Ocstamp cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ocstamp
Entrez Gene ID	74614
Full Name	osteoclast stimulatory transmembrane protein
Synonyms	4833422F24Rik,OC-STAMP
General protein information	Preferred Names osteoclast stimulatory transmembrane protein Names osteoclast stimulatory transmembrane protein transmembrane protein C20orf123 homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 H3

mRNA and Protein(s)

mRNA	Protein	Name
NM_029021.1	NP_083297.1	osteoclast stimulatory transmembrane protein

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	C20H20ORF123	XP_417382.2
Danio rerio (zebrafish)	ocstamp	NP_001014362.1
Bos taurus (cattle)	OCSTAMP	XP_005215103.1
Canis lupus familiaris (dog)	OCSTAMP	XP_005635411.1
Homo sapiens (human)	OCSTAMP	NP_542452.1
Pan troglodytes (chimpanzee)	OCSTAMP	XP_003954521.1
Mus musculus (house mouse)	Ocstamp	NP_083297.1
Rattus norvegicus (Norway rat)	Zfp334	XP_230857.5
Xenopus tropicalis (tropical clawed frog)	LOC100493211	XP_002933233.2

Gene Ontology
Bibliography

Related articles in PubMed

OC-STAMP promotes osteoclast fusion for pathogenic bone resorption in periodontitis via up-regulation of permissive fusogen CD9.
Ishii T, Ruiz-Torruella M, Ikeda A, Shindo S, Movila A, Mawardi H, Albassam A, Kayal RA, Al-Dharrab AA, Egashira K, Wisitrasameewong W, Yamamoto K, Mira AI, Sueishi K, Han X, Taubman MA, Miyamoto T, Kawai T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology32(7)4016-4030(2018 07)

Osteoclast stimulatory transmembrane protein induces a phenotypic switch in macrophage polarization suppressing an M1 pro-inflammatory state.
Yuan H, He J, Zhang G, Zhang D, Kong X, Chen F
Acta biochimica et biophysica Sinica49(10)935-944(2017 Oct)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bućan M, Murray SA
Nature537(7621)508-514(2016 09)

Studies of OC-STAMP in Osteoclast Fusion: A New Knockout Mouse Model, Rescue of Cell Fusion, and Transmembrane Topology.
Witwicka H, Hwang SY, Reyes-Gutierrez P, Jia H, Odgren PE, Donahue LR, Birnbaum MJ, Odgren PR
PloS one10(6)e0128275(2015)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ocstamp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ocstamp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18585	NM_029021.1 Latest version!	Mus musculus osteoclast stimulatory transmembrane protein (Ocstamp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ocstamp ( NM_029021.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_083297.1 Mus musculus osteoclast stimulatory transmembrane protein (Ocstamp), mRNA.

Price & Availability↑

CloneID	OMu18585
Clone ID Related Accession (Same CDS sequence)	NM_029021.1
Accession Version	NM_029021.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1497bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550246400000
Organism	Mus musculus(house mouse)
Product	osteoclast stimulatory transmembrane protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK014751.1. ##Evidence-Data-START## Transcript exon combination :: AK014751.1, AK042271.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END##

ATGAGGACCA TCAGGGCAGC CACGGAACAC CTCTTTGGCT TGGGGTGGAA GTTCTGGCGC 
TTGGGGATCT GCAAGGCAGT TGTTCCACTG CAGGCTGCCT GGAAAGCCTT CTCCCAGCCT 
GTCCCAGCCA GCTGTAACGA ACTACTGACC CAGCTTCTCC TGTGTGTTTC CTTGGCCAGT 
CTTATCGCAG GCCTGGCGCA TCACTGGCTG GTCTCTTTGC AGCTTTATCC TTTGGGACCC 
CCTGCCCTGG TGACCTCTCT CTGTGGTCTC TTCGTCTTCC TAAGCCTGGG CCTGGTGCCC 
CCCATCCGCT GCCTATTTGT GCTCAGTGTG CCAACCCTGG GCTCCAAGCA GGGCCGCCGC 
TTGCTCCTGT CCTACAGTGC AGCCAACCTG GCTGTCGCTG TGGTGCCAAA CGTCTTAGGC 
AATGTGCGTG CAGCTGGGCA AGTGCTGAGC TGTGTTACTG AGGGCTCTTT GGAGAGTCTG 
CTTAATACCA CTTACCAGCT GCGCCAGGCA GCCAGGGAAC TGGGCCCAGC CAGCCGAGCA 
GGCAGCCGCA GCCTGACATT TGAGGTCGAG GGCAAGGGCT CAGCCTTCCG CCTTCACATG 
CACACGATCA CTCAGGAGAT CCTGGAAGAC TTCTCTGGCC TGGAGTTCCT GGCTCGAGCA 
GCACTGGGCA CTCAGCGGGT GGTCACCGGG TTGTTCCTGC TGGGCCTCCT GGGAGAGTCG 
GCCTGGTACC TTCATCGCTA CCTCACTGAC CTGCGTTTCG ACAATATCTA CGCGACTCGG 
CAGCTGGTTC GGCAGCTGGC CCAGGCTGGT GCCACACATC TGCTGACCTC TCCGCCTCCG 
TGGCTGCTCC AAACAGCCCA GCCTAAGTTG TCACGGGAGG AGCTGCTGAG CTGTCTCCTA 
AGGCTGGGGC TACTGGCATT GCTCTTAGTA GCCACAGCTG TGACAGTGGC CTCAGACTAT 
GGGGCCTTCC TCTTGGCACA AGCAGCTGTA GCCTGGGCTC AGAAGTTACC CACTGTCCCA 
ATCACACTCA CAGTCAAATA TGACGCCTCA TATAAGGTTC TGGACTTCAT CCTCTTCGTC 
CTCAACCAAC CTCCGGTGGA GAGCGTGTTT GCCTCCATGC AGCGCTCCTT CCAGTGGGAG 
CTGCGCTTCA CGCCCCACGA CTGTCATCTA CCACAGGCTC AACCACCCCG TGTCACCGCT 
GCTCTGGCGG CGGGCGCCCT GCAACTGCTG GCGGGCGCCA CCTTGGTGCT ACAGGCCTAC 
GCCTGGCGCC TGCGCCACAC CATCGCAGCC TCCTTCTTCC CAGACCAGGA GGCCAGGAGG 
CTTAGCCACT TGCAGGCCCG GCTCCAGAGG AGACACAACC AGAGTGACCA CCTGAACAAA 
CAGCCCGGCA CTATGGCCAC CCGGGAATCC AGGAAGCCTG GACAGGGAAC TCGGACTCTG 
GAGTCACAGG GACCTCAGGC ACATGACTCC CTTGGGCCTC CATATGACCT CGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_083297.1
CDS	64..1560
Translation	MRTIRAATEHLFGLGWKFWRLGICKAVVPLQAAWKAFSQPVPASCNELLTQLLLCVSLASLIAGLAHHWLVSLQLYPLGPPALVTSLCGLFVFLSLGLVPPIRCLFVLSVPTLGSKQGRRLLLSYSAANLAVAVVPNVLGNVRAAGQVLSCVTEGSLESLLNTTYQLRQAARELGPASRAGSRSLTFEVEGKGSAFRLHMHTITQEILEDFSGLEFLARAALGTQRVVTGLFLLGLLGESAWYLHRYLTDLRFDNIYATRQLVRQLAQAGATHLLTSPPPWLLQTAQPKLSREELLSCLLRLGLLALLLVATAVTVASDYGAFLLAQAAVAWAQKLPTVPITLTVKYDASYKVLDFILFVLNQPPVESVFASMQRSFQWELRFTPHDCHLPQAQPPRVTAALAAGALQLLAGATLVLQAYAWRLRHTIAASFFPDQEARRLSHLQARLQRRHNQSDHLNKQPGTMATRESRKPGQGTRTLESQGPQAHDSLGPPYDLE

Target ORF information:

RefSeq Version	NM_029021.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus osteoclast stimulatory transmembrane protein (Ocstamp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_029021.1

ORF Insert Sequence:

ATGAGGACCA TCAGGGCAGC CACGGAACAC CTCTTTGGCT TGGGGTGGAA GTTCTGGCGC 
TTGGGGATCT GCAAGGCAGT TGTTCCACTG CAGGCTGCCT GGAAAGCCTT CTCCCAGCCT 
GTCCCAGCCA GCTGTAACGA ACTACTGACC CAGCTTCTCC TGTGTGTTTC CTTGGCCAGT 
CTTATCGCAG GCCTGGCGCA TCACTGGCTG GTCTCTTTGC AGCTTTATCC TTTGGGACCC 
CCTGCCCTGG TGACCTCTCT CTGTGGTCTC TTCGTCTTCC TAAGCCTGGG CCTGGTGCCC 
CCCATCCGCT GCCTATTTGT GCTCAGTGTG CCAACCCTGG GCTCCAAGCA GGGCCGCCGC 
TTGCTCCTGT CCTACAGTGC AGCCAACCTG GCTGTCGCTG TGGTGCCAAA CGTCTTAGGC 
AATGTGCGTG CAGCTGGGCA AGTGCTGAGC TGTGTTACTG AGGGCTCTTT GGAGAGTCTG 
CTTAATACCA CTTACCAGCT GCGCCAGGCA GCCAGGGAAC TGGGCCCAGC CAGCCGAGCA 
GGCAGCCGCA GCCTGACATT TGAGGTCGAG GGCAAGGGCT CAGCCTTCCG CCTTCACATG 
CACACGATCA CTCAGGAGAT CCTGGAAGAC TTCTCTGGCC TGGAGTTCCT GGCTCGAGCA 
GCACTGGGCA CTCAGCGGGT GGTCACCGGG TTGTTCCTGC TGGGCCTCCT GGGAGAGTCG 
GCCTGGTACC TTCATCGCTA CCTCACTGAC CTGCGTTTCG ACAATATCTA CGCGACTCGG 
CAGCTGGTTC GGCAGCTGGC CCAGGCTGGT GCCACACATC TGCTGACCTC TCCGCCTCCG 
TGGCTGCTCC AAACAGCCCA GCCTAAGTTG TCACGGGAGG AGCTGCTGAG CTGTCTCCTA 
AGGCTGGGGC TACTGGCATT GCTCTTAGTA GCCACAGCTG TGACAGTGGC CTCAGACTAT 
GGGGCCTTCC TCTTGGCACA AGCAGCTGTA GCCTGGGCTC AGAAGTTACC CACTGTCCCA 
ATCACACTCA CAGTCAAATA TGACGCCTCA TATAAGGTTC TGGACTTCAT CCTCTTCGTC 
CTCAACCAAC CTCCGGTGGA GAGCGTGTTT GCCTCCATGC AGCGCTCCTT CCAGTGGGAG 
CTGCGCTTCA CGCCCCACGA CTGTCATCTA CCACAGGCTC AACCACCCCG TGTCACCGCT 
GCTCTGGCGG CGGGCGCCCT GCAACTGCTG GCGGGCGCCA CCTTGGTGCT ACAGGCCTAC 
GCCTGGCGCC TGCGCCACAC CATCGCAGCC TCCTTCTTCC CAGACCAGGA GGCCAGGAGG 
CTTAGCCACT TGCAGGCCCG GCTCCAGAGG AGACACAACC AGAGTGACCA CCTGAACAAA 
CAGCCCGGCA CTATGGCCAC CCGGGAATCC AGGAAGCCTG GACAGGGAAC TCGGACTCTG 
GAGTCACAGG GACCTCAGGC ACATGACTCC CTTGGGCCTC CATATGACCT CGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

OC-STAMP promotes osteoclast fusion for pathogenic bone resorption in periodontitis via up-regulation of permissive fusogen CD9.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology32(7)4016-4030(2018 07)
Ishii T,Ruiz-Torruella M,Ikeda A,Shindo S,Movila A,Mawardi H,Albassam A,Kayal RA,Al-Dharrab AA,Egashira K,Wisitrasameewong W,Yamamoto K,Mira AI,Sueishi K,Han X,Taubman MA,Miyamoto T,Kawai T

Osteoclast stimulatory transmembrane protein induces a phenotypic switch in macrophage polarization suppressing an M1 pro-inflammatory state.
Acta biochimica et biophysica Sinica49(10)935-944(2017 Oct)
Yuan H,He J,Zhang G,Zhang D,Kong X,Chen F

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bućan M,Murray SA

Studies of OC-STAMP in Osteoclast Fusion: A New Knockout Mouse Model, Rescue of Cell Fusion, and Transmembrane Topology.
PloS one10(6)e0128275(2015)
Witwicka H,Hwang SY,Reyes-Gutierrez P,Jia H,Odgren PE,Donahue LR,Birnbaum MJ,Odgren PR

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

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Ocstamp cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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