For each citation that was shared on social media (LinkedIn, Facebook, or Twitter) with the “@GenScript” tag, the author will be rewarded with a $10 Amazon gift card or 2,000 GS points.

A C-terminal peptide from type I interferon protects the retina in a mouse model of autoimmune uveitis

PLoS One. 2020; 
Ahmed CM, Ildefonso CJ, Johnson HM, Lewin AS.
Products/Services Used Details Operation
Peptide Synthesis … Herein, we provide evidence that oral administration of IFNα-C can prevent the intraocular damage associated with EAU Materials and methods Peptide synthesis Human lipo-IFNα1 (152–189) peptide was synthesized by GenScript (Piscataway, NJ) … Get A Quote

Abstract

Experimental autoimmune uveitis (EAU) in rodents recapitulates many features of the disease in humans and has served as a useful tool for the development of therapeutics. A peptide from C-terminus of interferon α1, conjugated to palmitoyl-lysine for cell penetration, denoted as IFNα-C, was tested for its anti-inflammatory properties in ARPE-19 cells, followed by testing in a mouse model of EAU. Treatment with IFNα-C and evaluation by RT-qPCR showed the induction of anti-inflammatory cytokines and chemokine. Inflammatory markers induced by treatment with TNFα were suppressed when IFNα-C was simultaneously present. TNF-α mediated induction of NF-κB and signaling by IL-17A were attenuated by IFNα-C. Differ... More

Keywords