ADAM10 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	ADAM10
Entrez Gene ID	282132
Full Name	ADAM metallopeptidase domain 10
Synonyms	ADAM 10
General protein information	Preferred Names ADAM metallopeptidase domain 10 Names disintegrin and metalloproteinase domain-containing protein 10 kuzbanian protein homolog mammalian disintegrin-metalloprotease myelin-associated metalloproteinase
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174496.2	NP_776921.1	disintegrin and metalloproteinase domain-containing protein 10 preproprotein
XM_024997276.1	XP_024853044.1	disintegrin and metalloproteinase domain-containing protein 10 isoform X1
NM_174496.3	NP_776921.1	disintegrin and metalloproteinase domain-containing protein 10 preproprotein
XM_024997275.1	XP_024853043.1	disintegrin and metalloproteinase domain-containing protein 10 isoform X1

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	adam10	NP_001037869.1
Bos taurus (cattle)	ADAM10	NP_776921.1
Danio rerio (zebrafish)	adam10a	NP_001152786.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003070	XP_312756.5
Pan troglodytes (chimpanzee)	ADAM10	XP_001172405.1
Mus musculus (house mouse)	Adam10	NP_031425.2
Rattus norvegicus (Norway rat)	Adam10	NP_062127.1
Macaca mulatta (Rhesus monkey)	ADAM10	XP_001097016.1
Homo sapiens (human)	ADAM10	NP_001101.1
Canis lupus familiaris (dog)	ADAM10	XP_005638749.1
Gallus gallus (chicken)	ADAM10	NP_989592.2

Gene Ontology
Bibliography

Related articles in PubMed

The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression.
Haining EJ, Yang J, Bailey RL, Khan K, Collier R, Tsai S, Watson SP, Frampton J, Garcia P, Tomlinson MG
The Journal of biological chemistry287(47)39753-65(2012 Nov)

A disintegrin and metalloprotease 10 activity sheds the ectodomain of the amyloid precursor-like protein 2 and regulates protein expression in proximal tubule cells.
Cong R, Li Y, Biemesderfer D
American journal of physiology. Cell physiology300(6)C1366-74(2011 Jun)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marçais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Functional role of N-glycosylation from ADAM10 in processing, localization and activity of the enzyme.
Escrevente C, Morais VA, Keller S, Soares CM, Altevogt P, Costa J
Biochimica et biophysica acta1780(6)905-13(2008 Jun)

A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration.
Wild-Bode C, Fellerer K, Kugler J, Haass C, Capell A
The Journal of biological chemistry281(33)23824-9(2006 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ADAM10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADAM10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OBa258711	NM_174496.3 Latest version!	Bos taurus ADAM metallopeptidase domain 10 (ADAM10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OBa41466	NM_174496.2 Latest version!	Bos taurus ADAM metallopeptidase domain 10 (ADAM10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OBa219411	XM_024997276.1 Latest version!	Bos taurus ADAM metallopeptidase domain 10 (ADAM10), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OBa219411	XM_024997275.1 Latest version!	Bos taurus ADAM metallopeptidase domain 10 (ADAM10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ADAM10 ( NM_174496.3 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776921.1 Bos taurus ADAM metallopeptidase domain 10 (ADAM10), mRNA.

Price & Availability↑

CloneID	OBa258711
Clone ID Related Accession (Same CDS sequence)	NM_174496.3
Accession Version	NM_174496.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2247bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571932800000
Organism	Bos taurus(cattle)
Product	disintegrin and metalloproteinase domain-containing protein 10 preproprotein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from NKLS02000010.1. On May 15, 2019 this sequence version replaced NM_174496.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR5571262.34802.1, BC153863.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145422 [ECO:0000348] ##Evidence-Data-END##

ATGGTGTTGC TGAGAGTGTT AATTCTGCTC CTCTCCTGGG TTGCGGGGCT GGGAGGTCAG 
TATGGAAATC CTTTAAATAA ATACATTAGA CATTATGAAG GATTATCATA TGATGTGGAT 
TCATTACACC AAAAACACCA GCGTGCCAAA AGAGCAGTAT CACATGAGGA CCAGTTTTTA 
CGGCTAGATT TTCATGCTCA TGGAAGACAT TTCAACCTTC GAATGAAGAG GGATACTTCC 
CTTTTCAGTG AGGAGTTTAG GGTGGAAACA TCAAATGCAG TACTGGATTA TGATACTTCT 
CATATTTACA CTGGACATAT TTATGGTGAA GAAGGAAGTT TTAGCCATGG GTCTGTTATT 
GATGGAAGAT TTGAAGGATT CATTCAGACT CATGGTGGCA CATTTTATGT TGAACCAGCA 
GAGAGATATA TTAAAGACCG AACTCTGCCA TTTCACTCTG TCATTTATCA TGAAGATGAT 
ATTAAGTATC CCCATAAATA TGGTCCACAG GGGGGTTGTG CAGATCATTC AGTGTTTGAA 
AGAATGAGGA AGTACCAGAT GACTGGTGTA GAAGAAGTAA CACAGACACC TCAAGAAAAA 
CATGCTATTA ATGGTCCAGA ACTCCTGAGG AAAAAACGTA CAACTGTAGC TGAAAAAAAT 
ACCTGTCAGC TTTATATTCA GACTGATCAT CTGTTCTTTA AATATTACGG AACACGAGAA 
GCTGTGATTG CCCAGATATC CAGTCATGTT AAAGCAATTG ACACAATTTA CCAGACAACA 
GACTTCTCTG GAATCCGTAA CATCAGTTTC ATGGTGAAAC GCATAAGAAT CAACACAACT 
GCTGATGAGA AGGACCCTAC AAATCCATTC CGTTTTCCAA ATATTGGTGT GGAGAAGTTT 
CTGGAGCTGA ATTCTGAGCA GAATCATGAT GACTACTGTT TGGCCTACGT TTTCACAGAT 
CGAGATTTTG ATGATGGTGT CCTTGGTCTG GCGTGGGTTG GAGCACCTTC AGGAAGCTCT 
GGAGGAATAT GTGAAAAAAG TAAGCTCTAT TCAGATGGTA AGAAGAAGTC TTTAAACACT 
GGAATTATTA CTGTTCAGAA CTATGGGTCT CACGTACCCC CCAAAGTCTC TCACATTACG 
TTTGCTCATG AAGTTGGACA TAACTTTGGA TCTCCGCATG ATTCTGGAAC AGAGTGCACT 
CCAGGAGAAT CTAAGAATTT AGGACAAAAA GAAAATGGCA ACTACATCAT GTATGCAAGA 
GCAACATCTG GGGACAAACT TAACAACAAT AAATTCTCAC TCTGTAGTAT TAGAAATATA 
AGTCAAGTTC TTGAGAAGAA GAGAAACAAC TGTTTTGTTG AATCTGGCCA ACCTATTTGT 
GGAAATGGGA TGGTAGAACA AGGTGAAGAA TGTGATTGTG GTTATAGTGA CCAGTGTAAA 
GACGAGTGCT GCTACGATGC AAATCAGCCG GAGGGGAAAA AATGCAAGCT GAAACCTGGA 
AAGCAGTGCA GTCCAAGTCA AGGTCCCTGT TGTACAGCAC ATTGTGCATT CAAGTCAAAA 
ACTGAAAAGT GTCGGGATGA TTCAGACTGT GCAAAAGAAG GAATATGTAA TGGCATCACA 
GCTCTCTGCC CAGCCTCTGA TCCTAAACCG AACTTCACAG ACTGTAATAG ACATACGCAA 
GTGTGCATTA ATGGGCAATG TGCAGGTTCT ATCTGTGAGA AACATGGCTT GGAGGAGTGT 
ACCTGTGCCA GTTCTGATGG CAAAGATGAT AAGGAATTAT GCCATGTCTG CTGTATGAAG 
AAGATGGAGC CATCAACTTG TGCCAGTACA GGGTCTGTGC AGTGGAACAA GTACTTCCTT 
GGTCGAACTA TCACCCTGCA ACCTGGATCC CCATGCAATG ATTTTAGAGG CTACTGTGAT 
GTTTTCATGC GGTGCAGATT AGTAGATGCT GATGGTCCTC TAGCGAGGCT TAAAAAAGCA 
ATTTTCAGTC CAGAGCTCTA TGAAAACATA GCTGAATGGA TTGTGGCTTA CTGGTGGGCA 
GTATTACTTA TGGGAATTGC CCTGATCATG TTAATGGCTG GTTTTATTAA GATATGCAGT 
GTACACACTC CAAGTAGTAA TCCAAAGTTG CCTCCTCCTA AACCTCTTCC AGGCACTTTA 
AAGAGGAGAA GACCTCCCCA GCCCATTCAA CAGCCCCAGC GTCAGAGGCC CCGGGAGAGT 
TATCAGATGG GACACATGAG ACGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776921.1
CDS	226..2472
Translation	MVLLRVLILLLSWVAGLGGQYGNPLNKYIRHYEGLSYDVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSEEFRVETSNAVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTHGGTFYVEPAERYIKDRTLPFHSVIYHEDDIKYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQTPQEKHAINGPELLRKKRTTVAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCYDANQPEGKKCKLKPGKQCSPSQGPCCTAHCAFKSKTEKCRDDSDCAKEGICNGITALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKHGLEECTCASSDGKDDKELCHVCCMKKMEPSTCASTGSVQWNKYFLGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAYWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR

Target ORF information:

RefSeq Version	NM_174496.3
Organism	Bos taurus(cattle)
Definition	Bos taurus ADAM metallopeptidase domain 10 (ADAM10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174496.3

ORF Insert Sequence:

ATGGTGTTGC TGAGAGTGTT AATTCTGCTC CTCTCCTGGG TTGCGGGGCT GGGAGGTCAG 
TATGGAAATC CTTTAAATAA ATACATTAGA CATTATGAAG GATTATCATA TGATGTGGAT 
TCATTACACC AAAAACACCA GCGTGCCAAA AGAGCAGTAT CACATGAGGA CCAGTTTTTA 
CGGCTAGATT TTCATGCTCA TGGAAGACAT TTCAACCTTC GAATGAAGAG GGATACTTCC 
CTTTTCAGTG AGGAGTTTAG GGTGGAAACA TCAAATGCAG TACTGGATTA TGATACTTCT 
CATATTTACA CTGGACATAT TTATGGTGAA GAAGGAAGTT TTAGCCATGG GTCTGTTATT 
GATGGAAGAT TTGAAGGATT CATTCAGACT CATGGTGGCA CATTTTATGT TGAACCAGCA 
GAGAGATATA TTAAAGACCG AACTCTGCCA TTTCACTCTG TCATTTATCA TGAAGATGAT 
ATTAAGTATC CCCATAAATA TGGTCCACAG GGGGGTTGTG CAGATCATTC AGTGTTTGAA 
AGAATGAGGA AGTACCAGAT GACTGGTGTA GAAGAAGTAA CACAGACACC TCAAGAAAAA 
CATGCTATTA ATGGTCCAGA ACTCCTGAGG AAAAAACGTA CAACTGTAGC TGAAAAAAAT 
ACCTGTCAGC TTTATATTCA GACTGATCAT CTGTTCTTTA AATATTACGG AACACGAGAA 
GCTGTGATTG CCCAGATATC CAGTCATGTT AAAGCAATTG ACACAATTTA CCAGACAACA 
GACTTCTCTG GAATCCGTAA CATCAGTTTC ATGGTGAAAC GCATAAGAAT CAACACAACT 
GCTGATGAGA AGGACCCTAC AAATCCATTC CGTTTTCCAA ATATTGGTGT GGAGAAGTTT 
CTGGAGCTGA ATTCTGAGCA GAATCATGAT GACTACTGTT TGGCCTACGT TTTCACAGAT 
CGAGATTTTG ATGATGGTGT CCTTGGTCTG GCGTGGGTTG GAGCACCTTC AGGAAGCTCT 
GGAGGAATAT GTGAAAAAAG TAAGCTCTAT TCAGATGGTA AGAAGAAGTC TTTAAACACT 
GGAATTATTA CTGTTCAGAA CTATGGGTCT CACGTACCCC CCAAAGTCTC TCACATTACG 
TTTGCTCATG AAGTTGGACA TAACTTTGGA TCTCCGCATG ATTCTGGAAC AGAGTGCACT 
CCAGGAGAAT CTAAGAATTT AGGACAAAAA GAAAATGGCA ACTACATCAT GTATGCAAGA 
GCAACATCTG GGGACAAACT TAACAACAAT AAATTCTCAC TCTGTAGTAT TAGAAATATA 
AGTCAAGTTC TTGAGAAGAA GAGAAACAAC TGTTTTGTTG AATCTGGCCA ACCTATTTGT 
GGAAATGGGA TGGTAGAACA AGGTGAAGAA TGTGATTGTG GTTATAGTGA CCAGTGTAAA 
GACGAGTGCT GCTACGATGC AAATCAGCCG GAGGGGAAAA AATGCAAGCT GAAACCTGGA 
AAGCAGTGCA GTCCAAGTCA AGGTCCCTGT TGTACAGCAC ATTGTGCATT CAAGTCAAAA 
ACTGAAAAGT GTCGGGATGA TTCAGACTGT GCAAAAGAAG GAATATGTAA TGGCATCACA 
GCTCTCTGCC CAGCCTCTGA TCCTAAACCG AACTTCACAG ACTGTAATAG ACATACGCAA 
GTGTGCATTA ATGGGCAATG TGCAGGTTCT ATCTGTGAGA AACATGGCTT GGAGGAGTGT 
ACCTGTGCCA GTTCTGATGG CAAAGATGAT AAGGAATTAT GCCATGTCTG CTGTATGAAG 
AAGATGGAGC CATCAACTTG TGCCAGTACA GGGTCTGTGC AGTGGAACAA GTACTTCCTT 
GGTCGAACTA TCACCCTGCA ACCTGGATCC CCATGCAATG ATTTTAGAGG CTACTGTGAT 
GTTTTCATGC GGTGCAGATT AGTAGATGCT GATGGTCCTC TAGCGAGGCT TAAAAAAGCA 
ATTTTCAGTC CAGAGCTCTA TGAAAACATA GCTGAATGGA TTGTGGCTTA CTGGTGGGCA 
GTATTACTTA TGGGAATTGC CCTGATCATG TTAATGGCTG GTTTTATTAA GATATGCAGT 
GTACACACTC CAAGTAGTAA TCCAAAGTTG CCTCCTCCTA AACCTCTTCC AGGCACTTTA 
AAGAGGAGAA GACCTCCCCA GCCCATTCAA CAGCCCCAGC GTCAGAGGCC CCGGGAGAGT 
TATCAGATGG GACACATGAG ACGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADAM10 ( NM_174496.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776921.1 Bos taurus ADAM metallopeptidase domain 10 (ADAM10), mRNA.

Price & Availability↑

CloneID	OBa41466
Clone ID Related Accession (Same CDS sequence)	NM_174496.2
Accession Version	NM_174496.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2247bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550160000000
Organism	Bos taurus(cattle)
Product	disintegrin and metalloproteinase domain-containing protein 10 preproprotein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Z21961.1. On or before Mar 29, 2005 this sequence version replaced XM_607174.1, NM_174496.1. ##Evidence-Data-START## Transcript exon combination :: Z21961.1, BC153863.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145422 [ECO:0000348] ##Evidence-Data-END##

ATGGTGTTGC TGAGAGTGTT AATTCTGCTC CTCTCCTGGG TTGCGGGGCT GGGAGGTCAG 
TATGGAAATC CTTTAAATAA ATACATTAGA CATTATGAAG GATTATCATA TGATGTGGAT 
TCATTACACC AAAAACACCA GCGTGCCAAA AGAGCAGTAT CACATGAGGA CCAGTTTTTA 
CGGCTAGATT TTCATGCTCA TGGAAGACAT TTCAACCTTC GAATGAAGAG GGATACTTCC 
CTTTTCAGTG AGGAGTTTAG GGTGGAAACA TCAAATGCAG TACTGGATTA TGATACTTCT 
CATATTTACA CTGGACATAT TTATGGTGAA GAAGGAAGTT TTAGCCATGG GTCTGTTATT 
GATGGAAGAT TTGAAGGATT CATTCAGACT CATGGTGGCA CATTTTATGT TGAACCAGCA 
GAGAGATATA TTAAAGACCG AACTCTGCCA TTTCACTCTG TCATTTATCA TGAAGATGAT 
ATTAAGTATC CCCATAAATA TGGTCCACAG GGGGGTTGTG CAGATCATTC AGTGTTTGAA 
AGAATGAGGA AGTACCAGAT GACTGGTGTA GAAGAAGTAA CACAGACACC TCAAGAAAAA 
CATGCTATTA ATGGTCCAGA ACTCCTGAGG AAAAAACGTA CAACTGTAGC TGAAAAAAAT 
ACCTGTCAGC TTTATATTCA GACCGATCAT CTGTTCTTTA AATATTACGG AACACGAGAA 
GCTGTGATTG CCCAGATATC CAGTCATGTT AAAGCAATTG ACACAATTTA CCAGACAACA 
GACTTCTCTG GAATCCGTAA CATCAGTTTC ATGGTGAAAC GCATAAGAAT CAACACAACT 
GCTGATGAGA AGGACCCTAC AAATCCATTC CGTTTTCCAA ATATTGGTGT GGAGAAGTTT 
CTGGAGCTGA ATTCTGAGCA GAATCATGAT GACTACTGTT TGGCCTACGT TTTCACAGAT 
CGAGATTTTG ATGATGGTGT CCTTGGTCTG GCGTGGGTTG GAGCACCTTC AGGAAGCTCT 
GGAGGAATAT GTGAAAAAAG TAAGCTCTAT TCAGATGGTA AGAAGAAGTC TTTAAACACT 
GGAATTATTA CTGTTCAGAA CTATGGGTCT CACGTACCCC CCAAAGTCTC TCACATTACG 
TTTGCTCATG AAGTTGGACA TAACTTTGGA TCTCCGCATG ATTCTGGAAC AGAGTGCACT 
CCAGGAGAAT CTAAGAATTT AGGACAAAAA GAAAATGGCA ACTACATCAT GTATGCAAGA 
GCAACATCTG GGGACAAACT TAACAACAAT AAATTCTCAC TCTGTAGTAT TAGAAATATA 
AGTCAAGTTC TTGAGAAGAA GAGAAACAAC TGTTTTGTTG AATCTGGCCA ACCTATTTGT 
GGAAATGGGA TGGTAGAACA AGGTGAAGAA TGTGATTGTG GTTATAGTGA CCAGTGTAAA 
GACGAGTGCT GCTACGATGC AAATCAGCCG GAGGGGAAAA AATGCAAGCT GAAACCTGGA 
AAGCAGTGCA GTCCAAGTCA AGGTCCCTGT TGTACAGCAC ATTGTGCATT CAAGTCAAAA 
ACTGAAAAGT GTCGGGATGA TTCAGACTGT GCAAAAGAAG GAATATGTAA TGGCATCACA 
GCTCTCTGCC CAGCCTCTGA TCCTAAACCG AACTTCACAG ACTGTAATAG ACATACGCAA 
GTGTGCATTA ATGGGCAATG TGCAGGTTCT ATCTGTGAGA AACATGGCTT GGAGGAGTGT 
ACCTGTGCCA GTTCTGATGG CAAAGATGAT AAGGAATTAT GCCATGTCTG CTGTATGAAG 
AAGATGGAGC CATCAACTTG TGCCAGTACA GGGTCTGTGC AGTGGAACAA GTACTTCCTT 
GGTCGAACTA TCACCCTGCA ACCTGGATCC CCATGCAATG ATTTTAGAGG CTACTGTGAT 
GTTTTCATGC GGTGCAGATT AGTAGATGCT GATGGTCCTC TAGCGAGGCT TAAAAAAGCA 
ATTTTCAGTC CAGAGCTCTA TGAAAACATA GCTGAATGGA TTGTGGCTTA CTGGTGGGCA 
GTATTACTTA TGGGAATTGC CCTGATCATG TTAATGGCTG GTTTTATTAA GATATGCAGT 
GTACACACTC CAAGTAGTAA TCCAAAGTTG CCTCCTCCTA AACCTCTTCC AGGCACTTTA 
AAGAGGAGAA GACCTCCCCA GCCCATTCAA CAGCCCCAGC GTCAGAGGCC CCGGGAGAGT 
TATCAGATGG GACACATGAG ACGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776921.1
CDS	17..2263
Translation	MVLLRVLILLLSWVAGLGGQYGNPLNKYIRHYEGLSYDVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSEEFRVETSNAVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTHGGTFYVEPAERYIKDRTLPFHSVIYHEDDIKYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQTPQEKHAINGPELLRKKRTTVAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCYDANQPEGKKCKLKPGKQCSPSQGPCCTAHCAFKSKTEKCRDDSDCAKEGICNGITALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKHGLEECTCASSDGKDDKELCHVCCMKKMEPSTCASTGSVQWNKYFLGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAYWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR

Target ORF information:

RefSeq Version	NM_174496.2
Organism	Bos taurus(cattle)
Definition	Bos taurus ADAM metallopeptidase domain 10 (ADAM10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174496.2

ORF Insert Sequence:

ATGGTGTTGC TGAGAGTGTT AATTCTGCTC CTCTCCTGGG TTGCGGGGCT GGGAGGTCAG 
TATGGAAATC CTTTAAATAA ATACATTAGA CATTATGAAG GATTATCATA TGATGTGGAT 
TCATTACACC AAAAACACCA GCGTGCCAAA AGAGCAGTAT CACATGAGGA CCAGTTTTTA 
CGGCTAGATT TTCATGCTCA TGGAAGACAT TTCAACCTTC GAATGAAGAG GGATACTTCC 
CTTTTCAGTG AGGAGTTTAG GGTGGAAACA TCAAATGCAG TACTGGATTA TGATACTTCT 
CATATTTACA CTGGACATAT TTATGGTGAA GAAGGAAGTT TTAGCCATGG GTCTGTTATT 
GATGGAAGAT TTGAAGGATT CATTCAGACT CATGGTGGCA CATTTTATGT TGAACCAGCA 
GAGAGATATA TTAAAGACCG AACTCTGCCA TTTCACTCTG TCATTTATCA TGAAGATGAT 
ATTAAGTATC CCCATAAATA TGGTCCACAG GGGGGTTGTG CAGATCATTC AGTGTTTGAA 
AGAATGAGGA AGTACCAGAT GACTGGTGTA GAAGAAGTAA CACAGACACC TCAAGAAAAA 
CATGCTATTA ATGGTCCAGA ACTCCTGAGG AAAAAACGTA CAACTGTAGC TGAAAAAAAT 
ACCTGTCAGC TTTATATTCA GACCGATCAT CTGTTCTTTA AATATTACGG AACACGAGAA 
GCTGTGATTG CCCAGATATC CAGTCATGTT AAAGCAATTG ACACAATTTA CCAGACAACA 
GACTTCTCTG GAATCCGTAA CATCAGTTTC ATGGTGAAAC GCATAAGAAT CAACACAACT 
GCTGATGAGA AGGACCCTAC AAATCCATTC CGTTTTCCAA ATATTGGTGT GGAGAAGTTT 
CTGGAGCTGA ATTCTGAGCA GAATCATGAT GACTACTGTT TGGCCTACGT TTTCACAGAT 
CGAGATTTTG ATGATGGTGT CCTTGGTCTG GCGTGGGTTG GAGCACCTTC AGGAAGCTCT 
GGAGGAATAT GTGAAAAAAG TAAGCTCTAT TCAGATGGTA AGAAGAAGTC TTTAAACACT 
GGAATTATTA CTGTTCAGAA CTATGGGTCT CACGTACCCC CCAAAGTCTC TCACATTACG 
TTTGCTCATG AAGTTGGACA TAACTTTGGA TCTCCGCATG ATTCTGGAAC AGAGTGCACT 
CCAGGAGAAT CTAAGAATTT AGGACAAAAA GAAAATGGCA ACTACATCAT GTATGCAAGA 
GCAACATCTG GGGACAAACT TAACAACAAT AAATTCTCAC TCTGTAGTAT TAGAAATATA 
AGTCAAGTTC TTGAGAAGAA GAGAAACAAC TGTTTTGTTG AATCTGGCCA ACCTATTTGT 
GGAAATGGGA TGGTAGAACA AGGTGAAGAA TGTGATTGTG GTTATAGTGA CCAGTGTAAA 
GACGAGTGCT GCTACGATGC AAATCAGCCG GAGGGGAAAA AATGCAAGCT GAAACCTGGA 
AAGCAGTGCA GTCCAAGTCA AGGTCCCTGT TGTACAGCAC ATTGTGCATT CAAGTCAAAA 
ACTGAAAAGT GTCGGGATGA TTCAGACTGT GCAAAAGAAG GAATATGTAA TGGCATCACA 
GCTCTCTGCC CAGCCTCTGA TCCTAAACCG AACTTCACAG ACTGTAATAG ACATACGCAA 
GTGTGCATTA ATGGGCAATG TGCAGGTTCT ATCTGTGAGA AACATGGCTT GGAGGAGTGT 
ACCTGTGCCA GTTCTGATGG CAAAGATGAT AAGGAATTAT GCCATGTCTG CTGTATGAAG 
AAGATGGAGC CATCAACTTG TGCCAGTACA GGGTCTGTGC AGTGGAACAA GTACTTCCTT 
GGTCGAACTA TCACCCTGCA ACCTGGATCC CCATGCAATG ATTTTAGAGG CTACTGTGAT 
GTTTTCATGC GGTGCAGATT AGTAGATGCT GATGGTCCTC TAGCGAGGCT TAAAAAAGCA 
ATTTTCAGTC CAGAGCTCTA TGAAAACATA GCTGAATGGA TTGTGGCTTA CTGGTGGGCA 
GTATTACTTA TGGGAATTGC CCTGATCATG TTAATGGCTG GTTTTATTAA GATATGCAGT 
GTACACACTC CAAGTAGTAA TCCAAAGTTG CCTCCTCCTA AACCTCTTCC AGGCACTTTA 
AAGAGGAGAA GACCTCCCCA GCCCATTCAA CAGCCCCAGC GTCAGAGGCC CCGGGAGAGT 
TATCAGATGG GACACATGAG ACGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADAM10 ( XM_024997276.1 ) cDNA ORF clone, Bos taurus(cattle) -> XP_024853044.1 Bos taurus ADAM metallopeptidase domain 10 (ADAM10), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OBa219411
Clone ID Related Accession (Same CDS sequence)	XM_024997276.1 , XM_024997275.1
Accession Version	XM_024997276.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2025bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1525536000000
Organism	Bos taurus(cattle)
Product	disintegrin and metalloproteinase domain-containing protein 10 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037337.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGAGGG ATACTTCCCT TTTCAGTGAG GAGTTTAGGG TGGAAACATC AAATGCAGTA 
CTGGATTATG ATACTTCTCA TATTTACACT GGACATATTT ATGGTGAAGA AGGAAGTTTT 
AGCCATGGGT CTGTTATTGA TGGAAGATTT GAAGGATTCA TTCAGACTCA TGGTGGCACA 
TTTTATGTTG AACCAGCAGA GAGATATATT AAAGACCGAA CTCTGCCATT TCACTCTGTC 
ATTTATCATG AAGATGATAT TAAGTATCCC CATAAATATG GTCCACAGGG GGGTTGTGCA 
GATCATTCAG TGTTTGAAAG AATGAGGAAG TACCAGATGA CTGGTGTAGA AGAAGTAACA 
CAGACACCTC AAGAAAAACA TGCTATTAAT GGTCCAGAAC TCCTGAGGAA AAAACGTACA 
ACTGTAGCTG AAAAAAATAC CTGTCAGCTT TATATTCAGA CTGATCATCT GTTCTTTAAA 
TATTACGGAA CACGAGAAGC TGTGATTGCC CAGATATCCA GTCATGTTAA AGCAATTGAC 
ACAATTTACC AGACAACAGA CTTCTCTGGA ATCCGTAACA TCAGTTTCAT GGTGAAACGC 
ATAAGAATCA ACACAACTGC TGATGAGAAG GACCCTACAA ATCCATTCCG TTTTCCAAAT 
ATTGGTGTGG AGAAGTTTCT GGAGCTGAAT TCTGAGCAGA ATCATGATGA CTACTGTTTG 
GCCTACGTTT TCACAGATCG AGATTTTGAT GATGGTGTCC TTGGTCTGGC GTGGGTTGGA 
GCACCTTCAG GAAGCTCTGG AGGAATATGT GAAAAAAGTA AGCTCTATTC AGATGGTAAG 
AAGAAGTCTT TAAACACTGG AATTATTACT GTTCAGAACT ATGGGTCTCA CGTACCCCCC 
AAAGTCTCTC ACATTACGTT TGCTCATGAA GTTGGACATA ACTTTGGATC TCCGCATGAT 
TCTGGAACAG AGTGCACTCC AGGAGAATCT AAGAATTTAG GACAAAAAGA AAATGGCAAC 
TACATCATGT ATGCAAGAGC AACATCTGGG GACAAACTTA ACAACAATAA ATTCTCACTC 
TGTAGTATTA GAAATATAAG TCAAGTTCTT GAGAAGAAGA GAAACAACTG TTTTGTTGAA 
TCTGGCCAAC CTATTTGTGG AAATGGGATG GTAGAACAAG GTGAAGAATG TGATTGTGGT 
TATAGTGACC AGTGTAAAGA CGAGTGCTGC TACGATGCAA ATCAGCCGGA GGGGAAAAAA 
TGCAAGCTGA AACCTGGAAA GCAGTGCAGT CCAAGTCAAG GTCCCTGTTG TACAGCACAT 
TGTGCATTCA AGTCAAAAAC TGAAAAGTGT CGGGATGATT CAGACTGTGC AAAAGAAGGA 
ATATGTAATG GCATCACAGC TCTCTGCCCA GCCTCTGATC CTAAACCGAA CTTCACAGAC 
TGTAATAGAC ATACGCAAGT GTGCATTAAT GGGCAATGTG CAGGTTCTAT CTGTGAGAAA 
CATGGCTTGG AGGAGTGTAC CTGTGCCAGT TCTGATGGCA AAGATGATAA GGAATTATGC 
CATGTCTGCT GTATGAAGAA GATGGAGCCA TCAACTTGTG CCAGTACAGG GTCTGTGCAG 
TGGAACAAGT ACTTCCTTGG TCGAACTATC ACCCTGCAAC CTGGATCCCC ATGCAATGAT 
TTTAGAGGCT ACTGTGATGT TTTCATGCGG TGCAGATTAG TAGATGCTGA TGGTCCTCTA 
GCGAGGCTTA AAAAAGCAAT TTTCAGTCCA GAGCTCTATG AAAACATAGC TGAATGGATT 
GTGGCTTACT GGTGGGCAGT ATTACTTATG GGAATTGCCC TGATCATGTT AATGGCTGGT 
TTTATTAAGA TATGCAGTGT ACACACTCCA AGTAGTAATC CAAAGTTGCC TCCTCCTAAA 
CCTCTTCCAG GCACTTTAAA GAGGAGAAGA CCTCCCCAGC CCATTCAACA GCCCCAGCGT 
CAGAGGCCCC GGGAGAGTTA TCAGATGGGA CACATGAGAC GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024853044.1
CDS	339..2363
Translation	MKRDTSLFSEEFRVETSNAVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTHGGTFYVEPAERYIKDRTLPFHSVIYHEDDIKYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQTPQEKHAINGPELLRKKRTTVAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCYDANQPEGKKCKLKPGKQCSPSQGPCCTAHCAFKSKTEKCRDDSDCAKEGICNGITALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKHGLEECTCASSDGKDDKELCHVCCMKKMEPSTCASTGSVQWNKYFLGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAYWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR

Target ORF information:

RefSeq Version	XM_024997276.1
Organism	Bos taurus(cattle)
Definition	Bos taurus ADAM metallopeptidase domain 10 (ADAM10), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024997276.1

ORF Insert Sequence:

ATGAAGAGGG ATACTTCCCT TTTCAGTGAG GAGTTTAGGG TGGAAACATC AAATGCAGTA 
CTGGATTATG ATACTTCTCA TATTTACACT GGACATATTT ATGGTGAAGA AGGAAGTTTT 
AGCCATGGGT CTGTTATTGA TGGAAGATTT GAAGGATTCA TTCAGACTCA TGGTGGCACA 
TTTTATGTTG AACCAGCAGA GAGATATATT AAAGACCGAA CTCTGCCATT TCACTCTGTC 
ATTTATCATG AAGATGATAT TAAGTATCCC CATAAATATG GTCCACAGGG GGGTTGTGCA 
GATCATTCAG TGTTTGAAAG AATGAGGAAG TACCAGATGA CTGGTGTAGA AGAAGTAACA 
CAGACACCTC AAGAAAAACA TGCTATTAAT GGTCCAGAAC TCCTGAGGAA AAAACGTACA 
ACTGTAGCTG AAAAAAATAC CTGTCAGCTT TATATTCAGA CTGATCATCT GTTCTTTAAA 
TATTACGGAA CACGAGAAGC TGTGATTGCC CAGATATCCA GTCATGTTAA AGCAATTGAC 
ACAATTTACC AGACAACAGA CTTCTCTGGA ATCCGTAACA TCAGTTTCAT GGTGAAACGC 
ATAAGAATCA ACACAACTGC TGATGAGAAG GACCCTACAA ATCCATTCCG TTTTCCAAAT 
ATTGGTGTGG AGAAGTTTCT GGAGCTGAAT TCTGAGCAGA ATCATGATGA CTACTGTTTG 
GCCTACGTTT TCACAGATCG AGATTTTGAT GATGGTGTCC TTGGTCTGGC GTGGGTTGGA 
GCACCTTCAG GAAGCTCTGG AGGAATATGT GAAAAAAGTA AGCTCTATTC AGATGGTAAG 
AAGAAGTCTT TAAACACTGG AATTATTACT GTTCAGAACT ATGGGTCTCA CGTACCCCCC 
AAAGTCTCTC ACATTACGTT TGCTCATGAA GTTGGACATA ACTTTGGATC TCCGCATGAT 
TCTGGAACAG AGTGCACTCC AGGAGAATCT AAGAATTTAG GACAAAAAGA AAATGGCAAC 
TACATCATGT ATGCAAGAGC AACATCTGGG GACAAACTTA ACAACAATAA ATTCTCACTC 
TGTAGTATTA GAAATATAAG TCAAGTTCTT GAGAAGAAGA GAAACAACTG TTTTGTTGAA 
TCTGGCCAAC CTATTTGTGG AAATGGGATG GTAGAACAAG GTGAAGAATG TGATTGTGGT 
TATAGTGACC AGTGTAAAGA CGAGTGCTGC TACGATGCAA ATCAGCCGGA GGGGAAAAAA 
TGCAAGCTGA AACCTGGAAA GCAGTGCAGT CCAAGTCAAG GTCCCTGTTG TACAGCACAT 
TGTGCATTCA AGTCAAAAAC TGAAAAGTGT CGGGATGATT CAGACTGTGC AAAAGAAGGA 
ATATGTAATG GCATCACAGC TCTCTGCCCA GCCTCTGATC CTAAACCGAA CTTCACAGAC 
TGTAATAGAC ATACGCAAGT GTGCATTAAT GGGCAATGTG CAGGTTCTAT CTGTGAGAAA 
CATGGCTTGG AGGAGTGTAC CTGTGCCAGT TCTGATGGCA AAGATGATAA GGAATTATGC 
CATGTCTGCT GTATGAAGAA GATGGAGCCA TCAACTTGTG CCAGTACAGG GTCTGTGCAG 
TGGAACAAGT ACTTCCTTGG TCGAACTATC ACCCTGCAAC CTGGATCCCC ATGCAATGAT 
TTTAGAGGCT ACTGTGATGT TTTCATGCGG TGCAGATTAG TAGATGCTGA TGGTCCTCTA 
GCGAGGCTTA AAAAAGCAAT TTTCAGTCCA GAGCTCTATG AAAACATAGC TGAATGGATT 
GTGGCTTACT GGTGGGCAGT ATTACTTATG GGAATTGCCC TGATCATGTT AATGGCTGGT 
TTTATTAAGA TATGCAGTGT ACACACTCCA AGTAGTAATC CAAAGTTGCC TCCTCCTAAA 
CCTCTTCCAG GCACTTTAAA GAGGAGAAGA CCTCCCCAGC CCATTCAACA GCCCCAGCGT 
CAGAGGCCCC GGGAGAGTTA TCAGATGGGA CACATGAGAC GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADAM10 ( XM_024997275.1 ) cDNA ORF clone, Bos taurus(cattle) -> XP_024853043.1 Bos taurus ADAM metallopeptidase domain 10 (ADAM10), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OBa219411
Clone ID Related Accession (Same CDS sequence)	XM_024997276.1 , XM_024997275.1
Accession Version	XM_024997275.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2025bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1525536000000
Organism	Bos taurus(cattle)
Product	disintegrin and metalloproteinase domain-containing protein 10 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037337.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGAGGG ATACTTCCCT TTTCAGTGAG GAGTTTAGGG TGGAAACATC AAATGCAGTA 
CTGGATTATG ATACTTCTCA TATTTACACT GGACATATTT ATGGTGAAGA AGGAAGTTTT 
AGCCATGGGT CTGTTATTGA TGGAAGATTT GAAGGATTCA TTCAGACTCA TGGTGGCACA 
TTTTATGTTG AACCAGCAGA GAGATATATT AAAGACCGAA CTCTGCCATT TCACTCTGTC 
ATTTATCATG AAGATGATAT TAAGTATCCC CATAAATATG GTCCACAGGG GGGTTGTGCA 
GATCATTCAG TGTTTGAAAG AATGAGGAAG TACCAGATGA CTGGTGTAGA AGAAGTAACA 
CAGACACCTC AAGAAAAACA TGCTATTAAT GGTCCAGAAC TCCTGAGGAA AAAACGTACA 
ACTGTAGCTG AAAAAAATAC CTGTCAGCTT TATATTCAGA CTGATCATCT GTTCTTTAAA 
TATTACGGAA CACGAGAAGC TGTGATTGCC CAGATATCCA GTCATGTTAA AGCAATTGAC 
ACAATTTACC AGACAACAGA CTTCTCTGGA ATCCGTAACA TCAGTTTCAT GGTGAAACGC 
ATAAGAATCA ACACAACTGC TGATGAGAAG GACCCTACAA ATCCATTCCG TTTTCCAAAT 
ATTGGTGTGG AGAAGTTTCT GGAGCTGAAT TCTGAGCAGA ATCATGATGA CTACTGTTTG 
GCCTACGTTT TCACAGATCG AGATTTTGAT GATGGTGTCC TTGGTCTGGC GTGGGTTGGA 
GCACCTTCAG GAAGCTCTGG AGGAATATGT GAAAAAAGTA AGCTCTATTC AGATGGTAAG 
AAGAAGTCTT TAAACACTGG AATTATTACT GTTCAGAACT ATGGGTCTCA CGTACCCCCC 
AAAGTCTCTC ACATTACGTT TGCTCATGAA GTTGGACATA ACTTTGGATC TCCGCATGAT 
TCTGGAACAG AGTGCACTCC AGGAGAATCT AAGAATTTAG GACAAAAAGA AAATGGCAAC 
TACATCATGT ATGCAAGAGC AACATCTGGG GACAAACTTA ACAACAATAA ATTCTCACTC 
TGTAGTATTA GAAATATAAG TCAAGTTCTT GAGAAGAAGA GAAACAACTG TTTTGTTGAA 
TCTGGCCAAC CTATTTGTGG AAATGGGATG GTAGAACAAG GTGAAGAATG TGATTGTGGT 
TATAGTGACC AGTGTAAAGA CGAGTGCTGC TACGATGCAA ATCAGCCGGA GGGGAAAAAA 
TGCAAGCTGA AACCTGGAAA GCAGTGCAGT CCAAGTCAAG GTCCCTGTTG TACAGCACAT 
TGTGCATTCA AGTCAAAAAC TGAAAAGTGT CGGGATGATT CAGACTGTGC AAAAGAAGGA 
ATATGTAATG GCATCACAGC TCTCTGCCCA GCCTCTGATC CTAAACCGAA CTTCACAGAC 
TGTAATAGAC ATACGCAAGT GTGCATTAAT GGGCAATGTG CAGGTTCTAT CTGTGAGAAA 
CATGGCTTGG AGGAGTGTAC CTGTGCCAGT TCTGATGGCA AAGATGATAA GGAATTATGC 
CATGTCTGCT GTATGAAGAA GATGGAGCCA TCAACTTGTG CCAGTACAGG GTCTGTGCAG 
TGGAACAAGT ACTTCCTTGG TCGAACTATC ACCCTGCAAC CTGGATCCCC ATGCAATGAT 
TTTAGAGGCT ACTGTGATGT TTTCATGCGG TGCAGATTAG TAGATGCTGA TGGTCCTCTA 
GCGAGGCTTA AAAAAGCAAT TTTCAGTCCA GAGCTCTATG AAAACATAGC TGAATGGATT 
GTGGCTTACT GGTGGGCAGT ATTACTTATG GGAATTGCCC TGATCATGTT AATGGCTGGT 
TTTATTAAGA TATGCAGTGT ACACACTCCA AGTAGTAATC CAAAGTTGCC TCCTCCTAAA 
CCTCTTCCAG GCACTTTAAA GAGGAGAAGA CCTCCCCAGC CCATTCAACA GCCCCAGCGT 
CAGAGGCCCC GGGAGAGTTA TCAGATGGGA CACATGAGAC GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024853043.1
CDS	646..2670
Translation	MKRDTSLFSEEFRVETSNAVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTHGGTFYVEPAERYIKDRTLPFHSVIYHEDDIKYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQTPQEKHAINGPELLRKKRTTVAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCYDANQPEGKKCKLKPGKQCSPSQGPCCTAHCAFKSKTEKCRDDSDCAKEGICNGITALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKHGLEECTCASSDGKDDKELCHVCCMKKMEPSTCASTGSVQWNKYFLGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAYWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR

Target ORF information:

RefSeq Version	XM_024997275.1
Organism	Bos taurus(cattle)
Definition	Bos taurus ADAM metallopeptidase domain 10 (ADAM10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024997275.1

ORF Insert Sequence:

ATGAAGAGGG ATACTTCCCT TTTCAGTGAG GAGTTTAGGG TGGAAACATC AAATGCAGTA 
CTGGATTATG ATACTTCTCA TATTTACACT GGACATATTT ATGGTGAAGA AGGAAGTTTT 
AGCCATGGGT CTGTTATTGA TGGAAGATTT GAAGGATTCA TTCAGACTCA TGGTGGCACA 
TTTTATGTTG AACCAGCAGA GAGATATATT AAAGACCGAA CTCTGCCATT TCACTCTGTC 
ATTTATCATG AAGATGATAT TAAGTATCCC CATAAATATG GTCCACAGGG GGGTTGTGCA 
GATCATTCAG TGTTTGAAAG AATGAGGAAG TACCAGATGA CTGGTGTAGA AGAAGTAACA 
CAGACACCTC AAGAAAAACA TGCTATTAAT GGTCCAGAAC TCCTGAGGAA AAAACGTACA 
ACTGTAGCTG AAAAAAATAC CTGTCAGCTT TATATTCAGA CTGATCATCT GTTCTTTAAA 
TATTACGGAA CACGAGAAGC TGTGATTGCC CAGATATCCA GTCATGTTAA AGCAATTGAC 
ACAATTTACC AGACAACAGA CTTCTCTGGA ATCCGTAACA TCAGTTTCAT GGTGAAACGC 
ATAAGAATCA ACACAACTGC TGATGAGAAG GACCCTACAA ATCCATTCCG TTTTCCAAAT 
ATTGGTGTGG AGAAGTTTCT GGAGCTGAAT TCTGAGCAGA ATCATGATGA CTACTGTTTG 
GCCTACGTTT TCACAGATCG AGATTTTGAT GATGGTGTCC TTGGTCTGGC GTGGGTTGGA 
GCACCTTCAG GAAGCTCTGG AGGAATATGT GAAAAAAGTA AGCTCTATTC AGATGGTAAG 
AAGAAGTCTT TAAACACTGG AATTATTACT GTTCAGAACT ATGGGTCTCA CGTACCCCCC 
AAAGTCTCTC ACATTACGTT TGCTCATGAA GTTGGACATA ACTTTGGATC TCCGCATGAT 
TCTGGAACAG AGTGCACTCC AGGAGAATCT AAGAATTTAG GACAAAAAGA AAATGGCAAC 
TACATCATGT ATGCAAGAGC AACATCTGGG GACAAACTTA ACAACAATAA ATTCTCACTC 
TGTAGTATTA GAAATATAAG TCAAGTTCTT GAGAAGAAGA GAAACAACTG TTTTGTTGAA 
TCTGGCCAAC CTATTTGTGG AAATGGGATG GTAGAACAAG GTGAAGAATG TGATTGTGGT 
TATAGTGACC AGTGTAAAGA CGAGTGCTGC TACGATGCAA ATCAGCCGGA GGGGAAAAAA 
TGCAAGCTGA AACCTGGAAA GCAGTGCAGT CCAAGTCAAG GTCCCTGTTG TACAGCACAT 
TGTGCATTCA AGTCAAAAAC TGAAAAGTGT CGGGATGATT CAGACTGTGC AAAAGAAGGA 
ATATGTAATG GCATCACAGC TCTCTGCCCA GCCTCTGATC CTAAACCGAA CTTCACAGAC 
TGTAATAGAC ATACGCAAGT GTGCATTAAT GGGCAATGTG CAGGTTCTAT CTGTGAGAAA 
CATGGCTTGG AGGAGTGTAC CTGTGCCAGT TCTGATGGCA AAGATGATAA GGAATTATGC 
CATGTCTGCT GTATGAAGAA GATGGAGCCA TCAACTTGTG CCAGTACAGG GTCTGTGCAG 
TGGAACAAGT ACTTCCTTGG TCGAACTATC ACCCTGCAAC CTGGATCCCC ATGCAATGAT 
TTTAGAGGCT ACTGTGATGT TTTCATGCGG TGCAGATTAG TAGATGCTGA TGGTCCTCTA 
GCGAGGCTTA AAAAAGCAAT TTTCAGTCCA GAGCTCTATG AAAACATAGC TGAATGGATT 
GTGGCTTACT GGTGGGCAGT ATTACTTATG GGAATTGCCC TGATCATGTT AATGGCTGGT 
TTTATTAAGA TATGCAGTGT ACACACTCCA AGTAGTAATC CAAAGTTGCC TCCTCCTAAA 
CCTCTTCCAG GCACTTTAAA GAGGAGAAGA CCTCCCCAGC CCATTCAACA GCCCCAGCGT 
CAGAGGCCCC GGGAGAGTTA TCAGATGGGA CACATGAGAC GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression.
The Journal of biological chemistry287(47)39753-65(2012 Nov)
Haining EJ,Yang J,Bailey RL,Khan K,Collier R,Tsai S,Watson SP,Frampton J,Garcia P,Tomlinson MG

A disintegrin and metalloprotease 10 activity sheds the ectodomain of the amyloid precursor-like protein 2 and regulates protein expression in proximal tubule cells.
American journal of physiology. Cell physiology300(6)C1366-74(2011 Jun)
Cong R,Li Y,Biemesderfer D

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Marçais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Functional role of N-glycosylation from ADAM10 in processing, localization and activity of the enzyme.
Biochimica et biophysica acta1780(6)905-13(2008 Jun)
Escrevente C,Morais VA,Keller S,Soares CM,Altevogt P,Costa J

A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration.
The Journal of biological chemistry281(33)23824-9(2006 Aug)
Wild-Bode C,Fellerer K,Kugler J,Haass C,Capell A

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ADAM10 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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