Nr1d1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nr1d1
Entrez Gene ID	252917
Full Name	nuclear receptor subfamily 1, group D, member 1
Synonyms	REV-ERBAALPHA
General protein information	Preferred Names nuclear receptor subfamily 1, group D, member 1 Names nuclear receptor subfamily 1 group D member 1 EAR-1 V-erbA-related protein 1 V-erbA-related protein EAR-1 rev-erb alpha rev-erbA-alpha
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q31
Summary	This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (Arntl). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Feb 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_145775.2	NP_665718.2	nuclear receptor subfamily 1 group D member 1 isoform 2
NM_001113422.1	NP_001106893.1	nuclear receptor subfamily 1 group D member 1 isoform 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NR1D1	XP_003435298.1
Rattus norvegicus (Norway rat)	Nr1d1	NP_001106893.1
Danio rerio (zebrafish)	nr1d1	NP_991292.1
Homo sapiens (human)	NR1D1	NP_068370.1
Pan troglodytes (chimpanzee)	NR1D1	XP_511468.2
Bos taurus (cattle)	NR1D1	NP_001071568.1
Mus musculus (house mouse)	Nr1d1	NP_663409.2
Xenopus tropicalis (tropical clawed frog)	nr1d1	NP_001093675.1

Gene Ontology
Bibliography

Related articles in PubMed

Circadian clock protein Rev-erbα regulates neuroinflammation.
Griffin P, Dimitry JM, Sheehan PW, Lananna BV, Guo C, Robinette ML, Hayes ME, Cedeño MR, Nadarajah CJ, Ezerskiy LA, Colonna M, Zhang J, Bauer AQ, Burris TP, Musiek ES
Proceedings of the National Academy of Sciences of the United States of America116(11)5102-5107(2019 03)

Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock.
Dyar KA, Hubert MJ, Mir AA, Ciciliot S, Lutter D, Greulich F, Quagliarini F, Kleinert M, Fischer K, Eichmann TO, Wright LE, Peña Paz MI, Casarin A, Pertegato V, Romanello V, Albiero M, Mazzucco S, Rizzuto R, Salviati L, Biolo G, Blaauw B, Schiaffino S, Uhlenhaut NH
PLoS biology16(8)e2005886(2018 08)

E4bp4 regulates carboxylesterase 2 enzymes through repression of the nuclear receptor Rev-erbα in mice.
Zhao M, Zhang T, Yu F, Guo L, Wu B
Biochemical pharmacology152293-301(2018 06)

Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation.
Pariollaud M, Gibbs JE, Hopwood TW, Brown S, Begley N, Vonslow R, Poolman T, Guo B, Saer B, Jones DH, Tellam JP, Bresciani S, Tomkinson NC, Wojno-Picon J, Cooper AW, Daniels DA, Trump RP, Grant D, Zuercher W, Willson TM, MacDonald AS, Bolognese B, Podolin PL, Sanchez Y, Loudon AS, Ray DW
The Journal of clinical investigation128(6)2281-2296(2018 06)

Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity.
Zhang T, Yu F, Guo L, Chen M, Yuan X, Wu B
Theranostics8(19)5246-5258(2018)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Nr1d1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nr1d1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00979	NM_001113422.1 Latest version!	Rattus norvegicus nuclear receptor subfamily 1, group D, member 1 (Nr1d1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa02680	NM_145775.2 Latest version!	Rattus norvegicus nuclear receptor subfamily 1, group D, member 1 (Nr1d1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nr1d1 ( NM_001113422.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001106893.1 Rattus norvegicus nuclear receptor subfamily 1, group D, member 1 (Nr1d1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa00979
Clone ID Related Accession (Same CDS sequence)	NM_001113422.1
Accession Version	NM_001113422.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1848bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Rattus norvegicus(Norway rat)
Product	nuclear receptor subfamily 1 group D member 1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC062047.1, DN948099.1 and BP475989.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC062047.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00632259 [ECO:0000348] ##Evidence-Data-END##

ATGACGACCC TAGACTCCAA CAACAACACA GGTGGTGTTA TCACCTACAT TGGCTCCAGC 
GGATCCTCCC CCAGCCGGAC CAGCCCAGAG TCCCTCTATA GTGACAGCTC CAATGGCAGC 
TTCCAGTCCC TGACTCAAGG TTGTCCCACA TACTTCCCAC CATCACCTAC TGGCTCCCTC 
ACCCAGGACC CTGCCCGCTC ATTTGGCACT GTGCCACCCA GCCTCAGTGA TGATAGCTCC 
CCTTCTTCTG CTTCATCATC ATCATCATCT TCCTCCTCCT CCTTCTATAA TGGGAGCCCC 
CCCGGAAGTC TACAAGTGGC CATGGAAGAC AGCAGCCGAG TGTCCCCCAG CAAGGGCACC 
AGCAACATTA CCAAGCTTAA CGGCATGGTG CTACTGTGTA AAGTGTGTGG GGACGTGGCC 
TCAGGCTTCC ACTATGGCGT GCATGCCTGC GAGGGCTGCA AGGGCTTTTT CCGCCGGAGC 
ATCCAGCAGA ACATCCAGTA CAAGCGGTGT TTGAAAAACG AGAACTGCTC CATTGTCCGT 
ATCAATCGCA ACCGCTGCCA GCAGTGTCGC TTCAAGAAGT GTCTCTCCGT TGGCATGTCT 
AGAGACGCTG TGCGTTTTGG ACGTATCCCC AAGAGAGAGA AGCAACGAAT GCTTGCTGAG 
ATGCAGAACG CCATGAACTT GGCCAACAAC CAACTGAGCA GCCTGTGCCC TCTAGAGACC 
TCACCTGCCC CGCACCCCAC CTCAGGCTCC GTGGGCCCCT CACCACCTCC TGCACCAGCC 
CCGACACCTT TGGTGGGCTT CTCTCAGTTC CCACAACAGC TGACACCACC CAGATCCCCG 
AGTCCTGAGC CCACCGTGGA GGATGTGATA TCCCAGGTGG CCAGGGCCCA TCGAGAAATC 
TTCACCTATG CCCATGACAA ATTAGGCACC TCACCTGGCA ACTTCAATGC CAATCATGCA 
TCAGGTAGCC CTCCGGCTAC CACTCCACAG TGCTGGGAGA GTCAGGGATG CCCGTCTACC 
CCCAACGACA ACAACCTTTT GGCGGCTCAG CGTCATAATG AAGCACTGAA TGGTCTACGC 
CAGGGCCCCT CCTCCTACCC TCCTACCTGG CCTTCTGGCC CTGCCCACCA CAGCTGCCAC 
CAGCCTAACA GCAATGGGCA TCGCCTGTGC CCCACCCACG TATACTCGGC CCCAGAAGGC 
AAGGCACCTG CCAACGGTCT ACGGCAAGGC AACACCAAGA ATGTTCTGCT GGCATGTCCC 
ATGAACATGT ATCCCCATGG ACGTAGTGGC CGGACTGTGC AGGAGATCTG GGAAGACTTC 
TCTATGAGCT TCACACCCGC TGTGCGGGAG GTGGTAGAAT TTGCCAAACA CATCCCCGGC 
TTCCGTGACC TTTCTCAGCA CGACCAGGTG ACCCTGCTTA AGGCTGGCAC CTTTGAGGTG 
CTGATGGTGC GCTTTGCGTC ATTGTTCAAC GTGAAGGACC AGACAGTCAT GTTCCTGAGC 
CGCACAACCT ACAGCCTGCA GGAGCTCGGT GCCATGGGCA TGGGTGACCT GCTCAATGCC 
ATGTTTGACT TCAGCGAGAA GCTCAACTCT CTGGCGCTTA CTGAGGAGGA GCTGGGCCTT 
TTCACGGCAG TGGTACTTGT CTCTGCAGAC CGCTCGGGAA TGGAGAATTC CGCTTCGGTG 
GAGCAGCTCC AGGAGACGCT GCTGCGGGCT CTTCGGGCTC TGGTGCTGAA GAACCGGCCC 
TCGGAGACTT CCCGCTTCAC CAAACTGCTG CTCAAGCTGC CGGACCTGCG GACCCTGAAC 
AACATGCATT CCGAGAAGCT GCTGTCCTTC CGGGTGGACG CCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001106893.1
CDS	211..2058
Translation	MTTLDSNNNTGGVITYIGSSGSSPSRTSPESLYSDSSNGSFQSLTQGCPTYFPPSPTGSLTQDPARSFGTVPPSLSDDSSPSSASSSSSSSSSSFYNGSPPGSLQVAMEDSSRVSPSKGTSNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQNAMNLANNQLSSLCPLETSPAPHPTSGSVGPSPPPAPAPTPLVGFSQFPQQLTPPRSPSPEPTVEDVISQVARAHREIFTYAHDKLGTSPGNFNANHASGSPPATTPQCWESQGCPSTPNDNNLLAAQRHNEALNGLRQGPSSYPPTWPSGPAHHSCHQPNSNGHRLCPTHVYSAPEGKAPANGLRQGNTKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMGMGDLLNAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNRPSETSRFTKLLLKLPDLRTLNNMHSEKLLSFRVDAQ

Target ORF information:

RefSeq Version	NM_001113422.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nuclear receptor subfamily 1, group D, member 1 (Nr1d1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001113422.1

ORF Insert Sequence:

ATGACGACCC TAGACTCCAA CAACAACACA GGTGGTGTTA TCACCTACAT TGGCTCCAGC 
GGATCCTCCC CCAGCCGGAC CAGCCCAGAG TCCCTCTATA GTGACAGCTC CAATGGCAGC 
TTCCAGTCCC TGACTCAAGG TTGTCCCACA TACTTCCCAC CATCACCTAC TGGCTCCCTC 
ACCCAGGACC CTGCCCGCTC ATTTGGCACT GTGCCACCCA GCCTCAGTGA TGATAGCTCC 
CCTTCTTCTG CTTCATCATC ATCATCATCT TCCTCCTCCT CCTTCTATAA TGGGAGCCCC 
CCCGGAAGTC TACAAGTGGC CATGGAAGAC AGCAGCCGAG TGTCCCCCAG CAAGGGCACC 
AGCAACATTA CCAAGCTTAA CGGCATGGTG CTACTGTGTA AAGTGTGTGG GGACGTGGCC 
TCAGGCTTCC ACTATGGCGT GCATGCCTGC GAGGGCTGCA AGGGCTTTTT CCGCCGGAGC 
ATCCAGCAGA ACATCCAGTA CAAGCGGTGT TTGAAAAACG AGAACTGCTC CATTGTCCGT 
ATCAATCGCA ACCGCTGCCA GCAGTGTCGC TTCAAGAAGT GTCTCTCCGT TGGCATGTCT 
AGAGACGCTG TGCGTTTTGG ACGTATCCCC AAGAGAGAGA AGCAACGAAT GCTTGCTGAG 
ATGCAGAACG CCATGAACTT GGCCAACAAC CAACTGAGCA GCCTGTGCCC TCTAGAGACC 
TCACCTGCCC CGCACCCCAC CTCAGGCTCC GTGGGCCCCT CACCACCTCC TGCACCAGCC 
CCGACACCTT TGGTGGGCTT CTCTCAGTTC CCACAACAGC TGACACCACC CAGATCCCCG 
AGTCCTGAGC CCACCGTGGA GGATGTGATA TCCCAGGTGG CCAGGGCCCA TCGAGAAATC 
TTCACCTATG CCCATGACAA ATTAGGCACC TCACCTGGCA ACTTCAATGC CAATCATGCA 
TCAGGTAGCC CTCCGGCTAC CACTCCACAG TGCTGGGAGA GTCAGGGATG CCCGTCTACC 
CCCAACGACA ACAACCTTTT GGCGGCTCAG CGTCATAATG AAGCACTGAA TGGTCTACGC 
CAGGGCCCCT CCTCCTACCC TCCTACCTGG CCTTCTGGCC CTGCCCACCA CAGCTGCCAC 
CAGCCTAACA GCAATGGGCA TCGCCTGTGC CCCACCCACG TATACTCGGC CCCAGAAGGC 
AAGGCACCTG CCAACGGTCT ACGGCAAGGC AACACCAAGA ATGTTCTGCT GGCATGTCCC 
ATGAACATGT ATCCCCATGG ACGTAGTGGC CGGACTGTGC AGGAGATCTG GGAAGACTTC 
TCTATGAGCT TCACACCCGC TGTGCGGGAG GTGGTAGAAT TTGCCAAACA CATCCCCGGC 
TTCCGTGACC TTTCTCAGCA CGACCAGGTG ACCCTGCTTA AGGCTGGCAC CTTTGAGGTG 
CTGATGGTGC GCTTTGCGTC ATTGTTCAAC GTGAAGGACC AGACAGTCAT GTTCCTGAGC 
CGCACAACCT ACAGCCTGCA GGAGCTCGGT GCCATGGGCA TGGGTGACCT GCTCAATGCC 
ATGTTTGACT TCAGCGAGAA GCTCAACTCT CTGGCGCTTA CTGAGGAGGA GCTGGGCCTT 
TTCACGGCAG TGGTACTTGT CTCTGCAGAC CGCTCGGGAA TGGAGAATTC CGCTTCGGTG 
GAGCAGCTCC AGGAGACGCT GCTGCGGGCT CTTCGGGCTC TGGTGCTGAA GAACCGGCCC 
TCGGAGACTT CCCGCTTCAC CAAACTGCTG CTCAAGCTGC CGGACCTGCG GACCCTGAAC 
AACATGCATT CCGAGAAGCT GCTGTCCTTC CGGGTGGACG CCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nr1d1 ( NM_145775.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_665718.2 Rattus norvegicus nuclear receptor subfamily 1, group D, member 1 (Nr1d1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa02680
Clone ID Related Accession (Same CDS sequence)	NM_145775.2
Accession Version	NM_145775.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1527bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577289600000
Organism	Rattus norvegicus(Norway rat)
Product	nuclear receptor subfamily 1 group D member 1 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from M25804.1, DN948099.1, BC062047.1 and BP475989.1. On Jan 12, 2008 this sequence version replaced NM_145775.1. Transcript Variant: This variant (2) has an alternate 5' exon and uses a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) is shorter at the N-temrinus, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M25804.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGAAGACA GCAGCCGAGT GTCCCCCAGC AAGGGCACCA GCAACATTAC CAAGCTTAAC 
GGCATGGTGC TACTGTGTAA AGTGTGTGGG GACGTGGCCT CAGGCTTCCA CTATGGCGTG 
CATGCCTGCG AGGGCTGCAA GGGCTTTTTC CGCCGGAGCA TCCAGCAGAA CATCCAGTAC 
AAGCGGTGTT TGAAAAACGA GAACTGCTCC ATTGTCCGTA TCAATCGCAA CCGCTGCCAG 
CAGTGTCGCT TCAAGAAGTG TCTCTCCGTT GGCATGTCTA GAGACGCTGT GCGTTTTGGA 
CGTATCCCCA AGAGAGAGAA GCAACGAATG CTTGCTGAGA TGCAGAACGC CATGAACTTG 
GCCAACAACC AACTGAGCAG CCTGTGCCCT CTAGAGACCT CACCTGCCCC GCACCCCACC 
TCAGGCTCCG TGGGCCCCTC ACCACCTCCT GCACCAGCCC CGACACCTTT GGTGGGCTTC 
TCTCAGTTCC CACAACAGCT GACACCACCC AGATCCCCGA GTCCTGAGCC CACCGTGGAG 
GATGTGATAT CCCAGGTGGC CAGGGCCCAT CGAGAAATCT TCACCTATGC CCATGACAAA 
TTAGGCACCT CACCTGGCAA CTTCAATGCC AATCATGCAT CAGGTAGCCC TCCGGCTACC 
ACTCCACAGT GCTGGGAGAG TCAGGGATGC CCGTCTACCC CCAACGACAA CAACCTTTTG 
GCGGCTCAGC GTCATAATGA AGCACTGAAT GGTCTACGCC AGGGCCCCTC CTCCTACCCT 
CCTACCTGGC CTTCTGGCCC TGCCCACCAC AGCTGCCACC AGCCTAACAG CAATGGGCAT 
CGCCTGTGCC CCACCCACGT ATACTCGGCC CCAGAAGGCA AGGCACCTGC CAACGGTCTA 
CGGCAAGGCA ACACCAAGAA TGTTCTGCTG GCATGTCCCA TGAACATGTA TCCCCATGGA 
CGTAGTGGCC GGACTGTGCA GGAGATCTGG GAAGACTTCT CTATGAGCTT CACACCCGCT 
GTGCGGGAGG TGGTAGAATT TGCCAAACAC ATCCCCGGCT TCCGTGACCT TTCTCAGCAC 
GACCAGGTGA CCCTGCTTAA GGCTGGCACC TTTGAGGTGC TGATGGTGCG CTTTGCGTCA 
TTGTTCAACG TGAAGGACCA GACAGTCATG TTCCTGAGCC GCACAACCTA CAGCCTGCAG 
GAGCTCGGTG CCATGGGCAT GGGTGACCTG CTCAATGCCA TGTTTGACTT CAGCGAGAAG 
CTCAACTCTC TGGCGCTTAC TGAGGAGGAG CTGGGCCTTT TCACGGCAGT GGTACTTGTC 
TCTGCAGACC GCTCGGGAAT GGAGAATTCC GCTTCGGTGG AGCAGCTCCA GGAGACGCTG 
CTGCGGGCTC TTCGGGCTCT GGTGCTGAAG AACCGGCCCT CGGAGACTTC CCGCTTCACC 
AAACTGCTGC TCAAGCTGCC GGACCTGCGG ACCCTGAACA ACATGCATTC CGAGAAGCTG 
CTGTCCTTCC GGGTGGACGC CCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_665718.2
CDS	502..2028
Translation	MEDSSRVSPSKGTSNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQNAMNLANNQLSSLCPLETSPAPHPTSGSVGPSPPPAPAPTPLVGFSQFPQQLTPPRSPSPEPTVEDVISQVARAHREIFTYAHDKLGTSPGNFNANHASGSPPATTPQCWESQGCPSTPNDNNLLAAQRHNEALNGLRQGPSSYPPTWPSGPAHHSCHQPNSNGHRLCPTHVYSAPEGKAPANGLRQGNTKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMGMGDLLNAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNRPSETSRFTKLLLKLPDLRTLNNMHSEKLLSFRVDAQ

Target ORF information:

RefSeq Version	NM_145775.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nuclear receptor subfamily 1, group D, member 1 (Nr1d1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145775.2

ORF Insert Sequence:

ATGGAAGACA GCAGCCGAGT GTCCCCCAGC AAGGGCACCA GCAACATTAC CAAGCTTAAC 
GGCATGGTGC TACTGTGTAA AGTGTGTGGG GACGTGGCCT CAGGCTTCCA CTATGGCGTG 
CATGCCTGCG AGGGCTGCAA GGGCTTTTTC CGCCGGAGCA TCCAGCAGAA CATCCAGTAC 
AAGCGGTGTT TGAAAAACGA GAACTGCTCC ATTGTCCGTA TCAATCGCAA CCGCTGCCAG 
CAGTGTCGCT TCAAGAAGTG TCTCTCCGTT GGCATGTCTA GAGACGCTGT GCGTTTTGGA 
CGTATCCCCA AGAGAGAGAA GCAACGAATG CTTGCTGAGA TGCAGAACGC CATGAACTTG 
GCCAACAACC AACTGAGCAG CCTGTGCCCT CTAGAGACCT CACCTGCCCC GCACCCCACC 
TCAGGCTCCG TGGGCCCCTC ACCACCTCCT GCACCAGCCC CGACACCTTT GGTGGGCTTC 
TCTCAGTTCC CACAACAGCT GACACCACCC AGATCCCCGA GTCCTGAGCC CACCGTGGAG 
GATGTGATAT CCCAGGTGGC CAGGGCCCAT CGAGAAATCT TCACCTATGC CCATGACAAA 
TTAGGCACCT CACCTGGCAA CTTCAATGCC AATCATGCAT CAGGTAGCCC TCCGGCTACC 
ACTCCACAGT GCTGGGAGAG TCAGGGATGC CCGTCTACCC CCAACGACAA CAACCTTTTG 
GCGGCTCAGC GTCATAATGA AGCACTGAAT GGTCTACGCC AGGGCCCCTC CTCCTACCCT 
CCTACCTGGC CTTCTGGCCC TGCCCACCAC AGCTGCCACC AGCCTAACAG CAATGGGCAT 
CGCCTGTGCC CCACCCACGT ATACTCGGCC CCAGAAGGCA AGGCACCTGC CAACGGTCTA 
CGGCAAGGCA ACACCAAGAA TGTTCTGCTG GCATGTCCCA TGAACATGTA TCCCCATGGA 
CGTAGTGGCC GGACTGTGCA GGAGATCTGG GAAGACTTCT CTATGAGCTT CACACCCGCT 
GTGCGGGAGG TGGTAGAATT TGCCAAACAC ATCCCCGGCT TCCGTGACCT TTCTCAGCAC 
GACCAGGTGA CCCTGCTTAA GGCTGGCACC TTTGAGGTGC TGATGGTGCG CTTTGCGTCA 
TTGTTCAACG TGAAGGACCA GACAGTCATG TTCCTGAGCC GCACAACCTA CAGCCTGCAG 
GAGCTCGGTG CCATGGGCAT GGGTGACCTG CTCAATGCCA TGTTTGACTT CAGCGAGAAG 
CTCAACTCTC TGGCGCTTAC TGAGGAGGAG CTGGGCCTTT TCACGGCAGT GGTACTTGTC 
TCTGCAGACC GCTCGGGAAT GGAGAATTCC GCTTCGGTGG AGCAGCTCCA GGAGACGCTG 
CTGCGGGCTC TTCGGGCTCT GGTGCTGAAG AACCGGCCCT CGGAGACTTC CCGCTTCACC 
AAACTGCTGC TCAAGCTGCC GGACCTGCGG ACCCTGAACA ACATGCATTC CGAGAAGCTG 
CTGTCCTTCC GGGTGGACGC CCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Circadian clock protein Rev-erbα regulates neuroinflammation.
Proceedings of the National Academy of Sciences of the United States of America116(11)5102-5107(2019 03)
Griffin P,Dimitry JM,Sheehan PW,Lananna BV,Guo C,Robinette ML,Hayes ME,Cedeño MR,Nadarajah CJ,Ezerskiy LA,Colonna M,Zhang J,Bauer AQ,Burris TP,Musiek ES

Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock.
PLoS biology16(8)e2005886(2018 08)
Dyar KA,Hubert MJ,Mir AA,Ciciliot S,Lutter D,Greulich F,Quagliarini F,Kleinert M,Fischer K,Eichmann TO,Wright LE,Peña Paz MI,Casarin A,Pertegato V,Romanello V,Albiero M,Mazzucco S,Rizzuto R,Salviati L,Biolo G,Blaauw B,Schiaffino S,Uhlenhaut NH

E4bp4 regulates carboxylesterase 2 enzymes through repression of the nuclear receptor Rev-erbα in mice.
Biochemical pharmacology152293-301(2018 06)
Zhao M,Zhang T,Yu F,Guo L,Wu B

Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation.
The Journal of clinical investigation128(6)2281-2296(2018 06)
Pariollaud M,Gibbs JE,Hopwood TW,Brown S,Begley N,Vonslow R,Poolman T,Guo B,Saer B,Jones DH,Tellam JP,Bresciani S,Tomkinson NC,Wojno-Picon J,Cooper AW,Daniels DA,Trump RP,Grant D,Zuercher W,Willson TM,MacDonald AS,Bolognese B,Podolin PL,Sanchez Y,Loudon AS,Ray DW

Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity.
Theranostics8(19)5246-5258(2018)
Zhang T,Yu F,Guo L,Chen M,Yuan X,Wu B

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Nr1d1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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