npas4a cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	npas4a
Entrez Gene ID	724016
Full Name	neuronal PAS domain protein 4a
Synonyms	npas4,wu:fj52d04,zgc:136764
General protein information	Preferred Names neuronal PAS domain protein 4a Names neuronal PAS domain-containing protein 4A HLH-PAS transcription factor NXF bHLH-PAS type transcription factor NXF neuronal PAS domain protein 4 neuronal PAS domain-containing protein 4 neuronal PAS4 neuronal PAS4A
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001045321.1	NP_001038786.1	neuronal PAS domain-containing protein 4A

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NPAS4	XP_540832.2
Danio rerio (zebrafish)	npas4a	NP_001038786.1
Gallus gallus (chicken)	LOC101750093	XP_004940231.1
Pan troglodytes (chimpanzee)	NPAS4	XP_001171566.1
Danio rerio (zebrafish)	LOC794051	XP_001333944.2
Mus musculus (house mouse)	Npas4	NP_705781.1
Xenopus tropicalis (tropical clawed frog)	npas4	NP_001072906.2
Danio rerio (zebrafish)	LOC100534657	XP_003200884.2
Homo sapiens (human)	NPAS4	NP_849195.2
Macaca mulatta (Rhesus monkey)	NPAS4	XP_001110331.1
Bos taurus (cattle)	NPAS4	XP_002699401.1
Rattus norvegicus (Norway rat)	Npas4	NP_705890.1

Gene Ontology
Bibliography

Related articles in PubMed

Novel neurotoxic peptides from Protopalythoa variabilis virtually interact with voltage-gated sodium channel and display anti-epilepsy and neuroprotective activities in zebrafish.
Liao Q, Li S, Siu SWI, Morlighem JRL, Wong CTT, Wang X, Rádis-Baptista G, Lee SM
Archives of toxicology93(1)189-206(2019 01)

Identification of sex differences in zebrafish (Danio rerio) brains during early sexual differentiation and masculinization using 17α-methyltestoterone.
Lee SLJ, Horsfield JA, Black MA, Rutherford K, Gemmell NJ
Biology of reproduction99(2)446-460(2018 08)

Dopaminergic dysregulation and impaired associative learning behavior in zebrafish during chronic dietary exposure to selenium.
Naderi M, Salahinejad A, Ferrari MCO, Niyogi S, Chivers DP
Environmental pollution (Barking, Essex : 1987)237174-185(2018 Jun)

The neuronal transcription factor NPAS4 is a strong inducer of sprouting angiogenesis and tip cell formation.
Esser JS, Charlet A, Schmidt M, Heck S, Allen A, Lother A, Epting D, Patterson C, Bode C, Moser M
Cardiovascular research113(2)222-223(2017 02)

Maternal Rest/Nrsf Regulates Zebrafish Behavior through snap25a/b.
Moravec CE, Samuel J, Weng W, Wood IC, Sirotkin HI
The Journal of neuroscience : the official journal of the Society for Neuroscience36(36)9407-19(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following npas4a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the npas4a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa38231	NM_001045321.1 Latest version!	Danio rerio neuronal PAS domain protein 4a (npas4a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

npas4a ( NM_001045321.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001038786.1 Danio rerio neuronal PAS domain protein 4a (npas4a), mRNA.

Price & Availability↑

CloneID	ODa38231
Clone ID Related Accession (Same CDS sequence)	NM_001045321.1
Accession Version	NM_001045321.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2802bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571328000000
Organism	Danio rerio(zebrafish)
Product	neuronal PAS domain-containing protein 4A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC117648.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC117648.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGTATCGGT CCACTAAAGG AGCCTCGAAA GCTCGAAGGG ACCAAATAAA TGCGGAAATT 
AGGAACCTGA AGGACTTGTT GCCCATCTCC GATGCGGACA AGTCTCGGCT CTCCTACCTG 
CATATCATGT CGCTGGCGTG CATGTACACG AGAAAGTCTG TCTTCTTCAG TCAAGATATA 
ACTACAGCTA GCAGTGCAGA GGAAACGACG GGATTCCTTT CATTTTATGA ATTGAATGAG 
TTAATACAAG GGATGCCAGG CTTTCTTCTG CTATTGACTG GAGAAGGAAA GTTACTGTAC 
CTGTCAGACA GCGTCTCTGA CCACCTCGGA CACTCAATGG TAGATTTGGT CGCTCAAGGG 
GACAGTGTGT ATGACATAAT AGACACTGCT GACCACTTTA TTATGAGGAG TAACCTGGTG 
CCTCCAACTT CACCTGACAC AGATCGCTTG TTTCGCTGCA GATTCAACAC CTCCAAATCA 
GTGCGTAGGC AAAGTGCGGG CAATAAGCTT GTTTTAATTC GAGCACGCTG CCTGTCACAA 
ACTCCTAGTG AGTCTTCCCC AGGATCCTAT TGGACTTCCA ACCCTGTGTG GGTATGTTTC 
TGTGCTCCTC TGGAGCCTCA CACTTCCAGA GGTGGAACTG CCTCAGACAG AGAATCAACC 
TCAGCTTCAG CACTAGAGAG CAGCTTCTTC CTGCCATGTT TCCGTTCTCA GCATAGCCGA 
GACATGAGGC TTCATGAAGC ACAAGAGAGT GTAAGTGTTT ATTTGGGTCT AAATGTGGAG 
ATTCTGCGGT CCCAGTCTTG GTACAGCTTC CTCCATCCTC AGGATCTTTC ACATGCCTCA 
GCTCAGCACT GCAGCCTATT AAGAGAAGGA GGAGAGGGCA GAGCTGAGAT GGTGGTTCGT 
GTAGAGACAG CAGATCACTC ATGGGTCTGG CTTTACATGG TCTTGCAGCT GGAAACTGGG 
GAAACCCCTA TTGTCAGTAA CAATTACATC ATCAGTGAGA CAGAGGCTTG GTCAGTCAGG 
CAACAGCTGA GCTCTGAACA GACCCAACTC TCCTTGGTGC TGGGCTCAAG CACTTCTCAA 
CAAGAAAGCG TCAGCTTACA GAGTCCAGAA ACACTCTCAA GCCCTGATCA AGTGTTCACG 
CCAGGAAGCA GTGGGCTATC TGGTCAGTCT TTCGACTTCA GCACAGCAGC ATGCAGTACA 
GGATCTACTG AGGAACAAGG TGGCAGCTCC TCAATGGAGC CTGCACAAGT GGAGAGTGGC 
CCACGTTCCA GTCTCTCCTC TATGGAAGAG GAGACCTTCT TCCAGCATGA GCCCAGTGAA 
CCTATGGCCA GTCCCTCTTC TGCATCATCT CCCATTCCAG TTACGGTTGC AACAGTGTCA 
GATTTGGACT TCCTCACTCA GAATATTTTG CTGCCACCGG CATTCCAGAT AGATCCTCCT 
TTGCCAGTCC TGCCCCTTCC TCTTCCACCT GTGCCTACCT CCCAGGCACA ACAGACCAAA 
GAGTTTGTGT GCACACCCCC ATACACACCT CAGCTAGGTG GAAGCAATTT CCCCTTCGGG 
GAACCTCACT TTAGCTTTGA TCCCACTGGA GCCACCTCAC CACCTCCACT TGGTCAAACC 
GCAACAGTAA CAACGACAAC AGCACCATCT CTTTCTCCAT CCGCGCCATC AAACCCACAA 
AGCAGCCCAC CACCTCCAAC AACAACACTC TCATCTCTTT TGCCACTCAC GATAACATCT 
CCAACCACAG AGATTCTCTT TCCAGTGGAG CCGTGTAGTG GGTCACTCTA TGAGAAACTC 
CCTCCTACTC CTGACAGTCC TGGTGACGGT GACTGCACAG TCATGACTTT ACCTGAAGTT 
CGGGGTCCGC TATACGTGGA CGTCCCTCAC GGGCCGCTCC CTTACCCACC AGAAGGTCTC 
CTAACACCAG AAGCCTCACC TGGAAAACAG CCAAGTCTGC CCTTCTTCTC CTCACTGCGT 
GACAGAGAAA AGGAGAGAAC GGAGATCTCG CTTTTAGCAC AGCACATCAG TACACTAGCA 
GAGGGCTTCT ACCTAGATCC ACTCCTGGCC AAGCTGGTCC CGTCCACCCT TTCTGAACAC 
TCTCAGTCTC CGGACTCTGA TGGACTTGAT TCAATTCCAC TGCTGGGTGA ATTCTACCCA 
CTCAAGTCCT GGAAAGGCTT GGACCTGCCC ATCTTCCAGG ATGACGAGTC GCTGTTCGAG 
GAGAGTGTCT TAGAGACCCT TCTCCAGGAC CTCTCATCCT CCCCTCCGCT CTCACCGACT 
CCCTCTTCCT CCTCTCACTC TAGCCCCCCC TCTTCTCCCT CCACTCCTGA GTGCTGGTGT 
CCATCCTTGC ACTTTGACGG GGTCTCTGCT GTGAGTGCCG GTCACTTCTG TAGCGTCCAA 
TCGGCGCACT GTAACAATGA GGCCGGGCGA GGGGCTATGA TGTCGCCAGT CAATGCAGGC 
AACATGACAG ATACGAAGGC AGCAGGCGAA GTTCCCATGG AGACAGACGT AGCATCATCG 
CCTCTGTTCA CGGGTATACC AACATCTCCA CCACTGCAGC TGACCGCCTC CCCTGCCTCC 
CCTATATTGA TGCCTGTCTC CTCGCCTGTC AGCCCCCCAT CGCCCGGCCT GCCCTGCGCC 
CAGTCCCTCC TCGAGGAGCT GGCCGCCCTG GAACCCATGT TTGGGGCAGG TGCCTCGATC 
GCCCCCGGCC TGGGGCAACA ACCTGAGTTG TATCAACTCC AAAGTCATGT GCCGCAACAG 
TGCTTCCGCA AAGATGGGAG TGGAAGTGAT CCTCCGTTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001038786.1
CDS	302..3103
Translation	MYRSTKGASKARRDQINAEIRNLKDLLPISDADKSRLSYLHIMSLACMYTRKSVFFSQDITTASSAEETTGFLSFYELNELIQGMPGFLLLLTGEGKLLYLSDSVSDHLGHSMVDLVAQGDSVYDIIDTADHFIMRSNLVPPTSPDTDRLFRCRFNTSKSVRRQSAGNKLVLIRARCLSQTPSESSPGSYWTSNPVWVCFCAPLEPHTSRGGTASDRESTSASALESSFFLPCFRSQHSRDMRLHEAQESVSVYLGLNVEILRSQSWYSFLHPQDLSHASAQHCSLLREGGEGRAEMVVRVETADHSWVWLYMVLQLETGETPIVSNNYIISETEAWSVRQQLSSEQTQLSLVLGSSTSQQESVSLQSPETLSSPDQVFTPGSSGLSGQSFDFSTAACSTGSTEEQGGSSSMEPAQVESGPRSSLSSMEEETFFQHEPSEPMASPSSASSPIPVTVATVSDLDFLTQNILLPPAFQIDPPLPVLPLPLPPVPTSQAQQTKEFVCTPPYTPQLGGSNFPFGEPHFSFDPTGATSPPPLGQTATVTTTTAPSLSPSAPSNPQSSPPPPTTTLSSLLPLTITSPTTEILFPVEPCSGSLYEKLPPTPDSPGDGDCTVMTLPEVRGPLYVDVPHGPLPYPPEGLLTPEASPGKQPSLPFFSSLRDREKERTEISLLAQHISTLAEGFYLDPLLAKLVPSTLSEHSQSPDSDGLDSIPLLGEFYPLKSWKGLDLPIFQDDESLFEESVLETLLQDLSSSPPLSPTPSSSSHSSPPSSPSTPECWCPSLHFDGVSAVSAGHFCSVQSAHCNNEAGRGAMMSPVNAGNMTDTKAAGEVPMETDVASSPLFTGIPTSPPLQLTASPASPILMPVSSPVSPPSPGLPCAQSLLEELAALEPMFGAGASIAPGLGQQPELYQLQSHVPQQCFRKDGSGSDPPF

Target ORF information:

RefSeq Version	NM_001045321.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio neuronal PAS domain protein 4a (npas4a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001045321.1

ORF Insert Sequence:

ATGTATCGGT CCACTAAAGG AGCCTCGAAA GCTCGAAGGG ACCAAATAAA TGCGGAAATT 
AGGAACCTGA AGGACTTGTT GCCCATCTCC GATGCGGACA AGTCTCGGCT CTCCTACCTG 
CATATCATGT CGCTGGCGTG CATGTACACG AGAAAGTCTG TCTTCTTCAG TCAAGATATA 
ACTACAGCTA GCAGTGCAGA GGAAACGACG GGATTCCTTT CATTTTATGA ATTGAATGAG 
TTAATACAAG GGATGCCAGG CTTTCTTCTG CTATTGACTG GAGAAGGAAA GTTACTGTAC 
CTGTCAGACA GCGTCTCTGA CCACCTCGGA CACTCAATGG TAGATTTGGT CGCTCAAGGG 
GACAGTGTGT ATGACATAAT AGACACTGCT GACCACTTTA TTATGAGGAG TAACCTGGTG 
CCTCCAACTT CACCTGACAC AGATCGCTTG TTTCGCTGCA GATTCAACAC CTCCAAATCA 
GTGCGTAGGC AAAGTGCGGG CAATAAGCTT GTTTTAATTC GAGCACGCTG CCTGTCACAA 
ACTCCTAGTG AGTCTTCCCC AGGATCCTAT TGGACTTCCA ACCCTGTGTG GGTATGTTTC 
TGTGCTCCTC TGGAGCCTCA CACTTCCAGA GGTGGAACTG CCTCAGACAG AGAATCAACC 
TCAGCTTCAG CACTAGAGAG CAGCTTCTTC CTGCCATGTT TCCGTTCTCA GCATAGCCGA 
GACATGAGGC TTCATGAAGC ACAAGAGAGT GTAAGTGTTT ATTTGGGTCT AAATGTGGAG 
ATTCTGCGGT CCCAGTCTTG GTACAGCTTC CTCCATCCTC AGGATCTTTC ACATGCCTCA 
GCTCAGCACT GCAGCCTATT AAGAGAAGGA GGAGAGGGCA GAGCTGAGAT GGTGGTTCGT 
GTAGAGACAG CAGATCACTC ATGGGTCTGG CTTTACATGG TCTTGCAGCT GGAAACTGGG 
GAAACCCCTA TTGTCAGTAA CAATTACATC ATCAGTGAGA CAGAGGCTTG GTCAGTCAGG 
CAACAGCTGA GCTCTGAACA GACCCAACTC TCCTTGGTGC TGGGCTCAAG CACTTCTCAA 
CAAGAAAGCG TCAGCTTACA GAGTCCAGAA ACACTCTCAA GCCCTGATCA AGTGTTCACG 
CCAGGAAGCA GTGGGCTATC TGGTCAGTCT TTCGACTTCA GCACAGCAGC ATGCAGTACA 
GGATCTACTG AGGAACAAGG TGGCAGCTCC TCAATGGAGC CTGCACAAGT GGAGAGTGGC 
CCACGTTCCA GTCTCTCCTC TATGGAAGAG GAGACCTTCT TCCAGCATGA GCCCAGTGAA 
CCTATGGCCA GTCCCTCTTC TGCATCATCT CCCATTCCAG TTACGGTTGC AACAGTGTCA 
GATTTGGACT TCCTCACTCA GAATATTTTG CTGCCACCGG CATTCCAGAT AGATCCTCCT 
TTGCCAGTCC TGCCCCTTCC TCTTCCACCT GTGCCTACCT CCCAGGCACA ACAGACCAAA 
GAGTTTGTGT GCACACCCCC ATACACACCT CAGCTAGGTG GAAGCAATTT CCCCTTCGGG 
GAACCTCACT TTAGCTTTGA TCCCACTGGA GCCACCTCAC CACCTCCACT TGGTCAAACC 
GCAACAGTAA CAACGACAAC AGCACCATCT CTTTCTCCAT CCGCGCCATC AAACCCACAA 
AGCAGCCCAC CACCTCCAAC AACAACACTC TCATCTCTTT TGCCACTCAC GATAACATCT 
CCAACCACAG AGATTCTCTT TCCAGTGGAG CCGTGTAGTG GGTCACTCTA TGAGAAACTC 
CCTCCTACTC CTGACAGTCC TGGTGACGGT GACTGCACAG TCATGACTTT ACCTGAAGTT 
CGGGGTCCGC TATACGTGGA CGTCCCTCAC GGGCCGCTCC CTTACCCACC AGAAGGTCTC 
CTAACACCAG AAGCCTCACC TGGAAAACAG CCAAGTCTGC CCTTCTTCTC CTCACTGCGT 
GACAGAGAAA AGGAGAGAAC GGAGATCTCG CTTTTAGCAC AGCACATCAG TACACTAGCA 
GAGGGCTTCT ACCTAGATCC ACTCCTGGCC AAGCTGGTCC CGTCCACCCT TTCTGAACAC 
TCTCAGTCTC CGGACTCTGA TGGACTTGAT TCAATTCCAC TGCTGGGTGA ATTCTACCCA 
CTCAAGTCCT GGAAAGGCTT GGACCTGCCC ATCTTCCAGG ATGACGAGTC GCTGTTCGAG 
GAGAGTGTCT TAGAGACCCT TCTCCAGGAC CTCTCATCCT CCCCTCCGCT CTCACCGACT 
CCCTCTTCCT CCTCTCACTC TAGCCCCCCC TCTTCTCCCT CCACTCCTGA GTGCTGGTGT 
CCATCCTTGC ACTTTGACGG GGTCTCTGCT GTGAGTGCCG GTCACTTCTG TAGCGTCCAA 
TCGGCGCACT GTAACAATGA GGCCGGGCGA GGGGCTATGA TGTCGCCAGT CAATGCAGGC 
AACATGACAG ATACGAAGGC AGCAGGCGAA GTTCCCATGG AGACAGACGT AGCATCATCG 
CCTCTGTTCA CGGGTATACC AACATCTCCA CCACTGCAGC TGACCGCCTC CCCTGCCTCC 
CCTATATTGA TGCCTGTCTC CTCGCCTGTC AGCCCCCCAT CGCCCGGCCT GCCCTGCGCC 
CAGTCCCTCC TCGAGGAGCT GGCCGCCCTG GAACCCATGT TTGGGGCAGG TGCCTCGATC 
GCCCCCGGCC TGGGGCAACA ACCTGAGTTG TATCAACTCC AAAGTCATGT GCCGCAACAG 
TGCTTCCGCA AAGATGGGAG TGGAAGTGAT CCTCCGTTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel neurotoxic peptides from Protopalythoa variabilis virtually interact with voltage-gated sodium channel and display anti-epilepsy and neuroprotective activities in zebrafish.
Archives of toxicology93(1)189-206(2019 01)
Liao Q,Li S,Siu SWI,Morlighem JRL,Wong CTT,Wang X,Rádis-Baptista G,Lee SM

Identification of sex differences in zebrafish (Danio rerio) brains during early sexual differentiation and masculinization using 17α-methyltestoterone.
Biology of reproduction99(2)446-460(2018 08)
Lee SLJ,Horsfield JA,Black MA,Rutherford K,Gemmell NJ

Dopaminergic dysregulation and impaired associative learning behavior in zebrafish during chronic dietary exposure to selenium.
Environmental pollution (Barking, Essex : 1987)237174-185(2018 Jun)
Naderi M,Salahinejad A,Ferrari MCO,Niyogi S,Chivers DP

The neuronal transcription factor NPAS4 is a strong inducer of sprouting angiogenesis and tip cell formation.
Cardiovascular research113(2)222-223(2017 02)
Esser JS,Charlet A,Schmidt M,Heck S,Allen A,Lother A,Epting D,Patterson C,Bode C,Moser M

Maternal Rest/Nrsf Regulates Zebrafish Behavior through snap25a/b.
The Journal of neuroscience : the official journal of the Society for Neuroscience36(36)9407-19(2016 09)
Moravec CE,Samuel J,Weng W,Wood IC,Sirotkin HI

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npas4a cDNA ORF clone, Danio rerio(zebrafish)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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