Cdkl5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cdkl5
Entrez Gene ID	382253
Full Name	cyclin-dependent kinase-like 5
Synonyms	BC038161,Stk9
General protein information	Preferred Names cyclin-dependent kinase-like 5 Names cyclin-dependent kinase-like 5 serine/threonine kinase 9
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X F4\|X 73.95 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001024624.2	NP_001019795.1	cyclin-dependent kinase-like 5

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CDKL5	XP_002700425.2
Gallus gallus (chicken)	CDKL5	XP_425571.2
Xenopus tropicalis (tropical clawed frog)	cdkl5	XP_004911815.1
Rattus norvegicus (Norway rat)	Cdkl5	XP_006256971.1
Pan troglodytes (chimpanzee)	CDKL5	XP_003317430.1
Homo sapiens (human)	CDKL5	NP_001032420.1
Canis lupus familiaris (dog)	CDKL5	XP_005641221.1
Mus musculus (house mouse)	Cdkl5	NP_001019795.1
Danio rerio (zebrafish)	cdkl5	NP_001124243.1
Macaca mulatta (Rhesus monkey)	LOC693974	XP_002808564.1

Gene Ontology
Bibliography

Related articles in PubMed

Site-specific abnormalities in the visual system of a mouse model of CDKL5 deficiency disorder.
Lupori L, Sagona G, Fuchs C, Mazziotti R, Stefanov A, Putignano E, Napoli D, Strettoi E, Ciani E, Pizzorusso T
Human molecular genetics28(17)2851-2861(2019 09)

Neuron-Type Specific Loss of CDKL5 Leads to Alterations in mTOR Signaling and Synaptic Markers.
Schroeder E, Yuan L, Seong E, Ligon C, DeKorver N, Gurumurthy CB, Arikkath J
Molecular neurobiology56(6)4151-4162(2019 Jun)

Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder.
Tang S, Terzic B, Wang IJ, Sarmiento N, Sizov K, Cui Y, Takano H, Marsh ED, Zhou Z, Coulter DA
Nature communications10(1)2655(2019 06)

AMPA Receptor Dysregulation and Therapeutic Interventions in a Mouse Model of CDKL5 Deficiency Disorder.
Yennawar M, White RS, Jensen FE
The Journal of neuroscience : the official journal of the Society for Neuroscience39(24)4814-4828(2019 Jun)

Functional and Structural Impairments in the Perirhinal Cortex of a Mouse Model of CDKL5 Deficiency Disorder Are Rescued by a TrkB Agonist.
Ren E, Roncacé V, Trazzi S, Fuchs C, Medici G, Gennaccaro L, Loi M, Galvani G, Ye K, Rimondini R, Aicardi G, Ciani E
Frontiers in cellular neuroscience13169(2019)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Cdkl5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdkl5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11884	NM_001024624.2 Latest version!	Mus musculus cyclin-dependent kinase-like 5 (Cdkl5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cdkl5 ( NM_001024624.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001019795.1 Mus musculus cyclin-dependent kinase-like 5 (Cdkl5), mRNA.

Price & Availability↑

CloneID	OMu11884
Clone ID Related Accession (Same CDS sequence)	NM_001024624.2
Accession Version	NM_001024624.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2817bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577808000000
Organism	Mus musculus(house mouse)
Product	cyclin-dependent kinase-like 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY291331.1 and AK139220.1. On Feb 6, 2008 this sequence version replaced NM_001024624.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK139220.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGAAGATTC CTAACATTGG TAATGTGATG AATAAATTTG AGATCCTTGG GGTTGTCGGT 
GAAGGAGCCT ATGGAGTTGT ACTTAAATGC AGACACAAGG AAACACATGA AATTGTGGCA 
ATCAAGAAAT TCAAGGACAG CGAAGAAAAT GAAGAAGTCA AGGAGACGAC CTTACGAGAG 
CTTAAAATGC TTCGCACTCT CAAGCAGGAA AACATTGTGG AGCTGAAGGA AGCTTTTCGT 
CGGAGAGGAA AATTATACCT GGTGTTTGAA TATGTTGAGA AGAATATGCT TGAATTGCTG 
GAAGAAATGC CAAATGGAGT TCCACCTGAA AAAGTCAAGA GCTATATCTA CCAACTAATC 
AAAGCTATCC ACTGGTGCCA CAAGAACGAC ATCGTCCACA GAGATATAAA GCCTGAAAAT 
CTCTTAATCA GCCACAATGA TGTCCTGAAA CTATGTGACT TTGGTTTTGC TCGCAATCTC 
TCAGAGGGCA ATAATGCTAA TTATACAGAG TATGTGGCTA CAAGGTGGTA CCGATCCCCA 
GAACTGCTAC TTGGAGCCCC CTATGGAAAG TCAGTGGACA TGTGGTCAGT GGGCTGTATT 
CTTGGAGAGC TTAGTGATGG CCAGCCCTTA TTTCCTGGAG AAAGTGAAAT TGACCAACTC 
TTTACTATTC AGAAGGTGCT AGGACCACTT CCATCTGAGC AAATGAAGCT CTTCTACAGT 
AACCCTCGTT TCCATGGGCT CCGGTTCCCA GCTGTTAACC ATCCTCAGTC ATTAGAGAGA 
AGATACCTTG GAATTTTAAA TAGTGTTTTA CTTGACCTAA TGAAGAATTT ACTGAAGTTG 
GACCCAGCTG ACAGATACTT GACAGAGCAG TGTTTAAATC ATCCTACATT TCAGACTCAG 
AGACTTTTGG ACCGGTCTCC TTCAAGATCA ACAAAAAGGA AACCTTATCA TGTGGAAAGC 
AGCACCCTGT CTAATAGAAA CCAATCCACC AAGGGTGCTG CCTTACAGAC TCACCACAGA 
TCCAACAGCA AGGACATTCA GAACTTAAGT GTGGGTCTGC CCAGGGCTGA GGAAGGCCTG 
CCTGCAAACG AAAGCTTCCT CAATGGAAAC CTTGCTGGAG CAACTCTCAG CCCAATGCAC 
ACCAAAACCT ACCAAGCAAG CACCCAGCCT GGCTCTTCCA GCAAAGATCT CACAAACAAC 
AACATACCAC ACCTTCTCAG TCCAAAAGAA GCCAAGTCCA AAACAGAGTT TGACTTCAAT 
ATTGACACAA AGCCTTCAGA AGGTCCAGGC ACAAAGTACC TCAAGTCCAG CACCAGATCT 
CAGCAGAACA GGCACTCATT CATGGAAAGC TCCCAGAGCA AAGCTGGGAC CCTGCAGCCC 
AGTGAGAAGC AGAGTCGGCA CAGCTATATT GACACCATTC CCCAGTCCTC CCGGAGTCCA 
TCCTACAGGA CAAAGGCCAA AAGCCATGGG GCGTTGAGTG ACTCCAAGTC TGTGAGCAAC 
CTTTCCGAAG CCAGAGCCCA AATCACAGAG ACTAATACCA GTAGATACTT CCCATCCAGT 
TGTTTGGACT TGAACTCTCC CACCAGCCCA ACCCCCACCA GGCACACTGA TACGAGAACT 
TTGCTCAGCC CTTCCGGTCG AAATAATAGA AATGAAGGCA CTCTGGACTC ACGGCGAACC 
ACCACTAGAC ACTCAAAAAC CATGGAGGAG TTGAAGCTGC CTGAACACAT GGACAGCAGC 
CATTCGCATT CACTGTCTGC ACCTCATGAA TCATTTTCTT ATGGGCTAGG CTACACCAGC 
CCCTTCTCCT CTCAGCAGCG TCCTCACAGG CATTCCATGT ACGTGACCCG GGACAAAGTG 
AGAGCGAAAG GCCTTGATGG AAGCTTGAGC ATAGGACAAG GGATGGCAGC CAGAGCCAAC 
AGTTTGCAGC TCTTATCACC CCAGCCTGGA GAACAGCTCC CTCCAGAGAT GACTGTGGCA 
AGACCTTCTG TTAAAGAGTC CTCCCGAGAA GGCGCCTCTT CATTCCACAC CCGTCAGAAG 
TCTGAGGGTG GAGTATACCA TGACCCACAC TCTGACGACG GCACAGCTCC CAAAGAAAAT 
CGGCATCTGT ACAATGACCC TGTCCCAAGG AGAGTTGGTA GCTTTTATAG AGTGCCATCT 
CCACGACCAG ACAATTCTTT CCATGAAAAT AATGTGTCCA CTCGAGTTTC TTCTCTGCCA 
TCTGATAGCA GTTCTGGTAC AAATCATTCA AAAAGACAAC CAGGATTTGA TCCATGGAAA 
AGTCCTGAAA ACATTAGTCA TGCCGATCAA CTCAAAGAAA AGGAGAAGCA AGGTTTTTTC 
AGGTCAATGA AAAAGAAAAA GAAGAAAACT CAAACAGTGC CCAACACTGA CGGTCCTGAT 
CTATTGACCT TACAGAAAGC CATTCATTCT TCTAGCACTG CAAGCAGCAG ACCAAAGGAG 
TGGCGACCTG AGAAGCTCTC AGATCTACAG ACCCAGAGCC AACCACTAAA ATCTCTTCGA 
AAGCTGTTGC ATCTGTCTTC ATCAACCAAT CATCCAGCTT CTTCAGATCC TCGGTTCCAG 
CCCTTAACAG CTCAACAAGC CAAAAATTCC TTCTCAGAAA TTCGGATTCA CCCTCTGAGT 
CAGGCCACTG GTGGGAGCAG CAACATCCGG CAGGAGCCTA CACCAAAAGG CAGACCAGCC 
CTTCAGTTGC CAGGATCTTC CCTCTTAAGG TACAACGGAT GGAAACACTC AAGATCAAGA 
TCCAGCCAGC CAGACGAAGT GATCTTCTTG GCATCCCATG AGAAATGGAA ACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001019795.1
CDS	259..3075
Translation	MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSTKRKPYHVESSTLSNRNQSTKGAALQTHHRSNSKDIQNLSVGLPRAEEGLPANESFLNGNLAGATLSPMHTKTYQASTQPGSSSKDLTNNNIPHLLSPKEAKSKTEFDFNIDTKPSEGPGTKYLKSSTRSQQNRHSFMESSQSKAGTLQPSEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQITETNTSRYFPSSCLDLNSPTSPTPTRHTDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARPSVKESSREGASSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSDSSSGTNHSKRQPGFDPWKSPENISHADQLKEKEKQGFFRSMKKKKKKTQTVPNTDGPDLLTLQKAIHSSSTASSRPKEWRPEKLSDLQTQSQPLKSLRKLLHLSSSTNHPASSDPRFQPLTAQQAKNSFSEIRIHPLSQATGGSSNIRQEPTPKGRPALQLPGSSLLRYNGWKHSRSRSSQPDEVIFLASHEKWKQ

Target ORF information:

RefSeq Version	NM_001024624.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus cyclin-dependent kinase-like 5 (Cdkl5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001024624.2

ORF Insert Sequence:

ATGAAGATTC CTAACATTGG TAATGTGATG AATAAATTTG AGATCCTTGG GGTTGTCGGT 
GAAGGAGCCT ATGGAGTTGT ACTTAAATGC AGACACAAGG AAACACATGA AATTGTGGCA 
ATCAAGAAAT TCAAGGACAG CGAAGAAAAT GAAGAAGTCA AGGAGACGAC CTTACGAGAG 
CTTAAAATGC TTCGCACTCT CAAGCAGGAA AACATTGTGG AGCTGAAGGA AGCTTTTCGT 
CGGAGAGGAA AATTATACCT GGTGTTTGAA TATGTTGAGA AGAATATGCT TGAATTGCTG 
GAAGAAATGC CAAATGGAGT TCCACCTGAA AAAGTCAAGA GCTATATCTA CCAACTAATC 
AAAGCTATCC ACTGGTGCCA CAAGAACGAC ATCGTCCACA GAGATATAAA GCCTGAAAAT 
CTCTTAATCA GCCACAATGA TGTCCTGAAA CTATGTGACT TTGGTTTTGC TCGCAATCTC 
TCAGAGGGCA ATAATGCTAA TTATACAGAG TATGTGGCTA CAAGGTGGTA CCGATCCCCA 
GAACTGCTAC TTGGAGCCCC CTATGGAAAG TCAGTGGACA TGTGGTCAGT GGGCTGTATT 
CTTGGAGAGC TTAGTGATGG CCAGCCCTTA TTTCCTGGAG AAAGTGAAAT TGACCAACTC 
TTTACTATTC AGAAGGTGCT AGGACCACTT CCATCTGAGC AAATGAAGCT CTTCTACAGT 
AACCCTCGTT TCCATGGGCT CCGGTTCCCA GCTGTTAACC ATCCTCAGTC ATTAGAGAGA 
AGATACCTTG GAATTTTAAA TAGTGTTTTA CTTGACCTAA TGAAGAATTT ACTGAAGTTG 
GACCCAGCTG ACAGATACTT GACAGAGCAG TGTTTAAATC ATCCTACATT TCAGACTCAG 
AGACTTTTGG ACCGGTCTCC TTCAAGATCA ACAAAAAGGA AACCTTATCA TGTGGAAAGC 
AGCACCCTGT CTAATAGAAA CCAATCCACC AAGGGTGCTG CCTTACAGAC TCACCACAGA 
TCCAACAGCA AGGACATTCA GAACTTAAGT GTGGGTCTGC CCAGGGCTGA GGAAGGCCTG 
CCTGCAAACG AAAGCTTCCT CAATGGAAAC CTTGCTGGAG CAACTCTCAG CCCAATGCAC 
ACCAAAACCT ACCAAGCAAG CACCCAGCCT GGCTCTTCCA GCAAAGATCT CACAAACAAC 
AACATACCAC ACCTTCTCAG TCCAAAAGAA GCCAAGTCCA AAACAGAGTT TGACTTCAAT 
ATTGACACAA AGCCTTCAGA AGGTCCAGGC ACAAAGTACC TCAAGTCCAG CACCAGATCT 
CAGCAGAACA GGCACTCATT CATGGAAAGC TCCCAGAGCA AAGCTGGGAC CCTGCAGCCC 
AGTGAGAAGC AGAGTCGGCA CAGCTATATT GACACCATTC CCCAGTCCTC CCGGAGTCCA 
TCCTACAGGA CAAAGGCCAA AAGCCATGGG GCGTTGAGTG ACTCCAAGTC TGTGAGCAAC 
CTTTCCGAAG CCAGAGCCCA AATCACAGAG ACTAATACCA GTAGATACTT CCCATCCAGT 
TGTTTGGACT TGAACTCTCC CACCAGCCCA ACCCCCACCA GGCACACTGA TACGAGAACT 
TTGCTCAGCC CTTCCGGTCG AAATAATAGA AATGAAGGCA CTCTGGACTC ACGGCGAACC 
ACCACTAGAC ACTCAAAAAC CATGGAGGAG TTGAAGCTGC CTGAACACAT GGACAGCAGC 
CATTCGCATT CACTGTCTGC ACCTCATGAA TCATTTTCTT ATGGGCTAGG CTACACCAGC 
CCCTTCTCCT CTCAGCAGCG TCCTCACAGG CATTCCATGT ACGTGACCCG GGACAAAGTG 
AGAGCGAAAG GCCTTGATGG AAGCTTGAGC ATAGGACAAG GGATGGCAGC CAGAGCCAAC 
AGTTTGCAGC TCTTATCACC CCAGCCTGGA GAACAGCTCC CTCCAGAGAT GACTGTGGCA 
AGACCTTCTG TTAAAGAGTC CTCCCGAGAA GGCGCCTCTT CATTCCACAC CCGTCAGAAG 
TCTGAGGGTG GAGTATACCA TGACCCACAC TCTGACGACG GCACAGCTCC CAAAGAAAAT 
CGGCATCTGT ACAATGACCC TGTCCCAAGG AGAGTTGGTA GCTTTTATAG AGTGCCATCT 
CCACGACCAG ACAATTCTTT CCATGAAAAT AATGTGTCCA CTCGAGTTTC TTCTCTGCCA 
TCTGATAGCA GTTCTGGTAC AAATCATTCA AAAAGACAAC CAGGATTTGA TCCATGGAAA 
AGTCCTGAAA ACATTAGTCA TGCCGATCAA CTCAAAGAAA AGGAGAAGCA AGGTTTTTTC 
AGGTCAATGA AAAAGAAAAA GAAGAAAACT CAAACAGTGC CCAACACTGA CGGTCCTGAT 
CTATTGACCT TACAGAAAGC CATTCATTCT TCTAGCACTG CAAGCAGCAG ACCAAAGGAG 
TGGCGACCTG AGAAGCTCTC AGATCTACAG ACCCAGAGCC AACCACTAAA ATCTCTTCGA 
AAGCTGTTGC ATCTGTCTTC ATCAACCAAT CATCCAGCTT CTTCAGATCC TCGGTTCCAG 
CCCTTAACAG CTCAACAAGC CAAAAATTCC TTCTCAGAAA TTCGGATTCA CCCTCTGAGT 
CAGGCCACTG GTGGGAGCAG CAACATCCGG CAGGAGCCTA CACCAAAAGG CAGACCAGCC 
CTTCAGTTGC CAGGATCTTC CCTCTTAAGG TACAACGGAT GGAAACACTC AAGATCAAGA 
TCCAGCCAGC CAGACGAAGT GATCTTCTTG GCATCCCATG AGAAATGGAA ACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Site-specific abnormalities in the visual system of a mouse model of CDKL5 deficiency disorder.
Human molecular genetics28(17)2851-2861(2019 09)
Lupori L,Sagona G,Fuchs C,Mazziotti R,Stefanov A,Putignano E,Napoli D,Strettoi E,Ciani E,Pizzorusso T

Neuron-Type Specific Loss of CDKL5 Leads to Alterations in mTOR Signaling and Synaptic Markers.
Molecular neurobiology56(6)4151-4162(2019 Jun)
Schroeder E,Yuan L,Seong E,Ligon C,DeKorver N,Gurumurthy CB,Arikkath J

Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder.
Nature communications10(1)2655(2019 06)
Tang S,Terzic B,Wang IJ,Sarmiento N,Sizov K,Cui Y,Takano H,Marsh ED,Zhou Z,Coulter DA

AMPA Receptor Dysregulation and Therapeutic Interventions in a Mouse Model of CDKL5 Deficiency Disorder.
The Journal of neuroscience : the official journal of the Society for Neuroscience39(24)4814-4828(2019 Jun)
Yennawar M,White RS,Jensen FE

Functional and Structural Impairments in the Perirhinal Cortex of a Mouse Model of CDKL5 Deficiency Disorder Are Rescued by a TrkB Agonist.
Frontiers in cellular neuroscience13169(2019)
Ren E,Roncacé V,Trazzi S,Fuchs C,Medici G,Gennaccaro L,Loi M,Galvani G,Ye K,Rimondini R,Aicardi G,Ciani E

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Cdkl5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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