CACNA1A cDNA ORF clone, Oryctolagus cuniculus(rabbit)

Gene
Clones
gRNAs

Summary

Gene Symbol	CACNA1A
Entrez Gene ID	100009265
Full Name	calcium voltage-gated channel subunit alpha1 A
Synonyms	CACH4,CACN3,CACNL1A4
Gene Type	protein-coding
Organism	Oryctolagus cuniculus(rabbit)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001101693.1	NP_001095163.1	voltage-dependent P/Q-type calcium channel subunit alpha-1A

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Molecular determinants of Gem protein inhibition of P/Q-type Ca2+ channels.
Fan M, Zhang WK, Buraei Z, Yang J
The Journal of biological chemistry287(27)22749-58(2012 Jun)

A mutation in the first intracellular loop of CACNA1A prevents P/Q channel modulation by SNARE proteins and lowers exocytosis.
Serra SA, Cuenca-León E, Llobet A, Rubio-Moscardo F, Plata C, Carreño O, Fernàndez-Castillo N, Corominas R, Valverde MA, Macaya A, Cormand B, Fernández-Fernández JM
Proceedings of the National Academy of Sciences of the United States of America107(4)1672-7(2010 Jan)

Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit.
Pragnell M, De Waard M, Mori Y, Tanabe T, Snutch TP, Campbell KP
Nature368(6466)67-70(1994 Mar)

Primary structure and functional expression from complementary DNA of a brain calcium channel.
Mori Y, Friedrich T, Kim MS, Mikami A, Nakai J, Ruth P, Bosse E, Hofmann F, Flockerzi V, Furuichi T
Nature350(6317)398-402(1991 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CACNA1A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CACNA1A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OOb30959	NM_001101693.1 Latest version!	Oryctolagus cuniculus calcium voltage-gated channel subunit alpha1 A (CACNA1A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	29-31	$1091.30 $1559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CACNA1A ( NM_001101693.1 ) cDNA ORF clone, Oryctolagus cuniculus(rabbit) -> NP_001095163.1 Oryctolagus cuniculus calcium voltage-gated channel subunit alpha1 A (CACNA1A), mRNA.

Price & Availability↑

CloneID	OOb30959
Clone ID Related Accession (Same CDS sequence)	NM_001101693.1
Accession Version	NM_001101693.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 6822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Oryctolagus cuniculus(rabbit)
Product	voltage-dependent P/Q-type calcium channel subunit alpha-1A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X57476.1. ##Evidence-Data-START## Transcript exon combination :: X57476.1 [ECO:0000332] ##Evidence-Data-END##

ATGGCCCGTT TCGGAGACGA GATGCCTGCC CGCTACGGGG GAGGAGGCGC CGGGGCAGCC 
GCCGGGGTGG TCGTGGGCGC CGCAGGCGGG CGAGGAGCCG GGGGCAGCCG GCAGGGCGGG 
CAGCCCGGGG CGCAAAGGAT GTACAAGCAA TCCATGGCGC AGAGGGCACG GACCATGGCC 
CTGTACAACC CCATCCCGGT CCGACAGAAC TGCCTCACGG TCAACCGCTC CCTCTTCCTC 
TTCAGCGAGG ACAACGTGGT GAGAAAATAC GCGAAGAAGA TCACCGAATG GCCTCCCTTT 
GAGTACATGA TTTTAGCCAC CATCATAGCA AACTGCATTG TCCTGGCGCT GGAGCAGCAT 
CTGCCAGATG ACGACAAGAC CCCGATGTCT GAGCGGCTGG ATGACACAGA ACCGTACTTC 
ATTGGCATTT TTTGTTTCGA GGCTGGAATT AAAATTATCG CCCTGGGGTT TGCCTTCCAC 
AAAGGGTCCT ACCTAAGGAA CGGTTGGAAC GTGATGGACT TTGTGGTGGT GCTAACTGGC 
ATCTTGGCGA CAGTTGGGAC AGAGTTTGAC CTTCGGACAC TGCGAGCAGT GCGGGTGCTG 
CGGCCGCTCA AGCTGGTGTC TGGAATCCCA AGTTTACAAG TCGTCTTGAA GTCAATCATG 
AAGGCGATGA TTCCTCTGCT GCAGATCGGA CTCCTCCTAT TTTTTGCAAT ACTTATTTTT 
GCAATCATAG GGTTAGAATT TTATATGGGA AAATTTCATA CCACCTGCTT TGAAGAGGGG 
ACAGACGACA TTCAGGGGGA GTCTCCGGCT CCATGCGGGA CAGAGGAACC CGCCCGCACC 
TGCCCCAATG GGACCAGATG CCAGCCCTAC TGGGAAGGAC CCAACAATGG GATCACCCAG 
TTCGACAACA TCCTGTTCGC CGTACTGACT GTTTTTCAGT GCATCACAAT GGAAGGATGG 
ACGGACCTCC TTTACAACAG CAACGATGCC TCAGGGAACA CTTGGAACTG GTTGTACTTC 
ATCCCCCTCA TCATCATCGG CTCCTTTTTT ATGCTGAACC TCGTGCTGGG TGTGCTGTCA 
GGGGAGTTTG CCAAAGAAAG GGAGCGGGTG GAGAACCGGC GCGCATTCCT GAAGCTGCGG 
CGGCAGCAGC AGATTGAACG CGAGCTCAAC GGGTACATGG AGTGGATCTC AAAAGCAGAA 
GAGGTGATCC TCGCAGAGGA CGAGACCGAC GTGGAGCAGA GACATCCCTT TGATGGAGCT 
CTGCGGAGAG CCACTATCAA GAAGAGCAAG ACGGACCTGC TCCACCCAGA GGAGGCGGAG 
GATCAGCTGG CCGACATCGC CTCCGTGGGG TCTCCCTTTG CCCGAGCCAG CATTAAAAGT 
GCCAAGCTGG AGAACTCGAG TTTTTTCCAC AAAAAAGAGA GGAGAATGCG TTTCTACATC 
CGTCGCATGG TCAAAACTCA GGCCTTCTAC TGGACTGTGC TCAGTCTGGT AGCCCTCAAC 
ACGCTGTGCG TGGCTATCGT CCATTACAAC CAGCCCGAGT GGCTCTCCGA CTTCCTGTAC 
TATGCAGAAT TCATTTTCTT AGGACTCTTT ATGTCCGAAA TGTTTATAAA AATGTACGGG 
CTTGGGACGC GGCCTTACTT CCACTCCTCT TTCAACTGCT TTGACTGTGG GGTCATCATC 
GGCAGTATCT TTGAAGTCAT CTGGGCTGTC ATAAAACCCG GCACGTCCTT TGGGATCAGC 
GTGTTACGAG CCCTCAGGTT ACTGCGTATT TTCAAAGTCA CAAAGTACTG GGCGTCTCTC 
CGAAACCTGG TCGTGTCACT TCTCAACTCC ATGAAATCCA TCATCAGTCT GCTGTTCCTC 
CTCTTCCTGT TTATCGTTGT CTTTGCACTT CTGGGGATGC AGCTCTTCGG TGGCCAGTTT 
AATTTCGACG AAGGAACTCC TCCCACCAAC TTTGACACCT TTCCGGCAGC AATAATGACG 
GTGTTTCAGA TCCTGACGGG AGAGGACTGG AACGAGGTCA TGTACGACGG CATCAAGTCG 
CAGGGCGGCG TGCAGGGCGG CATGGTGTTC TCCATCTACT TCATCGTCCT CACACTCTTT 
GGGAACTACA CCCTCCTGAA TGTGTTCTTG GCCATCGCCG TGGACAACCT GGCCAATGCC 
CAGGAGCTCA CCAAGGATGA GCAAGAGGAA GAGGAGGCCG TCAATCAAAA GCTTGCCCTG 
CAGAAGGCCA AGGAGGTGGC GGAAGTGAGT CCCCTGTCTG CAGCCAACAT GTCCATAGCC 
ATGAAGGAAC AGCAAAAGAA CCAGAAGCCG GCCAAGTCGG TGTGGGAGCA GCGGACCAGC 
GAGATGCGGA AACAGAACCT GCTGGCCAGC CGCGAGGCCC TGTACAGCGA GATGGACCCG 
GAGGAGCGCT GGAAGGCGTC GTACGCGCGC CACCTGCGGC CGGACATGAA AACGCACCTG 
GACCGGCCGC TGGTCGTGGA CCCGCAGGAG AACCGCAACA ACAACACCAA CAAGAGCCGC 
GTGGCCGAGC CCACGGTGGA CCAGCGCCTC GGGCAGCAGC GGGCCGAGGA CTTCCTCCGG 
AAGCAGGCCC GCCACCACGA TCGCGCGCGG GACCCCAGCG CCCACGCCGC CGCCGGCCTG 
GACGCGCGCA GGCCCTGGGC GGGCAGCCAG GAGGCCGAGC TGAGCCGGGA GGGGCCGTAC 
GGCCGCGAGT CGGACCACCA GGCCCGGGAG GGCGGCCTGG AGCCTCCGGG CTTCTGGGAG 
GGCGAGGCGG AGCGGGGCAA GGCTGGGGAC CCGCACCGCA GGCACGCGCA CCGGCAAGGC 
GTTGGCGGCA GCGGGGGTAG CCGCAGCGGC TCGCCCCGCA CCGGCACCGC CGACGGGGAG 
CCCCGCAGGC ACCGGGTCCA TCGCAGGCCC GGAGAGGACG GACCGGACGA CAAGGCCGAA 
AGGAGGGGCC GGCATCGCGA GGGCAGCCGG CCAGCCCGGA GCGGCGAGGG AGAGGCCGAG 
GGGCCGGACG GCGGTGGCGG TGGTGGTGGC GAACGCAGGA GGCGGCATCG GCATGGCCCC 
CCGCCCGCCT ACGACCCCGA CGCGCGGAGG GACGACAGGG AACGCAGGCA CCGGAGGAGG 
AAAGACACCC AGGGCTCCGG CGTCCCCGTG TCCGGCCCCA ACCTCTCCAC CACCCGGCCG 
ATCCAGCAGG ATCTGAGCCG CCAGGAGCCC CCGCTGGCCG AGGACATGGA CAACCTGAAG 
AACAGCCGGC TAGCCACCGC CGAGCCGGTC AGCCCCCACG AGAACCTCAG CCACGCCGGC 
CTGCCCCAGA GCCCGGCCAA GATGGGGAGC AGCACCGACC CCGCCGGCCC CACGCCGGCC 
ACGGCCGCCA ACCCCCAGAA CAGCACCGCC AGCCGCCGCA CACCCAACAA CCCGGGGAAC 
CCGTCCAACC CCGGCCCCCC CAAGACCCCC GAGAACAGCC TTATCGTCAC CAACCCCAGC 
ACCGCCCAAA CCAACTCAGC CAAGACTGCC AGGAAACCTG ACCACACCAC GGTGGAAATC 
CCACCAGCCT GCCCACCGCC CCTCAACCAC ACCGTGGTCC AAGTGAACAA AAATGCCAAC 
CCGGACCCAC TACCAAAGAA AGAAGATGAG AAGAAGGAGG AGGTGGACGA GGGCCCTGGG 
GAAGACGGCC CCAAGCCCAT GCCTCCCTAC AGTTCCATGT TTATCCTGTC CACCACCAAC 
CCCCTTCGCC GCCTGTGCCA TTACATCCTG AACCTGCGCT ACTTCGAGAT GTGCATCCTC 
ATGGTCATCG CCATGAGCAG CATCGCCCTG GCCGCCGAGG ACCCCGTGCA GCCCAATGCG 
CCGCGCAACA ACGTGCTGCG ATATTTCGAC TACGTTTTCA CTGGCGTCTT TACCTTTGAG 
ATGGTGATCA AGATGATCGA CTTAGGGCTT GTCCTGCATC AAGGTGCCTA CTTCCGGGAC 
CTCTGGAACA TTCTCGACTT CATAGTGGTC AGTGGGGCCC TGGTGGCCTT TGCTTTCACC 
GGCAATAGCA AAGGGAAGGA TATAAACACG ATCAAATCCC TCCGAGTGCT CCGGGTGCTA 
CGACCTCTCA AAACCATCAA GCGGTTGCCA AAGCTCAAGG CCGTGTTCGA CTGCGTGGTG 
AACTCACTCA AAAACGTCTT CAACATCCTC ATTGTGTACA TGCTGTTCAT GTTCATCTTC 
GCCGTGGTGG CTGTCCAGCT GTTCAAGGGC AAGTTTTTTC ACTGCACCGA TGAGTCCAAG 
GAATTTGAGA AAGATTGTCG CGGCAAGTAC CTCCTGTACG AGAAGAACGA GGTGAAAGCC 
CGCGATCGCG AGTGGAAGAA GTACGAGTTT CACTATGACA ACGTGCTGTG GGCCCTGCTC 
ACCCTCTTCA CCGTGTCCAC GGGAGAAGGC TGGCCACAGG TCCTCAAGCA CTCGGTGGAC 
GCCACCTTTG AAAACCAGGG CCCCAGCCCC GGCTACCGCA TGGAGATGTC CATCTTCTAC 
GTGGTCTACT TCGTCGTCTT CCCTTTCTTC TTTGTCAACA TCTTCGTGGC CTTGATCATC 
ATCACCTTCC AGGAGCAGGG CGACAAGATG ATGGAGGAGT ACAGCTTGGA GAAAAACGAG 
AGGGCCTGCA TCGACTTCGC CATCAGTGCC AAGCCGCTGA CCAGGCACAT GCCCCAGAAC 
AAGCAGAGCT TCCAGTACCG CATGTGGCAG TTCGTGGTGT CCCCGCCCTT CGAGTACACC 
ATCATGGCCA TGATCGCCCT CAACACCATC GTGCTGATGA TGAAGTTCTA CGGAGCCTCA 
GTGGCCTACG ACAATGCCCT GAAGGTATTC AACATCGTCT TCACCTCGCT CTTCTCCCTG 
GAGTGCCTGC TAAAGGTCCT GGCTTTTGGG ATTCTGAATT ATTTCCGCGA TGCCTGGAAT 
ATCTTTGACT TTGTGACCGT CCTCGGTAGC ATCACCGACA TCCTTGTGAC GGAGTTTGGG 
AACAACTTCA TCAACCTGAG CTTCCTGCGC CTCTTCCGCG CCGCGCGGCT CATCAAGCTC 
CTGCGGCAGG GCTACACCAT CCGCATCCTC CTCTGGACGT TCGTGCAGTC CTTCAAGGCG 
CTGCCCTACG TCTGCCTGCT GATCGCCATG CTCTTCTTCA TCTACGCCAT CATCGGGATG 
CAGGTGTTCG GCAACATCGG CATCGACATG GAGGACGAGG ACAGCGACGA GGACGAGTTC 
CAGATCACCG AGCACAATAA CTTCCGGACC TTCTTCCAGG CCCTCATGCT GCTCTTCCGG 
AGCGCCACCG GAGAAGCCTG GCACAACATC ATGCTGTCCT GCCTCAGCGG GAAGCCGTGC 
GACAAGAACT CGGGCATCCT GACGCCTGAG TGCGGCAACG AATTTGCCTA TTTTTACTTC 
GTGTCCTTCA TCTTCCTCTG CTCCTTCCTG ATGTTGAACC TCTTTGTGGC CGTCATCATG 
GACAACTTCG AGTACCTCAC GCGCGACTCC TCCATCCTGG GCCCCCACCA CCTGGATGAA 
TACGTGCGGG TCTGGGCCGA GTACGACCCT GCTGCTTGGG GACGCATGCT TTACCGGGAC 
ATGTATGCGA TGCTGAGACA CATGCCCCCA CCCCTGGGTC TGGGGAAGAA CTGCCCGGCC 
AGAGTGGCCT ACAAGAGGCT CCTGCGGATG GATCTGCCCG TGGCCGACGA CAACACTGTG 
CACTTCAACT CCACACTCAT GGCTTTGATC CGTACGGCGC TGGACATCAA GATCGCCAAG 
GGCGGAGCAG ATAAACAGCA GATGGACGCT GAGCTGCGCA AAGAGATGAT GGCCATTTGG 
CCCAACCTGT CCCAGAAGAC ACTGGACCTG CTGGTCACAC CCCACAAGTC CACGGACCTG 
ACAGTGGGCA AGATCTATGC CGCCATGATG ATCATGGAGT ACTACCGGCA GAGCAAAGCC 
AAAAAGCTGC AGGCCATGCG CGAGGAGCAG AACCGGACAC CGCTCATGTT CCAGCGCATG 
GAGCCCCCGC CGGATGAGGG GGGCGCCGGC CAGAACGCCC TGCCCTCCAC GCAGCTGGAC 
CCGGCAGGAG GCCTGATGGC TCACGAAGAC GGCCTCAAAG ACAGCCCATC CTGGGTGACC 
CAGCGCGCTC AGGAGATGTT CCAGAAGACG GGCACGTGGA GCCCGGAGCG CGCGCCCCCC 
GCCGACATGG CCGACAGCCA GCCCAAGCCT CAGTCCGTGG AGATGCGAGA AATGAGCCAG 
GACGGCTACT CGGACAGCGA GCACTGCCTC CCCATGGAAG GCCAGGCCCG CGCCGCCTCT 
ATGCCCCGCC TCCCCGCCGA GAACCAGAGG AGAAGGGGCC GGCCACGTGG GAGTGATCTC 
AGTACCATCT GTGACACCAG CCCCATGAAG CGCTCGGCCT CCGTGCTGGG CCCCAAGGCG 
TCCCGGCGCC TGGACGACTA CTCCCTGGAG CGCGTCCCAC CCGAGGAGAA CCAGCGACAC 
CACCCGCGGC GTCGCGAGCG CGCGCATCGC ACCTCCGAGC GCTCCCTGGG CCGCTACACC 
GACGTGGACA CAGGCTTGGG CACGGACCTC AGCATGACCA CCCAGTCCGG GGACCTGCCG 
TCCAGAGAGC GAGAGCAGGA GCGCGGCCGG CCCAAGGACC GGAAGCACCG GCCGCATCAC 
CACCACCACC ACCACCACCA CCCCGGCCCG GCGGCCGCCG ACAAGGAACG CTACGGCCCG 
CAGGACCGGC CCGACCATGG CCACGGCCGC GCCCGCGCCC GGGACCAGCG CTGGTCCCGC 
TCGCCCAGCG AGGGCCGGGA GCACACCACG CACCGGCAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001095163.1
CDS	294..7115
Translation	MARFGDEMPARYGGGGAGAAAGVVVGAAGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTRCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDVEQRHPFDGALRRATIKKSKTDLLHPEEAEDQLADIASVGSPFARASIKSAKLENSSFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAVNQKLALQKAKEVAEVSPLSAANMSIAMKEQQKNQKPAKSVWEQRTSEMRKQNLLASREALYSEMDPEERWKASYARHLRPDMKTHLDRPLVVDPQENRNNNTNKSRVAEPTVDQRLGQQRAEDFLRKQARHHDRARDPSAHAAAGLDARRPWAGSQEAELSREGPYGRESDHQAREGGLEPPGFWEGEAERGKAGDPHRRHAHRQGVGGSGGSRSGSPRTGTADGEPRRHRVHRRPGEDGPDDKAERRGRHREGSRPARSGEGEAEGPDGGGGGGGERRRRHRHGPPPAYDPDARRDDRERRHRRRKDTQGSGVPVSGPNLSTTRPIQQDLSRQEPPLAEDMDNLKNSRLATAEPVSPHENLSHAGLPQSPAKMGSSTDPAGPTPATAANPQNSTASRRTPNNPGNPSNPGPPKTPENSLIVTNPSTAQTNSAKTARKPDHTTVEIPPACPPPLNHTVVQVNKNANPDPLPKKEDEKKEEVDEGPGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYDNALKVFNIVFTSLFSLECLLKVLAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDMEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTPECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMLYRDMYAMLRHMPPPLGLGKNCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQNRTPLMFQRMEPPPDEGGAGQNALPSTQLDPAGGLMAHEDGLKDSPSWVTQRAQEMFQKTGTWSPERAPPADMADSQPKPQSVEMREMSQDGYSDSEHCLPMEGQARAASMPRLPAENQRRRGRPRGSDLSTICDTSPMKRSASVLGPKASRRLDDYSLERVPPEENQRHHPRRRERAHRTSERSLGRYTDVDTGLGTDLSMTTQSGDLPSREREQERGRPKDRKHRPHHHHHHHHHPGPAAADKERYGPQDRPDHGHGRARARDQRWSRSPSEGREHTTHRQ

Target ORF information:

RefSeq Version	NM_001101693.1
Organism	Oryctolagus cuniculus(rabbit)
Definition	Oryctolagus cuniculus calcium voltage-gated channel subunit alpha1 A (CACNA1A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001101693.1

ORF Insert Sequence:

ATGGCCCGTT TCGGAGACGA GATGCCTGCC CGCTACGGGG GAGGAGGCGC CGGGGCAGCC 
GCCGGGGTGG TCGTGGGCGC CGCAGGCGGG CGAGGAGCCG GGGGCAGCCG GCAGGGCGGG 
CAGCCCGGGG CGCAAAGGAT GTACAAGCAA TCCATGGCGC AGAGGGCACG GACCATGGCC 
CTGTACAACC CCATCCCGGT CCGACAGAAC TGCCTCACGG TCAACCGCTC CCTCTTCCTC 
TTCAGCGAGG ACAACGTGGT GAGAAAATAC GCGAAGAAGA TCACCGAATG GCCTCCCTTT 
GAGTACATGA TTTTAGCCAC CATCATAGCA AACTGCATTG TCCTGGCGCT GGAGCAGCAT 
CTGCCAGATG ACGACAAGAC CCCGATGTCT GAGCGGCTGG ATGACACAGA ACCGTACTTC 
ATTGGCATTT TTTGTTTCGA GGCTGGAATT AAAATTATCG CCCTGGGGTT TGCCTTCCAC 
AAAGGGTCCT ACCTAAGGAA CGGTTGGAAC GTGATGGACT TTGTGGTGGT GCTAACTGGC 
ATCTTGGCGA CAGTTGGGAC AGAGTTTGAC CTTCGGACAC TGCGAGCAGT GCGGGTGCTG 
CGGCCGCTCA AGCTGGTGTC TGGAATCCCA AGTTTACAAG TCGTCTTGAA GTCAATCATG 
AAGGCGATGA TTCCTCTGCT GCAGATCGGA CTCCTCCTAT TTTTTGCAAT ACTTATTTTT 
GCAATCATAG GGTTAGAATT TTATATGGGA AAATTTCATA CCACCTGCTT TGAAGAGGGG 
ACAGACGACA TTCAGGGGGA GTCTCCGGCT CCATGCGGGA CAGAGGAACC CGCCCGCACC 
TGCCCCAATG GGACCAGATG CCAGCCCTAC TGGGAAGGAC CCAACAATGG GATCACCCAG 
TTCGACAACA TCCTGTTCGC CGTACTGACT GTTTTTCAGT GCATCACAAT GGAAGGATGG 
ACGGACCTCC TTTACAACAG CAACGATGCC TCAGGGAACA CTTGGAACTG GTTGTACTTC 
ATCCCCCTCA TCATCATCGG CTCCTTTTTT ATGCTGAACC TCGTGCTGGG TGTGCTGTCA 
GGGGAGTTTG CCAAAGAAAG GGAGCGGGTG GAGAACCGGC GCGCATTCCT GAAGCTGCGG 
CGGCAGCAGC AGATTGAACG CGAGCTCAAC GGGTACATGG AGTGGATCTC AAAAGCAGAA 
GAGGTGATCC TCGCAGAGGA CGAGACCGAC GTGGAGCAGA GACATCCCTT TGATGGAGCT 
CTGCGGAGAG CCACTATCAA GAAGAGCAAG ACGGACCTGC TCCACCCAGA GGAGGCGGAG 
GATCAGCTGG CCGACATCGC CTCCGTGGGG TCTCCCTTTG CCCGAGCCAG CATTAAAAGT 
GCCAAGCTGG AGAACTCGAG TTTTTTCCAC AAAAAAGAGA GGAGAATGCG TTTCTACATC 
CGTCGCATGG TCAAAACTCA GGCCTTCTAC TGGACTGTGC TCAGTCTGGT AGCCCTCAAC 
ACGCTGTGCG TGGCTATCGT CCATTACAAC CAGCCCGAGT GGCTCTCCGA CTTCCTGTAC 
TATGCAGAAT TCATTTTCTT AGGACTCTTT ATGTCCGAAA TGTTTATAAA AATGTACGGG 
CTTGGGACGC GGCCTTACTT CCACTCCTCT TTCAACTGCT TTGACTGTGG GGTCATCATC 
GGCAGTATCT TTGAAGTCAT CTGGGCTGTC ATAAAACCCG GCACGTCCTT TGGGATCAGC 
GTGTTACGAG CCCTCAGGTT ACTGCGTATT TTCAAAGTCA CAAAGTACTG GGCGTCTCTC 
CGAAACCTGG TCGTGTCACT TCTCAACTCC ATGAAATCCA TCATCAGTCT GCTGTTCCTC 
CTCTTCCTGT TTATCGTTGT CTTTGCACTT CTGGGGATGC AGCTCTTCGG TGGCCAGTTT 
AATTTCGACG AAGGAACTCC TCCCACCAAC TTTGACACCT TTCCGGCAGC AATAATGACG 
GTGTTTCAGA TCCTGACGGG AGAGGACTGG AACGAGGTCA TGTACGACGG CATCAAGTCG 
CAGGGCGGCG TGCAGGGCGG CATGGTGTTC TCCATCTACT TCATCGTCCT CACACTCTTT 
GGGAACTACA CCCTCCTGAA TGTGTTCTTG GCCATCGCCG TGGACAACCT GGCCAATGCC 
CAGGAGCTCA CCAAGGATGA GCAAGAGGAA GAGGAGGCCG TCAATCAAAA GCTTGCCCTG 
CAGAAGGCCA AGGAGGTGGC GGAAGTGAGT CCCCTGTCTG CAGCCAACAT GTCCATAGCC 
ATGAAGGAAC AGCAAAAGAA CCAGAAGCCG GCCAAGTCGG TGTGGGAGCA GCGGACCAGC 
GAGATGCGGA AACAGAACCT GCTGGCCAGC CGCGAGGCCC TGTACAGCGA GATGGACCCG 
GAGGAGCGCT GGAAGGCGTC GTACGCGCGC CACCTGCGGC CGGACATGAA AACGCACCTG 
GACCGGCCGC TGGTCGTGGA CCCGCAGGAG AACCGCAACA ACAACACCAA CAAGAGCCGC 
GTGGCCGAGC CCACGGTGGA CCAGCGCCTC GGGCAGCAGC GGGCCGAGGA CTTCCTCCGG 
AAGCAGGCCC GCCACCACGA TCGCGCGCGG GACCCCAGCG CCCACGCCGC CGCCGGCCTG 
GACGCGCGCA GGCCCTGGGC GGGCAGCCAG GAGGCCGAGC TGAGCCGGGA GGGGCCGTAC 
GGCCGCGAGT CGGACCACCA GGCCCGGGAG GGCGGCCTGG AGCCTCCGGG CTTCTGGGAG 
GGCGAGGCGG AGCGGGGCAA GGCTGGGGAC CCGCACCGCA GGCACGCGCA CCGGCAAGGC 
GTTGGCGGCA GCGGGGGTAG CCGCAGCGGC TCGCCCCGCA CCGGCACCGC CGACGGGGAG 
CCCCGCAGGC ACCGGGTCCA TCGCAGGCCC GGAGAGGACG GACCGGACGA CAAGGCCGAA 
AGGAGGGGCC GGCATCGCGA GGGCAGCCGG CCAGCCCGGA GCGGCGAGGG AGAGGCCGAG 
GGGCCGGACG GCGGTGGCGG TGGTGGTGGC GAACGCAGGA GGCGGCATCG GCATGGCCCC 
CCGCCCGCCT ACGACCCCGA CGCGCGGAGG GACGACAGGG AACGCAGGCA CCGGAGGAGG 
AAAGACACCC AGGGCTCCGG CGTCCCCGTG TCCGGCCCCA ACCTCTCCAC CACCCGGCCG 
ATCCAGCAGG ATCTGAGCCG CCAGGAGCCC CCGCTGGCCG AGGACATGGA CAACCTGAAG 
AACAGCCGGC TAGCCACCGC CGAGCCGGTC AGCCCCCACG AGAACCTCAG CCACGCCGGC 
CTGCCCCAGA GCCCGGCCAA GATGGGGAGC AGCACCGACC CCGCCGGCCC CACGCCGGCC 
ACGGCCGCCA ACCCCCAGAA CAGCACCGCC AGCCGCCGCA CACCCAACAA CCCGGGGAAC 
CCGTCCAACC CCGGCCCCCC CAAGACCCCC GAGAACAGCC TTATCGTCAC CAACCCCAGC 
ACCGCCCAAA CCAACTCAGC CAAGACTGCC AGGAAACCTG ACCACACCAC GGTGGAAATC 
CCACCAGCCT GCCCACCGCC CCTCAACCAC ACCGTGGTCC AAGTGAACAA AAATGCCAAC 
CCGGACCCAC TACCAAAGAA AGAAGATGAG AAGAAGGAGG AGGTGGACGA GGGCCCTGGG 
GAAGACGGCC CCAAGCCCAT GCCTCCCTAC AGTTCCATGT TTATCCTGTC CACCACCAAC 
CCCCTTCGCC GCCTGTGCCA TTACATCCTG AACCTGCGCT ACTTCGAGAT GTGCATCCTC 
ATGGTCATCG CCATGAGCAG CATCGCCCTG GCCGCCGAGG ACCCCGTGCA GCCCAATGCG 
CCGCGCAACA ACGTGCTGCG ATATTTCGAC TACGTTTTCA CTGGCGTCTT TACCTTTGAG 
ATGGTGATCA AGATGATCGA CTTAGGGCTT GTCCTGCATC AAGGTGCCTA CTTCCGGGAC 
CTCTGGAACA TTCTCGACTT CATAGTGGTC AGTGGGGCCC TGGTGGCCTT TGCTTTCACC 
GGCAATAGCA AAGGGAAGGA TATAAACACG ATCAAATCCC TCCGAGTGCT CCGGGTGCTA 
CGACCTCTCA AAACCATCAA GCGGTTGCCA AAGCTCAAGG CCGTGTTCGA CTGCGTGGTG 
AACTCACTCA AAAACGTCTT CAACATCCTC ATTGTGTACA TGCTGTTCAT GTTCATCTTC 
GCCGTGGTGG CTGTCCAGCT GTTCAAGGGC AAGTTTTTTC ACTGCACCGA TGAGTCCAAG 
GAATTTGAGA AAGATTGTCG CGGCAAGTAC CTCCTGTACG AGAAGAACGA GGTGAAAGCC 
CGCGATCGCG AGTGGAAGAA GTACGAGTTT CACTATGACA ACGTGCTGTG GGCCCTGCTC 
ACCCTCTTCA CCGTGTCCAC GGGAGAAGGC TGGCCACAGG TCCTCAAGCA CTCGGTGGAC 
GCCACCTTTG AAAACCAGGG CCCCAGCCCC GGCTACCGCA TGGAGATGTC CATCTTCTAC 
GTGGTCTACT TCGTCGTCTT CCCTTTCTTC TTTGTCAACA TCTTCGTGGC CTTGATCATC 
ATCACCTTCC AGGAGCAGGG CGACAAGATG ATGGAGGAGT ACAGCTTGGA GAAAAACGAG 
AGGGCCTGCA TCGACTTCGC CATCAGTGCC AAGCCGCTGA CCAGGCACAT GCCCCAGAAC 
AAGCAGAGCT TCCAGTACCG CATGTGGCAG TTCGTGGTGT CCCCGCCCTT CGAGTACACC 
ATCATGGCCA TGATCGCCCT CAACACCATC GTGCTGATGA TGAAGTTCTA CGGAGCCTCA 
GTGGCCTACG ACAATGCCCT GAAGGTATTC AACATCGTCT TCACCTCGCT CTTCTCCCTG 
GAGTGCCTGC TAAAGGTCCT GGCTTTTGGG ATTCTGAATT ATTTCCGCGA TGCCTGGAAT 
ATCTTTGACT TTGTGACCGT CCTCGGTAGC ATCACCGACA TCCTTGTGAC GGAGTTTGGG 
AACAACTTCA TCAACCTGAG CTTCCTGCGC CTCTTCCGCG CCGCGCGGCT CATCAAGCTC 
CTGCGGCAGG GCTACACCAT CCGCATCCTC CTCTGGACGT TCGTGCAGTC CTTCAAGGCG 
CTGCCCTACG TCTGCCTGCT GATCGCCATG CTCTTCTTCA TCTACGCCAT CATCGGGATG 
CAGGTGTTCG GCAACATCGG CATCGACATG GAGGACGAGG ACAGCGACGA GGACGAGTTC 
CAGATCACCG AGCACAATAA CTTCCGGACC TTCTTCCAGG CCCTCATGCT GCTCTTCCGG 
AGCGCCACCG GAGAAGCCTG GCACAACATC ATGCTGTCCT GCCTCAGCGG GAAGCCGTGC 
GACAAGAACT CGGGCATCCT GACGCCTGAG TGCGGCAACG AATTTGCCTA TTTTTACTTC 
GTGTCCTTCA TCTTCCTCTG CTCCTTCCTG ATGTTGAACC TCTTTGTGGC CGTCATCATG 
GACAACTTCG AGTACCTCAC GCGCGACTCC TCCATCCTGG GCCCCCACCA CCTGGATGAA 
TACGTGCGGG TCTGGGCCGA GTACGACCCT GCTGCTTGGG GACGCATGCT TTACCGGGAC 
ATGTATGCGA TGCTGAGACA CATGCCCCCA CCCCTGGGTC TGGGGAAGAA CTGCCCGGCC 
AGAGTGGCCT ACAAGAGGCT CCTGCGGATG GATCTGCCCG TGGCCGACGA CAACACTGTG 
CACTTCAACT CCACACTCAT GGCTTTGATC CGTACGGCGC TGGACATCAA GATCGCCAAG 
GGCGGAGCAG ATAAACAGCA GATGGACGCT GAGCTGCGCA AAGAGATGAT GGCCATTTGG 
CCCAACCTGT CCCAGAAGAC ACTGGACCTG CTGGTCACAC CCCACAAGTC CACGGACCTG 
ACAGTGGGCA AGATCTATGC CGCCATGATG ATCATGGAGT ACTACCGGCA GAGCAAAGCC 
AAAAAGCTGC AGGCCATGCG CGAGGAGCAG AACCGGACAC CGCTCATGTT CCAGCGCATG 
GAGCCCCCGC CGGATGAGGG GGGCGCCGGC CAGAACGCCC TGCCCTCCAC GCAGCTGGAC 
CCGGCAGGAG GCCTGATGGC TCACGAAGAC GGCCTCAAAG ACAGCCCATC CTGGGTGACC 
CAGCGCGCTC AGGAGATGTT CCAGAAGACG GGCACGTGGA GCCCGGAGCG CGCGCCCCCC 
GCCGACATGG CCGACAGCCA GCCCAAGCCT CAGTCCGTGG AGATGCGAGA AATGAGCCAG 
GACGGCTACT CGGACAGCGA GCACTGCCTC CCCATGGAAG GCCAGGCCCG CGCCGCCTCT 
ATGCCCCGCC TCCCCGCCGA GAACCAGAGG AGAAGGGGCC GGCCACGTGG GAGTGATCTC 
AGTACCATCT GTGACACCAG CCCCATGAAG CGCTCGGCCT CCGTGCTGGG CCCCAAGGCG 
TCCCGGCGCC TGGACGACTA CTCCCTGGAG CGCGTCCCAC CCGAGGAGAA CCAGCGACAC 
CACCCGCGGC GTCGCGAGCG CGCGCATCGC ACCTCCGAGC GCTCCCTGGG CCGCTACACC 
GACGTGGACA CAGGCTTGGG CACGGACCTC AGCATGACCA CCCAGTCCGG GGACCTGCCG 
TCCAGAGAGC GAGAGCAGGA GCGCGGCCGG CCCAAGGACC GGAAGCACCG GCCGCATCAC 
CACCACCACC ACCACCACCA CCCCGGCCCG GCGGCCGCCG ACAAGGAACG CTACGGCCCG 
CAGGACCGGC CCGACCATGG CCACGGCCGC GCCCGCGCCC GGGACCAGCG CTGGTCCCGC 
TCGCCCAGCG AGGGCCGGGA GCACACCACG CACCGGCAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Molecular determinants of Gem protein inhibition of P/Q-type Ca2+ channels.
The Journal of biological chemistry287(27)22749-58(2012 Jun)
Fan M,Zhang WK,Buraei Z,Yang J

A mutation in the first intracellular loop of CACNA1A prevents P/Q channel modulation by SNARE proteins and lowers exocytosis.
Proceedings of the National Academy of Sciences of the United States of America107(4)1672-7(2010 Jan)
Serra SA,Cuenca-León E,Llobet A,Rubio-Moscardo F,Plata C,Carreño O,Fernàndez-Castillo N,Corominas R,Valverde MA,Macaya A,Cormand B,Fernández-Fernández JM

Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit.
Nature368(6466)67-70(1994 Mar)
Pragnell M,De Waard M,Mori Y,Tanabe T,Snutch TP,Campbell KP

Primary structure and functional expression from complementary DNA of a brain calcium channel.
Nature350(6317)398-402(1991 Apr)
Mori Y,Friedrich T,Kim MS,Mikami A,Nakai J,Ruth P,Bosse E,Hofmann F,Flockerzi V,Furuichi T

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CACNA1A cDNA ORF clone, Oryctolagus cuniculus(rabbit)

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Target ORF information:

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