| Gene Symbol | OAZ3 |
| Entrez Gene ID | 100444055 |
| Full Name | ornithine decarboxylase antizyme 3 |
| Gene Type | protein-coding |
| Organism | Pongo abelii(Sumatran orangutan) |
| Summary | The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake, however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies in mice showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been noted for this gene. [provided by RefSeq, Aug 2014]. |
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OAZ3 cDNA ORF clone, Pongo abelii(Sumatran orangutan)
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Gene
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Clones
gRNAs
The following OAZ3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OAZ3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OSa49442 Clone ID Related Accession (Same CDS sequence) NM_001290272.2 Accession Version NM_001290272.2 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 573bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1556899200000 Organism Pongo abelii(Sumatran orangutan) Product ornithine decarboxylase antizyme 3 isoform 2 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from NDHI03003420.1. On Aug 19, 2014 this sequence version replaced NM_001290272.1. Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation from an AUG start codon, compared to variant 1. The resulting isoform (2) is shorter with a distinct N-terminus compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2058381, SAMEA2058383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END##
1
61
121
181
241
301
361
421
481
541ATGACCGTGC CCTGGCGGCC AGGAAAGCGA CGCATCACTT ATAAGGAAAA GGAGGACTTG
ACACTCCAGC CCCGTTCCTG CCTCCAGTGC TCCGAGTCCC TAGTAGGCCT CCAGGAGGGC
AAAAGCACCG AGCAGGGTAA CCACGACCAG CTTAAAGAAC TGTATTCGGC TGGGAACTTG
ACGGTGCTGG CTACTGACCC CCTGCTCCAC CAGGACCCAG TACAGTTAGA CTTTCACTTC
CGCCTCACCT CCCAGACCTC TGCCCATTGG CACGGCCTTC TCTGTGACCG TCGACTCTTC
CTGGATATCC CGTATCGGGC CTTGGATCAA GGCAACCGGG AAAGTTTGAC CGCAACCCTG
GAGTATGTGG AAGAGAAGAC AAATGTGGAC TCTGTGTTTG TGAACTTCCA GAATGATCGG
AACGACAGAG GTGCCCTGCT GCGGGCCTTC AGCTACATGG GCTTTGAGGT GGTCAGACCA
GGTCACCCTG CCCTCCCTCC CTTGGACAAC GTCATCTTTA TGGTGTATCC CCTTGAAAGG
GTTGTTGGCC ACCTGCCCAG TGAGCCTCCT TGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001277201.1 CDS join(168..260,262..741) Translation 
Target ORF information:
RefSeq Version NM_001290272.2 Organism Pongo abelii(Sumatran orangutan) Definition Pongo abelii ornithine decarboxylase antizyme 3 (OAZ3), transcript variant 2, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_001290272.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541ATGACCGTGC CCTGGCGGCC AGGAAAGCGA CGCATCACTT ATAAGGAAAA GGAGGACTTG
ACACTCCAGC CCCGTTCCTG CCTCCAGTGC TCCGAGTCCC TAGTAGGCCT CCAGGAGGGC
AAAAGCACCG AGCAGGGTAA CCACGACCAG CTTAAAGAAC TGTATTCGGC TGGGAACTTG
ACGGTGCTGG CTACTGACCC CCTGCTCCAC CAGGACCCAG TACAGTTAGA CTTTCACTTC
CGCCTCACCT CCCAGACCTC TGCCCATTGG CACGGCCTTC TCTGTGACCG TCGACTCTTC
CTGGATATCC CGTATCGGGC CTTGGATCAA GGCAACCGGG AAAGTTTGAC CGCAACCCTG
GAGTATGTGG AAGAGAAGAC AAATGTGGAC TCTGTGTTTG TGAACTTCCA GAATGATCGG
AACGACAGAG GTGCCCTGCT GCGGGCCTTC AGCTACATGG GCTTTGAGGT GGTCAGACCA
GGTCACCCTG CCCTCCCTCC CTTGGACAAC GTCATCTTTA TGGTGTATCC CCTTGAAAGG
GTTGTTGGCC ACCTGCCCAG TGAGCCTCCT TGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OSa49443 Clone ID Related Accession (Same CDS sequence) NM_001301411.1 Accession Version NM_001301411.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 708bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1556899200000 Organism Pongo abelii(Sumatran orangutan) Product ornithine decarboxylase antizyme 3 isoform 1 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from NDHI03003420.1. Transcript Variant: This variant (1) initiates translation from a non-AUG (CUG) start codon, and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2058381, SAMEA2058383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END##
1
61
121
181
241
301
361
421
481
541
601
661CTGCCTTGTA ACAGGTGTCG CCCCTCTGTC TACTCCCTTT CTTATATCAA GAGGGGAAAA
ACACGTAACT ACCTCTACCC GATCTGGTCA CCATACGCCT ATTACCTTTA CTGTTACAAG
TACCGGATCA CCCTCCGGGA GAAGATGCTG CCTCGTTGTT ATAAAAGCAT CACTTATAAG
GAAAAGGAGG ACTTGACACT CCAGCCCCGT TCCTGCCTCC AGTGCTCCGA GTCCCTAGTA
GGCCTCCAGG AGGGCAAAAG CACCGAGCAG GGTAACCACG ACCAGCTTAA AGAACTGTAT
TCGGCTGGGA ACTTGACGGT GCTGGCTACT GACCCCCTGC TCCACCAGGA CCCAGTACAG
TTAGACTTTC ACTTCCGCCT CACCTCCCAG ACCTCTGCCC ATTGGCACGG CCTTCTCTGT
GACCGTCGAC TCTTCCTGGA TATCCCGTAT CGGGCCTTGG ATCAAGGCAA CCGGGAAAGT
TTGACCGCAA CCCTGGAGTA TGTGGAAGAG AAGACAAATG TGGACTCTGT GTTTGTGAAC
TTCCAGAATG ATCGGAACGA CAGAGGTGCC CTGCTGCGGG CCTTCAGCTA CATGGGCTTT
GAGGTGGTCA GACCAGGTCA CCCTGCCCTC CCTCCCTTGG ACAACGTCAT CTTTATGGTG
TATCCCCTTG AAAGGGTTGT TGGCCACCTG CCCAGTGAGC CTCCTTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001288340.1 CDS join(68..295,297..776) Translation
Target ORF information:
RefSeq Version NM_001301411.1 Organism Pongo abelii(Sumatran orangutan) Definition Pongo abelii ornithine decarboxylase antizyme 3 (OAZ3), transcript variant 1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_001301411.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661CTGCCTTGTA ACAGGTGTCG CCCCTCTGTC TACTCCCTTT CTTATATCAA GAGGGGAAAA
ACACGTAACT ACCTCTACCC GATCTGGTCA CCATACGCCT ATTACCTTTA CTGTTACAAG
TACCGGATCA CCCTCCGGGA GAAGATGCTG CCTCGTTGTT ATAAAAGCAT CACTTATAAG
GAAAAGGAGG ACTTGACACT CCAGCCCCGT TCCTGCCTCC AGTGCTCCGA GTCCCTAGTA
GGCCTCCAGG AGGGCAAAAG CACCGAGCAG GGTAACCACG ACCAGCTTAA AGAACTGTAT
TCGGCTGGGA ACTTGACGGT GCTGGCTACT GACCCCCTGC TCCACCAGGA CCCAGTACAG
TTAGACTTTC ACTTCCGCCT CACCTCCCAG ACCTCTGCCC ATTGGCACGG CCTTCTCTGT
GACCGTCGAC TCTTCCTGGA TATCCCGTAT CGGGCCTTGG ATCAAGGCAA CCGGGAAAGT
TTGACCGCAA CCCTGGAGTA TGTGGAAGAG AAGACAAATG TGGACTCTGT GTTTGTGAAC
TTCCAGAATG ATCGGAACGA CAGAGGTGCC CTGCTGCGGG CCTTCAGCTA CATGGGCTTT
GAGGTGGTCA GACCAGGTCA CCCTGCCCTC CCTCCCTTGG ACAACGTCAT CTTTATGGTG
TATCCCCTTG AAAGGGTTGT TGGCCACCTG CCCAGTGAGC CTCCTTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Nucleic acids research35(6)1842-58(2007)
Ivanov IP,Atkins JF
Polyamines in spermiogenesis: not now, darling.
Proceedings of the National Academy of Sciences of the United States of America97(9)4421-3(2000 Apr)
Coffino P
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