Pggt1b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pggt1b
Entrez Gene ID	225467
Full Name	protein geranylgeranyltransferase type I, beta subunit
Synonyms	2010207C17Rik,2610100E13,AI451237,AI551093,BGG1,GGT1
General protein information	Preferred Names protein geranylgeranyltransferase type I, beta subunit Names geranylgeranyl transferase type-1 subunit beta GGTase-I-beta geranylgeranyl transferase type I subunit beta type I protein geranyl-geranyltransferase subunit beta
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18\|18 C

mRNA and Protein(s)

mRNA	Protein	Name
XM_006525866.3	XP_006525929.1	geranylgeranyl transferase type-1 subunit beta isoform X1
XM_006525866.4	XP_006525929.1	geranylgeranyl transferase type-1 subunit beta isoform X1
NM_172627.3	NP_766215.1	geranylgeranyl transferase type-1 subunit beta

Pathways from BioSystems

Homologies

Homo sapiens (human)	PGGT1B	NP_005014.2
Mus musculus (house mouse)	Pggt1b	NP_766215.1
Gallus gallus (chicken)	PGGT1B	XP_003643150.1
Arabidopsis thaliana (thale cress)	PGGT-I	NP_181487.1
Xenopus tropicalis (tropical clawed frog)	pggt1b	NP_001008137.1
Pan troglodytes (chimpanzee)	PGGT1B	XP_526978.2
Canis lupus familiaris (dog)	PGGT1B	XP_538560.2
Rattus norvegicus (Norway rat)	Pggt1b	NP_112344.1
Drosophila melanogaster (fruit fly)	betaggt-I	NP_001260061.1
Bos taurus (cattle)	PGGT1B	NP_001015560.1
Oryza sativa (rice)	Os01g0150100	NP_001042031.1
Macaca mulatta (Rhesus monkey)	LOC696437	XP_002808482.1
Danio rerio (zebrafish)	pggt1b	NP_001025426.1
Caenorhabditis elegans (roundworm)	Y48E1B.3	NP_001254397.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008406	XP_317045.4

Gene Ontology
Bibliography

Related articles in PubMed

Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice.
López-Posadas R, Fastancz P, Martínez-Sánchez LDC, Panteleev-Ivlev J, Thonn V, Kisseleva T, Becker LS, Schulz-Kuhnt A, Zundler S, Wirtz S, Atreya R, Carlé B, Friedrich O, Schürmann S, Waldner MJ, Neufert C, Brakebusch CH, Bergö MO, Neurath MF, Atreya I
Gastroenterology157(5)1293-1309(2019 11)

Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation.
Balaz M, Becker AS, Balazova L, Straub L, Müller J, Gashi G, Maushart CI, Sun W, Dong H, Moser C, Horvath C, Efthymiou V, Rachamin Y, Modica S, Zellweger C, Bacanovic S, Stefanicka P, Varga L, Ukropcova B, Profant M, Opitz L, Amri EZ, Akula MK, Bergo M, Ukropec J, Falk C, Zamboni N, Betz MJ, Burger IA, Wolfrum C
Cell metabolism29(4)901-916.e8(2019 04)

Systemic or Forebrain Neuron-Specific Deficiency of Geranylgeranyltransferase-1 Impairs Synaptic Plasticity and Reduces Dendritic Spine Density.
Hottman D, Cheng S, Gram A, LeBlanc K, Yuan LL, Li L
Neuroscience373207-217(2018 03)

Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway.
Steinmetz CC, Tatavarty V, Sugino K, Shima Y, Joseph A, Lin H, Rutlin M, Lambo M, Hempel CM, Okaty BW, Paradis S, Nelson SB, Turrigiano GG
Cell reports16(10)2711-2722(2016 09)

Control of the innate immune response by the mevalonate pathway.
Akula MK, Shi M, Jiang Z, Foster CE, Miao D, Li AS, Zhang X, Gavin RM, Forde SD, Germain G, Carpenter S, Rosadini CV, Gritsman K, Chae JJ, Hampton R, Silverman N, Gravallese EM, Kagan JC, Fitzgerald KA, Kastner DL, Golenbock DT, Bergo MO, Wang D
Nature immunology17(8)922-9(2016 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Pggt1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pggt1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu19742	NM_172627.3 Latest version!	Mus musculus protein geranylgeranyltransferase type I, beta subunit (Pggt1b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OMu54536	XM_006525866.4 Latest version!	Mus musculus protein geranylgeranyltransferase type I, beta subunit (Pggt1b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu54536	XM_006525866.3	Mus musculus protein geranylgeranyltransferase type I, beta subunit (Pggt1b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pggt1b ( NM_172627.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_766215.1 Mus musculus protein geranylgeranyltransferase type I, beta subunit (Pggt1b), mRNA.

Price & Availability↑

CloneID	OMu19742
Clone ID Related Accession (Same CDS sequence)	NM_172627.3
Accession Version	NM_172627.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1134bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Mus musculus(house mouse)
Product	geranylgeranyl transferase type-1 subunit beta
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC124717.3. On May 2, 2007 this sequence version replaced NM_172627.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK081731.1, SRR1660811.155383.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138 [ECO:0000348] ##Evidence-Data-END##

ATGGCCACCA CCGAGGACGA CAGGCTGGCG GGGAGCGGAG AAGGAGAACG GCTGGATTTC 
CTGCGGGACC GGCACGTGCG GTTCTTTCAG CGCTGCCTCC AGGTCTTGCC GGAGCGGTAT 
TCCTCGCTGG AGACCAGCAG GTTGACAATT GCCTTTTTTG CACTCTCTGG GCTGGATATG 
CTGGACTCCT TGGATGTGGT GAACAAAGAC GATATAATAG AGTGGATCTA CTCCCTGCAG 
GTTCTTCCCA CAGAAGACAG GTCAAATCTG AGTCGCTGTG GTTTCCGAGG TTCTTCATAC 
CTGGGTATTC CATTCAATCC ATCAAAGAAT CCAGGAGCAG CCCATCCTTA CGACAGTGGA 
CACATAGCGA TGACGTACAC GGGGCTTTCC TGTCTGATCA TCCTTGGAGA TGACTTAGGC 
CGTGTGGATA AAGAGGCTTG CTTAGCAGGC TTGAGAGCGC TTCAGCTGGA AGACGGGAGC 
TTCTGTGCGG TTCCTGAAGG CAGTGAGAAT GACATGAGGT TTGTGTACTG CGCATCCTGC 
ATTTGCTATA TGCTCAACAA CTGGTCGGGC ATGGATATGA AGAAAGCCAT CAGCTACATT 
AGAAGAAGTA TGTCCTATGA CAATGGGCTG GCCCAGGGAG CAGGCCTTGA GTCTCATGGA 
GGATCCACCT TCTGTGGCAT TGCGTCACTG TGCCTGATGG GTAAACTGGA AGAAGTTTTT 
TCAGAGAAAG AACTGAACAG GATAAAGAGG TGGTGCATAA TGAGGCAGCA GAACGGGTAC 
CACGGGAGGC CTAACAAGCC CGTCGACACC TGCTACTCCT TCTGGGTGGG CGCAACACTG 
AAGCTTTTGA AAATTTTCCA GTACACTAAC TTTGAGAAGA ATAGGAACTA CATCTTATCA 
ACTCAAGATC GCCTTGTTGG GGGATTTGCT AAATGGCCAG ACAGTCATCC AGATGCTTTG 
CACGCGTACT TCGGGATCTG CGGCCTGTCA CTCATGGAGG AGAGTGGGAT TTGTAAAGTG 
CACCCTGCTC TGAATGTAAG CACACGGACT TCCGAGCGCC TCCGTGATCT CCATCAAAGC 
TGGAAGACCA AGGACTCCAA ACAGTGCTCA GACAATGTCC ACATTGCCAC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_766215.1
CDS	32..1165
Translation	MATTEDDRLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLSRCGFRGSSYLGIPFNPSKNPGAAHPYDSGHIAMTYTGLSCLIILGDDLGRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKTKDSKQCSDNVHIAT

Target ORF information:

RefSeq Version	NM_172627.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus protein geranylgeranyltransferase type I, beta subunit (Pggt1b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172627.3

ORF Insert Sequence:

ATGGCCACCA CCGAGGACGA CAGGCTGGCG GGGAGCGGAG AAGGAGAACG GCTGGATTTC 
CTGCGGGACC GGCACGTGCG GTTCTTTCAG CGCTGCCTCC AGGTCTTGCC GGAGCGGTAT 
TCCTCGCTGG AGACCAGCAG GTTGACAATT GCCTTTTTTG CACTCTCTGG GCTGGATATG 
CTGGACTCCT TGGATGTGGT GAACAAAGAC GATATAATAG AGTGGATCTA CTCCCTGCAG 
GTTCTTCCCA CAGAAGACAG GTCAAATCTG AGTCGCTGTG GTTTCCGAGG TTCTTCATAC 
CTGGGTATTC CATTCAATCC ATCAAAGAAT CCAGGAGCAG CCCATCCTTA CGACAGTGGA 
CACATAGCGA TGACGTACAC GGGGCTTTCC TGTCTGATCA TCCTTGGAGA TGACTTAGGC 
CGTGTGGATA AAGAGGCTTG CTTAGCAGGC TTGAGAGCGC TTCAGCTGGA AGACGGGAGC 
TTCTGTGCGG TTCCTGAAGG CAGTGAGAAT GACATGAGGT TTGTGTACTG CGCATCCTGC 
ATTTGCTATA TGCTCAACAA CTGGTCGGGC ATGGATATGA AGAAAGCCAT CAGCTACATT 
AGAAGAAGTA TGTCCTATGA CAATGGGCTG GCCCAGGGAG CAGGCCTTGA GTCTCATGGA 
GGATCCACCT TCTGTGGCAT TGCGTCACTG TGCCTGATGG GTAAACTGGA AGAAGTTTTT 
TCAGAGAAAG AACTGAACAG GATAAAGAGG TGGTGCATAA TGAGGCAGCA GAACGGGTAC 
CACGGGAGGC CTAACAAGCC CGTCGACACC TGCTACTCCT TCTGGGTGGG CGCAACACTG 
AAGCTTTTGA AAATTTTCCA GTACACTAAC TTTGAGAAGA ATAGGAACTA CATCTTATCA 
ACTCAAGATC GCCTTGTTGG GGGATTTGCT AAATGGCCAG ACAGTCATCC AGATGCTTTG 
CACGCGTACT TCGGGATCTG CGGCCTGTCA CTCATGGAGG AGAGTGGGAT TTGTAAAGTG 
CACCCTGCTC TGAATGTAAG CACACGGACT TCCGAGCGCC TCCGTGATCT CCATCAAAGC 
TGGAAGACCA AGGACTCCAA ACAGTGCTCA GACAATGTCC ACATTGCCAC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pggt1b ( XM_006525866.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006525929.1 Mus musculus protein geranylgeranyltransferase type I, beta subunit (Pggt1b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu54536
Clone ID Related Accession (Same CDS sequence)	XM_006525866.3 , XM_006525866.4
Accession Version	XM_006525866.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 765bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1466438400000
Organism	Mus musculus(house mouse)
Product	geranylgeranyl transferase type-1 subunit beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000084.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006525866.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACGTACA CGGGGCTTTC CTGTCTGATC ATCCTTGGAG ATGACTTAGG CCGTGTGGAT 
AAAGAGGCTT GCTTAGCAGG CTTGAGAGCG CTTCAGCTGG AAGACGGGAG CTTCTGTGCG 
GTTCCTGAAG GCAGTGAGAA TGACATGAGG TTTGTGTACT GCGCATCCTG CATTTGCTAT 
ATGCTCAACA ACTGGTCGGG CATGGATATG AAGAAAGCCA TCAGCTACAT TAGAAGAAGT 
ATGTCCTATG ACAATGGGCT GGCCCAGGGA GCAGGCCTTG AGTCTCATGG AGGATCCACC 
TTCTGTGGCA TTGCGTCACT GTGCCTGATG GGTAAACTGG AAGAAGTTTT TTCAGAGAAA 
GAACTGAACA GGATAAAGAG GTGGTGCATA ATGAGGCAGC AGAACGGGTA CCACGGGAGG 
CCTAACAAGC CCGTCGACAC CTGCTACTCC TTCTGGGTGG GCGCAACACT GAAGCTTTTG 
AAAATTTTCC AGTACACTAA CTTTGAGAAG AATAGGAACT ACATCTTATC AACTCAAGAT 
CGCCTTGTTG GGGGATTTGC TAAATGGCCA GACAGTCATC CAGATGCTTT GCACGCGTAC 
TTCGGGATCT GCGGCCTGTC ACTCATGGAG GAGAGTGGGA TTTGTAAAGT GCACCCTGCT 
CTGAATGTAA GCACACGGAC TTCCGAGCGC CTCCGTGATC TCCATCAAAG CTGGAAGACC 
AAGGACTCCA AACAGTGCTC AGACAATGTC CACATTGCCA CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006525929.1
CDS	382..1146
Translation	MTYTGLSCLIILGDDLGRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKTKDSKQCSDNVHIAT

Target ORF information:

RefSeq Version	XM_006525866.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus protein geranylgeranyltransferase type I, beta subunit (Pggt1b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006525866.3

ORF Insert Sequence:

ATGACGTACA CGGGGCTTTC CTGTCTGATC ATCCTTGGAG ATGACTTAGG CCGTGTGGAT 
AAAGAGGCTT GCTTAGCAGG CTTGAGAGCG CTTCAGCTGG AAGACGGGAG CTTCTGTGCG 
GTTCCTGAAG GCAGTGAGAA TGACATGAGG TTTGTGTACT GCGCATCCTG CATTTGCTAT 
ATGCTCAACA ACTGGTCGGG CATGGATATG AAGAAAGCCA TCAGCTACAT TAGAAGAAGT 
ATGTCCTATG ACAATGGGCT GGCCCAGGGA GCAGGCCTTG AGTCTCATGG AGGATCCACC 
TTCTGTGGCA TTGCGTCACT GTGCCTGATG GGTAAACTGG AAGAAGTTTT TTCAGAGAAA 
GAACTGAACA GGATAAAGAG GTGGTGCATA ATGAGGCAGC AGAACGGGTA CCACGGGAGG 
CCTAACAAGC CCGTCGACAC CTGCTACTCC TTCTGGGTGG GCGCAACACT GAAGCTTTTG 
AAAATTTTCC AGTACACTAA CTTTGAGAAG AATAGGAACT ACATCTTATC AACTCAAGAT 
CGCCTTGTTG GGGGATTTGC TAAATGGCCA GACAGTCATC CAGATGCTTT GCACGCGTAC 
TTCGGGATCT GCGGCCTGTC ACTCATGGAG GAGAGTGGGA TTTGTAAAGT GCACCCTGCT 
CTGAATGTAA GCACACGGAC TTCCGAGCGC CTCCGTGATC TCCATCAAAG CTGGAAGACC 
AAGGACTCCA AACAGTGCTC AGACAATGTC CACATTGCCA CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pggt1b ( XM_006525866.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006525929.1 Mus musculus protein geranylgeranyltransferase type I, beta subunit (Pggt1b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu54536
Clone ID Related Accession (Same CDS sequence)	XM_006525866.3 , XM_006525866.4
Accession Version	XM_006525866.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 765bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565107200000
Organism	Mus musculus(house mouse)
Product	geranylgeranyl transferase type-1 subunit beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000084.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006525866.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACGTACA CGGGGCTTTC CTGTCTGATC ATCCTTGGAG ATGACTTAGG CCGTGTGGAT 
AAAGAGGCTT GCTTAGCAGG CTTGAGAGCG CTTCAGCTGG AAGACGGGAG CTTCTGTGCG 
GTTCCTGAAG GCAGTGAGAA TGACATGAGG TTTGTGTACT GCGCATCCTG CATTTGCTAT 
ATGCTCAACA ACTGGTCGGG CATGGATATG AAGAAAGCCA TCAGCTACAT TAGAAGAAGT 
ATGTCCTATG ACAATGGGCT GGCCCAGGGA GCAGGCCTTG AGTCTCATGG AGGATCCACC 
TTCTGTGGCA TTGCGTCACT GTGCCTGATG GGTAAACTGG AAGAAGTTTT TTCAGAGAAA 
GAACTGAACA GGATAAAGAG GTGGTGCATA ATGAGGCAGC AGAACGGGTA CCACGGGAGG 
CCTAACAAGC CCGTCGACAC CTGCTACTCC TTCTGGGTGG GCGCAACACT GAAGCTTTTG 
AAAATTTTCC AGTACACTAA CTTTGAGAAG AATAGGAACT ACATCTTATC AACTCAAGAT 
CGCCTTGTTG GGGGATTTGC TAAATGGCCA GACAGTCATC CAGATGCTTT GCACGCGTAC 
TTCGGGATCT GCGGCCTGTC ACTCATGGAG GAGAGTGGGA TTTGTAAAGT GCACCCTGCT 
CTGAATGTAA GCACACGGAC TTCCGAGCGC CTCCGTGATC TCCATCAAAG CTGGAAGACC 
AAGGACTCCA AACAGTGCTC AGACAATGTC CACATTGCCA CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006525929.1
CDS	644..1408
Translation	MTYTGLSCLIILGDDLGRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKTKDSKQCSDNVHIAT

Target ORF information:

RefSeq Version	XM_006525866.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus protein geranylgeranyltransferase type I, beta subunit (Pggt1b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006525866.4

ORF Insert Sequence:

ATGACGTACA CGGGGCTTTC CTGTCTGATC ATCCTTGGAG ATGACTTAGG CCGTGTGGAT 
AAAGAGGCTT GCTTAGCAGG CTTGAGAGCG CTTCAGCTGG AAGACGGGAG CTTCTGTGCG 
GTTCCTGAAG GCAGTGAGAA TGACATGAGG TTTGTGTACT GCGCATCCTG CATTTGCTAT 
ATGCTCAACA ACTGGTCGGG CATGGATATG AAGAAAGCCA TCAGCTACAT TAGAAGAAGT 
ATGTCCTATG ACAATGGGCT GGCCCAGGGA GCAGGCCTTG AGTCTCATGG AGGATCCACC 
TTCTGTGGCA TTGCGTCACT GTGCCTGATG GGTAAACTGG AAGAAGTTTT TTCAGAGAAA 
GAACTGAACA GGATAAAGAG GTGGTGCATA ATGAGGCAGC AGAACGGGTA CCACGGGAGG 
CCTAACAAGC CCGTCGACAC CTGCTACTCC TTCTGGGTGG GCGCAACACT GAAGCTTTTG 
AAAATTTTCC AGTACACTAA CTTTGAGAAG AATAGGAACT ACATCTTATC AACTCAAGAT 
CGCCTTGTTG GGGGATTTGC TAAATGGCCA GACAGTCATC CAGATGCTTT GCACGCGTAC 
TTCGGGATCT GCGGCCTGTC ACTCATGGAG GAGAGTGGGA TTTGTAAAGT GCACCCTGCT 
CTGAATGTAA GCACACGGAC TTCCGAGCGC CTCCGTGATC TCCATCAAAG CTGGAAGACC 
AAGGACTCCA AACAGTGCTC AGACAATGTC CACATTGCCA CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice.
Gastroenterology157(5)1293-1309(2019 11)
López-Posadas R,Fastancz P,Martínez-Sánchez LDC,Panteleev-Ivlev J,Thonn V,Kisseleva T,Becker LS,Schulz-Kuhnt A,Zundler S,Wirtz S,Atreya R,Carlé B,Friedrich O,Schürmann S,Waldner MJ,Neufert C,Brakebusch CH,Bergö MO,Neurath MF,Atreya I

Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation.
Cell metabolism29(4)901-916.e8(2019 04)
Balaz M,Becker AS,Balazova L,Straub L,Müller J,Gashi G,Maushart CI,Sun W,Dong H,Moser C,Horvath C,Efthymiou V,Rachamin Y,Modica S,Zellweger C,Bacanovic S,Stefanicka P,Varga L,Ukropcova B,Profant M,Opitz L,Amri EZ,Akula MK,Bergo M,Ukropec J,Falk C,Zamboni N,Betz MJ,Burger IA,Wolfrum C

Systemic or Forebrain Neuron-Specific Deficiency of Geranylgeranyltransferase-1 Impairs Synaptic Plasticity and Reduces Dendritic Spine Density.
Neuroscience373207-217(2018 03)
Hottman D,Cheng S,Gram A,LeBlanc K,Yuan LL,Li L

Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway.
Cell reports16(10)2711-2722(2016 09)
Steinmetz CC,Tatavarty V,Sugino K,Shima Y,Joseph A,Lin H,Rutlin M,Lambo M,Hempel CM,Okaty BW,Paradis S,Nelson SB,Turrigiano GG

Control of the innate immune response by the mevalonate pathway.
Nature immunology17(8)922-9(2016 08)
Akula MK,Shi M,Jiang Z,Foster CE,Miao D,Li AS,Zhang X,Gavin RM,Forde SD,Germain G,Carpenter S,Rosadini CV,Gritsman K,Chae JJ,Hampton R,Silverman N,Gravallese EM,Kagan JC,Fitzgerald KA,Kastner DL,Golenbock DT,Bergo MO,Wang D

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Pggt1b cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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