Pomgnt1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pomgnt1
Entrez Gene ID	362567
Full Name	protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
General protein information	Preferred Names protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) Names protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 O-linked mannose beta1,2-N-acetylglucosaminyltransferase protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q35

mRNA and Protein(s)

mRNA	Protein	Name
XM_006238683.3	XP_006238745.1	protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 isoform X1
NM_001007747.1	NP_001007748.1	protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Pomgnt1	NP_080927.1
Gallus gallus (chicken)	POMGNT1	XP_426653.3
Danio rerio (zebrafish)	pomgnt1	NP_001036152.3
Bos taurus (cattle)	POMGNT1	NP_001019656.2
Rattus norvegicus (Norway rat)	Pomgnt1	NP_001007748.1
Xenopus tropicalis (tropical clawed frog)	pomgnt1	NP_001121493.1
Canis lupus familiaris (dog)	POMGNT1	XP_861245.1
Homo sapiens (human)	POMGNT1	NP_060209.3

Gene Ontology
Bibliography

Related articles in PubMed

Carbohydrate-binding domain of the POMGnT1 stem region modulates O-mannosylation sites of α-dystroglycan.
Kuwabara N, Manya H, Yamada T, Tateno H, Kanagawa M, Kobayashi K, Akasaka-Manya K, Hirose Y, Mizuno M, Ikeguchi M, Toda T, Hirabayashi J, Senda T, Endo T, Kato R
Proceedings of the National Academy of Sciences of the United States of America113(33)9280-5(2016 08)

Homozygosity Mapping and Whole-Genome Sequencing Links a Missense Mutation in POMGNT1 to Autosomal Recessive Retinitis Pigmentosa.
Wang NH, Chen SJ, Yang CF, Chen HW, Chuang HP, Lu YH, Chen CH, Wu JY, Niu DM, Chen YT
Investigative ophthalmology & visual science57(8)3601-9(2016 Jul)

Mutations in POMGNT1 cause non-syndromic retinitis pigmentosa.
Xu M, Yamada T, Sun Z, Eblimit A, Lopez I, Wang F, Manya H, Xu S, Zhao L, Li Y, Kimchi A, Sharon D, Sui R, Endo T, Koenekoop RK, Chen R
Human molecular genetics25(8)1479-88(2016 Apr)

Novel POMGnT1 mutations cause muscle-eye-brain disease in Chinese patients.
Jiao H, Manya H, Wang S, Zhang Y, Li X, Xiao J, Yang Y, Kobayashi K, Toda T, Endo T, Wu X, Xiong H
Molecular genetics and genomics : MGG288(7-8)297-308(2013 Aug)

Novel POMGNT1 point mutations and intragenic rearrangements associated with muscle-eye-brain disease.
Saredi S, Ardissone A, Ruggieri A, Mottarelli E, Farina L, Rinaldi R, Silvestri E, Gandioli C, D'Arrigo S, Salerno F, Morandi L, Grammatico P, Pantaleoni C, Moroni I, Mora M
Journal of the neurological sciences318(1-2)45-50(2012 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Pomgnt1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pomgnt1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00058	NM_001007747.1 Latest version!	Rattus norvegicus protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) (Pomgnt1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa28486	XM_006238683.3 Latest version!	Rattus norvegicus protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) (Pomgnt1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pomgnt1 ( NM_001007747.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001007748.1 Rattus norvegicus protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) (Pomgnt1), mRNA.

Price & Availability↑

CloneID	ORa00058
Clone ID Related Accession (Same CDS sequence)	NM_001007747.1
Accession Version	NM_001007747.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1983bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577289600000
Organism	Rattus norvegicus(Norway rat)
Product	protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC083641.1. On Nov 29, 2004 this sequence version replaced XM_342885.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC083641.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGATGACT GGAAGCCTAG TCCCCTCATC AAGCCCTTTG GGGCTAGGAA GAAACGGAGC 
TGGTATCTTA CCTGGAAGTA TAAACTGACA AACCAGCGGG CCCTGCGAAG ATTCTGTCAG 
ACAGGAGCTG TGCTTTTCCT GCTGGTGACT GTCATTGTGA ACATCAAGTT GATCCTAGAC 
ACTCGGAGAG CCATCAGCGA GGCCAATGAA GACCCTGAAC CAGAGCAAGA CTACGATGAG 
GCCCTAGGAC GCTTAGAGTC CCCTCGGCAC AGAGGCAGCA GTCCCCGACG CGTGCTGGAT 
GTGGAAGTAT ACTCCAGTAG AAGCAAAGTG TATGTGGCGG TAGATGGCAC TACGGTGCTA 
GAGGATGAGG CCCGGGAGCA GGGCCGAGGC ATCCATGTCA TCGTCCTCAA CCAGGCCACG 
GGCCACGTGA TGGCAAAGCG TGTGTTTGAC ACGTACTCTC CTCATGAGGA TGAGGCCATG 
GTGCTATTCC TCAACATGGT GGCGCCCGGC CGTGTACTGA TCTGCACAGT TAAGGATGAG 
GGCTCCTTCC ACCTCAAGGA CACAGCAAAG GCTCTGCTGA GGAGCCTGGG AAGCCAGGCA 
GGCCCTGCCC TTGGCTGGAG GGACACCTGG GCCTTCGTGG GACGAAAAGG AGGTCCTGTT 
CTTGGCGAGA AGCATTCTAA ATCTCCTGCC CTCTCCTCCT GGGGTGACCC AGTCCTGCTG 
AAGACAGATG TGCCACTCAG CTCAGCTGAA GAGGCTGAGT GTCACTGGGC AGATACAGAG 
TTGAACCGCC GCCGCAGGCG CTTCTGCAGC AAAGTCGAGG GCTACGGGAG CGTGTGCAGC 
TGCAAGGACC CAACACCTAT TGAGTTCAGC CCTGACCCAC TTCCAGACAA TAAAGTCCTC 
AATGTGCCTG TGGCTGTCAT TGCAGGGAAC CGGCCCAATT ACCTGTACAG GATGCTGCGC 
TCTCTGCTGT CAGCCCAAGG GGTATCTCCA CAGATGATAA CAGTCTTCAT TGATGGCTAC 
TATGAGGAGC CAATGGATGT GGTGGCACTG TTTGGTCTGA GAGGCATCCA GCACACTCCC 
ATCAGCATCA AGAACGCCCG TGTGTCTCAG CACTACAAGG CCAGCCTCAC TGCCACTTTC 
AACCTGTTTC CGGAGGCCAA GTTTGCTGTG GTTCTGGAAG AGGACCTGGA CATCGCTGTG 
GACTTTTTCA GTTTCCTGAG CCAGTCCATC CACCTGCTGG AGGAAGATGA CAGCCTGTAC 
TGCATCTCTG CTTGGAATGA CCAGGGGTAT GAACACACAG CTGAGGATCC AGCACTACTG 
TACCGTGTGG AGACCATGCC TGGGTTGGGA TGGGTGCTCA GGAAATCTCT ATACAAGGAG 
GAGCTTGAGC CCAAGTGGCC CACACCAGAA AAGCTGTGGG ACTGGGACAT GTGGATGCGG 
ATGCCGGAAC AGCGCCGTGG CCGTGAGTGC ATCATCCCGG ATGTTTCCCG ATCCTACCAC 
TTTGGCATCG TGGGCCTCAA CATGAATGGC TACTTTCATG AGGCCTACTT CAAGAAGCAC 
AAGTTCAACA CAGTCCCAGG TGTCCAGCTC AGGAATGTAG ACAGTCTGAA GAAAGAAGCT 
TATGAAGTGG AAATTCACAG GCTGCTCAGT GAGGCCGAGG TTTTGGACCA CAGCAAGGAC 
CCTTGTGAAG ACTCCTTCCT GCCAGACACA GAGGGCCATA CCTATGTGGC ATTTATCCGG 
ATGGAGAAAG ATGATGACTT CACCACCTGG ACTCAGCTTG CCAAGTGCCT CCACATTTGG 
GATCTGGACG TTCGTGGCAA CCACCGGGGC CTGTGGAGAT TATTTCGGAA GAAGAACCAC 
TTTTTGGTGG TGGGGGTCCC AGCCTCCCCT TACTCAGTGA AGAAGCCACC CTCAGTCACC 
CCTATTTTCC TGGAGCCACC CCCAAAGGAA GAAGGAGCCC CAGGGGCTGC TGAACAAACA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001007748.1
CDS	153..2135
Translation	MDDWKPSPLIKPFGARKKRSWYLTWKYKLTNQRALRRFCQTGAVLFLLVTVIVNIKLILDTRRAISEANEDPEPEQDYDEALGRLESPRHRGSSPRRVLDVEVYSSRSKVYVAVDGTTVLEDEAREQGRGIHVIVLNQATGHVMAKRVFDTYSPHEDEAMVLFLNMVAPGRVLICTVKDEGSFHLKDTAKALLRSLGSQAGPALGWRDTWAFVGRKGGPVLGEKHSKSPALSSWGDPVLLKTDVPLSSAEEAECHWADTELNRRRRRFCSKVEGYGSVCSCKDPTPIEFSPDPLPDNKVLNVPVAVIAGNRPNYLYRMLRSLLSAQGVSPQMITVFIDGYYEEPMDVVALFGLRGIQHTPISIKNARVSQHYKASLTATFNLFPEAKFAVVLEEDLDIAVDFFSFLSQSIHLLEEDDSLYCISAWNDQGYEHTAEDPALLYRVETMPGLGWVLRKSLYKEELEPKWPTPEKLWDWDMWMRMPEQRRGRECIIPDVSRSYHFGIVGLNMNGYFHEAYFKKHKFNTVPGVQLRNVDSLKKEAYEVEIHRLLSEAEVLDHSKDPCEDSFLPDTEGHTYVAFIRMEKDDDFTTWTQLAKCLHIWDLDVRGNHRGLWRLFRKKNHFLVVGVPASPYSVKKPPSVTPIFLEPPPKEEGAPGAAEQT

Target ORF information:

RefSeq Version	NM_001007747.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) (Pomgnt1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001007747.1

ORF Insert Sequence:

ATGGATGACT GGAAGCCTAG TCCCCTCATC AAGCCCTTTG GGGCTAGGAA GAAACGGAGC 
TGGTATCTTA CCTGGAAGTA TAAACTGACA AACCAGCGGG CCCTGCGAAG ATTCTGTCAG 
ACAGGAGCTG TGCTTTTCCT GCTGGTGACT GTCATTGTGA ACATCAAGTT GATCCTAGAC 
ACTCGGAGAG CCATCAGCGA GGCCAATGAA GACCCTGAAC CAGAGCAAGA CTACGATGAG 
GCCCTAGGAC GCTTAGAGTC CCCTCGGCAC AGAGGCAGCA GTCCCCGACG CGTGCTGGAT 
GTGGAAGTAT ACTCCAGTAG AAGCAAAGTG TATGTGGCGG TAGATGGCAC TACGGTGCTA 
GAGGATGAGG CCCGGGAGCA GGGCCGAGGC ATCCATGTCA TCGTCCTCAA CCAGGCCACG 
GGCCACGTGA TGGCAAAGCG TGTGTTTGAC ACGTACTCTC CTCATGAGGA TGAGGCCATG 
GTGCTATTCC TCAACATGGT GGCGCCCGGC CGTGTACTGA TCTGCACAGT TAAGGATGAG 
GGCTCCTTCC ACCTCAAGGA CACAGCAAAG GCTCTGCTGA GGAGCCTGGG AAGCCAGGCA 
GGCCCTGCCC TTGGCTGGAG GGACACCTGG GCCTTCGTGG GACGAAAAGG AGGTCCTGTT 
CTTGGCGAGA AGCATTCTAA ATCTCCTGCC CTCTCCTCCT GGGGTGACCC AGTCCTGCTG 
AAGACAGATG TGCCACTCAG CTCAGCTGAA GAGGCTGAGT GTCACTGGGC AGATACAGAG 
TTGAACCGCC GCCGCAGGCG CTTCTGCAGC AAAGTCGAGG GCTACGGGAG CGTGTGCAGC 
TGCAAGGACC CAACACCTAT TGAGTTCAGC CCTGACCCAC TTCCAGACAA TAAAGTCCTC 
AATGTGCCTG TGGCTGTCAT TGCAGGGAAC CGGCCCAATT ACCTGTACAG GATGCTGCGC 
TCTCTGCTGT CAGCCCAAGG GGTATCTCCA CAGATGATAA CAGTCTTCAT TGATGGCTAC 
TATGAGGAGC CAATGGATGT GGTGGCACTG TTTGGTCTGA GAGGCATCCA GCACACTCCC 
ATCAGCATCA AGAACGCCCG TGTGTCTCAG CACTACAAGG CCAGCCTCAC TGCCACTTTC 
AACCTGTTTC CGGAGGCCAA GTTTGCTGTG GTTCTGGAAG AGGACCTGGA CATCGCTGTG 
GACTTTTTCA GTTTCCTGAG CCAGTCCATC CACCTGCTGG AGGAAGATGA CAGCCTGTAC 
TGCATCTCTG CTTGGAATGA CCAGGGGTAT GAACACACAG CTGAGGATCC AGCACTACTG 
TACCGTGTGG AGACCATGCC TGGGTTGGGA TGGGTGCTCA GGAAATCTCT ATACAAGGAG 
GAGCTTGAGC CCAAGTGGCC CACACCAGAA AAGCTGTGGG ACTGGGACAT GTGGATGCGG 
ATGCCGGAAC AGCGCCGTGG CCGTGAGTGC ATCATCCCGG ATGTTTCCCG ATCCTACCAC 
TTTGGCATCG TGGGCCTCAA CATGAATGGC TACTTTCATG AGGCCTACTT CAAGAAGCAC 
AAGTTCAACA CAGTCCCAGG TGTCCAGCTC AGGAATGTAG ACAGTCTGAA GAAAGAAGCT 
TATGAAGTGG AAATTCACAG GCTGCTCAGT GAGGCCGAGG TTTTGGACCA CAGCAAGGAC 
CCTTGTGAAG ACTCCTTCCT GCCAGACACA GAGGGCCATA CCTATGTGGC ATTTATCCGG 
ATGGAGAAAG ATGATGACTT CACCACCTGG ACTCAGCTTG CCAAGTGCCT CCACATTTGG 
GATCTGGACG TTCGTGGCAA CCACCGGGGC CTGTGGAGAT TATTTCGGAA GAAGAACCAC 
TTTTTGGTGG TGGGGGTCCC AGCCTCCCCT TACTCAGTGA AGAAGCCACC CTCAGTCACC 
CCTATTTTCC TGGAGCCACC CCCAAAGGAA GAAGGAGCCC CAGGGGCTGC TGAACAAACA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pomgnt1 ( XM_006238683.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006238745.1 Rattus norvegicus protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) (Pomgnt1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa28486
Clone ID Related Accession (Same CDS sequence)	XM_006238683.3
Accession Version	XM_006238683.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1917bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006238683.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGGGA GCAAAGAAGC CAAAGACTCA AATGGGAGAG TACAAGACCA CTCGACAGGA 
GCTGTGCTTT TCCTGCTGGT GACTGTCATT GTGAACATCA AGTTGATCCT AGACACTCGG 
AGAGCCATCA GCGAGGCCAA TGAAGACCCT GAACCAGAGC AAGACTACGA TGAGGCCCTA 
GGACGCTTAG AGTCCCCTCG GCACAGAGGC AGCAGTCCCC GACGCGTGCT GGATGTGGAA 
GTATACTCCA GTAGAAGCAA AGTGTATGTG GCGGTAGATG GCACTACGGT GCTAGAGGAT 
GAGGCCCGGG AGCAGGGCCG AGGCATCCAT GTCATCGTCC TCAACCAGGC CACGGGCCAC 
GTGATGGCAA AGCGTGTGTT TGACACGTAC TCTCCTCATG AGGATGAGGC CATGGTGCTA 
TTCCTCAACA TGGTGGCGCC CGGCCGTGTA CTGATCTGCA CAGTTAAGGA TGAGGGCTCC 
TTCCACCTCA AGGACACAGC AAAGGCTCTG CTGAGGAGCC TGGGAAGCCA GGCAGGCCCT 
GCCCTTGGCT GGAGGGACAC CTGGGCCTTC GTGGGACGAA AAGGAGGTCC TGTTCTTGGC 
GAGAAGCATT CTAAATCTCC TGCCCTCTCC TCCTGGGGTG ACCCAGTCCT GCTGAAGACA 
GATGTGCCAC TCAGCTCAGC TGAAGAGGCT GAGTGTCACT GGGCAGATAC AGAGTTGAAC 
CGCCGCCGCA GGCGCTTCTG CAGCAAAGTC GAGGGCTACG GGAGCGTGTG CAGCTGCAAG 
GACCCAACAC CTATTGAGTT CAGCCCTGAC CCACTTCCAG ACAATAAAGT CCTCAATGTG 
CCTGTGGCTG TCATTGCAGG GAACCGGCCC AATTACCTGT ACAGGATGCT GCGCTCTCTG 
CTGTCAGCCC AAGGGGTATC TCCACAGATG ATAACAGTCT TCATTGATGG CTACTATGAG 
GAGCCAATGG ATGTGGTGGC ACTGTTTGGT CTGAGAGGCA TCCAGCACAC TCCCATCAGC 
ATCAAGAACG CCCGTGTGTC TCAGCACTAC AAGGCCAGCC TCACTGCCAC TTTCAACCTG 
TTTCCGGAGG CCAAGTTTGC TGTGGTTCTG GAAGAGGACC TGGACATCGC TGTGGACTTT 
TTCAGTTTCC TGAGCCAGTC CATCCACCTG CTGGAGGAAG ATGACAGCCT GTACTGCATC 
TCTGCTTGGA ATGACCAGGG GTATGAACAC ACAGCTGAGG ATCCAGCACT ACTGTACCGT 
GTGGAGACCA TGCCTGGGTT GGGATGGGTG CTCAGGAAAT CTCTATACAA GGAGGAGCTT 
GAGCCCAAGT GGCCCACACC AGAAAAGCTG TGGGACTGGG ACATGTGGAT GCGGATGCCG 
GAACAGCGCC GTGGCCGTGA GTGCATCATC CCGGATGTTT CCCGATCCTA CCACTTTGGC 
ATCGTGGGCC TCAACATGAA TGGCTACTTT CATGAGGCCT ACTTCAAGAA GCACAAGTTC 
AACACAGTCC CAGGTGTCCA GCTCAGGAAT GTAGACAGTC TGAAGAAAGA AGCTTATGAA 
GTGGAAATTC ACAGGCTGCT CAGTGAGGCC GAGGTTTTGG ACCACAGCAA GGACCCTTGT 
GAAGACTCCT TCCTGCCAGA CACAGAGGGC CATACCTATG TGGCATTTAT CCGGATGGAG 
AAAGATGATG ACTTCACCAC CTGGACTCAG CTTGCCAAGT GCCTCCACAT TTGGGATCTG 
GACGTTCGTG GCAACCACCG GGGCCTGTGG AGATTATTTC GGAAGAAGAA CCACTTTTTG 
GTGGTGGGGG TCCCAGCCTC CCCTTACTCA GTGAAGAAGC CACCCTCAGT CACCCCTATT 
TTCCTGGAGC CACCCCCAAA GGAAGAAGGA GCCCCAGGGG CTGCTGAACA AACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006238745.1
CDS	322..2238
Translation	MEGSKEAKDSNGRVQDHSTGAVLFLLVTVIVNIKLILDTRRAISEANEDPEPEQDYDEALGRLESPRHRGSSPRRVLDVEVYSSRSKVYVAVDGTTVLEDEAREQGRGIHVIVLNQATGHVMAKRVFDTYSPHEDEAMVLFLNMVAPGRVLICTVKDEGSFHLKDTAKALLRSLGSQAGPALGWRDTWAFVGRKGGPVLGEKHSKSPALSSWGDPVLLKTDVPLSSAEEAECHWADTELNRRRRRFCSKVEGYGSVCSCKDPTPIEFSPDPLPDNKVLNVPVAVIAGNRPNYLYRMLRSLLSAQGVSPQMITVFIDGYYEEPMDVVALFGLRGIQHTPISIKNARVSQHYKASLTATFNLFPEAKFAVVLEEDLDIAVDFFSFLSQSIHLLEEDDSLYCISAWNDQGYEHTAEDPALLYRVETMPGLGWVLRKSLYKEELEPKWPTPEKLWDWDMWMRMPEQRRGRECIIPDVSRSYHFGIVGLNMNGYFHEAYFKKHKFNTVPGVQLRNVDSLKKEAYEVEIHRLLSEAEVLDHSKDPCEDSFLPDTEGHTYVAFIRMEKDDDFTTWTQLAKCLHIWDLDVRGNHRGLWRLFRKKNHFLVVGVPASPYSVKKPPSVTPIFLEPPPKEEGAPGAAEQT

Target ORF information:

RefSeq Version	XM_006238683.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) (Pomgnt1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006238683.3

ORF Insert Sequence:

ATGGAGGGGA GCAAAGAAGC CAAAGACTCA AATGGGAGAG TACAAGACCA CTCGACAGGA 
GCTGTGCTTT TCCTGCTGGT GACTGTCATT GTGAACATCA AGTTGATCCT AGACACTCGG 
AGAGCCATCA GCGAGGCCAA TGAAGACCCT GAACCAGAGC AAGACTACGA TGAGGCCCTA 
GGACGCTTAG AGTCCCCTCG GCACAGAGGC AGCAGTCCCC GACGCGTGCT GGATGTGGAA 
GTATACTCCA GTAGAAGCAA AGTGTATGTG GCGGTAGATG GCACTACGGT GCTAGAGGAT 
GAGGCCCGGG AGCAGGGCCG AGGCATCCAT GTCATCGTCC TCAACCAGGC CACGGGCCAC 
GTGATGGCAA AGCGTGTGTT TGACACGTAC TCTCCTCATG AGGATGAGGC CATGGTGCTA 
TTCCTCAACA TGGTGGCGCC CGGCCGTGTA CTGATCTGCA CAGTTAAGGA TGAGGGCTCC 
TTCCACCTCA AGGACACAGC AAAGGCTCTG CTGAGGAGCC TGGGAAGCCA GGCAGGCCCT 
GCCCTTGGCT GGAGGGACAC CTGGGCCTTC GTGGGACGAA AAGGAGGTCC TGTTCTTGGC 
GAGAAGCATT CTAAATCTCC TGCCCTCTCC TCCTGGGGTG ACCCAGTCCT GCTGAAGACA 
GATGTGCCAC TCAGCTCAGC TGAAGAGGCT GAGTGTCACT GGGCAGATAC AGAGTTGAAC 
CGCCGCCGCA GGCGCTTCTG CAGCAAAGTC GAGGGCTACG GGAGCGTGTG CAGCTGCAAG 
GACCCAACAC CTATTGAGTT CAGCCCTGAC CCACTTCCAG ACAATAAAGT CCTCAATGTG 
CCTGTGGCTG TCATTGCAGG GAACCGGCCC AATTACCTGT ACAGGATGCT GCGCTCTCTG 
CTGTCAGCCC AAGGGGTATC TCCACAGATG ATAACAGTCT TCATTGATGG CTACTATGAG 
GAGCCAATGG ATGTGGTGGC ACTGTTTGGT CTGAGAGGCA TCCAGCACAC TCCCATCAGC 
ATCAAGAACG CCCGTGTGTC TCAGCACTAC AAGGCCAGCC TCACTGCCAC TTTCAACCTG 
TTTCCGGAGG CCAAGTTTGC TGTGGTTCTG GAAGAGGACC TGGACATCGC TGTGGACTTT 
TTCAGTTTCC TGAGCCAGTC CATCCACCTG CTGGAGGAAG ATGACAGCCT GTACTGCATC 
TCTGCTTGGA ATGACCAGGG GTATGAACAC ACAGCTGAGG ATCCAGCACT ACTGTACCGT 
GTGGAGACCA TGCCTGGGTT GGGATGGGTG CTCAGGAAAT CTCTATACAA GGAGGAGCTT 
GAGCCCAAGT GGCCCACACC AGAAAAGCTG TGGGACTGGG ACATGTGGAT GCGGATGCCG 
GAACAGCGCC GTGGCCGTGA GTGCATCATC CCGGATGTTT CCCGATCCTA CCACTTTGGC 
ATCGTGGGCC TCAACATGAA TGGCTACTTT CATGAGGCCT ACTTCAAGAA GCACAAGTTC 
AACACAGTCC CAGGTGTCCA GCTCAGGAAT GTAGACAGTC TGAAGAAAGA AGCTTATGAA 
GTGGAAATTC ACAGGCTGCT CAGTGAGGCC GAGGTTTTGG ACCACAGCAA GGACCCTTGT 
GAAGACTCCT TCCTGCCAGA CACAGAGGGC CATACCTATG TGGCATTTAT CCGGATGGAG 
AAAGATGATG ACTTCACCAC CTGGACTCAG CTTGCCAAGT GCCTCCACAT TTGGGATCTG 
GACGTTCGTG GCAACCACCG GGGCCTGTGG AGATTATTTC GGAAGAAGAA CCACTTTTTG 
GTGGTGGGGG TCCCAGCCTC CCCTTACTCA GTGAAGAAGC CACCCTCAGT CACCCCTATT 
TTCCTGGAGC CACCCCCAAA GGAAGAAGGA GCCCCAGGGG CTGCTGAACA AACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Carbohydrate-binding domain of the POMGnT1 stem region modulates O-mannosylation sites of α-dystroglycan.
Proceedings of the National Academy of Sciences of the United States of America113(33)9280-5(2016 08)
Kuwabara N,Manya H,Yamada T,Tateno H,Kanagawa M,Kobayashi K,Akasaka-Manya K,Hirose Y,Mizuno M,Ikeguchi M,Toda T,Hirabayashi J,Senda T,Endo T,Kato R

Homozygosity Mapping and Whole-Genome Sequencing Links a Missense Mutation in POMGNT1 to Autosomal Recessive Retinitis Pigmentosa.
Investigative ophthalmology & visual science57(8)3601-9(2016 Jul)
Wang NH,Chen SJ,Yang CF,Chen HW,Chuang HP,Lu YH,Chen CH,Wu JY,Niu DM,Chen YT

Mutations in POMGNT1 cause non-syndromic retinitis pigmentosa.
Human molecular genetics25(8)1479-88(2016 Apr)
Xu M,Yamada T,Sun Z,Eblimit A,Lopez I,Wang F,Manya H,Xu S,Zhao L,Li Y,Kimchi A,Sharon D,Sui R,Endo T,Koenekoop RK,Chen R

Novel POMGnT1 mutations cause muscle-eye-brain disease in Chinese patients.
Molecular genetics and genomics : MGG288(7-8)297-308(2013 Aug)
Jiao H,Manya H,Wang S,Zhang Y,Li X,Xiao J,Yang Y,Kobayashi K,Toda T,Endo T,Wu X,Xiong H

Novel POMGNT1 point mutations and intragenic rearrangements associated with muscle-eye-brain disease.
Journal of the neurological sciences318(1-2)45-50(2012 Jul)
Saredi S,Ardissone A,Ruggieri A,Mottarelli E,Farina L,Rinaldi R,Silvestri E,Gandioli C,D'Arrigo S,Salerno F,Morandi L,Grammatico P,Pantaleoni C,Moroni I,Mora M

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Pomgnt1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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