slbp cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	slbp
Entrez Gene ID	407727
Full Name	stem-loop binding protein
Synonyms	cb157,sb:cb157,si:dkey-102m7.2
General protein information	Preferred Names stem-loop binding protein Names histone RNA hairpin-binding protein
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001256193.1	NP_001243122.1	histone RNA hairpin-binding protein isoform 1
NM_001256194.1	NP_001243123.1	histone RNA hairpin-binding protein isoform 2

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	slbp	NP_001004836.1
Pan troglodytes (chimpanzee)	SLBP	NP_001233401.1
Danio rerio (zebrafish)	slbp	NP_001243122.1
Homo sapiens (human)	SLBP	NP_006518.1
Canis lupus familiaris (dog)	SLBP	XP_545928.2
Mus musculus (house mouse)	Slbp	NP_033219.1
Macaca mulatta (Rhesus monkey)	LOC722546	XP_002802217.1
Bos taurus (cattle)	SLBP	NP_001039345.1
Rattus norvegicus (Norway rat)	Slbp	NP_001124460.1
Gallus gallus (chicken)	SLBP	NP_001004403.1

Gene Ontology
Bibliography

Related articles in PubMed

Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits.
Turner KJ, Hoyle J, Valdivia LE, Cerveny KL, Hart W, Mangoli M, Geisler R, Rees M, Houart C, Poole RJ, Wilson SW, Gestri G
PloS one14(1)e0211073(2019)

Oocyte-specific maternal Slbp2 is required for replication-dependent histone storage and early nuclear cleavage in zebrafish oogenesis and embryogenesis.
He WX, Wu M, Liu Z, Li Z, Wang Y, Zhou J, Yu P, Zhang XJ, Zhou L, Gui JF
RNA (New York, N.Y.)24(12)1738-1748(2018 12)

Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2.
Dankert JF, Rona G, Clijsters L, Geter P, Skaar JR, Bermudez-Hernandez K, Sassani E, Fenyö D, Ueberheide B, Schneider R, Pagano M
Molecular cell64(3)507-519(2016 11)

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

Stem-loop binding protein is required for retinal cell proliferation, neurogenesis, and intraretinal axon pathfinding in zebrafish.
Imai F, Yoshizawa A, Matsuzaki A, Oguri E, Araragi M, Nishiwaki Y, Masai I
Developmental biology394(1)94-109(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following slbp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the slbp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa03980	NM_001256193.1 Latest version!	Danio rerio stem-loop binding protein (slbp), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ODa36190	NM_001256194.1 Latest version!	Danio rerio stem-loop binding protein (slbp), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

slbp ( NM_001256193.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001243122.1 Danio rerio stem-loop binding protein (slbp), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ODa03980
Clone ID Related Accession (Same CDS sequence)	NM_001256193.1
Accession Version	NM_001256193.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1572019200000
Organism	Danio rerio(zebrafish)
Product	histone RNA hairpin-binding protein isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH496507.1, EH578014.1 and BX323828.7. On or before Jan 12, 2012 this sequence version replaced XM_692625.4, XM_002664346.1. Transcript Variant: This variant represents the longer transcript and encodes the longer protein (isoform 1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: GFIL01038204.1, GDQH01019661.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2168446, SAMEA2168447 [ECO:0000348] ##Evidence-Data-END##

ATGTCTGAAC AACAAAAATA CAAATACGAA AACGATTACA AATCTAGTGA AGACAGGAAC 
AAAGGAGCTT CAAGGTGGTC ACAGTGTAGG AAACGTGGAG CAGATGGTAT TCTGAGGAAG 
TCTCATGCTG ATGAAGAGCC AGGCAAAGAT CAAAGATGTT CGAAGAGATC AGAAAGTTTT 
ACAACCCCAG AGAGTGAAGG ACCAGTGTCC AGAATAAAAA ACTGGGGCGA TGAGGTGGAG 
GAACAGGAAA TGCGCACAAA TGTCCGGCGT GATTTTCATC GTTACAGAAG GAGGATTCTT 
GCGAGTGATT TCCCTCAAAG AGACAGAAAA ATCTCATCTG GAAGTTCAGA CTCCAGAGAC 
TCTAGGGATT CGAAAGAGTC GCCTGCTAAA GGTGACATCG AGACCGATGA GACCACCCTC 
ATCAGAAGAC AGAAGCAGAT AAATTACGGG AAAAATACTC TTGCGTACGA CAGATACATT 
AAAGAAGTTC CAAAGCATTT GAGACAACCA GGTGTTCATC CAAAGACTCC AAACAAGTTC 
AAGAAGTACA GCAGACGCTC CTGGGACCAG CAGATTAAAT TGTGGCGGGT CAAACTTCAT 
GCATGGGACC CTCCTGCAGA AGAGGGAAGC GACTTTCAGC AAATAGAGGA GATCGACCTT 
GGTGAAATTA TGGACTTTGA GTTGGATGTG GAAACGACAG AGAATACTGA ATCCCAATGC 
TCATCAAGCA ATGGAGCAGC ACAGTCTTTA CAAGAGGACG CGTTCATGGA AACACCGAAA 
AAGATGATGA AAATTGAGGA TTCCGACATG TCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243122.1
CDS	89..904
Translation	MSEQQKYKYENDYKSSEDRNKGASRWSQCRKRGADGILRKSHADEEPGKDQRCSKRSESFTTPESEGPVSRIKNWGDEVEEQEMRTNVRRDFHRYRRRILASDFPQRDRKISSGSSDSRDSRDSKESPAKGDIETDETTLIRRQKQINYGKNTLAYDRYIKEVPKHLRQPGVHPKTPNKFKKYSRRSWDQQIKLWRVKLHAWDPPAEEGSDFQQIEEIDLGEIMDFELDVETTENTESQCSSSNGAAQSLQEDAFMETPKKMMKIEDSDMS

Target ORF information:

RefSeq Version	NM_001256193.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio stem-loop binding protein (slbp), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256193.1

ORF Insert Sequence:

ATGTCTGAAC AACAAAAATA CAAATACGAA AACGATTACA AATCTAGTGA AGACAGGAAC 
AAAGGAGCTT CAAGGTGGTC ACAGTGTAGG AAACGTGGAG CAGATGGTAT TCTGAGGAAG 
TCTCATGCTG ATGAAGAGCC AGGCAAAGAT CAAAGATGTT CGAAGAGATC AGAAAGTTTT 
ACAACCCCAG AGAGTGAAGG ACCAGTGTCC AGAATAAAAA ACTGGGGCGA TGAGGTGGAG 
GAACAGGAAA TGCGCACAAA TGTCCGGCGT GATTTTCATC GTTACAGAAG GAGGATTCTT 
GCGAGTGATT TCCCTCAAAG AGACAGAAAA ATCTCATCTG GAAGTTCAGA CTCCAGAGAC 
TCTAGGGATT CGAAAGAGTC GCCTGCTAAA GGTGACATCG AGACCGATGA GACCACCCTC 
ATCAGAAGAC AGAAGCAGAT AAATTACGGG AAAAATACTC TTGCGTACGA CAGATACATT 
AAAGAAGTTC CAAAGCATTT GAGACAACCA GGTGTTCATC CAAAGACTCC AAACAAGTTC 
AAGAAGTACA GCAGACGCTC CTGGGACCAG CAGATTAAAT TGTGGCGGGT CAAACTTCAT 
GCATGGGACC CTCCTGCAGA AGAGGGAAGC GACTTTCAGC AAATAGAGGA GATCGACCTT 
GGTGAAATTA TGGACTTTGA GTTGGATGTG GAAACGACAG AGAATACTGA ATCCCAATGC 
TCATCAAGCA ATGGAGCAGC ACAGTCTTTA CAAGAGGACG CGTTCATGGA AACACCGAAA 
AAGATGATGA AAATTGAGGA TTCCGACATG TCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

slbp ( NM_001256194.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001243123.1 Danio rerio stem-loop binding protein (slbp), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ODa36190
Clone ID Related Accession (Same CDS sequence)	NM_001256194.1
Accession Version	NM_001256194.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 711bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1572019200000
Organism	Danio rerio(zebrafish)
Product	histone RNA hairpin-binding protein isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX323828.7 and EH543353.1. Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: EH544622.1, EH543353.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2168446, SAMEA2168447 [ECO:0000348] ##Evidence-Data-END##

ATGTCTGAAC AACAAAAATA CAAATACGAA AACGATTACA AATCTAGTGA AGACAGGAAC 
AAAGGAGCTT CAAGGTGGTC ACAGTGTAGG AAACGTGGAG CAGATGGTAT TCTGAGGAAG 
TCTCATGCTG ATGAAGAGCC AGGCAAAGAT CAAAGATGTT CGAAGAGATC AGAAAGTTAC 
AGAAGGAGGA TTCTTGCGAG TGATTTCCCT CAAAGAGACA GAAAAATCTC ATCTGGAAGT 
TCAGACTCCA GAGACTCTAG GGATTCGAAA GAGTCGCCTG CTAAAGGTGA CATCGAGACC 
GATGAGACCA CCCTCATCAG AAGACAGAAG CAGATAAATT ACGGGAAAAA TACTCTTGCG 
TACGACAGAT ACATTAAAGA AGTTCCAAAG CATTTGAGAC AACCAGGTGT TCATCCAAAG 
ACTCCAAACA AGTTCAAGAA GTACAGCAGA CGCTCCTGGG ACCAGCAGAT TAAATTGTGG 
CGGGTCAAAC TTCATGCATG GGACCCTCCT GCAGAAGAGG GAAGCGACTT TCAGCAAATA 
GAGGAGATCG ACCTTGGTGA AATTATGGAC TTTGAGTTGG ATGTGGAAAC GACAGAGAAT 
ACTGAATCCC AATGCTCATC AAGCAATGGA GCAGCACAGT CTTTACAAGA GGACGCGTTC 
ATGGAAACAC CGAAAAAGAT GATGAAAATT GAGGATTCCG ACATGTCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243123.1
CDS	89..799
Translation	MSEQQKYKYENDYKSSEDRNKGASRWSQCRKRGADGILRKSHADEEPGKDQRCSKRSESYRRRILASDFPQRDRKISSGSSDSRDSRDSKESPAKGDIETDETTLIRRQKQINYGKNTLAYDRYIKEVPKHLRQPGVHPKTPNKFKKYSRRSWDQQIKLWRVKLHAWDPPAEEGSDFQQIEEIDLGEIMDFELDVETTENTESQCSSSNGAAQSLQEDAFMETPKKMMKIEDSDMS

Target ORF information:

RefSeq Version	NM_001256194.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio stem-loop binding protein (slbp), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256194.1

ORF Insert Sequence:

ATGTCTGAAC AACAAAAATA CAAATACGAA AACGATTACA AATCTAGTGA AGACAGGAAC 
AAAGGAGCTT CAAGGTGGTC ACAGTGTAGG AAACGTGGAG CAGATGGTAT TCTGAGGAAG 
TCTCATGCTG ATGAAGAGCC AGGCAAAGAT CAAAGATGTT CGAAGAGATC AGAAAGTTAC 
AGAAGGAGGA TTCTTGCGAG TGATTTCCCT CAAAGAGACA GAAAAATCTC ATCTGGAAGT 
TCAGACTCCA GAGACTCTAG GGATTCGAAA GAGTCGCCTG CTAAAGGTGA CATCGAGACC 
GATGAGACCA CCCTCATCAG AAGACAGAAG CAGATAAATT ACGGGAAAAA TACTCTTGCG 
TACGACAGAT ACATTAAAGA AGTTCCAAAG CATTTGAGAC AACCAGGTGT TCATCCAAAG 
ACTCCAAACA AGTTCAAGAA GTACAGCAGA CGCTCCTGGG ACCAGCAGAT TAAATTGTGG 
CGGGTCAAAC TTCATGCATG GGACCCTCCT GCAGAAGAGG GAAGCGACTT TCAGCAAATA 
GAGGAGATCG ACCTTGGTGA AATTATGGAC TTTGAGTTGG ATGTGGAAAC GACAGAGAAT 
ACTGAATCCC AATGCTCATC AAGCAATGGA GCAGCACAGT CTTTACAAGA GGACGCGTTC 
ATGGAAACAC CGAAAAAGAT GATGAAAATT GAGGATTCCG ACATGTCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits.
PloS one14(1)e0211073(2019)
Turner KJ,Hoyle J,Valdivia LE,Cerveny KL,Hart W,Mangoli M,Geisler R,Rees M,Houart C,Poole RJ,Wilson SW,Gestri G

Oocyte-specific maternal Slbp2 is required for replication-dependent histone storage and early nuclear cleavage in zebrafish oogenesis and embryogenesis.
RNA (New York, N.Y.)24(12)1738-1748(2018 12)
He WX,Wu M,Liu Z,Li Z,Wang Y,Zhou J,Yu P,Zhang XJ,Zhou L,Gui JF

Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2.
Molecular cell64(3)507-519(2016 11)
Dankert JF,Rona G,Clijsters L,Geter P,Skaar JR,Bermudez-Hernandez K,Sassani E,Fenyö D,Ueberheide B,Schneider R,Pagano M

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
BMC genomics17368(2016 05)
Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J

Stem-loop binding protein is required for retinal cell proliferation, neurogenesis, and intraretinal axon pathfinding in zebrafish.
Developmental biology394(1)94-109(2014 Oct)
Imai F,Yoshizawa A,Matsuzaki A,Oguri E,Araragi M,Nishiwaki Y,Masai I

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slbp cDNA ORF clone, Danio rerio(zebrafish)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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