CTLA4 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	CTLA4
Entrez Gene ID	281732
Full Name	cytotoxic T-lymphocyte associated protein 4
Synonyms	CD152,CTLA-4
General protein information	Preferred Names cytotoxic T-lymphocyte associated protein 4 Names cytotoxic T-lymphocyte protein 4 cytotoxic T-lymphocyte antigen 4
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
XM_024998565.1	XP_024854333.1	cytotoxic T-lymphocyte protein 4 isoform X2
XM_024998560.1	XP_024854328.1	cytotoxic T-lymphocyte protein 4 isoform X1
XM_005202600.3	XP_005202657.1	cytotoxic T-lymphocyte protein 4 isoform X1
NM_174297.1	NP_776722.1	cytotoxic T-lymphocyte protein 4 precursor
XM_005202600.4	XP_005202657.1	cytotoxic T-lymphocyte protein 4 isoform X3

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Ctla4	NP_113862.1
Pan troglodytes (chimpanzee)	CTLA4	XP_526000.1
Mus musculus (house mouse)	Ctla4	NP_033973.2
Xenopus tropicalis (tropical clawed frog)	ctla4	XP_002936576.1
Bos taurus (cattle)	CTLA4	NP_776722.1
Homo sapiens (human)	CTLA4	NP_005205.2
Macaca mulatta (Rhesus monkey)	CTLA4	NP_001038204.1
Canis lupus familiaris (dog)	CTLA4	NP_001003106.1
Gallus gallus (chicken)	CTLA4	NP_001035180.1

Gene Ontology
Bibliography

Related articles in PubMed

ZAP-70, CTLA-4 and proximal T cell receptor signaling in cows infected with Mycobacterium avium subsp. paratuberculosis.
Leite FL, Eslabão LB, Pesch B, Bannantine JP, Reinhardt TA, Stabel JR
Veterinary immunology and immunopathology167(1-2)15-21(2015 Sep)

Increased expression of the regulatory T cell-associated marker CTLA-4 in bovine leukemia virus infection.
Suzuki S, Konnai S, Okagawa T, Ikebuchi R, Nishimori A, Kohara J, Mingala CN, Murata S, Ohashi K
Veterinary immunology and immunopathology163(3-4)115-24(2015 Feb)

Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves.
Palomares RA, Hurley DJ, Woolums AR, Parrish JE, Brock KV
Comparative immunology, microbiology and infectious diseases37(5-6)331-8(2014 Dec)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marçais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Cattle CTLA-4, CD28 and chicken CD28 bind CD86: MYPPPY is not conserved in cattle CD28.
Parsons KR, Young JR, Collins BA, Howard CJ
Immunogenetics43(6)388-91(1996)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CTLA4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CTLA4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OBa38883	NM_174297.1 Latest version!	Bos taurus cytotoxic T-lymphocyte associated protein 4 (CTLA4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OBa16537	XM_005202600.4 Latest version!	Bos taurus cytotoxic T-lymphocyte associated protein 4 (CTLA4), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OBa227137	XM_024998565.1 Latest version!	Bos taurus cytotoxic T-lymphocyte associated protein 4 (CTLA4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OBa45209	XM_024998560.1 Latest version!	Bos taurus cytotoxic T-lymphocyte associated protein 4 (CTLA4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OBa16537	XM_005202600.3	Bos taurus cytotoxic T-lymphocyte associated protein 4 (CTLA4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CTLA4 ( NM_174297.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776722.1 Bos taurus cytotoxic T-lymphocyte associated protein 4 (CTLA4), mRNA.

Price & Availability↑

CloneID	OBa38883
Clone ID Related Accession (Same CDS sequence)	NM_174297.1
Accession Version	NM_174297.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 666bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1526140800000
Organism	Bos taurus(cattle)
Product	cytotoxic T-lymphocyte protein 4 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X93305.1. ##Evidence-Data-START## Transcript exon combination :: X93305.1, CK835834.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145426, SAMN03145433 [ECO:0000348] ##Evidence-Data-END##

ATGGCTTGCT CTGGATTCCA GAGTCATGGG ACTTGGTGGA CATCTAGGAC CTGGCCCTGC 
ACTGCCCTAT TTTTTCTTGT CTTCATTCCT GTTTTCTCTA AAGGGATGAA TGTGACCCAG 
CCTCCAGTGG TGCTGGCTAG CAGCCGGGGT GTTGCCAGCT TCTCATGTGA ATATGAGTCT 
TCAGGCAAAG CTGACGAGGT CCGGGTGACA GTGCTGCGGG AGGCAGGCAG CCAGGTGACC 
GAAGTCTGTG CTGGGACCTA CATGGTGGAG GATGAGCTAA CCTTCCTGGA TGATTCCACT 
TGCATTGGCA CCTCCAGAGG AAACAAAGTG AACCTCACCA TCCAAGGGCT GAGGGCCATG 
GACACTGGGC TCTATGTCTG CAAAGTGGAG CTCATGTACC CGCCGCCCTA CTACGTGGGC 
ATCGGCAATG GAACCCAGAT TTACGTCATT GATCCAGAAC CATGCCCGGA TTCTGATTTT 
CTCCTCTGGA TCCTGGCAGC AGTTAGTTCA GGGTTGTTTT TCTACAGCTT CCTCATCACA 
GCTGTTTCTT TGAGCAAAAT GCTAAAGAAA AGAAGCCCTC TTACTACAGG GGTCTATGTG 
AAAATGCCCC CAACAGAGCC AGAATGTGAA AAGCAATTTC AGCCTTATTT TATTCCCATC 
AATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776722.1
CDS	1..666
Translation	MACSGFQSHGTWWTSRTWPCTALFFLVFIPVFSKGMNVTQPPVVLASSRGVASFSCEYESSGKADEVRVTVLREAGSQVTEVCAGTYMVEDELTFLDDSTCIGTSRGNKVNLTIQGLRAMDTGLYVCKVELMYPPPYYVGIGNGTQIYVIDPEPCPDSDFLLWILAAVSSGLFFYSFLITAVSLSKMLKKRSPLTTGVYVKMPPTEPECEKQFQPYFIPIN

Target ORF information:

RefSeq Version	NM_174297.1
Organism	Bos taurus(cattle)
Definition	Bos taurus cytotoxic T-lymphocyte associated protein 4 (CTLA4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174297.1

ORF Insert Sequence:

ATGGCTTGCT CTGGATTCCA GAGTCATGGG ACTTGGTGGA CATCTAGGAC CTGGCCCTGC 
ACTGCCCTAT TTTTTCTTGT CTTCATTCCT GTTTTCTCTA AAGGGATGAA TGTGACCCAG 
CCTCCAGTGG TGCTGGCTAG CAGCCGGGGT GTTGCCAGCT TCTCATGTGA ATATGAGTCT 
TCAGGCAAAG CTGACGAGGT CCGGGTGACA GTGCTGCGGG AGGCAGGCAG CCAGGTGACC 
GAAGTCTGTG CTGGGACCTA CATGGTGGAG GATGAGCTAA CCTTCCTGGA TGATTCCACT 
TGCATTGGCA CCTCCAGAGG AAACAAAGTG AACCTCACCA TCCAAGGGCT GAGGGCCATG 
GACACTGGGC TCTATGTCTG CAAAGTGGAG CTCATGTACC CGCCGCCCTA CTACGTGGGC 
ATCGGCAATG GAACCCAGAT TTACGTCATT GATCCAGAAC CATGCCCGGA TTCTGATTTT 
CTCCTCTGGA TCCTGGCAGC AGTTAGTTCA GGGTTGTTTT TCTACAGCTT CCTCATCACA 
GCTGTTTCTT TGAGCAAAAT GCTAAAGAAA AGAAGCCCTC TTACTACAGG GGTCTATGTG 
AAAATGCCCC CAACAGAGCC AGAATGTGAA AAGCAATTTC AGCCTTATTT TATTCCCATC 
AATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTLA4 ( XM_005202600.3 ) cDNA ORF clone, Bos taurus(cattle) -> XP_005202657.1 Bos taurus cytotoxic T-lymphocyte associated protein 4 (CTLA4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OBa16537
Clone ID Related Accession (Same CDS sequence)	XM_005202600.3 , XM_005202600.4
Accession Version	XM_005202600.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1453651200000
Organism	Bos taurus(cattle)
Product	cytotoxic T-lymphocyte protein 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003103845.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 26, 2016 this sequence version replaced XM_005202600.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Bos taurus Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTTGCT CTGGATTCCA GAGTCATGGG ACTTGGTGGA CATCTAGGAC CTGGCCCTGC 
ACTGCCCTAT TTTTTCTTGT CTTCATTCCT GTTTTCTCTA AAGGGATGAA TGTGACCCAG 
CCTCCAGTGG TGCTGGCTAG CAGCCGGGGT GTTGCCAGCT TCTCATGTGA ATATGAGTCT 
TCAGGCAAAG CTGACGAGGT CCGGGTGACA GTGCTGCGGG AGGCAGGCAG CCAGGTGACC 
GAAGTCTGTG CTGGGACCTA CATGGTGGAG GATGAGCTAA CCTTCCTGGA TGATTCCACT 
TGCATTGGCA CCTCCAGAGG AAACAAAGTG AACCTCACCA TCCAAGGGCT GAGGGCCATG 
GACACTGGGC TCTATGTCTG CAAAGTGGAG CTCATGTACC CGCCGCCCTA CTACGTGGGC 
ATCGGCAATG GAACCCAGAT TTACGTCATT GCTAAAGAAA AGAAGCCCTC TTACTACAGG 
GGTCTATGTG AAAATGCCCC CAACAGAGCC AGAATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005202657.1
CDS	158..676
Translation	MACSGFQSHGTWWTSRTWPCTALFFLVFIPVFSKGMNVTQPPVVLASSRGVASFSCEYESSGKADEVRVTVLREAGSQVTEVCAGTYMVEDELTFLDDSTCIGTSRGNKVNLTIQGLRAMDTGLYVCKVELMYPPPYYVGIGNGTQIYVIAKEKKPSYYRGLCENAPNRARM

Target ORF information:

RefSeq Version	XM_005202600.3
Organism	Bos taurus(cattle)
Definition	Bos taurus cytotoxic T-lymphocyte associated protein 4 (CTLA4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005202600.3

ORF Insert Sequence:

ATGGCTTGCT CTGGATTCCA GAGTCATGGG ACTTGGTGGA CATCTAGGAC CTGGCCCTGC 
ACTGCCCTAT TTTTTCTTGT CTTCATTCCT GTTTTCTCTA AAGGGATGAA TGTGACCCAG 
CCTCCAGTGG TGCTGGCTAG CAGCCGGGGT GTTGCCAGCT TCTCATGTGA ATATGAGTCT 
TCAGGCAAAG CTGACGAGGT CCGGGTGACA GTGCTGCGGG AGGCAGGCAG CCAGGTGACC 
GAAGTCTGTG CTGGGACCTA CATGGTGGAG GATGAGCTAA CCTTCCTGGA TGATTCCACT 
TGCATTGGCA CCTCCAGAGG AAACAAAGTG AACCTCACCA TCCAAGGGCT GAGGGCCATG 
GACACTGGGC TCTATGTCTG CAAAGTGGAG CTCATGTACC CGCCGCCCTA CTACGTGGGC 
ATCGGCAATG GAACCCAGAT TTACGTCATT GCTAAAGAAA AGAAGCCCTC TTACTACAGG 
GGTCTATGTG AAAATGCCCC CAACAGAGCC AGAATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTLA4 ( XM_005202600.4 ) cDNA ORF clone, Bos taurus(cattle) -> XP_005202657.1 Bos taurus cytotoxic T-lymphocyte associated protein 4 (CTLA4), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OBa16537
Clone ID Related Accession (Same CDS sequence)	XM_005202600.3 , XM_005202600.4
Accession Version	XM_005202600.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1525536000000
Organism	Bos taurus(cattle)
Product	cytotoxic T-lymphocyte protein 4 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037329.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 7, 2018 this sequence version replaced XM_005202600.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTTGCT CTGGATTCCA GAGTCATGGG ACTTGGTGGA CATCTAGGAC CTGGCCCTGC 
ACTGCCCTAT TTTTTCTTGT CTTCATTCCT GTTTTCTCTA AAGGGATGAA TGTGACCCAG 
CCTCCAGTGG TGCTGGCTAG CAGCCGGGGT GTTGCCAGCT TCTCATGTGA ATATGAGTCT 
TCAGGCAAAG CTGACGAGGT CCGGGTGACA GTGCTGCGGG AGGCAGGCAG CCAGGTGACC 
GAAGTCTGTG CTGGGACCTA CATGGTGGAG GATGAGCTAA CCTTCCTGGA TGATTCCACT 
TGCATTGGCA CCTCCAGAGG AAACAAAGTG AACCTCACCA TCCAAGGGCT GAGGGCCATG 
GACACTGGGC TCTATGTCTG CAAAGTGGAG CTCATGTACC CGCCGCCCTA CTACGTGGGC 
ATCGGCAATG GAACCCAGAT TTACGTCATT GCTAAAGAAA AGAAGCCCTC TTACTACAGG 
GGTCTATGTG AAAATGCCCC CAACAGAGCC AGAATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005202657.1
CDS	184..702
Translation	MACSGFQSHGTWWTSRTWPCTALFFLVFIPVFSKGMNVTQPPVVLASSRGVASFSCEYESSGKADEVRVTVLREAGSQVTEVCAGTYMVEDELTFLDDSTCIGTSRGNKVNLTIQGLRAMDTGLYVCKVELMYPPPYYVGIGNGTQIYVIAKEKKPSYYRGLCENAPNRARM

Target ORF information:

RefSeq Version	XM_005202600.4
Organism	Bos taurus(cattle)
Definition	Bos taurus cytotoxic T-lymphocyte associated protein 4 (CTLA4), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005202600.4

ORF Insert Sequence:

ATGGCTTGCT CTGGATTCCA GAGTCATGGG ACTTGGTGGA CATCTAGGAC CTGGCCCTGC 
ACTGCCCTAT TTTTTCTTGT CTTCATTCCT GTTTTCTCTA AAGGGATGAA TGTGACCCAG 
CCTCCAGTGG TGCTGGCTAG CAGCCGGGGT GTTGCCAGCT TCTCATGTGA ATATGAGTCT 
TCAGGCAAAG CTGACGAGGT CCGGGTGACA GTGCTGCGGG AGGCAGGCAG CCAGGTGACC 
GAAGTCTGTG CTGGGACCTA CATGGTGGAG GATGAGCTAA CCTTCCTGGA TGATTCCACT 
TGCATTGGCA CCTCCAGAGG AAACAAAGTG AACCTCACCA TCCAAGGGCT GAGGGCCATG 
GACACTGGGC TCTATGTCTG CAAAGTGGAG CTCATGTACC CGCCGCCCTA CTACGTGGGC 
ATCGGCAATG GAACCCAGAT TTACGTCATT GCTAAAGAAA AGAAGCCCTC TTACTACAGG 
GGTCTATGTG AAAATGCCCC CAACAGAGCC AGAATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTLA4 ( XM_024998565.1 ) cDNA ORF clone, Bos taurus(cattle) -> XP_024854333.1 Bos taurus cytotoxic T-lymphocyte associated protein 4 (CTLA4), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OBa227137
Clone ID Related Accession (Same CDS sequence)	XM_024998565.1
Accession Version	XM_024998565.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1525536000000
Organism	Bos taurus(cattle)
Product	cytotoxic T-lymphocyte protein 4 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037329.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAATGTGA CCCAGCCTCC AGTGGTGCTG GCTAGCAGCC GGGGTGTTGC CAGCTTCTCA 
TGTGAATATG AGTCTTCAGG CAAAGCTGAC GAGGTCCGGG TGACAGTGCT GCGGGAGGCA 
GGCAGCCAGG TGACCGAAGT CTGTGCTGGG ACCTACATGG TGGAGGATGA GCTAACCTTC 
CTGGATGATT CCACTTGCAT TGGCACCTCC AGAGGAAACA AAGTGAACCT CACCATCCAA 
GGGCTGAGGG CCATGGACAC TGGGCTCTAT GTCTGCAAAG TGGAGCTCAT GTACCCGCCG 
CCCTACTACG TGGGCATCGG CAATGGAACC CAGATTTACG TCATTGATCC AGAACCATGC 
CCGGATTCTG ATTTTCTCCT CTGGATCCTG GCAGCAGTTA GTTCAGGGTT GTTTTTCTAC 
AGCTTCCTCA TCACAGCTGT TTCTTTGAGC AAAATGCTAA AGAAAAGAAG CCCTCTTACT 
ACAGGGGTCT ATGTGAAAAT GCCCCCAACA GAGCCAGAAT GTGAAAAGCA ATTTCAGCCT 
TATTTTATTC CCATCAATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024854333.1
CDS	2220..2780
Translation	MNVTQPPVVLASSRGVASFSCEYESSGKADEVRVTVLREAGSQVTEVCAGTYMVEDELTFLDDSTCIGTSRGNKVNLTIQGLRAMDTGLYVCKVELMYPPPYYVGIGNGTQIYVIDPEPCPDSDFLLWILAAVSSGLFFYSFLITAVSLSKMLKKRSPLTTGVYVKMPPTEPECEKQFQPYFIPIN

Target ORF information:

RefSeq Version	XM_024998565.1
Organism	Bos taurus(cattle)
Definition	Bos taurus cytotoxic T-lymphocyte associated protein 4 (CTLA4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024998565.1

ORF Insert Sequence:

ATGAATGTGA CCCAGCCTCC AGTGGTGCTG GCTAGCAGCC GGGGTGTTGC CAGCTTCTCA 
TGTGAATATG AGTCTTCAGG CAAAGCTGAC GAGGTCCGGG TGACAGTGCT GCGGGAGGCA 
GGCAGCCAGG TGACCGAAGT CTGTGCTGGG ACCTACATGG TGGAGGATGA GCTAACCTTC 
CTGGATGATT CCACTTGCAT TGGCACCTCC AGAGGAAACA AAGTGAACCT CACCATCCAA 
GGGCTGAGGG CCATGGACAC TGGGCTCTAT GTCTGCAAAG TGGAGCTCAT GTACCCGCCG 
CCCTACTACG TGGGCATCGG CAATGGAACC CAGATTTACG TCATTGATCC AGAACCATGC 
CCGGATTCTG ATTTTCTCCT CTGGATCCTG GCAGCAGTTA GTTCAGGGTT GTTTTTCTAC 
AGCTTCCTCA TCACAGCTGT TTCTTTGAGC AAAATGCTAA AGAAAAGAAG CCCTCTTACT 
ACAGGGGTCT ATGTGAAAAT GCCCCCAACA GAGCCAGAAT GTGAAAAGCA ATTTCAGCCT 
TATTTTATTC CCATCAATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTLA4 ( XM_024998560.1 ) cDNA ORF clone, Bos taurus(cattle) -> XP_024854328.1 Bos taurus cytotoxic T-lymphocyte associated protein 4 (CTLA4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OBa45209
Clone ID Related Accession (Same CDS sequence)	XM_024998560.1
Accession Version	XM_024998560.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1525536000000
Organism	Bos taurus(cattle)
Product	cytotoxic T-lymphocyte protein 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037329.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAGGGA AAATGAAGGC TATGAGGGAG GCACAGCTTT CCCCAAACCA TCTATTTCAT 
GGGATGAATG TGACCCAGCC TCCAGTGGTG CTGGCTAGCA GCCGGGGTGT TGCCAGCTTC 
TCATGTGAAT ATGAGTCTTC AGGCAAAGCT GACGAGGTCC GGGTGACAGT GCTGCGGGAG 
GCAGGCAGCC AGGTGACCGA AGTCTGTGCT GGGACCTACA TGGTGGAGGA TGAGCTAACC 
TTCCTGGATG ATTCCACTTG CATTGGCACC TCCAGAGGAA ACAAAGTGAA CCTCACCATC 
CAAGGGCTGA GGGCCATGGA CACTGGGCTC TATGTCTGCA AAGTGGAGCT CATGTACCCG 
CCGCCCTACT ACGTGGGCAT CGGCAATGGA ACCCAGATTT ACGTCATTGA TCCAGAACCA 
TGCCCGGATT CTGATTTTCT CCTCTGGATC CTGGCAGCAG TTAGTTCAGG GTTGTTTTTC 
TACAGCTTCC TCATCACAGC TGTTTCTTTG AGCAAAATGC TAAAGAAAAG AAGCCCTCTT 
ACTACAGGGG TCTATGTGAA AATGCCCCCA ACAGAGCCAG AATGTGAAAA GCAATTTCAG 
CCTTATTTTA TTCCCATCAA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024854328.1
CDS	93..716
Translation	MGGKMKAMREAQLSPNHLFHGMNVTQPPVVLASSRGVASFSCEYESSGKADEVRVTVLREAGSQVTEVCAGTYMVEDELTFLDDSTCIGTSRGNKVNLTIQGLRAMDTGLYVCKVELMYPPPYYVGIGNGTQIYVIDPEPCPDSDFLLWILAAVSSGLFFYSFLITAVSLSKMLKKRSPLTTGVYVKMPPTEPECEKQFQPYFIPIN

Target ORF information:

RefSeq Version	XM_024998560.1
Organism	Bos taurus(cattle)
Definition	Bos taurus cytotoxic T-lymphocyte associated protein 4 (CTLA4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024998560.1

ORF Insert Sequence:

ATGGGAGGGA AAATGAAGGC TATGAGGGAG GCACAGCTTT CCCCAAACCA TCTATTTCAT 
GGGATGAATG TGACCCAGCC TCCAGTGGTG CTGGCTAGCA GCCGGGGTGT TGCCAGCTTC 
TCATGTGAAT ATGAGTCTTC AGGCAAAGCT GACGAGGTCC GGGTGACAGT GCTGCGGGAG 
GCAGGCAGCC AGGTGACCGA AGTCTGTGCT GGGACCTACA TGGTGGAGGA TGAGCTAACC 
TTCCTGGATG ATTCCACTTG CATTGGCACC TCCAGAGGAA ACAAAGTGAA CCTCACCATC 
CAAGGGCTGA GGGCCATGGA CACTGGGCTC TATGTCTGCA AAGTGGAGCT CATGTACCCG 
CCGCCCTACT ACGTGGGCAT CGGCAATGGA ACCCAGATTT ACGTCATTGA TCCAGAACCA 
TGCCCGGATT CTGATTTTCT CCTCTGGATC CTGGCAGCAG TTAGTTCAGG GTTGTTTTTC 
TACAGCTTCC TCATCACAGC TGTTTCTTTG AGCAAAATGC TAAAGAAAAG AAGCCCTCTT 
ACTACAGGGG TCTATGTGAA AATGCCCCCA ACAGAGCCAG AATGTGAAAA GCAATTTCAG 
CCTTATTTTA TTCCCATCAA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ZAP-70, CTLA-4 and proximal T cell receptor signaling in cows infected with Mycobacterium avium subsp. paratuberculosis.
Veterinary immunology and immunopathology167(1-2)15-21(2015 Sep)
Leite FL,Eslabão LB,Pesch B,Bannantine JP,Reinhardt TA,Stabel JR

Increased expression of the regulatory T cell-associated marker CTLA-4 in bovine leukemia virus infection.
Veterinary immunology and immunopathology163(3-4)115-24(2015 Feb)
Suzuki S,Konnai S,Okagawa T,Ikebuchi R,Nishimori A,Kohara J,Mingala CN,Murata S,Ohashi K

Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves.
Comparative immunology, microbiology and infectious diseases37(5-6)331-8(2014 Dec)
Palomares RA,Hurley DJ,Woolums AR,Parrish JE,Brock KV

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Marçais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Cattle CTLA-4, CD28 and chicken CD28 bind CD86: MYPPPY is not conserved in cattle CD28.
Immunogenetics43(6)388-91(1996)
Parsons KR,Young JR,Collins BA,Howard CJ

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CTLA4 cDNA ORF clone, Bos taurus(cattle)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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ORF Insert Sequence:

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ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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