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Peptide Technical Resources

Have you ever experienced experiment failure just because your peptides or peptide libraries were not designed properly? These webinars provide guidance, techniques and suggestions for overcoming common peptide design pitfalls.

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Using A Predictive Bioinformatics Algorithm of Difficult Neoantigen Peptide Synthesis For Precision Immuno-Oncology Therapeutic Development New

Neoantigen based personalized immuno-oncology drugs are a relatively new therapeutic avenue that have shown strong anti-tumor efficacy in the clinic. Neoantigen peptides have been widely reported to be difficult to synthesize due to their hydrophobicity, length, and charge. This presentation will highlight how NeoPreTM identifies synthesis difficulty and review successful cases of difficult neoantigen peptide synthesis from several researchers.

Presented by: Raymond Miller, Ph.D., Senior Global product Manager of Therapeutic Materials at GenScript

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Amplified Extracellular Vesicles Generation Triggered by Peptide Polymerization New

This webinar introduces a novel invention using intercellular polymerization of a synthetic peptide precursor to amplify the generation of extracellular vesicles (EVs). By simply adding small peptides to therapeutic cells, the production of EVs in the cells was greatly enhanced when peptide polymerization was activated by enzymes.

Presented by: Hiroshi Matsui, Ph.D., Professor at City University of New York – Hunter College and Weill Cornell Medical College

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Identification of Relevant Antigenic Targets for Successful Liver Cancer Immunotherapy New

This webinar focuses on mutations that are expressed on cancer cells, like mutations in driver oncogenes. The central goal is to identify neoantigens in HCC and evaluate the presence of an immunological response to HCC- specific neoantigens with particular attention to hot-spot mutations in driver oncogenes.

Presented by: Anna Pasetto, Ph.D. Assistant Professor, Karolinska Institutet

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Examining the components of your peptide sample with AccuPep QC

Do you really know what components are in your lyophilized powder sample other than your desired peptide? Do you still think peptide purity is defined as the ratio between your desired peptide weight and the peptide powder weight? In this webinar, we will describe the major components or contaminants in your peptide samples, as well as the analytical tools that can help identify them.

Presented by: Yu Lu, Ph.D., Senior Scientist, GenScript Originally aired October 30, 2015

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Peptide libraries: applications, design options and considerations

Does your research involve peptides, and do you often find yourself purchasing different combinations over and over for your experiments? Peptide libraries can vastly decrease screening time and research accuracy by providing hundreds of peptides in parallel. As a result, they become an invaluable tool for many research applications: from development of cell-based assays, to vaccine design and epitope discovery. In this webinar, we will describe the fundamentals of peptide libraries and how they can be incorporated into your research. We will also discuss the different peptide library services that GenScript offers, as well as typical issues and considerations when designing your library.

Presented by: Laura Geuss, Ph.D.

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Peptide design strategy: basics, optimization, and application

Is your peptide sequence optimally designed for your unique research application? Peptide design effects the overall stability and usability of your peptide in experiments, as well as the turnaround time for your custom peptide. Is this session, we will review the basics of peptide design strategy including sequence design, modification selection, and purity choice. Case studies, best practices, and design tools will be introduced. In addition, we will explore specific trends in peptide design as it applies to research applications including drug discovery, drug delivery, structural biology, and biomaterials.

Presented by: Tiffany Gupton Campolongo, Ph.D. Originally aired November 25, 2014

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Avoiding peptide assay failure: hidden problems and solutions

Are your peptide-based enzyme, cellular, or tissue assays failing? Is your peptide-based assay data inconsistent or non-existent? The best planned peptide assays can fail if no consideration is given to the hidden intrinsic features of custom synthesized peptides which can cause aberrant cell growth and proliferation, variations in peptide bioactivity, and overall inconsistencies in your resulting data. This webinar will cover key aspects of peptide sequence design, peptide handling, assay preparation, and assay design, as related to the intrinsic properties of custom peptides. Case studies will be presented, and best practices will be provided for avoiding the pitfalls of custom peptide design and assay planning that can cause experimental failure.

Presented by: Tiffany Gupton Campolongo, Ph.D. Originally aired May 8th and June 10th, 2014

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