ORF » Species Summary » Homo sapiens » Reactome

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Homo sapiens (human)

Browse by Letter Index, Genomic Locus


rRNA processing in the nucleus and cytosol Protein-protein interactions at synapses
VLDLR internalisation and degradation Phosphate bond hydrolysis by NTPDase proteins
Josephin domain DUBs PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
PTK6 Activates STAT3 PTK6 Regulates Cell Cycle
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 Intra-Golgi and retrograde Golgi-to-ER traffic
Retrograde transport at the Trans-Golgi-Network Intra-Golgi traffic
Signaling by FGFR3 fusions in cancer Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 Wax biosynthesis
Threonine catabolism TP53 Regulates Transcription of Cell Death Genes
TP53 Regulates Transcription of Death Receptors and Ligands TP53 Regulates Transcription of Caspase Activators and Caspases
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Regulation of TP53 Expression tRNA processing in the nucleus
Resolution of D-Loop Structures HDR through Single Strand Annealing (SSA)
Global Genome Nucleotide Excision Repair (GG-NER) Dual Incision in GG-NER
Transcription-Coupled Nucleotide Excision Repair (TC-NER) Formation of TC-NER Pre-Incision Complex
Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) Glycogen storage disease type 0 (muscle GYS1)
Glycogen storage disease type XV (GYG1) Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)
Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Defective ST3GAL3 causes MCT12 and EIEE15
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism NOD1/2 Signaling Pathway
TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation
Cytosolic sensors of pathogen-associated DNA RIP-mediated NFkB activation via ZBP1
Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis
DAP12 interactions Negative feedback regulation of MAPK pathway
FCERI mediated NF-kB activation CLEC7A (Dectin-1) induces NFAT activation
Interleukin-1 signaling Interleukin-6 signaling
Fertilization Platelet sensitization by LDL
Platelet activation, signaling and aggregation GP1b-IX-V activation signalling
ADP signalling through P2Y purinoceptor 12 ADP signalling through P2Y purinoceptor 1
GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins
Effects of PIP2 hydrolysis Tie2 Signaling
Basigin interactions Signaling by FGFR
Spry regulation of FGF signaling Signaling by FGFR2
Negative regulation of FGFR2 signaling FGFR3b ligand binding and activation
FRS-mediated FGFR4 signaling PI-3K cascade:FGFR4
PDE3B signalling Signal attenuation
Insulin receptor recycling Activation of TRKA receptors
VEGFR2 mediated cell proliferation Regulation of KIT signaling
GRB2 events in ERBB2 signaling PLCG1 events in ERBB2 signaling
Nuclear signaling by ERBB4 MAPK family signaling cascades
RHO GTPase Effectors Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
RHO GTPases activate CIT RHO GTPases activate KTN1
RHO GTPases Activate NADPH Oxidases Signaling by BMP
Signaling by TGF-beta Receptor Complex Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Activated NOTCH1 Transmits Signal to the Nucleus GPCR ligand binding
Class A/1 (Rhodopsin-like receptors) Tachykinin receptors bind tachykinins
Adrenoceptors Serotonin receptors
Free fatty acid receptors G alpha (q) signalling events
G beta:gamma signalling through PLC beta G-protein mediated events
WNT mediated activation of DVL Regulation of FZD by ubiquitination
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