| Gene Symbol | CD59 |
| Entrez Gene ID | 397347 |
| Full Name | CD59 molecule (CD59 blood group) |
| Gene Type | protein-coding |
| Organism | Sus scrofa(pig) |
IVD Raw Materials
ORF » Species Summary » Sus scrofa » CD59 cDNA ORF clone
| Gene Symbol | CD59 |
| Entrez Gene ID | 397347 |
| Full Name | CD59 molecule (CD59 blood group) |
| Gene Type | protein-coding |
| Organism | Sus scrofa(pig) |
| mRNA | Protein | Name |
|---|---|---|
| NM_214170.1 | NP_999335.1 | CD59 glycoprotein precursor |
| XM_005661031.2 | XP_005661088.1 | CD59 glycoprotein isoform X1 |
| XM_005661031.3 | XP_005661088.1 | CD59 glycoprotein isoform X1 |
Resistance of neonatal porcine Sertoli cells to human xenoantibody and complement-mediated lysis is associated with low expression of alpha-Gal and high production of clusterin and CD59.
Yin Z, Wang L, Xiang Y, Ruan Y, Li J, Wang X, Ichim TE, Chen S, Chen G
Xenotransplantation17(3)215-23(2010 May-Jun)
IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway.
Grehan JF, Levay-Young BK, Fogelson JL, François-Bongarçon V, Benson BA, Dalmasso AP
Journal of immunology (Baltimore, Md. : 1950)175(3)1903-10(2005 Aug)
PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries.
Uenishi H, Eguchi T, Suzuki K, Sawazaki T, Toki D, Shinkai H, Okumura N, Hamasima N, Awata T
Nucleic acids research32(Database issue)D484-8(2004 Jan)
Structure/function characterization of porcine CD59: expression, chromosomal mapping, complement-inhibition, and costimulatory activity.
Maher SE, Pflugh DL, Larsen NJ, Rothschild MF, Bothwell AL
Transplantation66(8)1094-100(1998 Oct)
Molecular cloning and functional characterization of the pig analogue of CD59: relevance to xenotransplantation.
Hinchliffe SJ, Rushmere NK, Hanna SM, Morgan BP
Journal of immunology (Baltimore, Md. : 1950)160(8)3924-32(1998 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following CD59 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CD59 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OSe30448 | |
| Clone ID Related Accession (Same CDS sequence) | NM_214170.1 | |
| Accession Version | NM_214170.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 1571328000000 | |
| Organism | Sus scrofa(pig) | |
| Product | CD59 glycoprotein precursor | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF020302.1. ##Evidence-Data-START## Transcript exon combination :: AF020302.1, DB804577.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02584789 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGGAAGCA AAGGAGGGTT CATTTTGCTC TGGCTCCTGT CCATCCTGGC TGTTCTCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_999335.1 |
| CDS | 90..461 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_214170.1 |
1 | ATGGGAAGCA AAGGAGGGTT CATTTTGCTC TGGCTCCTGT CCATCCTGGC TGTTCTCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSe04519 | |
| Clone ID Related Accession (Same CDS sequence) | XM_005661031.2 , XM_005661031.3 | |
| Accession Version | XM_005661031.2 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 1441814400000 | |
| Organism | Sus scrofa(Pig) | |
| Product | CD59 glycoprotein isoform X1 | |
| Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003609551.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 11, 2015 this sequence version replaced XM_005661031.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Sus scrofa Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGGAAGCA AAGGAGGGTT CATTTTGCTC TGGCTCCTGT CCATCCTGGC TGTTCTCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_005661088.1 |
| CDS | 217..588 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_005661031.2 |
1 | ATGGGAAGCA AAGGAGGGTT CATTTTGCTC TGGCTCCTGT CCATCCTGGC TGTTCTCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSe04519 | |
| Clone ID Related Accession (Same CDS sequence) | XM_005661031.2 , XM_005661031.3 | |
| Accession Version | XM_005661031.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 1494518400000 | |
| Organism | Sus scrofa(pig) | |
| Product | CD59 glycoprotein isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_010444.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 13, 2017 this sequence version replaced XM_005661031.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Sus scrofa Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGGAAGCA AAGGAGGGTT CATTTTGCTC TGGCTCCTGT CCATCCTGGC TGTTCTCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_005661088.1 |
| CDS | 238..609 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_005661031.3 |
1 | ATGGGAAGCA AAGGAGGGTT CATTTTGCTC TGGCTCCTGT CCATCCTGGC TGTTCTCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Resistance of neonatal porcine Sertoli cells to human xenoantibody and complement-mediated lysis is associated with low expression of alpha-Gal and high production of clusterin and CD59. |
IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway. |
PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. |
Structure/function characterization of porcine CD59: expression, chromosomal mapping, complement-inhibition, and costimulatory activity. |
Molecular cloning and functional characterization of the pig analogue of CD59: relevance to xenotransplantation. |