Resources

List by Alphabet: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

spontaneous mutation

Spontaneous mutations are changes in the DNA nucleotide sequence that occur de novo through random errors. Spontaneous mutations may be introduced by mistakes in different biological processes, such as errors during DNA replication in mitosis or meiosis. Most spontaneous nucleotide changes, such as introducing the wrong nucleotide type or number, maybe fixed through different DNA repair mechanisms. For example, replication errors may be corrected immediately during DNA chain extension through proofreading mechanisms or after DNA replication through mismatch repair. However, when mistakes are not repaired, spontaneous mutations may become fixed in the DNA and give rise to new alleles passed down to other cells during mitosis or may become inheritable traits.

Next-generation sequencing (NGS ) approaches, such as whole-exome and whole-genome sequencing, have helped understand the connection between spontaneous mutations and human disease states. For example, exome sequencing has enabled the identification of de novo mutations associated with neurodevelopmental disorders such as autism and epilepsy. Additionally, NGS techniques have established connections between severe congenital heart malformations and de novo mutations, which underscore about 10% of all cases.

Related Biology Tools

  • GenSmart™ Codon Optimization

    GenSmart Optimization is a free online tool for performing codon optimization to improve gene expression. GenScript's patented algorithms are integrated into the tool to optimize the computing capability of high-performance sequence generation.

    Learn More

  • DNA Construct Design Tool

    GenSmart™ Design is a free online DNA construct design tool developed by GenScript. GenSmart™ Design has two design modules, the Create Construct module for individual plasmid design and the Create Library module for DNA library design.

    Learn More

  • Codon Frequency Tables

    This online tool shows commonly used genetic codon frequency table in expression host organisms including Escherichia coli and other common host organisms.

    Learn More

Service and Products

Cell Engineering

From lentivirus packaging to generating clonal cell lines, let us assist you on your assay cell line creation project.

Assay Cell Line Development

For Drug Discovery, Toxicity Testing and Basic Research.

Research Grade Lentiviral Vector Packaging

Lentiviruses are a powerful gene delivery vector that ensures long-term expression of your target transgene.

Research Grade AAV

Our beta-testers are important to us and we are offering heavily discounted prices and additional guarantees.

If you know of any terms that have been omitted from this glossary that you feel would be useful to include, please send detail to the Editorial Office at GenScript: website@genscript.com

If your term is adopted, we will send 1,000 EzCoupon points to your GenScript account.