Arg2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Arg2
Entrez Gene ID	29215
Full Name	arginase 2
General protein information	Preferred Names arginase 2 Names arginase-2, mitochondrial AII type II arginase arginase II arginase type II kidney-type arginase non-hepatic arginase type II arginase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q24
Summary	catalyzes the hydrolysis of arginine to ornithine and urea; may regulate nitric oxide production [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019168.1	NP_062041.1	arginase-2, mitochondrial precursor

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	ARG2	XP_001107412.1
Bos taurus (cattle)	ARG2	NP_001017942.1
Mus musculus (house mouse)	Arg2	NP_033835.1
Gallus gallus (chicken)	ARG2	NP_001186633.1
Drosophila melanogaster (fruit fly)	arg	NP_524875.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008783	XP_314912.4
Canis lupus familiaris (dog)	ARG2	NP_001138592.1
Pan troglodytes (chimpanzee)	ARG2	XP_510020.3
Rattus norvegicus (Norway rat)	Arg2	NP_062041.1
Danio rerio (zebrafish)	arg2	NP_955905.1
Xenopus tropicalis (tropical clawed frog)	arg2	NP_001072685.1
Homo sapiens (human)	ARG2	NP_001163.1

Gene Ontology
Bibliography

Related articles in PubMed

Arginase overexpression and NADPH oxidase stimulation underlie impaired vasodilation induced by advanced glycation end products.
El-Bassossy HM, Neamatallah T, Balamash KS, Abushareb AT, Watson ML
Biochemical and biophysical research communications499(4)992-997(2018 05)

Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2.
McGovern N, Shin A, Low G, Low D, Duan K, Yao LJ, Msallam R, Low I, Shadan NB, Sumatoh HR, Soon E, Lum J, Mok E, Hubert S, See P, Kunxiang EH, Lee YH, Janela B, Choolani M, Mattar CNZ, Fan Y, Lim TKH, Chan DKH, Tan KK, Tam JKC, Schuster C, Elbe-Bürger A, Wang XN, Bigley V, Collin M, Haniffa M, Schlitzer A, Poidinger M, Albani S, Larbi A, Newell EW, Chan JKY, Ginhoux F
Nature546(7660)662-666(2017 06)

Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection.
Hardbower DM, Asim M, Murray-Stewart T, Casero RA Jr, Verriere T, Lewis ND, Chaturvedi R, Piazuelo MB, Wilson KT
Amino acids48(10)2375-88(2016 10)

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity.
Geiger R, Rieckmann JC, Wolf T, Basso C, Feng Y, Fuhrer T, Kogadeeva M, Picotti P, Meissner F, Mann M, Zamboni N, Sallusto F, Lanzavecchia A
Cell167(3)829-842.e13(2016 Oct)

Increased mitochondrial arginine metabolism supports bioenergetics in asthma.
Xu W, Ghosh S, Comhair SA, Asosingh K, Janocha AJ, Mavrakis DA, Bennett CD, Gruca LL, Graham BB, Queisser KA, Kao CC, Wedes SH, Petrich JM, Tuder RM, Kalhan SC, Erzurum SC
The Journal of clinical investigation126(7)2465-81(2016 07)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Arg2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Arg2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12825	NM_019168.1 Latest version!	Rattus norvegicus arginase 2 (Arg2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Arg2 ( NM_019168.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062041.1 Rattus norvegicus arginase 2 (Arg2), mRNA.

Price & Availability↑

CloneID	ORa12825
Clone ID Related Accession (Same CDS sequence)	NM_019168.1
Accession Version	NM_019168.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577289600000
Organism	Rattus norvegicus(Norway rat)
Product	arginase-2, mitochondrial precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U90887.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U90887.1, AF508019.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGTTCCTGA GGAGCAGCGT CTCCCGTCTC CTCCACGGGC AAATTCCTTG TGCCCTGACG 
AGATCCGTCC ACTCTGTAGC TGTAGTCGGA GCCCCTTTCT CTCGGGGACA GAAAAAGAAA 
GGAGTGGAAT ATGGCCCAGC CGCCATCCGA GAAGCTGGCT TGCTGAAGAG GCTTTCTATG 
TTGGGATGCC ATATAAAAGA CTTTGGAGAC TTGAGTTTTA CTAACGTTCC CAAAGATGAT 
CCCTACAATA ATCTGGTCGT GTATCCTCGC TCAGTGGGCA TTGCCAACCA GGAACTGGCT 
GAGGTGGTTA GTAGAGCTGT GTCAGGTGGC TACAGCTGTG TCACACTGGG AGGAGACCAC 
AGCCTGGCAA TCGGTACCAT TAGTGGCCAT GCCCGACACC ACCCAGATCT CTGTGTCATC 
TGGGTTGATG CTCATGCTGA CATTAATACA CCCCTCACCA CTGTATCAGG AAATATCCAT 
GGGCAGCCTC TTTCCTTTCT CATCAGAGAA CTACAAGACA AGGTACCACA ACTGCCAGGA 
TTTTCCTGGA TCAAACCTTG CCTCTCTCCC CCAAATCTTG TATACATTGG CTTACGAGAT 
GTGGAGCCTG CCGAACACTT TATTTTAAAG AGTTTTGACA TCCAGTATTT CTCCATGAGA 
GATATTGATC GACTTGGTAT CCAGAAGGTC ATGGAACAGA CATTTGATCG GCTGATTGGC 
AAGAGGAAGA GGCCGATCCA CCTGAGCTTT GACATAGATG CATTTGACCC TAAGCTGGCT 
CCAGCCACAG GAACCCCTGT GGTAGGGGGG CTGACCTACA GAGAAGGACT GTACATTACT 
GAAGAAATAC ATAGCACAGG GTTGCTGTCG GCTCTGGATC TTGTTGAAGT CAATCCTCAT 
TTGGCCACTT CTGAGGAAGA GGCCAAGGCT ACAGCCAGCC TAGCAGTGGA TGTGATTGCT 
TCAAGTTTTG GTCAGACAAG AGAAGGCGGA CACATTGCCT ATGACCACCT TCCTACTCCT 
AGTTCACCAC ATGAATCAGA AAAGGAAGAA TGTGTGAGAA TTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062041.1
CDS	104..1168
Translation	MFLRSSVSRLLHGQIPCALTRSVHSVAVVGAPFSRGQKKKGVEYGPAAIREAGLLKRLSMLGCHIKDFGDLSFTNVPKDDPYNNLVVYPRSVGIANQELAEVVSRAVSGGYSCVTLGGDHSLAIGTISGHARHHPDLCVIWVDAHADINTPLTTVSGNIHGQPLSFLIRELQDKVPQLPGFSWIKPCLSPPNLVYIGLRDVEPAEHFILKSFDIQYFSMRDIDRLGIQKVMEQTFDRLIGKRKRPIHLSFDIDAFDPKLAPATGTPVVGGLTYREGLYITEEIHSTGLLSALDLVEVNPHLATSEEEAKATASLAVDVIASSFGQTREGGHIAYDHLPTPSSPHESEKEECVRI

Target ORF information:

RefSeq Version	NM_019168.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus arginase 2 (Arg2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019168.1

ORF Insert Sequence:

ATGTTCCTGA GGAGCAGCGT CTCCCGTCTC CTCCACGGGC AAATTCCTTG TGCCCTGACG 
AGATCCGTCC ACTCTGTAGC TGTAGTCGGA GCCCCTTTCT CTCGGGGACA GAAAAAGAAA 
GGAGTGGAAT ATGGCCCAGC CGCCATCCGA GAAGCTGGCT TGCTGAAGAG GCTTTCTATG 
TTGGGATGCC ATATAAAAGA CTTTGGAGAC TTGAGTTTTA CTAACGTTCC CAAAGATGAT 
CCCTACAATA ATCTGGTCGT GTATCCTCGC TCAGTGGGCA TTGCCAACCA GGAACTGGCT 
GAGGTGGTTA GTAGAGCTGT GTCAGGTGGC TACAGCTGTG TCACACTGGG AGGAGACCAC 
AGCCTGGCAA TCGGTACCAT TAGTGGCCAT GCCCGACACC ACCCAGATCT CTGTGTCATC 
TGGGTTGATG CTCATGCTGA CATTAATACA CCCCTCACCA CTGTATCAGG AAATATCCAT 
GGGCAGCCTC TTTCCTTTCT CATCAGAGAA CTACAAGACA AGGTACCACA ACTGCCAGGA 
TTTTCCTGGA TCAAACCTTG CCTCTCTCCC CCAAATCTTG TATACATTGG CTTACGAGAT 
GTGGAGCCTG CCGAACACTT TATTTTAAAG AGTTTTGACA TCCAGTATTT CTCCATGAGA 
GATATTGATC GACTTGGTAT CCAGAAGGTC ATGGAACAGA CATTTGATCG GCTGATTGGC 
AAGAGGAAGA GGCCGATCCA CCTGAGCTTT GACATAGATG CATTTGACCC TAAGCTGGCT 
CCAGCCACAG GAACCCCTGT GGTAGGGGGG CTGACCTACA GAGAAGGACT GTACATTACT 
GAAGAAATAC ATAGCACAGG GTTGCTGTCG GCTCTGGATC TTGTTGAAGT CAATCCTCAT 
TTGGCCACTT CTGAGGAAGA GGCCAAGGCT ACAGCCAGCC TAGCAGTGGA TGTGATTGCT 
TCAAGTTTTG GTCAGACAAG AGAAGGCGGA CACATTGCCT ATGACCACCT TCCTACTCCT 
AGTTCACCAC ATGAATCAGA AAAGGAAGAA TGTGTGAGAA TTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Arginase overexpression and NADPH oxidase stimulation underlie impaired vasodilation induced by advanced glycation end products.
Biochemical and biophysical research communications499(4)992-997(2018 05)
El-Bassossy HM,Neamatallah T,Balamash KS,Abushareb AT,Watson ML

Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2.
Nature546(7660)662-666(2017 06)
McGovern N,Shin A,Low G,Low D,Duan K,Yao LJ,Msallam R,Low I,Shadan NB,Sumatoh HR,Soon E,Lum J,Mok E,Hubert S,See P,Kunxiang EH,Lee YH,Janela B,Choolani M,Mattar CNZ,Fan Y,Lim TKH,Chan DKH,Tan KK,Tam JKC,Schuster C,Elbe-Bürger A,Wang XN,Bigley V,Collin M,Haniffa M,Schlitzer A,Poidinger M,Albani S,Larbi A,Newell EW,Chan JKY,Ginhoux F

Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection.
Amino acids48(10)2375-88(2016 10)
Hardbower DM,Asim M,Murray-Stewart T,Casero RA Jr,Verriere T,Lewis ND,Chaturvedi R,Piazuelo MB,Wilson KT

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity.
Cell167(3)829-842.e13(2016 Oct)
Geiger R,Rieckmann JC,Wolf T,Basso C,Feng Y,Fuhrer T,Kogadeeva M,Picotti P,Meissner F,Mann M,Zamboni N,Sallusto F,Lanzavecchia A

Increased mitochondrial arginine metabolism supports bioenergetics in asthma.
The Journal of clinical investigation126(7)2465-81(2016 07)
Xu W,Ghosh S,Comhair SA,Asosingh K,Janocha AJ,Mavrakis DA,Bennett CD,Gruca LL,Graham BB,Queisser KA,Kao CC,Wedes SH,Petrich JM,Tuder RM,Kalhan SC,Erzurum SC

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Arg2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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