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The WD40 repeat (also known as the WD or beta-transducin repeat) is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. The human WD40 repeat protein interacting with phosphoinositides (WIPI) family functions at the onset of autophagy. WD40 repeat has been found in many proteins that do not share any prominent functional properties. Currently, the function of the repeated motif is unknown for any of these proteins. Interestingly, recent experiments in yeast indicate that several proteins containing the WD40 repeat are genetically associated with members of the TPR family, a protein family characterized by the presence of another repeated motif of unknown function: the tetratricopeptide repeat. It is conceivable that proteins containing the WD40 repeat interact physically with members of the TPR family via their respective repeated motifs.
GenSmart Optimization is a free online tool for performing codon optimization to improve gene expression. GenScript's patented algorithms are integrated into the tool to optimize the computing capability of high-performance sequence generation.
GenSmart™ Design is a free online DNA construct design tool developed by GenScript. GenSmart™ Design has two design modules, the Create Construct module for individual plasmid design and the Create Library module for DNA library design.
This online tool shows commonly used genetic codon frequency table in expression host organisms including Escherichia coli and other common host organisms.
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