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Digoxin

Digoxin is a drug commonly used to treat congestive heart failure and certain heartbeat irregularities that are obtained from leaves of the Foxglove (digitalis) plant. Digoxin overdose can be toxic. The level of the drug can be obtained from blood testing, which can aid in setting appropriate dose amounts.

Digoxin is one example of what is known as inotropic agents, which are drugs that directly affect the contraction of the heart muscle. Its action on the heart muscle results in an increase in the force of contraction, raising the output of a failing heart. In conditions where the heartbeat is irregular, digoxin can help by slowing and steadying the rhythm. Cardiac glycosides such as digoxin have been used as plant extracts since ancient Egyptian times, sometimes being employed as medicines and sometimes, in higher doses, as poisons. In the treatment of heart failure, the use of digoxin is generally reserved for patients who also have a disorder known as atrial fibrillation, where the upper chambers of the heart beat too quickly and irregularly. It is also used sometimes in cases of severe heart failure where other drugs have not worked.

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