalis (tropical clawed frog)	mcoln3	NP_001016804.1
Macaca mulatta (Rhesus monkey)	MCOLN3	XP_001108412.1
Mus musculus (house mouse)	Mcoln3	NP_598921.1
Rattus norvegicus (Norway rat)	Mcoln3	NP_001012059.1
Drosophila melanogaster (fruit fly)	trpml	NP_649145.1
Xenopus tropicalis (tropical clawed frog)	LOC101734792	XP_004920370.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007710	XP_001687855.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Trpml gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Trpml cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa19005	NM_140888.4 Latest version!	Drosophila melanogaster transient receptor potential cation channel, mucolipin (Trpml), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Trpml ( NM_140888.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_649145.1 Drosophila melanogaster transient receptor potential cation channel, mucolipin (Trpml), mRNA.

Price & Availability↑

CloneID	OFa19005
Clone ID Related Accession (Same CDS sequence)	NM_140888.4
Accession Version	NM_140888.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1959bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1556035200000
Organism	Drosophila melanogaster(fruit fly)
Product	transient receptor potential cation channel, mucolipin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_037436). On Jan 16, 2013 this sequence version replaced NM_140888.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGCAGAGCT ACGGCCCCGG AGCCCAGACA GCTCCGGCCG TCAAGCGCCG CACGGACAGC 
TACGAGGCTG CCCAGCAACA GCAGCAGTCG CCGGAGAGCG ACGAGGAGTA CGTGAACACC 
AGGATACTGC GGCGCCAAGT GCAGCTGCAG TCCACTCCGG TGGCCCCGGT GGTGCCCATG 
CCCATATCCG CCGGTAGTGG CACTGCCCCA CCCTCCGTGG ATGGCCGCGA GGAGCAGCCC 
GAATTCCCCG GATCCTCGGC TGCATCTTAC CAGGAGGAGC GAATGCGCAG GAAGCTTCAG 
TTCTTCTTTA TGAACCCCAT TGAGAAATGG CAGGCCAAGC GGAAATTTCC GTACAAGTTC 
GTTGTGCAGA TTGTAAAAAT CTTTCTGGTG ACGATGCAAT TGTGCCTTTT TGCCCACTCG 
CGGTATAACC ACATCAACTA CACGGGTGAT AACCGATTTG CCTTCTCACA TCTATTCCTG 
CGCGGCTGGG ATTCTTCCCG GGAGGTGGAG AGTTATCCGC CTGCTGTGGG TCCCTTTGCT 
CTATACCTCA AATCGGAGTT CTTCGACACT GTGCAGTATG CAGTCAATGG CTACGCGAAT 
GTAAGCCGAT CTATTGGACC ATACGACTAC CCGACGCCCA ATAACACAAT GCCGCCACTA 
AAGCTTTGCC TGCAGAACTA TAGAGAGGGC ACCATATTTG GCTTTAATGA GTCCTACATT 
TTCGATCCAC ATATCGACGA GGTGTGTGAG CGACTACCTC CGAACGTAAC CACCATTGGG 
GTGGAGAATT ACCTCAGGCA GCGCGATGTG GAGGTCAATT TTGCATCTCT TGTCTCCGCA 
CAGTTGACGT TCAAGATAAA GACGGTTAAT TTCAAGGCAA ATGGTGGACC TCTTTCTGCT 
CCTGATTGTT TTCGGTTTGA CATTTCCATA ACGTTTAACA ACCGAGACCA TGACGGGCAA 
ATGCTGCTCT CACTGGATGC GGAGGCGACG CGGCTGAAGT GCCACGGAGC AACGGACTTC 
ATATCAGACG CCAATTTCGA TTCCATGCTG CGAAGCGTAC TTAATATATT CGTCCTACTA 
ACATGCGCAC TATCCTTTGC ACTCTGTACA AGGGCTCTGT GGAGAGCATA TCTGCTGAGA 
TGTACAACTG TCAACTTTTT CCGTTCGCAA TTCGGCAAGG AGCTGAGCTT TGACGGCCGA 
CTGGAATTCG TTAACTTTTG GTACATCATG ATCATTTTCA ATGACGTCCT TTTGATCATT 
GGATCAGCTC TAAAAGAGCA AATCGAGGGA AGGTACTTGG TGGTGGACCA ATGGGATACC 
TGCTCGCTTT TTCTGGGAAT TGGCAACCTG CTTGTTTGGT TCGGAGTGCT GCGCTACCTC 
GGCTTCTTCA AAACCTACAA CGTTGTGATA CTGACGCTGA AAAAGGCGGC ACCAAAGATT 
CTGCGCTTCC TTATCGCCGC CTTGCTGATC TATGCTGGAT TTGTGTTTTG CGGCTGGCTG 
ATCTTGGGAC CCTATCACAT GAAGTTCCGA TCGCTGGCTA CAACGTCAGA GTGCTTGTTT 
GCGCTGATAA ACGGTGATGA TATGTTCGCC ACCTTTGCCA CGCTTTCCAG CAAGGCCACC 
TGGCTGTGGT GGTTCTGCCA GATCTACTTG TACTCGTTCA TATCCTTGTA CATTTATGTG 
GTCCTGTCGC TGTTCATTGC CGTCATAATG GATGCCTACG ACACGATAAA GGCGTATTAC 
AAGGATGGCT TTCCCACCAC CGATCTCAAG GCATTTGTCG GAACGCGCAC TGCAGAGGAC 
ATTAGTTCTG GTGTCTTCAT GACCGACCTG GACGACTTCG ACCAGACGAG CTTCCTTGAC 
GTGGTGAAGA GCATTTGCTG CTGTGGACGG TGCGGTCGGC ATCAGGAGCC CGCCCAGCCC 
AACAGTGGTT ACACCAGCCT TTCTAGTATT ATGAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_649145.1
CDS	261..2219
Translation	MQSYGPGAQTAPAVKRRTDSYEAAQQQQQSPESDEEYVNTRILRRQVQLQSTPVAPVVPMPISAGSGTAPPSVDGREEQPEFPGSSAASYQEERMRRKLQFFFMNPIEKWQAKRKFPYKFVVQIVKIFLVTMQLCLFAHSRYNHINYTGDNRFAFSHLFLRGWDSSREVESYPPAVGPFALYLKSEFFDTVQYAVNGYANVSRSIGPYDYPTPNNTMPPLKLCLQNYREGTIFGFNESYIFDPHIDEVCERLPPNVTTIGVENYLRQRDVEVNFASLVSAQLTFKIKTVNFKANGGPLSAPDCFRFDISITFNNRDHDGQMLLSLDAEATRLKCHGATDFISDANFDSMLRSVLNIFVLLTCALSFALCTRALWRAYLLRCTTVNFFRSQFGKELSFDGRLEFVNFWYIMIIFNDVLLIIGSALKEQIEGRYLVVDQWDTCSLFLGIGNLLVWFGVLRYLGFFKTYNVVILTLKKAAPKILRFLIAALLIYAGFVFCGWLILGPYHMKFRSLATTSECLFALINGDDMFATFATLSSKATWLWWFCQIYLYSFISLYIYVVLSLFIAVIMDAYDTIKAYYKDGFPTTDLKAFVGTRTAEDISSGVFMTDLDDFDQTSFLDVVKSICCCGRCGRHQEPAQPNSGYTSLSSIMK

Target ORF information:

RefSeq Version	NM_140888.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster transient receptor potential cation channel, mucolipin (Trpml), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_140888.4

ORF Insert Sequence:

ATGCAGAGCT ACGGCCCCGG AGCCCAGACA GCTCCGGCCG TCAAGCGCCG CACGGACAGC 
TACGAGGCTG CCCAGCAACA GCAGCAGTCG CCGGAGAGCG ACGAGGAGTA CGTGAACACC 
AGGATACTGC GGCGCCAAGT GCAGCTGCAG TCCACTCCGG TGGCCCCGGT GGTGCCCATG 
CCCATATCCG CCGGTAGTGG CACTGCCCCA CCCTCCGTGG ATGGCCGCGA GGAGCAGCCC 
GAATTCCCCG GATCCTCGGC TGCATCTTAC CAGGAGGAGC GAATGCGCAG GAAGCTTCAG 
TTCTTCTTTA TGAACCCCAT TGAGAAATGG CAGGCCAAGC GGAAATTTCC GTACAAGTTC 
GTTGTGCAGA TTGTAAAAAT CTTTCTGGTG ACGATGCAAT TGTGCCTTTT TGCCCACTCG 
CGGTATAACC ACATCAACTA CACGGGTGAT AACCGATTTG CCTTCTCACA TCTATTCCTG 
CGCGGCTGGG ATTCTTCCCG GGAGGTGGAG AGTTATCCGC CTGCTGTGGG TCCCTTTGCT 
CTATACCTCA AATCGGAGTT CTTCGACACT GTGCAGTATG CAGTCAATGG CTACGCGAAT 
GTAAGCCGAT CTATTGGACC ATACGACTAC CCGACGCCCA ATAACACAAT GCCGCCACTA 
AAGCTTTGCC TGCAGAACTA TAGAGAGGGC ACCATATTTG GCTTTAATGA GTCCTACATT 
TTCGATCCAC ATATCGACGA GGTGTGTGAG CGACTACCTC CGAACGTAAC CACCATTGGG 
GTGGAGAATT ACCTCAGGCA GCGCGATGTG GAGGTCAATT TTGCATCTCT TGTCTCCGCA 
CAGTTGACGT TCAAGATAAA GACGGTTAAT TTCAAGGCAA ATGGTGGACC TCTTTCTGCT 
CCTGATTGTT TTCGGTTTGA CATTTCCATA ACGTTTAACA ACCGAGACCA TGACGGGCAA 
ATGCTGCTCT CACTGGATGC GGAGGCGACG CGGCTGAAGT GCCACGGAGC AACGGACTTC 
ATATCAGACG CCAATTTCGA TTCCATGCTG CGAAGCGTAC TTAATATATT CGTCCTACTA 
ACATGCGCAC TATCCTTTGC ACTCTGTACA AGGGCTCTGT GGAGAGCATA TCTGCTGAGA 
TGTACAACTG TCAACTTTTT CCGTTCGCAA TTCGGCAAGG AGCTGAGCTT TGACGGCCGA 
CTGGAATTCG TTAACTTTTG GTACATCATG ATCATTTTCA ATGACGTCCT TTTGATCATT 
GGATCAGCTC TAAAAGAGCA AATCGAGGGA AGGTACTTGG TGGTGGACCA ATGGGATACC 
TGCTCGCTTT TTCTGGGAAT TGGCAACCTG CTTGTTTGGT TCGGAGTGCT GCGCTACCTC 
GGCTTCTTCA AAACCTACAA CGTTGTGATA CTGACGCTGA AAAAGGCGGC ACCAAAGATT 
CTGCGCTTCC TTATCGCCGC CTTGCTGATC TATGCTGGAT TTGTGTTTTG CGGCTGGCTG 
ATCTTGGGAC CCTATCACAT GAAGTTCCGA TCGCTGGCTA CAACGTCAGA GTGCTTGTTT 
GCGCTGATAA ACGGTGATGA TATGTTCGCC ACCTTTGCCA CGCTTTCCAG CAAGGCCACC 
TGGCTGTGGT GGTTCTGCCA GATCTACTTG TACTCGTTCA TATCCTTGTA CATTTATGTG 
GTCCTGTCGC TGTTCATTGC CGTCATAATG GATGCCTACG ACACGATAAA GGCGTATTAC 
AAGGATGGCT TTCCCACCAC CGATCTCAAG GCATTTGTCG GAACGCGCAC TGCAGAGGAC 
ATTAGTTCTG GTGTCTTCAT GACCGACCTG GACGACTTCG ACCAGACGAG CTTCCTTGAC 
GTGGTGAAGA GCATTTGCTG CTGTGGACGG TGCGGTCGGC ATCAGGAGCC CGCCCAGCCC 
AACAGTGGTT ACACCAGCCT TTCTAGTATT ATGAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Trpml cDNA ORF clone, Drosophila melanogaster(fruit fly)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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