| Gene Symbol | nat1 |
| Entrez Gene ID | 496405 |
| Full Name | eIF4G-related protein NAT1 |
| Synonyms | DAP5,EIF4G2,p97 |
| Gene Type | protein-coding |
| Organism | Xenopus laevis(African clawed frog) |
| Summary | Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates at a non-AUG (GUG) codon. [provided by RefSeq, Oct 2009]. |
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nat1 cDNA ORF clone, Xenopus laevis(African clawed frog)
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Gene
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Clones
gRNAs
The following nat1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the nat1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OAf02703 Clone ID Related Accession (Same CDS sequence) NM_001095550.1 Accession Version NM_001095550.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 2712bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1477584000000 Organism Xenopus laevis(African clawed frog) Product eIF4G-related protein NAT1 Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB096099.1. ##Evidence-Data-START## Transcript exon combination :: AB096099.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00012418, SAMN04158985 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation ##RefSeq-Attributes-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701GTGGAGAGTG CGATTGCAGA GGGGGGTGCT TCTCGTTTCA GTGCTTCGTC AAGTGGAGGA
GCTAGGGGTG CCTCTCAGCA CTATCCCAAG ACTGTCGGCA ACAGCGAGTA CCTGGGGAAA
ACCCCAGGGC CTGGCGTTCA AAGATGGGTT CCTTCACGAA GCACTAAACG AGATGTCAAC
TCCACAAACA ACTCCGCAAA TACTGCGCTC AGCTCCTCAA GCGAGAAAGA ACGGCACGAT
GCAATCTTTA GGAAAGTGAG AGGCATCTTA AACAAGCTTG CTCCTGAGAA GTTTGACAAG
CTATGCCTTG AGCTCCTCAA TGTGGGTGTA GATTCCAAAC TCATCCTTAA AGGAGTCATA
CTGCTTATTG TAGACAAAGC CCTTGAAGAG CCAAAGTACA GCTCACTCTA TGCTCAGCTA
TGTCTGCGAT TAGCAGAAGA TGCACCAAAC TTTGACGGTC CGTCAGCTGA CGGTCCCCCA
GGGCAGAAGC AAAGCACAAC GTTTAGACGC CTCCTAATAT CAAAACTTCA AGATGAATTT
GAGAACCGAT CCAGAAATGT TGAAGTATAT GACAAGCGGG ACAGCCCACT CCTTCCTGAG
GAAGAGGAGC AGAGAGCGAT CGCTAAGATT AAGATGCTGG GAAACATCAA ATTTATTGGA
GAGCTTGGCA AGCTTGACCT CATACATGAA TCTATCCTTC ATAGGTGCAT CAAAGCACTT
TTGGAAAAGA AGAAGAGAGT ACAACTTAAG GATATGGGGG AAGATTTGGA GTGTCTCTGT
CAGATAATGA GGACTGTGGG TCCAAGATTA GACCATGAAA AAGCCAAGTC CTTGATGGAT
CAGTACTTTG CCCGTATGTG CGCTTTGAAG GCAAATAAGG AGTTGCCAGC AAGGATTCGT
TTCCTGCTGC AAGATACTAT GGAGTTGCGA GCAAACAATT GGGCTCCTCG CACCGCTTTC
AATGACAATG GACCAAAGAC CATCACTCAA ATCCGCCATG ATGCAGTAAA AGATCTAGGA
GTTTTTATTC CTGCTTCTAT GTCTCAAGGA ATGAGAAATG ACTTCTTTTT GGATGGACCG
TTTATGCCAC CAAGAATGAA GCTGGACAGG GACCCACTAG GAGGACTTGC TGATATGTTC
AGGCAAATGC CAGGTAGCGG TATTGGTACT GGTCCAGGTG TTATACAAGA CAGGTTTTCG
CCAACAATGG GACGTCATCG TTCGAGCCAG CTATTCAATG GTCATGGAGG CCACATACTA
CCTCCTACAC AATCCCAGTT TGAGATTGGA AGCAAACCCT TCATGAAGAG TCAGGGGCAA
AGCCAACTTT ACCAGAGCCA AGGTCTCCTC TCACAGCAAG GACAGTCTAA GGATATGCCG
CCTAGGTTTA TCAAGAAAGG ACAACTAAAT GCAGATGAGA TCAGTCTGAG ACCTGCTCAG
TCTTTCCTAA TGAATAAAAG CCAAGTGCCA AAGCTCCAGC CTCAGACAAT GATGATTCCG
CCTCGTACTC AAACCCCACC CATGGGGCAG ACTCCTCAAC TTGGGCTGAA AACCAACCCG
CCGCCAATTC AAGAAAAACC TGCAAAGAGT ATTAAAAAGC CGCCTCCTTC TAAGGAAGAA
CTAATTAAAC TCACTGAAGC ATTTGTCACA GAATACTTGA ATAACGGAAA CGCAGCCGAT
GCCATAAACA GTGTGAAAGA AATGAGGGCT CCCAAGCATT TCATTCCTGA AATGATCAGC
AAAATAATCC TCCAATCACT CGACAGATCT GATGAGGATA AGGAAAGGGC CAGTGAGCTG
GTTGGTGTTC TGCGCCAGGA GGGCGTGGCC ACCAGTGATA ACTTCATGCA GGCTTTCTTG
ACTATATTGG ACCAGTGCCC GAAGCTTGAG GTGGACATCC CTCTTGTGAA ATCCTACCTG
GCGCAGTTTG CGGCTCGTGC CATAATTGCT GAGCTGGTGA GCCTTTCTGA GCTGGCTCAG
CCTCTTGAGA ACGGTACCCT CTTCCCTCTC TTCCTGCTCT GCCTTCAGCA ATTGGCCAAG
CTTCAAGATC GGGAATGGCT AACAGAACTC TTCCAGCAGA GCAAGATCAA CATGCAGAAG
ATGTTGCCAG AAATCGACCA GAACAAAGAC CGGATGTTGG AGATCTTGGA AGGAAAAGGA
CTGAGTTTCT TGTTTCCACT TATGAAGCTG GAGAAGGAGC TGCTGAAACA GATCCAAATG
GATCCCTCTC CTCAGACCAT TTATAAGTGG ATCAAGGATA ACATATCTCC GAAACTTCAT
TTAGATAAAG GATTTGTGAA TATTTTAATA ACCAGCTTTT TACAGTATAT TTCGAACGAT
GCATGCCTAG AGGAAGAATC TGACCTGTCT TCTGCTCCGG CCAAAGAGCA GTTGGATCAG
GAGAAGCAGC TGTTGCTTGC GTTCAAGCCA GTAATGCAGA AGTTTCTACA CGACCATGTG
GATCTGCAAG TCAGCGCCCT GTATGCACTC CAGGTGCACT GCTGTAGCAA AAACTATCCG
AAAGGCATGT TACTGCGGTT CTTTGTCCAT TTCTATGACA TGGAGATCAT CGAGGAGGAA
GCCTTTTTGG CATGGAAGGA AGATATTACA CAAGAGTTTC CAGGGAAAGG AAAAGCTTTA
TTCCAGGTGA ACCAATGGCT GACCTGGTTG GAAACTGCCG AGGAGGAAGA ATCTGAGGAA
GAAGCAGACT AAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001089019.1 CDS 219..2930 Translation 
Target ORF information:
RefSeq Version NM_001095550.1 Organism Xenopus laevis(African clawed frog) Definition Xenopus laevis eIF4G-related protein NAT1 (nat1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_001095550.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701GTGGAGAGTG CGATTGCAGA GGGGGGTGCT TCTCGTTTCA GTGCTTCGTC AAGTGGAGGA
GCTAGGGGTG CCTCTCAGCA CTATCCCAAG ACTGTCGGCA ACAGCGAGTA CCTGGGGAAA
ACCCCAGGGC CTGGCGTTCA AAGATGGGTT CCTTCACGAA GCACTAAACG AGATGTCAAC
TCCACAAACA ACTCCGCAAA TACTGCGCTC AGCTCCTCAA GCGAGAAAGA ACGGCACGAT
GCAATCTTTA GGAAAGTGAG AGGCATCTTA AACAAGCTTG CTCCTGAGAA GTTTGACAAG
CTATGCCTTG AGCTCCTCAA TGTGGGTGTA GATTCCAAAC TCATCCTTAA AGGAGTCATA
CTGCTTATTG TAGACAAAGC CCTTGAAGAG CCAAAGTACA GCTCACTCTA TGCTCAGCTA
TGTCTGCGAT TAGCAGAAGA TGCACCAAAC TTTGACGGTC CGTCAGCTGA CGGTCCCCCA
GGGCAGAAGC AAAGCACAAC GTTTAGACGC CTCCTAATAT CAAAACTTCA AGATGAATTT
GAGAACCGAT CCAGAAATGT TGAAGTATAT GACAAGCGGG ACAGCCCACT CCTTCCTGAG
GAAGAGGAGC AGAGAGCGAT CGCTAAGATT AAGATGCTGG GAAACATCAA ATTTATTGGA
GAGCTTGGCA AGCTTGACCT CATACATGAA TCTATCCTTC ATAGGTGCAT CAAAGCACTT
TTGGAAAAGA AGAAGAGAGT ACAACTTAAG GATATGGGGG AAGATTTGGA GTGTCTCTGT
CAGATAATGA GGACTGTGGG TCCAAGATTA GACCATGAAA AAGCCAAGTC CTTGATGGAT
CAGTACTTTG CCCGTATGTG CGCTTTGAAG GCAAATAAGG AGTTGCCAGC AAGGATTCGT
TTCCTGCTGC AAGATACTAT GGAGTTGCGA GCAAACAATT GGGCTCCTCG CACCGCTTTC
AATGACAATG GACCAAAGAC CATCACTCAA ATCCGCCATG ATGCAGTAAA AGATCTAGGA
GTTTTTATTC CTGCTTCTAT GTCTCAAGGA ATGAGAAATG ACTTCTTTTT GGATGGACCG
TTTATGCCAC CAAGAATGAA GCTGGACAGG GACCCACTAG GAGGACTTGC TGATATGTTC
AGGCAAATGC CAGGTAGCGG TATTGGTACT GGTCCAGGTG TTATACAAGA CAGGTTTTCG
CCAACAATGG GACGTCATCG TTCGAGCCAG CTATTCAATG GTCATGGAGG CCACATACTA
CCTCCTACAC AATCCCAGTT TGAGATTGGA AGCAAACCCT TCATGAAGAG TCAGGGGCAA
AGCCAACTTT ACCAGAGCCA AGGTCTCCTC TCACAGCAAG GACAGTCTAA GGATATGCCG
CCTAGGTTTA TCAAGAAAGG ACAACTAAAT GCAGATGAGA TCAGTCTGAG ACCTGCTCAG
TCTTTCCTAA TGAATAAAAG CCAAGTGCCA AAGCTCCAGC CTCAGACAAT GATGATTCCG
CCTCGTACTC AAACCCCACC CATGGGGCAG ACTCCTCAAC TTGGGCTGAA AACCAACCCG
CCGCCAATTC AAGAAAAACC TGCAAAGAGT ATTAAAAAGC CGCCTCCTTC TAAGGAAGAA
CTAATTAAAC TCACTGAAGC ATTTGTCACA GAATACTTGA ATAACGGAAA CGCAGCCGAT
GCCATAAACA GTGTGAAAGA AATGAGGGCT CCCAAGCATT TCATTCCTGA AATGATCAGC
AAAATAATCC TCCAATCACT CGACAGATCT GATGAGGATA AGGAAAGGGC CAGTGAGCTG
GTTGGTGTTC TGCGCCAGGA GGGCGTGGCC ACCAGTGATA ACTTCATGCA GGCTTTCTTG
ACTATATTGG ACCAGTGCCC GAAGCTTGAG GTGGACATCC CTCTTGTGAA ATCCTACCTG
GCGCAGTTTG CGGCTCGTGC CATAATTGCT GAGCTGGTGA GCCTTTCTGA GCTGGCTCAG
CCTCTTGAGA ACGGTACCCT CTTCCCTCTC TTCCTGCTCT GCCTTCAGCA ATTGGCCAAG
CTTCAAGATC GGGAATGGCT AACAGAACTC TTCCAGCAGA GCAAGATCAA CATGCAGAAG
ATGTTGCCAG AAATCGACCA GAACAAAGAC CGGATGTTGG AGATCTTGGA AGGAAAAGGA
CTGAGTTTCT TGTTTCCACT TATGAAGCTG GAGAAGGAGC TGCTGAAACA GATCCAAATG
GATCCCTCTC CTCAGACCAT TTATAAGTGG ATCAAGGATA ACATATCTCC GAAACTTCAT
TTAGATAAAG GATTTGTGAA TATTTTAATA ACCAGCTTTT TACAGTATAT TTCGAACGAT
GCATGCCTAG AGGAAGAATC TGACCTGTCT TCTGCTCCGG CCAAAGAGCA GTTGGATCAG
GAGAAGCAGC TGTTGCTTGC GTTCAAGCCA GTAATGCAGA AGTTTCTACA CGACCATGTG
GATCTGCAAG TCAGCGCCCT GTATGCACTC CAGGTGCACT GCTGTAGCAA AAACTATCCG
AAAGGCATGT TACTGCGGTT CTTTGTCCAT TTCTATGACA TGGAGATCAT CGAGGAGGAA
GCCTTTTTGG CATGGAAGGA AGATATTACA CAAGAGTTTC CAGGGAAAGG AAAAGCTTTA
TTCCAGGTGA ACCAATGGCT GACCTGGTTG GAAACTGCCG AGGAGGAAGA ATCTGAGGAA
GAAGCAGACT AAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Evolutionarily conserved non-AUG translation initiation in NAT1/p97/DAP5 (EIF4G2).
Genomics85(3)360-71(2005 Mar)
Takahashi K,Maruyama M,Tokuzawa Y,Murakami M,Oda Y,Yoshikane N,Makabe KW,Ichisaka T,Yamanaka S
Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative.
Developmental dynamics : an official publication of the American Association of Anatomists225(4)384-91(2002 Dec)
Klein SL,Strausberg RL,Wagner L,Pontius J,Clifton SW,Richardson P
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