Kcnh5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnh5
Entrez Gene ID	171146
Full Name	potassium voltage-gated channel subfamily H member 5
Synonyms	Eag2
General protein information	Preferred Names potassium voltage-gated channel subfamily H member 5 Names potassium voltage-gated channel subfamily H member 5 ether-a-go-go potassium channel 2 potassium channel, voltage gated eag related subfamily H, member 5 potassium voltage-gated channel, subfamily H (eag-related), member 5 rEAG2 voltage-gated potassium channel subunit Kv10.2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q24
Summary	voltage gated potassium channel pore-forming (alpha) subunit [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133610.2	NP_598294.1	potassium voltage-gated channel subfamily H member 5

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	KCNH5	XP_421414.2
Xenopus tropicalis (tropical clawed frog)	kcnh5	NP_001120909.1
Mus musculus (house mouse)	Kcnh5	NP_766393.2
Bos taurus (cattle)	KCNH5	NP_001179918.1
Homo sapiens (human)	KCNH5	NP_647479.2
Macaca mulatta (Rhesus monkey)	KCNH5	XP_001100052.1
Canis lupus familiaris (dog)	KCNH5	XP_547846.2
Rattus norvegicus (Norway rat)	Kcnh5	NP_598294.1
Danio rerio (zebrafish)	kcnh5a	NP_001263209.1

Gene Ontology
Bibliography

Related articles in PubMed

The subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domains.
Lin TF, Lin IW, Chen SC, Wu HH, Yang CS, Fang HY, Chiu MM, Jeng CJ
The Journal of biological chemistry289(33)22815-34(2014 Aug)

The punctate localization of rat Eag1 K+ channels is conferred by the proximal post-CNBHD region.
Chuang CC, Jow GM, Lin HM, Weng YH, Hu JH, Peng YJ, Chiu YC, Chiu MM, Jeng CJ
BMC neuroscience1523(2014 Feb)

Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.
Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY
Genes & development26(16)1780-96(2012 Aug)

Eag 1, Eag 2 and Kcnn3 gene brain expression of isolated reared rats.
Martin S, Lino-de-Oliveira C, Joca SR, Weffort de Oliveira R, Echeverry MB, Da Silva CA, Pardo L, Stühmer W, Bel ED
Genes, brain, and behavior9(8)918-24(2010 Nov)

Differential localization of rat Eag1 and Eag2 potassium channels in the retina.
Jow GM, Jeng CJ
Neuroscience letters431(1)12-6(2008 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Kcnh5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnh5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01067	NM_133610.2 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily H member 5 (Kcnh5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnh5 ( NM_133610.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_598294.1 Rattus norvegicus potassium voltage-gated channel subfamily H member 5 (Kcnh5), mRNA.

Price & Availability↑

CloneID	ORa01067
Clone ID Related Accession (Same CDS sequence)	NM_133610.2
Accession Version	NM_133610.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2967bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Rattus norvegicus(Norway rat)
Product	potassium voltage-gated channel subfamily H member 5
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ250280.1. On Aug 30, 2012 this sequence version replaced NM_133610.1. ##Evidence-Data-START## Transcript exon combination :: AJ250280.1, AF185637.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCGGGGG GCAAGAGAGG GCTGGTGGCT CCGCAGAACA CATTTTTGGA GAACATCGTC 
AGGCGCTCCA GTGAATCAAG TTTCTTACTG GGAAATGCCC AAATTGTGGA CTGGCCTGTA 
GTTTATAGTA ATGACGGATT TTGTAAACTC TCTGGATATC ATCGAGCTGA CGTCATGCAG 
AAAAGCAGCA CTTGCAGTTT TATGTATGGA GAACTGACCG ATAAGAAGAC CATTGAGAAA 
GTCAGGCAGA CTTTTGACAA CTACGAGTCA AACTGTTTTG AAGTTCTTCT GTATAAAAAA 
AACCGTACCC CCGTTTGGTT TTACATGCAA ATCGCACCAA TAAGAAACGA ACACGAGAAG 
GTGGTCTTGT TCCTGTGTAC GTTCAAGGAT ATCACGCTGT TCAAACAGCC CATAGAGGAT 
GACTCAACAA AAGGTTGGAC GAAATTTGCC CGGTTGACAC GGGCTTTGAC AAACAGCCGG 
AGTGTGTTAC AGCAGCTTAC ACCAATGAAT AAAACAGAGA CAGTCCACAA ACATTCAAGA 
CTGGCAGAAG TTCTTCAGCT GGGATCAGAC ATCCTTCCTC AGTACAAACA AGAAGCGCCA 
AAGACGCCGC CGCACATCAT CTTACATTAC TGTGCTTTCA AAACTACGTG GGATTGGGTG 
ATTTTAATTC TTACCTTCTA CACCGCCATC ATGGTTCCTT ACAACGTTTC CTTCAAAACA 
AAACAGAACA ATATCGCCTG GCTGGTTCTG GACAGCGTGG TGGACGTTAT TTTTCTGGTG 
GACATCGTTT TAAACTTTCA CACGACTTTT GTGGGGCCGG GTGGAGAGGT CATTTCTGAC 
CCAAAACTCA TACGGATGAA CTATCTGAAA ACTTGGTTTG TGATTGATCT GCTGTCTTGT 
TTACCTTATG ACATCATCAA TGCCTTTGAA AATGTGGATG AGGGAATCAG CAGTCTCTTC 
AGCTCTTTAA AGGTGGTACG CCTCTTACGC CTGGGCCGTG TTGCTAGGAA ACTGGACCAT 
TACCTGGAAT ATGGAGCAGC GGTCCTTGTG CTCCTGGTAT GTGTGTTTGG ACTGGTTGCC 
CACTGGCTGG CCTGCATCTG GTACAGCATT GGAGACTATG AGGTCATTGA TGAAGTCACC 
AACACCATTC AAATAGACAG CTGGCTCTAC CAGTTGGCCT TGAGCATTGG GACTCCATAT 
CGCTACAATA CCAGTGCAGG GATCTGGGAA GGAGGACCCA GCAAGGACTC CCTGTATGTG 
TCCTCCCTCT ACTTCACCAT GACGAGCCTT ACAACCATAG GATTTGGAAA CATAGCTCCG 
ACCACAGACG TGGAGAAGAT GTTCTCAGTG GCCATGATGA TGGTCGGCTC TCTTCTTTAT 
GCAACTATTT TTGGAAATGT TACCACAATT TTCCAGCAAA TGTATGCCAA CACCAACCGT 
TACCATGAGA TGCTGAACAA TGTTCGAGAT TTCCTGAAAT TATATCAGGT CCCGAAAGGC 
CTTAGTGAAC GAGTCATGGA TTACATTGTG TCAACGTGGT CAATGTCAAA AGGCATCGAC 
ACAGAGAAGG TCCTCTCCAT CTGCCCCAAG GACATGAGAG CTGACATCTG TGTTCATCTG 
AACCGGAAGG TTTTTAATGA ACATCCTGCA TTCCGATTGG CCAGCGATGG ATGTCTGCGT 
GCCTTGGCAG TGGAGTTCCA AACCATTCAC TGTGCTCCTG GGGACCTGAT TTACCATGCT 
GGAGAGAGTG TGGACGCCCT CTGCTTTGTG GTGTCAGGGT CCTTGGAGGT TATCCAGGAT 
GAGGAGGTGG TGGCTATCTT AGGGAAAGGT GATGTGTTTG GAGACATCTT CTGGAAGGAA 
ACCACCCTTG CTCATGCATG TGCCAATGTC CGGGCCCTGA CTTACTGTGA CCTGCACATC 
ATCAAGAGAG AAGCCTTGCT CAAAGTCCTT GACTTCTATA CAGCATTTGC AAACTCATTC 
TCCAGGAACC TCACTCTCAC TTGCAATCTA AGGAAGCGGA TCATCTTCCG TAAAATTAGT 
GATGTGAAAA AGGAGGAGGA GGAGCGGCTT CGACAGAAGA ATGAGGTGAC TCTGAGCATC 
CCCGTGGACC ACCCAGTGAG GAAGCTCTTC CAGAAGTTCA AACAGCAGAA GGAGCTGAGG 
AACCAGGGCT CAGCGCAGAG CGACCCTGAG AGGAGCCAGC TTCAGGTAGA GAGCCGCCCT 
TTGCAGAATG GAGCCTCCAT CACAGGTACC AGTGTGGTCA CTGTGTCACA GATTACCCCC 
ATCCAGACAT CGCTGGCCTA TGTGAAAACC AGCGAGACTC TTAAGCAGAA CAACCGTGAT 
GCCATGGAAC TGAAGCCCAA TGGTGGTGCT GAGCCCAAAT GTCTCAAGGT CAACAGCCCC 
ATCAGAATGA AAAACGGAAA TGGGAAGGGG TGGCTGAGAC TGAAGAACAA CATGGGGGCT 
CACGAGGAGA AAAAGGAAGA GTGGAATAAT GTCACCAAAG CTGAGTCCAT GGGGCTGTTG 
TCAGAGGACC CCAAGGGCAG TGACTCAGAG AACAGTGTGA CCAAGAACCC CTTAAGGAAA 
ACGGATTCTT GTGACAGTGG GATTACAAAA AGTGACCTTC GTTTGGATAA AGCTGGTGAG 
GCCCGAAGTC CTCTAGAACA CAGTCCCAGC CAGGCTGATG CCAAGCATCC CTTCTACCCC 
ATCCCCGAGC AGGCCTTACA AACCACACTG CAGGAGGTAA AACATGAACT CAAAGAGGAC 
ATCCAGCTGC TGAGCTGCAG AATGACTGCC CTGGAAAAGC AGGTGGCAGA GATTTTAAAA 
CTACTCTCAG AGAAAAGTGT ACCCCAGACA TCTTCTCCAA AACCCCAAAT TCCACTCCAA 
GTACCTCCCC AAATACCATG TCAGGATATT TTTAGTGTCT CAAGGCCTGA GTCACCTGAA 
TCTGACAAAG ATGAAATCAA CTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598294.1
CDS	267..3233
Translation	MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTETVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDEEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELRNQGSAQSDPERSQLQVESRPLQNGASITGTSVVTVSQITPIQTSLAYVKTSETLKQNNRDAMELKPNGGAEPKCLKVNSPIRMKNGNGKGWLRLKNNMGAHEEKKEEWNNVTKAESMGLLSEDPKGSDSENSVTKNPLRKTDSCDSGITKSDLRLDKAGEARSPLEHSPSQADAKHPFYPIPEQALQTTLQEVKHELKEDIQLLSCRMTALEKQVAEILKLLSEKSVPQTSSPKPQIPLQVPPQIPCQDIFSVSRPESPESDKDEINF

Target ORF information:

RefSeq Version	NM_133610.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily H member 5 (Kcnh5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133610.2

ORF Insert Sequence:

ATGCCGGGGG GCAAGAGAGG GCTGGTGGCT CCGCAGAACA CATTTTTGGA GAACATCGTC 
AGGCGCTCCA GTGAATCAAG TTTCTTACTG GGAAATGCCC AAATTGTGGA CTGGCCTGTA 
GTTTATAGTA ATGACGGATT TTGTAAACTC TCTGGATATC ATCGAGCTGA CGTCATGCAG 
AAAAGCAGCA CTTGCAGTTT TATGTATGGA GAACTGACCG ATAAGAAGAC CATTGAGAAA 
GTCAGGCAGA CTTTTGACAA CTACGAGTCA AACTGTTTTG AAGTTCTTCT GTATAAAAAA 
AACCGTACCC CCGTTTGGTT TTACATGCAA ATCGCACCAA TAAGAAACGA ACACGAGAAG 
GTGGTCTTGT TCCTGTGTAC GTTCAAGGAT ATCACGCTGT TCAAACAGCC CATAGAGGAT 
GACTCAACAA AAGGTTGGAC GAAATTTGCC CGGTTGACAC GGGCTTTGAC AAACAGCCGG 
AGTGTGTTAC AGCAGCTTAC ACCAATGAAT AAAACAGAGA CAGTCCACAA ACATTCAAGA 
CTGGCAGAAG TTCTTCAGCT GGGATCAGAC ATCCTTCCTC AGTACAAACA AGAAGCGCCA 
AAGACGCCGC CGCACATCAT CTTACATTAC TGTGCTTTCA AAACTACGTG GGATTGGGTG 
ATTTTAATTC TTACCTTCTA CACCGCCATC ATGGTTCCTT ACAACGTTTC CTTCAAAACA 
AAACAGAACA ATATCGCCTG GCTGGTTCTG GACAGCGTGG TGGACGTTAT TTTTCTGGTG 
GACATCGTTT TAAACTTTCA CACGACTTTT GTGGGGCCGG GTGGAGAGGT CATTTCTGAC 
CCAAAACTCA TACGGATGAA CTATCTGAAA ACTTGGTTTG TGATTGATCT GCTGTCTTGT 
TTACCTTATG ACATCATCAA TGCCTTTGAA AATGTGGATG AGGGAATCAG CAGTCTCTTC 
AGCTCTTTAA AGGTGGTACG CCTCTTACGC CTGGGCCGTG TTGCTAGGAA ACTGGACCAT 
TACCTGGAAT ATGGAGCAGC GGTCCTTGTG CTCCTGGTAT GTGTGTTTGG ACTGGTTGCC 
CACTGGCTGG CCTGCATCTG GTACAGCATT GGAGACTATG AGGTCATTGA TGAAGTCACC 
AACACCATTC AAATAGACAG CTGGCTCTAC CAGTTGGCCT TGAGCATTGG GACTCCATAT 
CGCTACAATA CCAGTGCAGG GATCTGGGAA GGAGGACCCA GCAAGGACTC CCTGTATGTG 
TCCTCCCTCT ACTTCACCAT GACGAGCCTT ACAACCATAG GATTTGGAAA CATAGCTCCG 
ACCACAGACG TGGAGAAGAT GTTCTCAGTG GCCATGATGA TGGTCGGCTC TCTTCTTTAT 
GCAACTATTT TTGGAAATGT TACCACAATT TTCCAGCAAA TGTATGCCAA CACCAACCGT 
TACCATGAGA TGCTGAACAA TGTTCGAGAT TTCCTGAAAT TATATCAGGT CCCGAAAGGC 
CTTAGTGAAC GAGTCATGGA TTACATTGTG TCAACGTGGT CAATGTCAAA AGGCATCGAC 
ACAGAGAAGG TCCTCTCCAT CTGCCCCAAG GACATGAGAG CTGACATCTG TGTTCATCTG 
AACCGGAAGG TTTTTAATGA ACATCCTGCA TTCCGATTGG CCAGCGATGG ATGTCTGCGT 
GCCTTGGCAG TGGAGTTCCA AACCATTCAC TGTGCTCCTG GGGACCTGAT TTACCATGCT 
GGAGAGAGTG TGGACGCCCT CTGCTTTGTG GTGTCAGGGT CCTTGGAGGT TATCCAGGAT 
GAGGAGGTGG TGGCTATCTT AGGGAAAGGT GATGTGTTTG GAGACATCTT CTGGAAGGAA 
ACCACCCTTG CTCATGCATG TGCCAATGTC CGGGCCCTGA CTTACTGTGA CCTGCACATC 
ATCAAGAGAG AAGCCTTGCT CAAAGTCCTT GACTTCTATA CAGCATTTGC AAACTCATTC 
TCCAGGAACC TCACTCTCAC TTGCAATCTA AGGAAGCGGA TCATCTTCCG TAAAATTAGT 
GATGTGAAAA AGGAGGAGGA GGAGCGGCTT CGACAGAAGA ATGAGGTGAC TCTGAGCATC 
CCCGTGGACC ACCCAGTGAG GAAGCTCTTC CAGAAGTTCA AACAGCAGAA GGAGCTGAGG 
AACCAGGGCT CAGCGCAGAG CGACCCTGAG AGGAGCCAGC TTCAGGTAGA GAGCCGCCCT 
TTGCAGAATG GAGCCTCCAT CACAGGTACC AGTGTGGTCA CTGTGTCACA GATTACCCCC 
ATCCAGACAT CGCTGGCCTA TGTGAAAACC AGCGAGACTC TTAAGCAGAA CAACCGTGAT 
GCCATGGAAC TGAAGCCCAA TGGTGGTGCT GAGCCCAAAT GTCTCAAGGT CAACAGCCCC 
ATCAGAATGA AAAACGGAAA TGGGAAGGGG TGGCTGAGAC TGAAGAACAA CATGGGGGCT 
CACGAGGAGA AAAAGGAAGA GTGGAATAAT GTCACCAAAG CTGAGTCCAT GGGGCTGTTG 
TCAGAGGACC CCAAGGGCAG TGACTCAGAG AACAGTGTGA CCAAGAACCC CTTAAGGAAA 
ACGGATTCTT GTGACAGTGG GATTACAAAA AGTGACCTTC GTTTGGATAA AGCTGGTGAG 
GCCCGAAGTC CTCTAGAACA CAGTCCCAGC CAGGCTGATG CCAAGCATCC CTTCTACCCC 
ATCCCCGAGC AGGCCTTACA AACCACACTG CAGGAGGTAA AACATGAACT CAAAGAGGAC 
ATCCAGCTGC TGAGCTGCAG AATGACTGCC CTGGAAAAGC AGGTGGCAGA GATTTTAAAA 
CTACTCTCAG AGAAAAGTGT ACCCCAGACA TCTTCTCCAA AACCCCAAAT TCCACTCCAA 
GTACCTCCCC AAATACCATG TCAGGATATT TTTAGTGTCT CAAGGCCTGA GTCACCTGAA 
TCTGACAAAG ATGAAATCAA CTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domains.
The Journal of biological chemistry289(33)22815-34(2014 Aug)
Lin TF,Lin IW,Chen SC,Wu HH,Yang CS,Fang HY,Chiu MM,Jeng CJ

The punctate localization of rat Eag1 K+ channels is conferred by the proximal post-CNBHD region.
BMC neuroscience1523(2014 Feb)
Chuang CC,Jow GM,Lin HM,Weng YH,Hu JH,Peng YJ,Chiu YC,Chiu MM,Jeng CJ

Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.
Genes & development26(16)1780-96(2012 Aug)
Huang X,Dubuc AM,Hashizume R,Berg J,He Y,Wang J,Chiang C,Cooper MK,Northcott PA,Taylor MD,Barnes MJ,Tihan T,Chen J,Hackett CS,Weiss WA,James CD,Rowitch DH,Shuman MA,Jan YN,Jan LY

Eag 1, Eag 2 and Kcnn3 gene brain expression of isolated reared rats.
Genes, brain, and behavior9(8)918-24(2010 Nov)
Martin S,Lino-de-Oliveira C,Joca SR,Weffort de Oliveira R,Echeverry MB,Da Silva CA,Pardo L,Stühmer W,Bel ED

Differential localization of rat Eag1 and Eag2 potassium channels in the retina.
Neuroscience letters431(1)12-6(2008 Jan)
Jow GM,Jeng CJ

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Kcnh5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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