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spliceosome

Spliceosome is a complex of (small nuclear RNA)-protein complexes and other proteins that assemble on a pre-mRNA and catalyze the excision of an intron in a process mechanistically similar to group II self-splicing. It acts presumably by forcing the intron into a loop and bridging the pre-mRNA at its splicing sites.

A spliceosome is a large ribonucleoprotein (RNP) complex found primarily within the nucleus of eukaryotic cells. The spliceosome is assembled from small nuclear RNAs (snRNA) and numerous proteins. snRNA molecules bind to specific proteins to form a small nuclear ribonucleoprotein complex (snRNP, pronounced “snurps”), which in turn combines with other snRNPs to form a large ribonucleoprotein complex called a spliceosome. A wide range of biochemical and genetic studies show that the spliceosome comprises three major RNA-protein subunits, U1, U2, and U4/U6.

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