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Pluripotency

Pluripotency describes the ability of a cell to develop into the three primary germ cell layers of the early embryo and, therefore, into all cells of the adult body, but not extra-embryonic tissues such as the placenta. Pluripotency also means the potential of a cell to develop into more than one type of mature cell, depending on the environment.

In cell biology, pluripotency refers to a stem cell that has the potential to differentiate into any of the three germ layers: endoderm (interior stomach lining, gastrointestinal tract, the lungs), mesoderm (muscle, bone, blood, urogenital), or ectoderm (epidermal tissues and nervous system), but not into extra-embryonic tissues like the placenta.

Although direct reprogramming of somatic cells by exogenous pluripotency genes eliminates the immune rejection and bioethical issues of pluripotent cells derived by SCNT and destruction of the resulting embryo, there will be several problems to be overcome on the way to the clinic, some the same as ESCs.

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If you know of any terms that have been omitted from this glossary that you feel would be useful to include, please send detail to the Editorial Office at GenScript: website@genscript.com

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