Abraxas2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Abraxas2
Entrez Gene ID	293570
Full Name	abraxas 2, BRISC complex subunit
Synonyms	Fam175b,RGD1308918
General protein information	Preferred Names abraxas 2, BRISC complex subunit Names BRISC complex subunit Abro1 family with sequence similarity 175, member B
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q41

mRNA and Protein(s)

mRNA	Protein	Name
NM_001106307.1	NP_001099777.2	BRISC complex subunit Abro1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Fam175b	NP_932134.3
Pan troglodytes (chimpanzee)	FAM175B	XP_003312863.1
Homo sapiens (human)	FAM175B	NP_115558.3
Macaca mulatta (Rhesus monkey)	LOC694886	XP_001083977.1
Canis lupus familiaris (dog)	FAM175B	XP_535051.4
Bos taurus (cattle)	FAM175B	NP_001160059.1
Rattus norvegicus (Norway rat)	Fam175b	NP_001099777.2
Xenopus tropicalis (tropical clawed frog)	fam175b	NP_001192104.1
Danio rerio (zebrafish)	fam175b	NP_998460.1
Danio rerio (zebrafish)	LOC100538340	XP_003200403.1
Gallus gallus (chicken)	FAM175B	NP_001026412.1

Gene Ontology
Bibliography

Related articles in PubMed

The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells.
Yan K, Li L, Wang X, Hong R, Zhang Y, Yang H, Lin M, Zhang S, He Q, Zheng D, Tang J, Yin Y, Shao G
The Journal of cell biology210(2)209-24(2015 Jul)

A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses.
Zheng H, Gupta V, Patterson-Fortin J, Bhattacharya S, Katlinski K, Wu J, Varghese B, Carbone CJ, Aressy B, Fuchs SY, Greenberg RA
Cell reports5(1)180-93(2013 Oct)

ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway.
Ambivero CT, Cilenti L, Zervos AS
Biochimica et biophysica acta1823(12)2149-56(2012 Dec)

Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitination.
Cilenti L, Balakrishnan MP, Wang XL, Ambivero C, Sterlicchi M, del Monte F, Ma XL, Zervos AS
Journal of molecular and cellular cardiology50(4)652-61(2011 Apr)

NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.
Wang B, Hurov K, Hofmann K, Elledge SJ
Genes & development23(6)729-39(2009 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Abraxas2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Abraxas2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00831	NM_001106307.1 Latest version!	Rattus norvegicus abraxas 2, BRISC complex subunit (Abraxas2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Abraxas2 ( NM_001106307.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099777.2 Rattus norvegicus abraxas 2, BRISC complex subunit (Abraxas2), mRNA.

Price & Availability↑

CloneID	ORa00831
Clone ID Related Accession (Same CDS sequence)	NM_001106307.1
Accession Version	NM_001106307.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506787200000
Organism	Rattus norvegicus(Norway rat)
Product	BRISC complex subunit Abro1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473953.1. On or before Oct 4, 2007 this sequence version replaced XM_001054804.1, XM_219441.3. ##Evidence-Data-START## Transcript exon combination :: FQ218234.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGAGG TGGAGATTTC CATCATGGCG GCTTCCATTT CGGGCTACAC CTTCAGCGCT 
GTGTGTTTCC ACAGCGCCAA CAGCAACGCC GACCACGAAG GATTTTTGCT GGGAGAGGTA 
AGACAAGAGG AAACGTTTAG CATCAGTGAC TCACAAATCA GCAACACAGA GTTTCTACAA 
GTAATTGAAA TCCATAACCA TCAACCCTGT TCAAAACTCT TTAGTTTTTA TGATTATGCA 
AGCAAAGTGA ATGAAGAGAG TTTGGACAGA ATTCTTAAAG ATCGGAGGAA GAAAGTCATC 
GGATGGTACA GATTCCGGAG AAACACCCAG CAGCAGATGT CCTACAGAGA GCAAGTCATC 
CACAAGCAGC TCACCCGCGT CCTCGGCGTG CCAGACCTGG TTTTCCTTCT CTTCAGCTTC 
ATCTCTACCG CCAACAACTC TACTCATGCG TTAGAATATG TTCTCTTTCG ACCAAATCGC 
AGGTATAATC AAAGGATATC ACTTGCTATT CCCAATCTAG GCAATACTAG CCAGCAAGAG 
TACAAAGTGT CTTCAGTGCC AAACACATCT CAGAGTTATG CCAAAGTTAT TAAAGAGCAT 
GGTACTGACT TTTTTGACAA GGATGGAGTC ATGAAGGACA TCAGGGCAAT TTATCAGGTT 
TATAATGCAC TTCAGGAGAA AGTACAGGCA GTGTGTGCAG ATGTAGAAAA GAGTGAGCGA 
GTTGTTGAAT CTTGTCAGGC AGAAGTGAAC AAATTGAGAA GACAAATCAC TCAGAAGAAA 
AATGAAAAGG AACAAGAAAG AAGACTGCAG CAGGCCCTGT TAAGCAGACA GATGCCATCT 
GAAAGCCTGG AGCCAGCATT CAGCCCTCGG ATGCCATATT CTGGGTTTTC AGCCGAAGGG 
AGAAGTACTC TAGCAGATGC CGAGCCCTCT GATCCTCCAC CTCCTTACTC CGATTTCCAC 
CCAAACAATC AAGAAAGTAC TCTGAGCCAT TCTCGCATAG AAAGGAGTGT CTTCATGCCC 
CGGCCTCAGG CTGTGGGCTC TTCCAACTAT GCTTCCACCA GTGCCGGACT GAAGTTCACT 
GGAAGTGGAG CAGATCTTCT TCCTTCCCAG AGTGCAGCTG GAGACAGCGG GGAGGAGACA 
GATGACAGTG ATTATGAAAA TTTGATTGAC CCTGCAGAGT CCCCTCATAG TGAATACTCA 
CATTCAAAGA ATTCACGGCC CACGACACAT CCTGACGAGG ACCCCAGGAA CACTCAGACC 
TCCCAGATTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099777.2
CDS	1..1272
Translation	MGEVEISIMAASISGYTFSAVCFHSANSNADHEGFLLGEVRQEETFSISDSQISNTEFLQVIEIHNHQPCSKLFSFYDYASKVNEESLDRILKDRRKKVIGWYRFRRNTQQQMSYREQVIHKQLTRVLGVPDLVFLLFSFISTANNSTHALEYVLFRPNRRYNQRISLAIPNLGNTSQQEYKVSSVPNTSQSYAKVIKEHGTDFFDKDGVMKDIRAIYQVYNALQEKVQAVCADVEKSERVVESCQAEVNKLRRQITQKKNEKEQERRLQQALLSRQMPSESLEPAFSPRMPYSGFSAEGRSTLADAEPSDPPPPYSDFHPNNQESTLSHSRIERSVFMPRPQAVGSSNYASTSAGLKFTGSGADLLPSQSAAGDSGEETDDSDYENLIDPAESPHSEYSHSKNSRPTTHPDEDPRNTQTSQI

Target ORF information:

RefSeq Version	NM_001106307.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus abraxas 2, BRISC complex subunit (Abraxas2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001106307.1

ORF Insert Sequence:

ATGGGGGAGG TGGAGATTTC CATCATGGCG GCTTCCATTT CGGGCTACAC CTTCAGCGCT 
GTGTGTTTCC ACAGCGCCAA CAGCAACGCC GACCACGAAG GATTTTTGCT GGGAGAGGTA 
AGACAAGAGG AAACGTTTAG CATCAGTGAC TCACAAATCA GCAACACAGA GTTTCTACAA 
GTAATTGAAA TCCATAACCA TCAACCCTGT TCAAAACTCT TTAGTTTTTA TGATTATGCA 
AGCAAAGTGA ATGAAGAGAG TTTGGACAGA ATTCTTAAAG ATCGGAGGAA GAAAGTCATC 
GGATGGTACA GATTCCGGAG AAACACCCAG CAGCAGATGT CCTACAGAGA GCAAGTCATC 
CACAAGCAGC TCACCCGCGT CCTCGGCGTG CCAGACCTGG TTTTCCTTCT CTTCAGCTTC 
ATCTCTACCG CCAACAACTC TACTCATGCG TTAGAATATG TTCTCTTTCG ACCAAATCGC 
AGGTATAATC AAAGGATATC ACTTGCTATT CCCAATCTAG GCAATACTAG CCAGCAAGAG 
TACAAAGTGT CTTCAGTGCC AAACACATCT CAGAGTTATG CCAAAGTTAT TAAAGAGCAT 
GGTACTGACT TTTTTGACAA GGATGGAGTC ATGAAGGACA TCAGGGCAAT TTATCAGGTT 
TATAATGCAC TTCAGGAGAA AGTACAGGCA GTGTGTGCAG ATGTAGAAAA GAGTGAGCGA 
GTTGTTGAAT CTTGTCAGGC AGAAGTGAAC AAATTGAGAA GACAAATCAC TCAGAAGAAA 
AATGAAAAGG AACAAGAAAG AAGACTGCAG CAGGCCCTGT TAAGCAGACA GATGCCATCT 
GAAAGCCTGG AGCCAGCATT CAGCCCTCGG ATGCCATATT CTGGGTTTTC AGCCGAAGGG 
AGAAGTACTC TAGCAGATGC CGAGCCCTCT GATCCTCCAC CTCCTTACTC CGATTTCCAC 
CCAAACAATC AAGAAAGTAC TCTGAGCCAT TCTCGCATAG AAAGGAGTGT CTTCATGCCC 
CGGCCTCAGG CTGTGGGCTC TTCCAACTAT GCTTCCACCA GTGCCGGACT GAAGTTCACT 
GGAAGTGGAG CAGATCTTCT TCCTTCCCAG AGTGCAGCTG GAGACAGCGG GGAGGAGACA 
GATGACAGTG ATTATGAAAA TTTGATTGAC CCTGCAGAGT CCCCTCATAG TGAATACTCA 
CATTCAAAGA ATTCACGGCC CACGACACAT CCTGACGAGG ACCCCAGGAA CACTCAGACC 
TCCCAGATTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells.
The Journal of cell biology210(2)209-24(2015 Jul)
Yan K,Li L,Wang X,Hong R,Zhang Y,Yang H,Lin M,Zhang S,He Q,Zheng D,Tang J,Yin Y,Shao G

A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses.
Cell reports5(1)180-93(2013 Oct)
Zheng H,Gupta V,Patterson-Fortin J,Bhattacharya S,Katlinski K,Wu J,Varghese B,Carbone CJ,Aressy B,Fuchs SY,Greenberg RA

ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway.
Biochimica et biophysica acta1823(12)2149-56(2012 Dec)
Ambivero CT,Cilenti L,Zervos AS

Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitination.
Journal of molecular and cellular cardiology50(4)652-61(2011 Apr)
Cilenti L,Balakrishnan MP,Wang XL,Ambivero C,Sterlicchi M,del Monte F,Ma XL,Zervos AS

NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.
Genes & development23(6)729-39(2009 Mar)
Wang B,Hurov K,Hofmann K,Elledge SJ