MC1R cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	MC1R
Entrez Gene ID	489652
Full Name	melanocortin 1 receptor
Synonyms	MC1-R,MSH-R
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001014282.2	NP_001014304.2	melanocyte-stimulating hormone receptor

Pathways from BioSystems

Homologies

Homo sapiens (human)	MC1R	NP_002377.4
Bos taurus (cattle)	MC1R	NP_776533.1
Pan troglodytes (chimpanzee)	MC1R	NP_001009152.1
Mus musculus (house mouse)	Mc1r	NP_032585.2
Canis lupus familiaris (dog)	MC1R	NP_001014304.1
Rattus norvegicus (Norway rat)	Mc1r	XP_006255857.1
Xenopus tropicalis (tropical clawed frog)	mc1r	XP_002937630.2
Gallus gallus (chicken)	MC1R	NP_001026633.1
Danio rerio (zebrafish)	mc1r	NP_851301.1

Gene Ontology
Bibliography

Related articles in PubMed

Two MC1R loss-of-function alleles in cream-coloured Australian Cattle Dogs and white Huskies.
Dürig N, Letko A, Lepori V, Hadji Rasouliha S, Loechel R, Kehl A, Hytönen MK, Lohi H, Mauri N, Dietrich J, Wiedmer M, Drögemüller M, Jagannathan V, Schmutz SM, Leeb T
Animal genetics49(4)284-290(2018 Aug)

Relationship between the melanocortin-1 receptor (MC1R) variant R306ter and physiological responses to mechanical or thermal stimuli in Labrador Retriever dogs.
Perez TE, Mealey KL, Burke NS, Grubb TL, Court MH, Greene SA
Veterinary anaesthesia and analgesia44(2)370-374(2017 Mar)

Characterization of different 5'-untranslated exons of the ASIP gene in black-and-tan Doberman Pinscher and brindle Boxer dogs.
Ciampolini R, Cecchi F, Spaterna A, Bramante A, Bardet SM, Oulmouden A
Animal genetics44(1)114-7(2013 Feb)

Signature of balancing selection at the MC1R gene in Kunming dog populations.
Wang GD, Cheng LG, Fan RX, Irwin DM, Tang SS, Peng JG, Zhang YP
PloS one8(2)e55469(2013)

Mutations in the melanocortin 1 receptor, β-defensin103 and agouti signaling protein genes, and their association with coat color phenotypes in Akita-inu dogs.
Oguro-Okano M, Honda M, Yamazaki K, Okano K
The Journal of veterinary medical science73(7)853-8(2011 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MC1R gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MC1R cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe45903	NM_001014282.2 Latest version!	Canis lupus familiaris melanocortin 1 receptor (MC1R), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MC1R ( NM_001014282.2 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001014304.2 Canis lupus familiaris melanocortin 1 receptor (MC1R), mRNA.

Price & Availability↑

CloneID	OCe45903
Clone ID Related Accession (Same CDS sequence)	NM_001014282.2
Accession Version	NM_001014282.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1576944000000
Organism	Canis lupus familiaris(dog)
Product	melanocyte-stimulating hormone receptor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AAEX03003947.1. On Sep 1, 2015 this sequence version replaced NM_001014282.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END##

ATGTCTGGGC AGGGCCCCCA GAGAAGGCTG CTGGGCTCTC TCAATGGCAC CTCCCCAGCC 
ACCCCTCACT TCGAGCTGGC TGCCAACCAG ACCGGGCCCC GGTGCCTGGA GGTGTCCATT 
CCCGACGGGC TGTTCCTCAG CCTGGGGCTG GTGAGCGTTG TGGAAAATGT GCTGGTGGTG 
GCCGCCATTG CCAAGAACCG CAACCTGCAC TCGCCCATGT ATTACTTCAT CGGTTGCCTG 
GCTGTGTCCG ACCTGCTGGT GAGCGTGAGC AATGTGCTGG AGACGGCCGT CATGCTGCTG 
GTGGCGGCAG GCGCCTTGGC TGCTCAGGCT GCTGTGGTGC AGCAGCTGGA CGACATCATT 
GACGTGCTCA TCTGTGGTTC CATGGTATCC AGCCTCTGCT TCCTGGGCGC CATTGCCGTG 
GACCGCTACC TCTCCATCTT CTACGCGCTG CGATACCACA GCATCGTCAC ACTCCCGCGG 
GCGTGGCGGG CCATCTCCGC TATCTGGGTG GCTAGCGTCC TCTCCAGCAC GCTCTTCATT 
GCCTACTACA ATCACACGGC CGTCCTGCTT TGTCTTGTCA GCTTCTTTGT AGCCATGCTG 
GTGCTCATGG CAGTGCTGTA CGTCCACATG CTTGCCCGCG CCTGCCAGCA CGCCCGAGGT 
ATTGCCCGGC TCCATAAGAG GCAGCACTTC ATCCCCCAGG GCTTTGGCCT CAAGGGCGCT 
GCCACACTCA CTATCCTGCT GGGCATTTTC TTTCTCTGCT GGGGCCCCTT CTTCTTGCAC 
CTCTCACTCG TGGTCCTCTG CCCTCAACAC CCCATCTGTG GCTGCGTCTT TCAGAACTTC 
AACCTCTTCC TCACCCTCAT CATCTGCAAC TCCATCATTG ACCCCTTCAT CTACGCCTTC 
CGCAGCCAGG AGCTCCGAAA GACTCTCCAA GAGGTAGTGC TATGTTCCTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001014304.2
CDS	1..954
Translation	MSGQGPQRRLLGSLNGTSPATPHFELAANQTGPRCLEVSIPDGLFLSLGLVSVVENVLVVAAIAKNRNLHSPMYYFIGCLAVSDLLVSVSNVLETAVMLLVAAGALAAQAAVVQQLDDIIDVLICGSMVSSLCFLGAIAVDRYLSIFYALRYHSIVTLPRAWRAISAIWVASVLSSTLFIAYYNHTAVLLCLVSFFVAMLVLMAVLYVHMLARACQHARGIARLHKRQHFIPQGFGLKGAATLTILLGIFFLCWGPFFLHLSLVVLCPQHPICGCVFQNFNLFLTLIICNSIIDPFIYAFRSQELRKTLQEVVLCSW

Target ORF information:

RefSeq Version	NM_001014282.2
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris melanocortin 1 receptor (MC1R), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001014282.2

ORF Insert Sequence:

ATGTCTGGGC AGGGCCCCCA GAGAAGGCTG CTGGGCTCTC TCAATGGCAC CTCCCCAGCC 
ACCCCTCACT TCGAGCTGGC TGCCAACCAG ACCGGGCCCC GGTGCCTGGA GGTGTCCATT 
CCCGACGGGC TGTTCCTCAG CCTGGGGCTG GTGAGCGTTG TGGAAAATGT GCTGGTGGTG 
GCCGCCATTG CCAAGAACCG CAACCTGCAC TCGCCCATGT ATTACTTCAT CGGTTGCCTG 
GCTGTGTCCG ACCTGCTGGT GAGCGTGAGC AATGTGCTGG AGACGGCCGT CATGCTGCTG 
GTGGCGGCAG GCGCCTTGGC TGCTCAGGCT GCTGTGGTGC AGCAGCTGGA CGACATCATT 
GACGTGCTCA TCTGTGGTTC CATGGTATCC AGCCTCTGCT TCCTGGGCGC CATTGCCGTG 
GACCGCTACC TCTCCATCTT CTACGCGCTG CGATACCACA GCATCGTCAC ACTCCCGCGG 
GCGTGGCGGG CCATCTCCGC TATCTGGGTG GCTAGCGTCC TCTCCAGCAC GCTCTTCATT 
GCCTACTACA ATCACACGGC CGTCCTGCTT TGTCTTGTCA GCTTCTTTGT AGCCATGCTG 
GTGCTCATGG CAGTGCTGTA CGTCCACATG CTTGCCCGCG CCTGCCAGCA CGCCCGAGGT 
ATTGCCCGGC TCCATAAGAG GCAGCACTTC ATCCCCCAGG GCTTTGGCCT CAAGGGCGCT 
GCCACACTCA CTATCCTGCT GGGCATTTTC TTTCTCTGCT GGGGCCCCTT CTTCTTGCAC 
CTCTCACTCG TGGTCCTCTG CCCTCAACAC CCCATCTGTG GCTGCGTCTT TCAGAACTTC 
AACCTCTTCC TCACCCTCAT CATCTGCAAC TCCATCATTG ACCCCTTCAT CTACGCCTTC 
CGCAGCCAGG AGCTCCGAAA GACTCTCCAA GAGGTAGTGC TATGTTCCTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Two MC1R loss-of-function alleles in cream-coloured Australian Cattle Dogs and white Huskies.
Animal genetics49(4)284-290(2018 Aug)
Dürig N,Letko A,Lepori V,Hadji Rasouliha S,Loechel R,Kehl A,Hytönen MK,Lohi H,Mauri N,Dietrich J,Wiedmer M,Drögemüller M,Jagannathan V,Schmutz SM,Leeb T

Relationship between the melanocortin-1 receptor (MC1R) variant R306ter and physiological responses to mechanical or thermal stimuli in Labrador Retriever dogs.
Veterinary anaesthesia and analgesia44(2)370-374(2017 Mar)
Perez TE,Mealey KL,Burke NS,Grubb TL,Court MH,Greene SA

Characterization of different 5'-untranslated exons of the ASIP gene in black-and-tan Doberman Pinscher and brindle Boxer dogs.
Animal genetics44(1)114-7(2013 Feb)
Ciampolini R,Cecchi F,Spaterna A,Bramante A,Bardet SM,Oulmouden A

Signature of balancing selection at the MC1R gene in Kunming dog populations.
PloS one8(2)e55469(2013)
Wang GD,Cheng LG,Fan RX,Irwin DM,Tang SS,Peng JG,Zhang YP

Mutations in the melanocortin 1 receptor, β-defensin103 and agouti signaling protein genes, and their association with coat color phenotypes in Akita-inu dogs.
The Journal of veterinary medical science73(7)853-8(2011 Jul)
Oguro-Okano M,Honda M,Yamazaki K,Okano K