ORF » Species Summary » Homo sapiens » Reactome

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Homo sapiens (human)

Browse by Letter Index, Genomic Locus


Synthesis of PC Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of 5-eicosatetraenoic acids Glycosphingolipid metabolism
Free fatty acids regulate insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Glucagon signaling in metabolic regulation PKA-mediated phosphorylation of key metabolic factors
Insulin effects increased synthesis of Xylulose-5-Phosphate Metabolism of nitric oxide
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
Formation of ATP by chemiosmotic coupling Purine metabolism
Purine salvage Pyrimidine biosynthesis
Pyrimidine salvage reactions Phosphate bond hydrolysis by NUDT proteins
Vitamin B1 (thiamin) metabolism Metabolism of folate and pterines
Amino acid synthesis and interconversion (transamination) Histidine catabolism
Carnitine synthesis Interconversion of polyamines
Methionine salvage pathway Regulation of ornithine decarboxylase (ODC)
Glyoxylate metabolism and glycine degradation Cytochrome P450 - arranged by substrate type
Amine Oxidase reactions Ethanol oxidation
Cytosolic sulfonation of small molecules Acetylation
Glutathione synthesis and recycling Conjugation of benzoate with glycine
Cell-Cell communication Tight junction interactions
Assembly of collagen fibrils and other multimeric structures Activation of NOXA and translocation to mitochondria
Activation of PUMA and translocation to mitochondria Activation of BMF and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Regulation of activated PAK-2p34 by proteasome mediated degradation
Signaling by Robo receptor Inactivation of Cdc42 and Rac
Role of Abl in Robo-Slit signaling Recycling pathway of L1
Interaction between L1 and Ankyrins Neurofascin interactions
Regulation of gene expression in beta cells Signaling by NODAL
Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine
Resolution of AP sites via the single-nucleotide replacement pathway Translesion synthesis by POLK
Termination of translesion DNA synthesis ALKBH2 mediated reversal of alkylation damage
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Cellular response to heat stress
Senescence-Associated Secretory Phenotype (SASP) Chromatin organization
Hh mutants abrogate ligand secretion Glycogen storage diseases
Myoclonic epilepsy of Lafora Defects in vitamin and cofactor metabolism
Defects in cobalamin (B12) metabolism Defective AMN causes hereditary megaloblastic anemia 1
Defective GIF causes intrinsic factor deficiency Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
Defective MUT causes methylmalonic aciduria mut type Defective CD320 causes methylmalonic aciduria
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization Vpu mediated degradation of CD4
ROS, RNS production in phagocytes TLR3 deficiency - HSE
UNC93B1 deficiency - HSE TRAF3 deficiency - HSE
IKBKB deficiency causes SCID tRNA processing
DNA Double Strand Break Response Processing of DNA double-strand break ends
HDR through Homologous Recombination (HRR) Presynaptic phase of homologous DNA pairing and strand exchange
HDR through MMEJ (alt-NHEJ) Nucleotide Excision Repair
DNA Damage Recognition in GG-NER Defective AVP causes neurohypophyseal diabetes insipidus (NDI)
Diseases associated with surfactant metabolism Ion influx/efflux at host-pathogen interface
Neutrophil degranulation Formation of the cornified envelope
Downregulation of ERBB2 signaling MET activates RAP1 and RAC1
Synthesis of active ubiquitin: roles of E1 and E2 enzymes Interleukin-4 and 13 signaling
RAB geranylgeranylation Synthesis of PIPs in the nucleus
Butyrophilin (BTN) family interactions E3 ubiquitin ligases ubiquitinate target proteins
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors TFAP2 (AP-2) family regulates transcription of other transcription factors
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