THRA cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	THRA
Entrez Gene ID	396251
Full Name	thyroid hormone receptor, alpha
General protein information	Preferred Names thyroid hormone receptor, alpha Names thyroid hormone receptor alpha c-erb-A protein nuclear receptor subfamily 1 group A member 1 thyroid hormone receptor beta thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_205313.2	NP_990644.1	thyroid hormone receptor alpha
NM_205313.1	NP_990644.1	thyroid hormone receptor alpha

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	THRA	XP_548137.2
Bos taurus (cattle)	THRA	NP_001039794.1
Xenopus tropicalis (tropical clawed frog)	thra	NP_001039261.1
Mus musculus (house mouse)	Thra	NP_835161.1
Homo sapiens (human)	THRA	NP_955366.1
Danio rerio (zebrafish)	thrab	XP_001921013.4
Rattus norvegicus (Norway rat)	Thra	NP_001017960.1
Gallus gallus (chicken)	THRA	NP_990644.1
Danio rerio (zebrafish)	thraa	NP_571471.1

Gene Ontology
Bibliography

Related articles in PubMed

Structural basis for negative cooperativity within agonist-bound TR:RXR heterodimers.
Putcha BD, Wright E, Brunzelle JS, Fernandez EJ
Proceedings of the National Academy of Sciences of the United States of America109(16)6084-7(2012 Apr)

Thyroid hormone treatment of cultured chondrocytes mimics in vivo stimulation of collagen X mRNA by increasing BMP 4 expression.
Lassová L, Niu Z, Golden EB, Cohen AJ, Adams SL
Journal of cellular physiology219(3)595-605(2009 Jun)

Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution.

Nature432(7018)695-716(2004 Dec)

PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors.
Mathur M, Tucker PW, Samuels HH
Molecular and cellular biology21(7)2298-311(2001 Apr)

The human transcription factor IID subunit human TATA-binding protein-associated factor 28 interacts in a ligand-reversible manner with the vitamin D(3) and thyroid hormone receptors.
Mengus G, Gangloff YG, Carré L, Lavigne AC, Davidson I
The Journal of biological chemistry275(14)10064-71(2000 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following THRA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the THRA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OGa26683	NM_205313.2 Latest version!	Gallus gallus thyroid hormone receptor, alpha (THRA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OGa26683	NM_205313.1	Gallus gallus thyroid hormone receptor, alpha (THRA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

THRA ( NM_205313.2 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_990644.1 Gallus gallus thyroid hormone receptor, alpha (THRA), mRNA.

Price & Availability↑

CloneID	OGa26683
Clone ID Related Accession (Same CDS sequence)	NM_205313.2 , NM_205313.1
Accession Version	NM_205313.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1227bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569254400000
Organism	Gallus gallus(chicken)
Product	thyroid hormone receptor alpha
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AADN05000735.1. On Mar 13, 2018 this sequence version replaced NM_205313.1.

ATGGAACAGA AGCCCAGCAC CCTGGACCCG CTGTCGGAGC CAGAGGACAC TCGGTGGCTG 
GATGGCAAGC GCAAAAGAAA GAGCAGCCAA TGTTTGGTGA AGAGCAGCAT GTCAGGGTAC 
ATCCCTAGCT ACCTGGACAA AGATGAACAG TGCGTGGTGT GCGGGGACAA AGCCACCGGC 
TACCACTACC GCTGCATCAC CTGCGAGGGC TGCAAGGGCT TTTTCCGTCG GACCATCCAG 
AAGAACCTGC ACCCCACCTA CTCCTGCAAG TACGATGGGT GCTGCGTCAT CGACAAGATC 
ACCCGCAACC AGTGCCAGCT GTGCCGCTTC AAGAAGTGCA TCTCCGTGGG CATGGCCATG 
GACCTGGTGC TGGACGACTC GAAGCGCGTA GCCAAGCGGA AGCTGATCGA GGAGAACCGG 
GAGCGGCGGC GCAAGGAGGA GATGATCAAA TCCCTGCAGC ACCGGCCCAG CCCCAGCGCA 
GAGGAGTGGG AGCTGATCCA CGTGGTGACC GAGGCGCACC GCAGCACCAA CGCGCAGGGC 
AGCCACTGGA AGCAGAAGAG GAAATTCCTG CCCGAAGATA TCGGTCAGTC GCCCATGGCC 
TCCATGCCTG ACGGGGACAA AGTGGACCTG GAGGCGTTCA GCGAGTTTAC AAAAATCATC 
ACGCCGGCCA TCACCCGCGT GGTCGACTTT GCCAAAAAAC TGCCCATGTT CTCGGAGCTG 
CCGTGCGAGG ATCAGATCAT CCTGCTGAAG GGCTGCTGCA TGGAGATCAT GTCGCTGCGC 
GCCGCCGTGC GCTACGACCC CGAGAGCGAA ACGCTGACGC TGAGCGGGGA AATGGCCGTC 
AAACGCGAGC AGCTGAAGAA CGGGGGGCTG GGGGTCGTGT CTGATGCCAT CTTCGACCTC 
GGCAAGTCGC TGTCTGCCTT CAACCTGGAC GACACCGAGG TGGCCCTGCT GCAGGCCGTG 
CTGCTCATGT CCTCAGACCG GACGGGGCTG ATCTGCGTGG ATAAGATAGA GAAGTGCCAG 
GAGACGTACC TGCTGGCGTT CGAGCACTAC ATCAACTACC GCAAACACAA CATTCCCCAC 
TTCTGGCCCA AGCTGCTGAT GAAGGTGACG GACCTGCGCA TGATCGGCGC CTGCCACGCC 
AGCCGCTTCC TGCACATGAA GGTGGAGTGC CCCACCGAGC TCTTCCCCCC CCTCTTCCTC 
GAGGTCTTCG AGGACCAGGA GGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_990644.1
CDS	288..1514
Translation	MEQKPSTLDPLSEPEDTRWLDGKRKRKSSQCLVKSSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDGCCVIDKITRNQCQLCRFKKCISVGMAMDLVLDDSKRVAKRKLIEENRERRRKEEMIKSLQHRPSPSAEEWELIHVVTEAHRSTNAQGSHWKQKRKFLPEDIGQSPMASMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLSGEMAVKREQLKNGGLGVVSDAIFDLGKSLSAFNLDDTEVALLQAVLLMSSDRTGLICVDKIEKCQETYLLAFEHYINYRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQEV

Target ORF information:

RefSeq Version	NM_205313.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus thyroid hormone receptor, alpha (THRA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_205313.2

ORF Insert Sequence:

ATGGAACAGA AGCCCAGCAC CCTGGACCCG CTGTCGGAGC CAGAGGACAC TCGGTGGCTG 
GATGGCAAGC GCAAAAGAAA GAGCAGCCAA TGTTTGGTGA AGAGCAGCAT GTCAGGGTAC 
ATCCCTAGCT ACCTGGACAA AGATGAACAG TGCGTGGTGT GCGGGGACAA AGCCACCGGC 
TACCACTACC GCTGCATCAC CTGCGAGGGC TGCAAGGGCT TTTTCCGTCG GACCATCCAG 
AAGAACCTGC ACCCCACCTA CTCCTGCAAG TACGATGGGT GCTGCGTCAT CGACAAGATC 
ACCCGCAACC AGTGCCAGCT GTGCCGCTTC AAGAAGTGCA TCTCCGTGGG CATGGCCATG 
GACCTGGTGC TGGACGACTC GAAGCGCGTA GCCAAGCGGA AGCTGATCGA GGAGAACCGG 
GAGCGGCGGC GCAAGGAGGA GATGATCAAA TCCCTGCAGC ACCGGCCCAG CCCCAGCGCA 
GAGGAGTGGG AGCTGATCCA CGTGGTGACC GAGGCGCACC GCAGCACCAA CGCGCAGGGC 
AGCCACTGGA AGCAGAAGAG GAAATTCCTG CCCGAAGATA TCGGTCAGTC GCCCATGGCC 
TCCATGCCTG ACGGGGACAA AGTGGACCTG GAGGCGTTCA GCGAGTTTAC AAAAATCATC 
ACGCCGGCCA TCACCCGCGT GGTCGACTTT GCCAAAAAAC TGCCCATGTT CTCGGAGCTG 
CCGTGCGAGG ATCAGATCAT CCTGCTGAAG GGCTGCTGCA TGGAGATCAT GTCGCTGCGC 
GCCGCCGTGC GCTACGACCC CGAGAGCGAA ACGCTGACGC TGAGCGGGGA AATGGCCGTC 
AAACGCGAGC AGCTGAAGAA CGGGGGGCTG GGGGTCGTGT CTGATGCCAT CTTCGACCTC 
GGCAAGTCGC TGTCTGCCTT CAACCTGGAC GACACCGAGG TGGCCCTGCT GCAGGCCGTG 
CTGCTCATGT CCTCAGACCG GACGGGGCTG ATCTGCGTGG ATAAGATAGA GAAGTGCCAG 
GAGACGTACC TGCTGGCGTT CGAGCACTAC ATCAACTACC GCAAACACAA CATTCCCCAC 
TTCTGGCCCA AGCTGCTGAT GAAGGTGACG GACCTGCGCA TGATCGGCGC CTGCCACGCC 
AGCCGCTTCC TGCACATGAA GGTGGAGTGC CCCACCGAGC TCTTCCCCCC CCTCTTCCTC 
GAGGTCTTCG AGGACCAGGA GGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

THRA ( NM_205313.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_990644.1 Gallus gallus thyroid hormone receptor, alpha (THRA), mRNA.

Price & Availability↑

CloneID	OGa26683
Clone ID Related Accession (Same CDS sequence)	NM_205313.2 , NM_205313.1
Accession Version	NM_205313.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1227bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514217600000
Organism	Gallus gallus(chicken)
Product	thyroid hormone receptor alpha
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Y00987.1. On or before Jan 17, 2016 this sequence version replaced XM_015299560.1, XM_429297.1. ##Evidence-Data-START## CDS exon combination :: Y00987.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2201377, SAMEA2201378 [ECO:0000348] ##Evidence-Data-END##

ATGGAACAGA AGCCCAGCAC CCTGGACCCG CTGTCGGAGC CAGAGGACAC TCGGTGGCTG 
GATGGCAAGC GCAAAAGAAA GAGCAGCCAA TGTTTGGTGA AGAGCAGCAT GTCAGGGTAC 
ATCCCTAGCT ACCTGGACAA AGATGAACAG TGCGTGGTGT GCGGGGACAA AGCCACCGGC 
TACCACTACC GCTGCATCAC CTGCGAGGGC TGCAAGGGCT TTTTCCGTCG GACCATCCAG 
AAGAACCTGC ACCCCACCTA CTCCTGCAAG TACGATGGGT GCTGCGTCAT CGACAAGATC 
ACCCGCAACC AGTGCCAGCT GTGCCGCTTC AAGAAGTGCA TCTCCGTGGG CATGGCCATG 
GACCTGGTGC TGGACGACTC GAAGCGCGTA GCCAAGCGGA AGCTGATCGA GGAGAACCGG 
GAGCGGCGGC GCAAGGAGGA GATGATCAAA TCCCTGCAGC ACCGGCCCAG CCCCAGCGCA 
GAGGAGTGGG AGCTGATCCA CGTGGTGACC GAGGCGCACC GCAGCACCAA CGCGCAGGGC 
AGCCACTGGA AGCAGAAGAG GAAATTCCTG CCCGAAGATA TCGGTCAGTC GCCCATGGCC 
TCCATGCCTG ACGGGGACAA AGTGGACCTG GAGGCGTTCA GCGAGTTTAC AAAAATCATC 
ACGCCGGCCA TCACCCGCGT GGTCGACTTT GCCAAAAAAC TGCCCATGTT CTCGGAGCTG 
CCGTGCGAGG ATCAGATCAT CCTGCTGAAG GGCTGCTGCA TGGAGATCAT GTCGCTGCGC 
GCCGCCGTGC GCTACGACCC CGAGAGCGAA ACGCTGACGC TGAGCGGGGA AATGGCCGTC 
AAACGCGAGC AGCTGAAGAA CGGGGGGCTG GGGGTCGTGT CTGATGCCAT CTTCGACCTC 
GGCAAGTCGC TGTCTGCCTT CAACCTGGAC GACACCGAGG TGGCCCTGCT GCAGGCCGTG 
CTGCTCATGT CCTCAGACCG GACGGGGCTG ATCTGCGTGG ATAAGATAGA GAAGTGCCAG 
GAGACGTACC TGCTGGCGTT CGAGCACTAC ATCAACTACC GCAAACACAA CATTCCCCAC 
TTCTGGCCCA AGCTGCTGAT GAAGGTGACG GACCTGCGCA TGATCGGCGC CTGCCACGCC 
AGCCGCTTCC TGCACATGAA GGTGGAGTGC CCCACCGAGC TCTTCCCCCC CCTCTTCCTC 
GAGGTCTTCG AGGACCAGGA GGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_990644.1
CDS	289..1515
Translation	MEQKPSTLDPLSEPEDTRWLDGKRKRKSSQCLVKSSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDGCCVIDKITRNQCQLCRFKKCISVGMAMDLVLDDSKRVAKRKLIEENRERRRKEEMIKSLQHRPSPSAEEWELIHVVTEAHRSTNAQGSHWKQKRKFLPEDIGQSPMASMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLSGEMAVKREQLKNGGLGVVSDAIFDLGKSLSAFNLDDTEVALLQAVLLMSSDRTGLICVDKIEKCQETYLLAFEHYINYRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQEV

Target ORF information:

RefSeq Version	NM_205313.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus thyroid hormone receptor, alpha (THRA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_205313.1

ORF Insert Sequence:

ATGGAACAGA AGCCCAGCAC CCTGGACCCG CTGTCGGAGC CAGAGGACAC TCGGTGGCTG 
GATGGCAAGC GCAAAAGAAA GAGCAGCCAA TGTTTGGTGA AGAGCAGCAT GTCAGGGTAC 
ATCCCTAGCT ACCTGGACAA AGATGAACAG TGCGTGGTGT GCGGGGACAA AGCCACCGGC 
TACCACTACC GCTGCATCAC CTGCGAGGGC TGCAAGGGCT TTTTCCGTCG GACCATCCAG 
AAGAACCTGC ACCCCACCTA CTCCTGCAAG TACGATGGGT GCTGCGTCAT CGACAAGATC 
ACCCGCAACC AGTGCCAGCT GTGCCGCTTC AAGAAGTGCA TCTCCGTGGG CATGGCCATG 
GACCTGGTGC TGGACGACTC GAAGCGCGTA GCCAAGCGGA AGCTGATCGA GGAGAACCGG 
GAGCGGCGGC GCAAGGAGGA GATGATCAAA TCCCTGCAGC ACCGGCCCAG CCCCAGCGCA 
GAGGAGTGGG AGCTGATCCA CGTGGTGACC GAGGCGCACC GCAGCACCAA CGCGCAGGGC 
AGCCACTGGA AGCAGAAGAG GAAATTCCTG CCCGAAGATA TCGGTCAGTC GCCCATGGCC 
TCCATGCCTG ACGGGGACAA AGTGGACCTG GAGGCGTTCA GCGAGTTTAC AAAAATCATC 
ACGCCGGCCA TCACCCGCGT GGTCGACTTT GCCAAAAAAC TGCCCATGTT CTCGGAGCTG 
CCGTGCGAGG ATCAGATCAT CCTGCTGAAG GGCTGCTGCA TGGAGATCAT GTCGCTGCGC 
GCCGCCGTGC GCTACGACCC CGAGAGCGAA ACGCTGACGC TGAGCGGGGA AATGGCCGTC 
AAACGCGAGC AGCTGAAGAA CGGGGGGCTG GGGGTCGTGT CTGATGCCAT CTTCGACCTC 
GGCAAGTCGC TGTCTGCCTT CAACCTGGAC GACACCGAGG TGGCCCTGCT GCAGGCCGTG 
CTGCTCATGT CCTCAGACCG GACGGGGCTG ATCTGCGTGG ATAAGATAGA GAAGTGCCAG 
GAGACGTACC TGCTGGCGTT CGAGCACTAC ATCAACTACC GCAAACACAA CATTCCCCAC 
TTCTGGCCCA AGCTGCTGAT GAAGGTGACG GACCTGCGCA TGATCGGCGC CTGCCACGCC 
AGCCGCTTCC TGCACATGAA GGTGGAGTGC CCCACCGAGC TCTTCCCCCC CCTCTTCCTC 
GAGGTCTTCG AGGACCAGGA GGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structural basis for negative cooperativity within agonist-bound TR:RXR heterodimers.
Proceedings of the National Academy of Sciences of the United States of America109(16)6084-7(2012 Apr)
Putcha BD,Wright E,Brunzelle JS,Fernandez EJ

Thyroid hormone treatment of cultured chondrocytes mimics in vivo stimulation of collagen X mRNA by increasing BMP 4 expression.
Journal of cellular physiology219(3)595-605(2009 Jun)
Lassová L,Niu Z,Golden EB,Cohen AJ,Adams SL

Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution.
Nature432(7018)695-716(2004 Dec)

PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors.
Molecular and cellular biology21(7)2298-311(2001 Apr)
Mathur M,Tucker PW,Samuels HH

The human transcription factor IID subunit human TATA-binding protein-associated factor 28 interacts in a ligand-reversible manner with the vitamin D(3) and thyroid hormone receptors.
The Journal of biological chemistry275(14)10064-71(2000 Apr)
Mengus G,Gangloff YG,Carré L,Lavigne AC,Davidson I