DLA-DQA1 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	DLA-DQA1
Entrez Gene ID	474861
Full Name	major histocompatibility complex, class II, DQ alpha 1
Synonyms	DLA-DQA,dqa 7
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001011726.1	NP_001011726.1	major histocompatibility complex, class II, DQ alpha precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	HLA-DQA2	NP_064440.1
Bos taurus (cattle)	BOLA-DQA5	NP_001012693.2
Xenopus tropicalis (tropical clawed frog)	hla-dqa1	NP_001106538.1
Pan troglodytes (chimpanzee)	PATR-DQA2	XP_527354.1
Xenopus tropicalis (tropical clawed frog)	LOC100495492	XP_002942061.2
Canis lupus familiaris (dog)	DLA-DQA1	NP_001011726.1

Gene Ontology
Bibliography

Related articles in PubMed

A study of the association between chronic superficial keratitis and polymorphisms in the upstream regulatory regions of DLA-DRB1, DLA-DQB1 and DLA-DQA1.
Barrientos LS, Zapata G, Crespi JA, Posik DM, Díaz S, It V, Peral-García P, Giovambattista G
Veterinary immunology and immunopathology156(3-4)205-10(2013 Dec)

MHC class II risk haplotype associated with canine chronic superficial keratitis in German Shepherd dogs.
Jokinen P, Rusanen EM, Kennedy LJ, Lohi H
Veterinary immunology and immunopathology140(1-2)37-41(2011 Mar)

Evaluation of the class II region of the major histocompatibility complex of the greyhound with the genomic matching technique and sequence-based typing.
Fliegner RA, Holloway SA, Lester S, McLure CA, Dawkins RL
Tissue antigens72(2)131-6(2008 Aug)

Uveodermatologic (VKH-like) syndrome in American Akita dogs is associated with an increased frequency of DQA1*00201.
Angles JM, Famula TR, Pedersen NC
Tissue antigens66(6)656-65(2005 Dec)

Frequency and distribution of alleles of canine MHC-II DLA-DQB1, DLA-DQA1 and DLA-DRB1 in 25 representative American Kennel Club breeds.
Angles JM, Kennedy LJ, Pedersen NC
Tissue antigens66(3)173-84(2005 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following DLA-DQA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DLA-DQA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe34196	NM_001011726.1 Latest version!	Canis lupus familiaris major histocompatibility complex, class II, DQ alpha 1 (DLA-DQA1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DLA-DQA1 ( NM_001011726.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001011726.1 Canis lupus familiaris major histocompatibility complex, class II, DQ alpha 1 (DLA-DQA1), mRNA.

Price & Availability↑

CloneID	OCe34196
Clone ID Related Accession (Same CDS sequence)	NM_001011726.1
Accession Version	NM_001011726.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 768bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1508515200000
Organism	Canis lupus familiaris(dog)
Product	major histocompatibility complex, class II, DQ alpha precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U42407.1. On Feb 10, 2005 this sequence version replaced XM_532096.1. ##Evidence-Data-START## Transcript exon combination :: U42407.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END##

ATGATCCTAA ACAGAGTTCT GATTCTGGGG ACCCTCATCC TGACTATTAT GATGAGCCCC 
TCTGGAGGTG AAGAGATTGT GGCTGACCAT GTTGCCAACT ACGGCATAAA TGTCTACCAG 
TCTTACGGTC CCTCTGGCCA GTACACCCAT GAATTTGATG GCGATGAGGA GTTCTACGTG 
GACCTGGAGA AGAAGGAAAC TGTCTGGCGG CTGCCTGTGT TTAGCACATT TAGAAGTTTT 
GACCCACAGG GTGCACTGAG AAACTTGGCT ATAATAAAAC AAAACTTGAA CATCATGACT 
AAAAGGTCCA ACCAAACTGC TGCTACCAAT GAGGTTCCTG AGGTGACTGT GTTTTCCAAG 
TCTCCTGTGA TGCTGGGTCA GCCCAACACC CTCATCTGTC TCGTGGACAA CATCTTTCCT 
CCTGTGATCA ATGTCACATG GTTGAAGAAT AGGCACTCAG TCACAGAAGG GGTTTCTGAA 
ACCAGCTTCT TCGCCAAAGG GGATCATTCC TTCTCAAAGA TCAGTTACCT CACCTTCCTA 
CCTTCTGCTG AGGATATTTA TGACTGCAAA GTAGAGCACT GGGGCCTGGA TGAGCCACTT 
CTGAAACACT GGGAACCTGA GGTTCCAACC CCTATGTCAG AGCTGACAGA GACTGTGGTC 
TGTGCCCTGG GGTTGGCTGT GGGCCTTGTG GGCATCGTGA TGGGCACCGT CTTCATTATC 
CAAGGCCTGC GCTCAGGTGG TACTTCCAGA CATCAAGGAC CTTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001011726.1
CDS	8..775
Translation	MILNRVLILGTLILTIMMSPSGGEEIVADHVANYGINVYQSYGPSGQYTHEFDGDEEFYVDLEKKETVWRLPVFSTFRSFDPQGALRNLAIIKQNLNIMTKRSNQTAATNEVPEVTVFSKSPVMLGQPNTLICLVDNIFPPVINVTWLKNRHSVTEGVSETSFFAKGDHSFSKISYLTFLPSAEDIYDCKVEHWGLDEPLLKHWEPEVPTPMSELTETVVCALGLAVGLVGIVMGTVFIIQGLRSGGTSRHQGPL

Target ORF information:

RefSeq Version	NM_001011726.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris major histocompatibility complex, class II, DQ alpha 1 (DLA-DQA1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001011726.1

ORF Insert Sequence:

ATGATCCTAA ACAGAGTTCT GATTCTGGGG ACCCTCATCC TGACTATTAT GATGAGCCCC 
TCTGGAGGTG AAGAGATTGT GGCTGACCAT GTTGCCAACT ACGGCATAAA TGTCTACCAG 
TCTTACGGTC CCTCTGGCCA GTACACCCAT GAATTTGATG GCGATGAGGA GTTCTACGTG 
GACCTGGAGA AGAAGGAAAC TGTCTGGCGG CTGCCTGTGT TTAGCACATT TAGAAGTTTT 
GACCCACAGG GTGCACTGAG AAACTTGGCT ATAATAAAAC AAAACTTGAA CATCATGACT 
AAAAGGTCCA ACCAAACTGC TGCTACCAAT GAGGTTCCTG AGGTGACTGT GTTTTCCAAG 
TCTCCTGTGA TGCTGGGTCA GCCCAACACC CTCATCTGTC TCGTGGACAA CATCTTTCCT 
CCTGTGATCA ATGTCACATG GTTGAAGAAT AGGCACTCAG TCACAGAAGG GGTTTCTGAA 
ACCAGCTTCT TCGCCAAAGG GGATCATTCC TTCTCAAAGA TCAGTTACCT CACCTTCCTA 
CCTTCTGCTG AGGATATTTA TGACTGCAAA GTAGAGCACT GGGGCCTGGA TGAGCCACTT 
CTGAAACACT GGGAACCTGA GGTTCCAACC CCTATGTCAG AGCTGACAGA GACTGTGGTC 
TGTGCCCTGG GGTTGGCTGT GGGCCTTGTG GGCATCGTGA TGGGCACCGT CTTCATTATC 
CAAGGCCTGC GCTCAGGTGG TACTTCCAGA CATCAAGGAC CTTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A study of the association between chronic superficial keratitis and polymorphisms in the upstream regulatory regions of DLA-DRB1, DLA-DQB1 and DLA-DQA1.
Veterinary immunology and immunopathology156(3-4)205-10(2013 Dec)
Barrientos LS,Zapata G,Crespi JA,Posik DM,Díaz S,It V,Peral-García P,Giovambattista G

MHC class II risk haplotype associated with canine chronic superficial keratitis in German Shepherd dogs.
Veterinary immunology and immunopathology140(1-2)37-41(2011 Mar)
Jokinen P,Rusanen EM,Kennedy LJ,Lohi H

Evaluation of the class II region of the major histocompatibility complex of the greyhound with the genomic matching technique and sequence-based typing.
Tissue antigens72(2)131-6(2008 Aug)
Fliegner RA,Holloway SA,Lester S,McLure CA,Dawkins RL

Uveodermatologic (VKH-like) syndrome in American Akita dogs is associated with an increased frequency of DQA1*00201.
Tissue antigens66(6)656-65(2005 Dec)
Angles JM,Famula TR,Pedersen NC

Frequency and distribution of alleles of canine MHC-II DLA-DQB1, DLA-DQA1 and DLA-DRB1 in 25 representative American Kennel Club breeds.
Tissue antigens66(3)173-84(2005 Sep)
Angles JM,Kennedy LJ,Pedersen NC