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Denticle pattern

6 rows of cells secret denticles while the remaining cells make bald cuticle patterning occurs progressively from the deployment of coarsely expressed gap genes to the more refined segment polarity genes (reviewed by Ingham, 1988) bald fate arises b/c shavenbaby veinlet contributes to the formation of denticle types 1-4 (Wiellete et al., 1999) Spitz proposed to specify different denticle types in a concentration-dependent manner mutants in Serrate, a gene that encodes a Notch ligand, have denticle defects Serrate expressed within prospective denticle belts, in a pattern that does not overlap with that of veinlet expression (Wiellette et al., 1999) 4 molecules activating 4 signaling pathways (Wg, Hh, Egfr, and Notch) are expressed in a precise spatial pattern within an 8-cell-wide band (Alexandre, 1999) Hh has diffenrential quantitative effects across three cell diameters (Alexandre, 1999)

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