IL18 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	IL18
Entrez Gene ID	403796
Full Name	interleukin 18
Synonyms	IGIF
General protein information	Preferred Names interleukin 18 Names interleukin-18 IFN-gamma-inducing factor IL-1 gamma IL-18 interferon gamma-inducing factor interleukin 18 (interferon-gamma-inducing factor) interleukin-1 gamma
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
XM_005619484.2	XP_005619541.1	interleukin-18 isoform X2
XM_005619484.3	XP_005619541.1	interleukin-18 isoform X2
XM_005619483.2	XP_005619540.1	interleukin-18 isoform X1
NM_001003169.1	NP_001003169.1	interleukin-18 precursor
XM_005619483.3	XP_005619540.1	interleukin-18 isoform X1

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	IL18	NP_001028006.1
Mus musculus (house mouse)	Il18	NP_032386.1
Homo sapiens (human)	IL18	NP_001553.1
Canis lupus familiaris (dog)	IL18	NP_001003169.1
Pan troglodytes (chimpanzee)	IL18	XP_003952084.1
Bos taurus (cattle)	IL18	NP_776516.1
Rattus norvegicus (Norway rat)	Il18	NP_062038.1

Gene Ontology
Bibliography

Related articles in PubMed

Canine interleukin-18 induces apoptosis and enhances Fas ligand mRNA expression in a canine carcinoma cell line.
Okano F, Yamada K
Anticancer research20(5B)3411-5(2000 Sep- Oct)

Semi-quantitative analysis of multiple cytokines in canine peripheral blood mononuclear cells by [correction of zby] a single tube RT-PCR.
Chamizo C, Rubio JM, Moreno J, Alvar J
Veterinary immunology and immunopathology83(3-4)191-202(2001 Dec)

Cloning, sequencing, and characterization of dog interleukin-18.
Argyle DJ, McGillivery C, Nicolson L, Onions DE
Immunogenetics49(6)541-3(1999 Jun)

Cloning of cDNA for canine interleukin-18 and canine interleukin-1beta converting enzyme and expression of canine interleukin-18.
Okano F, Satoh M, Ido T, Yamada K
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research19(1)27-32(1999 Jan)

Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production.
Micallef MJ, Ohtsuki T, Kohno K, Tanabe F, Ushio S, Namba M, Tanimoto T, Torigoe K, Fujii M, Ikeda M, Fukuda S, Kurimoto M
European journal of immunology26(7)1647-51(1996 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following IL18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OCe00413	NM_001003169.1 Latest version!	Canis lupus familiaris interleukin 18 (IL18), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OCe05634	XM_005619483.3 Latest version!	Canis lupus familiaris interleukin 18 (IL18), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OCe05635	XM_005619484.3 Latest version!	Canis lupus familiaris interleukin 18 (IL18), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OCe05635	XM_005619484.2	Canis lupus familiaris interleukin 18 (IL18), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OCe05634	XM_005619483.2	Canis lupus familiaris interleukin 18 (IL18), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL18 ( NM_001003169.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001003169.1 Canis lupus familiaris interleukin 18 (IL18), mRNA.

Price & Availability↑

CloneID	OCe00413
Clone ID Related Accession (Same CDS sequence)	NM_001003169.1
Accession Version	NM_001003169.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577030400000
Organism	Canis lupus familiaris(dog)
Product	interleukin-18 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Y11133.1. ##Evidence-Data-START## Transcript exon combination :: Y11133.1, DN268796.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGCTA ACCTAATAGA AGACAATTGC ATCAACCTTG TGAAAATGAA ATTTGTTAAC 
AATACACTGT ACTTTAAAGC GGAAAGTGAT GAAGGCCTGG AATCAGATTA CTTTGGCAAG 
CTTGAACCTA AACTCTCAAT CATACGAAAT TTGAACGACC AAGTCCTCTT CGTTAACGAG 
GGAAATCAAC CTGTATTTGA GGATATGCCC GATTCTGACT GTACAGATAA TGCACCCCAT 
ACCATATTTA TCATCTATAT GTATAAAGAT AGCCTCACTA GAGGTCTGGC AGTAACTATC 
TCTGTGAAGT ATAAGACAAT GTCTACTCTC TCCTGTAAGA ACAAAACTAT TTCCTTTCAG 
AAAATGAGTC CTCCGGATAG TATCAATGAT GAAGGAAATG ACATCATATT CTTTCAGAGA 
AGTGTTCCAG GCCATGATGA TAAGATACAA TTTGAGTCTT CATTGTACAA AGGACACTTT 
CTAGCTTGTA AAAAAGAGAA CGATCTTTTC AAACTCATTT TGAAAGACAA GGATGAAAAT 
GGGGATAAAT CCATAATGTT CACTGTTCAA AACAAGAGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003169.1
CDS	1..582
Translation	MAANLIEDNCINLVKMKFVNNTLYFKAESDEGLESDYFGKLEPKLSIIRNLNDQVLFVNEGNQPVFEDMPDSDCTDNAPHTIFIIYMYKDSLTRGLAVTISVKYKTMSTLSCKNKTISFQKMSPPDSINDEGNDIIFFQRSVPGHDDKIQFESSLYKGHFLACKKENDLFKLILKDKDENGDKSIMFTVQNKS

Target ORF information:

RefSeq Version	NM_001003169.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris interleukin 18 (IL18), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003169.1

ORF Insert Sequence:

ATGGCTGCTA ACCTAATAGA AGACAATTGC ATCAACCTTG TGAAAATGAA ATTTGTTAAC 
AATACACTGT ACTTTAAAGC GGAAAGTGAT GAAGGCCTGG AATCAGATTA CTTTGGCAAG 
CTTGAACCTA AACTCTCAAT CATACGAAAT TTGAACGACC AAGTCCTCTT CGTTAACGAG 
GGAAATCAAC CTGTATTTGA GGATATGCCC GATTCTGACT GTACAGATAA TGCACCCCAT 
ACCATATTTA TCATCTATAT GTATAAAGAT AGCCTCACTA GAGGTCTGGC AGTAACTATC 
TCTGTGAAGT ATAAGACAAT GTCTACTCTC TCCTGTAAGA ACAAAACTAT TTCCTTTCAG 
AAAATGAGTC CTCCGGATAG TATCAATGAT GAAGGAAATG ACATCATATT CTTTCAGAGA 
AGTGTTCCAG GCCATGATGA TAAGATACAA TTTGAGTCTT CATTGTACAA AGGACACTTT 
CTAGCTTGTA AAAAAGAGAA CGATCTTTTC AAACTCATTT TGAAAGACAA GGATGAAAAT 
GGGGATAAAT CCATAATGTT CACTGTTCAA AACAAGAGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL18 ( XM_005619483.2 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_005619540.1 Canis lupus familiaris interleukin 18 (IL18), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OCe05634
Clone ID Related Accession (Same CDS sequence)	XM_005619483.2 , XM_005619483.3
Accession Version	XM_005619483.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1442332800000
Organism	Canis lupus familiaris(Dog)
Product	interleukin-18 isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003726057.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 17, 2015 this sequence version replaced XM_005619483.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAAGAC CTCCTTTCCT GATGTCCGGA ATAAAGATGG CTACTAACCT AATAGAAGAC 
AATTGCATCA ATCTTGTGAA AATGAAATTT GTTAACAATA CACTGTACTT TAAAGCGGAA 
AGTGATGAAG GCCTGGAATC AGATTACTTT GGCAAGCTTG AACCTAAACT CTCAATCATA 
CGAAATTTGA ACGACCAAGT CCTCTTCGTT AACGAGGGAA ATCAACCTGT ATTTGAGGAT 
ATGCCCGATT CTGACTGTAC AGATAATGCA CCCCATACCA TATTTATCAT CTATATGTAT 
AAAGATAGCC TCACTAGAGG TCTGGCAGTA ACTATCTCTG TGAAGTATAA GACAATGTCT 
ACTCTCTCCT GTAAGAACAA AACTATTTCC TTTCAGAAAA TGAGTCCTCC GGATAGTATC 
AATGATGAAG GAAATGACAT CATATTCTTT CAGAGAAGTG TTCCAGGCCA TGATGATAAG 
ATACAATTTG AGTCTTCATT GTACAAAGGA CACTTTCTAG CTTGTAAAAA AGAGAACGAT 
CTTTTCAAAC TCATTTTGAA AGACAAGGAT GAAAATGGGG ATAAATCCAT AATGTTCACT 
GTTCAAAACA AGAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005619540.1
CDS	111..728
Translation	MGRPPFLMSGIKMATNLIEDNCINLVKMKFVNNTLYFKAESDEGLESDYFGKLEPKLSIIRNLNDQVLFVNEGNQPVFEDMPDSDCTDNAPHTIFIIYMYKDSLTRGLAVTISVKYKTMSTLSCKNKTISFQKMSPPDSINDEGNDIIFFQRSVPGHDDKIQFESSLYKGHFLACKKENDLFKLILKDKDENGDKSIMFTVQNKS

Target ORF information:

RefSeq Version	XM_005619483.2
Organism	Canis lupus familiaris(Dog)
Definition	Canis lupus familiaris interleukin 18 (IL18), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005619483.2

ORF Insert Sequence:

ATGGGAAGAC CTCCTTTCCT GATGTCCGGA ATAAAGATGG CTACTAACCT AATAGAAGAC 
AATTGCATCA ATCTTGTGAA AATGAAATTT GTTAACAATA CACTGTACTT TAAAGCGGAA 
AGTGATGAAG GCCTGGAATC AGATTACTTT GGCAAGCTTG AACCTAAACT CTCAATCATA 
CGAAATTTGA ACGACCAAGT CCTCTTCGTT AACGAGGGAA ATCAACCTGT ATTTGAGGAT 
ATGCCCGATT CTGACTGTAC AGATAATGCA CCCCATACCA TATTTATCAT CTATATGTAT 
AAAGATAGCC TCACTAGAGG TCTGGCAGTA ACTATCTCTG TGAAGTATAA GACAATGTCT 
ACTCTCTCCT GTAAGAACAA AACTATTTCC TTTCAGAAAA TGAGTCCTCC GGATAGTATC 
AATGATGAAG GAAATGACAT CATATTCTTT CAGAGAAGTG TTCCAGGCCA TGATGATAAG 
ATACAATTTG AGTCTTCATT GTACAAAGGA CACTTTCTAG CTTGTAAAAA AGAGAACGAT 
CTTTTCAAAC TCATTTTGAA AGACAAGGAT GAAAATGGGG ATAAATCCAT AATGTTCACT 
GTTCAAAACA AGAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL18 ( XM_005619483.3 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_005619540.1 Canis lupus familiaris interleukin 18 (IL18), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OCe05634
Clone ID Related Accession (Same CDS sequence)	XM_005619483.2 , XM_005619483.3
Accession Version	XM_005619483.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1504454400000
Organism	Canis lupus familiaris(dog)
Product	interleukin-18 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006587.3) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 5, 2017 this sequence version replaced XM_005619483.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAAGAC CTCCTTTCCT GATGTCCGGA ATAAAGATGG CTACTAACCT AATAGAAGAC 
AATTGCATCA ATCTTGTGAA AATGAAATTT GTTAACAATA CACTGTACTT TAAAGCGGAA 
AGTGATGAAG GCCTGGAATC AGATTACTTT GGCAAGCTTG AACCTAAACT CTCAATCATA 
CGAAATTTGA ACGACCAAGT CCTCTTCGTT AACGAGGGAA ATCAACCTGT ATTTGAGGAT 
ATGCCCGATT CTGACTGTAC AGATAATGCA CCCCATACCA TATTTATCAT CTATATGTAT 
AAAGATAGCC TCACTAGAGG TCTGGCAGTA ACTATCTCTG TGAAGTATAA GACAATGTCT 
ACTCTCTCCT GTAAGAACAA AACTATTTCC TTTCAGAAAA TGAGTCCTCC GGATAGTATC 
AATGATGAAG GAAATGACAT CATATTCTTT CAGAGAAGTG TTCCAGGCCA TGATGATAAG 
ATACAATTTG AGTCTTCATT GTACAAAGGA CACTTTCTAG CTTGTAAAAA AGAGAACGAT 
CTTTTCAAAC TCATTTTGAA AGACAAGGAT GAAAATGGGG ATAAATCCAT AATGTTCACT 
GTTCAAAACA AGAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005619540.1
CDS	130..747
Translation	MGRPPFLMSGIKMATNLIEDNCINLVKMKFVNNTLYFKAESDEGLESDYFGKLEPKLSIIRNLNDQVLFVNEGNQPVFEDMPDSDCTDNAPHTIFIIYMYKDSLTRGLAVTISVKYKTMSTLSCKNKTISFQKMSPPDSINDEGNDIIFFQRSVPGHDDKIQFESSLYKGHFLACKKENDLFKLILKDKDENGDKSIMFTVQNKS

Target ORF information:

RefSeq Version	XM_005619483.3
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris interleukin 18 (IL18), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005619483.3

ORF Insert Sequence:

ATGGGAAGAC CTCCTTTCCT GATGTCCGGA ATAAAGATGG CTACTAACCT AATAGAAGAC 
AATTGCATCA ATCTTGTGAA AATGAAATTT GTTAACAATA CACTGTACTT TAAAGCGGAA 
AGTGATGAAG GCCTGGAATC AGATTACTTT GGCAAGCTTG AACCTAAACT CTCAATCATA 
CGAAATTTGA ACGACCAAGT CCTCTTCGTT AACGAGGGAA ATCAACCTGT ATTTGAGGAT 
ATGCCCGATT CTGACTGTAC AGATAATGCA CCCCATACCA TATTTATCAT CTATATGTAT 
AAAGATAGCC TCACTAGAGG TCTGGCAGTA ACTATCTCTG TGAAGTATAA GACAATGTCT 
ACTCTCTCCT GTAAGAACAA AACTATTTCC TTTCAGAAAA TGAGTCCTCC GGATAGTATC 
AATGATGAAG GAAATGACAT CATATTCTTT CAGAGAAGTG TTCCAGGCCA TGATGATAAG 
ATACAATTTG AGTCTTCATT GTACAAAGGA CACTTTCTAG CTTGTAAAAA AGAGAACGAT 
CTTTTCAAAC TCATTTTGAA AGACAAGGAT GAAAATGGGG ATAAATCCAT AATGTTCACT 
GTTCAAAACA AGAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL18 ( XM_005619484.2 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_005619541.1 Canis lupus familiaris interleukin 18 (IL18), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OCe05635
Clone ID Related Accession (Same CDS sequence)	XM_005619484.2 , XM_005619484.3
Accession Version	XM_005619484.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1442332800000
Organism	Canis lupus familiaris(Dog)
Product	interleukin-18 isoform X2
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003726057.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 17, 2015 this sequence version replaced XM_005619484.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTACTA ACCTAATAGA AGACAATTGC ATCAATCTTG TGAAAATGAA ATTTGTTAAC 
AATACACTGT ACTTTAAAGC GGAAAGTGAT GAAGGCCTGG AATCAGATTA CTTTGGCAAG 
CTTGAACCTA AACTCTCAAT CATACGAAAT TTGAACGACC AAGTCCTCTT CGTTAACGAG 
GGAAATCAAC CTGTATTTGA GGATATGCCC GATTCTGACT GTACAGATAA TGCACCCCAT 
ACCATATTTA TCATCTATAT GTATAAAGAT AGCCTCACTA GAGGTCTGGC AGTAACTATC 
TCTGTGAAGT ATAAGACAAT GTCTACTCTC TCCTGTAAGA ACAAAACTAT TTCCTTTCAG 
AAAATGAGTC CTCCGGATAG TATCAATGAT GAAGGAAATG ACATCATATT CTTTCAGAGA 
AGTGTTCCAG GCCATGATGA TAAGATACAA TTTGAGTCTT CATTGTACAA AGGACACTTT 
CTAGCTTGTA AAAAAGAGAA CGATCTTTTC AAACTCATTT TGAAAGACAA GGATGAAAAT 
GGGGATAAAT CCATAATGTT CACTGTTCAA AACAAGAGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005619541.1
CDS	172..753
Translation	MATNLIEDNCINLVKMKFVNNTLYFKAESDEGLESDYFGKLEPKLSIIRNLNDQVLFVNEGNQPVFEDMPDSDCTDNAPHTIFIIYMYKDSLTRGLAVTISVKYKTMSTLSCKNKTISFQKMSPPDSINDEGNDIIFFQRSVPGHDDKIQFESSLYKGHFLACKKENDLFKLILKDKDENGDKSIMFTVQNKS

Target ORF information:

RefSeq Version	XM_005619484.2
Organism	Canis lupus familiaris(Dog)
Definition	Canis lupus familiaris interleukin 18 (IL18), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005619484.2

ORF Insert Sequence:

ATGGCTACTA ACCTAATAGA AGACAATTGC ATCAATCTTG TGAAAATGAA ATTTGTTAAC 
AATACACTGT ACTTTAAAGC GGAAAGTGAT GAAGGCCTGG AATCAGATTA CTTTGGCAAG 
CTTGAACCTA AACTCTCAAT CATACGAAAT TTGAACGACC AAGTCCTCTT CGTTAACGAG 
GGAAATCAAC CTGTATTTGA GGATATGCCC GATTCTGACT GTACAGATAA TGCACCCCAT 
ACCATATTTA TCATCTATAT GTATAAAGAT AGCCTCACTA GAGGTCTGGC AGTAACTATC 
TCTGTGAAGT ATAAGACAAT GTCTACTCTC TCCTGTAAGA ACAAAACTAT TTCCTTTCAG 
AAAATGAGTC CTCCGGATAG TATCAATGAT GAAGGAAATG ACATCATATT CTTTCAGAGA 
AGTGTTCCAG GCCATGATGA TAAGATACAA TTTGAGTCTT CATTGTACAA AGGACACTTT 
CTAGCTTGTA AAAAAGAGAA CGATCTTTTC AAACTCATTT TGAAAGACAA GGATGAAAAT 
GGGGATAAAT CCATAATGTT CACTGTTCAA AACAAGAGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL18 ( XM_005619484.3 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_005619541.1 Canis lupus familiaris interleukin 18 (IL18), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OCe05635
Clone ID Related Accession (Same CDS sequence)	XM_005619484.2 , XM_005619484.3
Accession Version	XM_005619484.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1504454400000
Organism	Canis lupus familiaris(dog)
Product	interleukin-18 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006587.3) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 5, 2017 this sequence version replaced XM_005619484.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTACTA ACCTAATAGA AGACAATTGC ATCAATCTTG TGAAAATGAA ATTTGTTAAC 
AATACACTGT ACTTTAAAGC GGAAAGTGAT GAAGGCCTGG AATCAGATTA CTTTGGCAAG 
CTTGAACCTA AACTCTCAAT CATACGAAAT TTGAACGACC AAGTCCTCTT CGTTAACGAG 
GGAAATCAAC CTGTATTTGA GGATATGCCC GATTCTGACT GTACAGATAA TGCACCCCAT 
ACCATATTTA TCATCTATAT GTATAAAGAT AGCCTCACTA GAGGTCTGGC AGTAACTATC 
TCTGTGAAGT ATAAGACAAT GTCTACTCTC TCCTGTAAGA ACAAAACTAT TTCCTTTCAG 
AAAATGAGTC CTCCGGATAG TATCAATGAT GAAGGAAATG ACATCATATT CTTTCAGAGA 
AGTGTTCCAG GCCATGATGA TAAGATACAA TTTGAGTCTT CATTGTACAA AGGACACTTT 
CTAGCTTGTA AAAAAGAGAA CGATCTTTTC AAACTCATTT TGAAAGACAA GGATGAAAAT 
GGGGATAAAT CCATAATGTT CACTGTTCAA AACAAGAGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005619541.1
CDS	177..758
Translation	MATNLIEDNCINLVKMKFVNNTLYFKAESDEGLESDYFGKLEPKLSIIRNLNDQVLFVNEGNQPVFEDMPDSDCTDNAPHTIFIIYMYKDSLTRGLAVTISVKYKTMSTLSCKNKTISFQKMSPPDSINDEGNDIIFFQRSVPGHDDKIQFESSLYKGHFLACKKENDLFKLILKDKDENGDKSIMFTVQNKS

Target ORF information:

RefSeq Version	XM_005619484.3
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris interleukin 18 (IL18), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005619484.3

ORF Insert Sequence:

ATGGCTACTA ACCTAATAGA AGACAATTGC ATCAATCTTG TGAAAATGAA ATTTGTTAAC 
AATACACTGT ACTTTAAAGC GGAAAGTGAT GAAGGCCTGG AATCAGATTA CTTTGGCAAG 
CTTGAACCTA AACTCTCAAT CATACGAAAT TTGAACGACC AAGTCCTCTT CGTTAACGAG 
GGAAATCAAC CTGTATTTGA GGATATGCCC GATTCTGACT GTACAGATAA TGCACCCCAT 
ACCATATTTA TCATCTATAT GTATAAAGAT AGCCTCACTA GAGGTCTGGC AGTAACTATC 
TCTGTGAAGT ATAAGACAAT GTCTACTCTC TCCTGTAAGA ACAAAACTAT TTCCTTTCAG 
AAAATGAGTC CTCCGGATAG TATCAATGAT GAAGGAAATG ACATCATATT CTTTCAGAGA 
AGTGTTCCAG GCCATGATGA TAAGATACAA TTTGAGTCTT CATTGTACAA AGGACACTTT 
CTAGCTTGTA AAAAAGAGAA CGATCTTTTC AAACTCATTT TGAAAGACAA GGATGAAAAT 
GGGGATAAAT CCATAATGTT CACTGTTCAA AACAAGAGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Canine interleukin-18 induces apoptosis and enhances Fas ligand mRNA expression in a canine carcinoma cell line.
Anticancer research20(5B)3411-5(2000 Sep- Oct)
Okano F,Yamada K

Semi-quantitative analysis of multiple cytokines in canine peripheral blood mononuclear cells by [correction of zby] a single tube RT-PCR.
Veterinary immunology and immunopathology83(3-4)191-202(2001 Dec)
Chamizo C,Rubio JM,Moreno J,Alvar J

Cloning, sequencing, and characterization of dog interleukin-18.
Immunogenetics49(6)541-3(1999 Jun)
Argyle DJ,McGillivery C,Nicolson L,Onions DE

Cloning of cDNA for canine interleukin-18 and canine interleukin-1beta converting enzyme and expression of canine interleukin-18.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research19(1)27-32(1999 Jan)
Okano F,Satoh M,Ido T,Yamada K

Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production.
European journal of immunology26(7)1647-51(1996 Jul)
Micallef MJ,Ohtsuki T,Kohno K,Tanabe F,Ushio S,Namba M,Tanimoto T,Torigoe K,Fujii M,Ikeda M,Fukuda S,Kurimoto M

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IL18 cDNA ORF clone, Canis lupus familiaris(dog)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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