GGH cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GGH
Entrez Gene ID	8836
Full Name	gamma-glutamyl hydrolase
Synonyms	GH
General protein information	Preferred Names gamma-glutamyl hydrolase Names gamma-glutamyl hydrolase gamma-Glu-X carboxypeptidase gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q12.3
Summary	This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008].
Disorder MIM:	601509

mRNA and Protein(s)

mRNA	Protein	Name
XM_011517623.3	XP_011515925.1	gamma-glutamyl hydrolase isoform X1
XM_011517623.2	XP_011515925.1	gamma-glutamyl hydrolase isoform X1
NM_003878.2	NP_003869.1	gamma-glutamyl hydrolase precursor
NM_003878.3	NP_003869.1	gamma-glutamyl hydrolase precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	ggh	NP_998487.1
Mus musculus (house mouse)	Ggh	NP_034411.2
Gallus gallus (chicken)	GGH	XP_419226.4
Drosophila melanogaster (fruit fly)	l(3)72Dp	NP_730119.1
Arabidopsis thaliana (thale cress)	GGH1	NP_177987.1
Xenopus tropicalis (tropical clawed frog)	ggh	NP_001025598.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006670	XP_316706.4
Rattus norvegicus (Norway rat)	Ggh	NP_037092.1
Homo sapiens (human)	GGH	NP_003869.1
Bos taurus (cattle)	GGH	NP_001098864.1
Arabidopsis thaliana (thale cress)	GGH2	NP_565186.2
Oryza sativa (rice)	Os05g0517500	NP_001056052.1
Pan troglodytes (chimpanzee)	GGH	XP_001159345.1
Macaca mulatta (Rhesus monkey)	GGH	XP_001091897.1
Arabidopsis thaliana (thale cress)	GGH3	NP_177988.1
Canis lupus familiaris (dog)	GGH	XP_003640062.1

Gene Ontology
Bibliography

Related articles in PubMed

Do SNPs in folate pharmacokinetic pathway alter levels of intracellular methotrexate polyglutamates and affect response? A prospective study in Indian patients.
Sandhu A, Ahmad S, Kaur J, Bhatnagar A, Dhawan V, Dhir V
Clinical rheumatology37(12)3221-3228(2018 Dec)

High-Level γ-Glutamyl-Hydrolase (GGH) Expression is Linked to Poor Prognosis in ERG Negative Prostate Cancer.
Melling N, Rashed M, Schroeder C, Hube-Magg C, Kluth M, Lang D, Simon R, Möller-Koop C, Steurer S, Sauter G, Jacobsen F, Büscheck F, Wittmer C, Clauditz T, Krech T, Tsourlakis MC, Minner S, Huland H, Graefen M, Budäus L, Thederan I, Salomon G, Schlomm T, Wilczak W
International journal of molecular sciences18(2)(2017 Jan)

Methylation level of CpG islands in GGH gene promoter in pediatric acute leukemia.
Li Y, Liu S, Wang H, Mai H, Yuan X, Li C, Chen X, Wen F
PloS one12(3)e0173472(2017)

Tumor-related gene expression levels in thymic carcinoma and Type B3 thymoma.
Karube Y, Kobayashi S, Maeda S, Sado T, Ishihama H, Chida M
Journal of cardiothoracic surgery11(1)85(2016 May)

Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis.
Shimamoto Y, Nukatsuka M, Takechi T, Fukushima M
International journal of molecular medicine37(2)319-28(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GGH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GGH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu62231	XM_011517623.3 Latest version!	Homo sapiens gamma-glutamyl hydrolase (GGH), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu19141	NM_003878.3 Latest version!	Homo sapiens gamma-glutamyl hydrolase (GGH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00
View Old Accession Versions >>
OHu62231	XM_011517623.2	Homo sapiens gamma-glutamyl hydrolase (GGH), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu19141	NM_003878.2	Homo sapiens gamma-glutamyl hydrolase (GGH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GGH ( XM_011517623.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011515925.1 Homo sapiens gamma-glutamyl hydrolase (GGH), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu62231
Clone ID Related Accession (Same CDS sequence)	XM_011517623.3 , XM_011517623.2
Accession Version	XM_011517623.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	gamma-glutamyl hydrolase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011517623.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCAGTC CGGGCTGCCT GCTGTGCGTG CTGGGCCTGC TACTCTGCGG GGCGGCGAGC 
CTCGAGCTGT CTAGACCCCA CGGCGACACC GCCAAGAAGC CCATCATCGG AATATTAATG 
CAAAAATGCC GTAATAAAGT CATGAAAAAC TATGGAAGAT ACTATATTGC TGCGTCCTAT 
GTAAAGTACT TGGAGTCTGC AGGTGCGAGA GTTGTACCAG TAAGGCTGGA TCTTACAGAG 
AAAGACTATG AAATACTTTT CAAATCTATT AATGGAATCC TTTTCCCTGG AGGAAGTGTT 
GACCTCAGAC GCTCAGATTA TGCTAAAGTG GCCAAAATAT TTTATAACTT GTCCATACAG 
AGTTTTGATG ATGGAGACTA TTTTCCTGTG TGGGGCACAT GCCTTGGATT TGAAGAGCTT 
TCACTGCTGA TTAGTGGAGA GTGCTTATTA ACTGCCACAG ATACTGTTGA CGTGGCAATG 
CCGCTGAACT TCACTGGAGG TCAATTGCAC AGCAGAATGT TCCAGAATTT TCCTACTGAG 
TTGTTGCTGT CATTAGCAGT AGAACCTCTG ACTGCCAATT TCCATAAGTG GAGCCTCTCC 
GTGAAGAATT TTACAATGAA TGAAAAGTTA AAGAAGTTTT TCAATGTCTT AACTACAAAT 
ACAGATGGCA AGATTGAGTT TATTTCAACA ATGGAAGTTT TCCTGGGTAT TTTCCTGAAT 
GGGGTGGTGA AGAAGAAAAG TAAAAGAATA AAGGGGGCAA GGATGAAGAA AGAAATGAAG 
AAAATGACTT CTGTTTCTAG CAATATTGCA GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011515925.1
CDS	35..850
Translation	MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCRNKVMKNYGRYYIAASYVKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRSDYAKVAKIFYNLSIQSFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTELLLSLAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTDGKIEFISTMEVFLGIFLNGVVKKKSKRIKGARMKKEMKKMTSVSSNIAD

Target ORF information:

RefSeq Version	XM_011517623.3
Organism	Homo sapiens(human)
Definition	Homo sapiens gamma-glutamyl hydrolase (GGH), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011517623.3

ORF Insert Sequence:

ATGGCCAGTC CGGGCTGCCT GCTGTGCGTG CTGGGCCTGC TACTCTGCGG GGCGGCGAGC 
CTCGAGCTGT CTAGACCCCA CGGCGACACC GCCAAGAAGC CCATCATCGG AATATTAATG 
CAAAAATGCC GTAATAAAGT CATGAAAAAC TATGGAAGAT ACTATATTGC TGCGTCCTAT 
GTAAAGTACT TGGAGTCTGC AGGTGCGAGA GTTGTACCAG TAAGGCTGGA TCTTACAGAG 
AAAGACTATG AAATACTTTT CAAATCTATT AATGGAATCC TTTTCCCTGG AGGAAGTGTT 
GACCTCAGAC GCTCAGATTA TGCTAAAGTG GCCAAAATAT TTTATAACTT GTCCATACAG 
AGTTTTGATG ATGGAGACTA TTTTCCTGTG TGGGGCACAT GCCTTGGATT TGAAGAGCTT 
TCACTGCTGA TTAGTGGAGA GTGCTTATTA ACTGCCACAG ATACTGTTGA CGTGGCAATG 
CCGCTGAACT TCACTGGAGG TCAATTGCAC AGCAGAATGT TCCAGAATTT TCCTACTGAG 
TTGTTGCTGT CATTAGCAGT AGAACCTCTG ACTGCCAATT TCCATAAGTG GAGCCTCTCC 
GTGAAGAATT TTACAATGAA TGAAAAGTTA AAGAAGTTTT TCAATGTCTT AACTACAAAT 
ACAGATGGCA AGATTGAGTT TATTTCAACA ATGGAAGTTT TCCTGGGTAT TTTCCTGAAT 
GGGGTGGTGA AGAAGAAAAG TAAAAGAATA AAGGGGGCAA GGATGAAGAA AGAAATGAAG 
AAAATGACTT CTGTTTCTAG CAATATTGCA GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GGH ( XM_011517623.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011515925.1 Homo sapiens gamma-glutamyl hydrolase (GGH), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu62231
Clone ID Related Accession (Same CDS sequence)	XM_011517623.3 , XM_011517623.2
Accession Version	XM_011517623.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1465056000000
Organism	Homo sapiens(human)
Product	gamma-glutamyl hydrolase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011517623.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCAGTC CGGGCTGCCT GCTGTGCGTG CTGGGCCTGC TACTCTGCGG GGCGGCGAGC 
CTCGAGCTGT CTAGACCCCA CGGCGACACC GCCAAGAAGC CCATCATCGG AATATTAATG 
CAAAAATGCC GTAATAAAGT CATGAAAAAC TATGGAAGAT ACTATATTGC TGCGTCCTAT 
GTAAAGTACT TGGAGTCTGC AGGTGCGAGA GTTGTACCAG TAAGGCTGGA TCTTACAGAG 
AAAGACTATG AAATACTTTT CAAATCTATT AATGGAATCC TTTTCCCTGG AGGAAGTGTT 
GACCTCAGAC GCTCAGATTA TGCTAAAGTG GCCAAAATAT TTTATAACTT GTCCATACAG 
AGTTTTGATG ATGGAGACTA TTTTCCTGTG TGGGGCACAT GCCTTGGATT TGAAGAGCTT 
TCACTGCTGA TTAGTGGAGA GTGCTTATTA ACTGCCACAG ATACTGTTGA CGTGGCAATG 
CCGCTGAACT TCACTGGAGG TCAATTGCAC AGCAGAATGT TCCAGAATTT TCCTACTGAG 
TTGTTGCTGT CATTAGCAGT AGAACCTCTG ACTGCCAATT TCCATAAGTG GAGCCTCTCC 
GTGAAGAATT TTACAATGAA TGAAAAGTTA AAGAAGTTTT TCAATGTCTT AACTACAAAT 
ACAGATGGCA AGATTGAGTT TATTTCAACA ATGGAAGTTT TCCTGGGTAT TTTCCTGAAT 
GGGGTGGTGA AGAAGAAAAG TAAAAGAATA AAGGGGGCAA GGATGAAGAA AGAAATGAAG 
AAAATGACTT CTGTTTCTAG CAATATTGCA GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011515925.1
CDS	35..850
Translation	MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCRNKVMKNYGRYYIAASYVKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRSDYAKVAKIFYNLSIQSFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTELLLSLAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTDGKIEFISTMEVFLGIFLNGVVKKKSKRIKGARMKKEMKKMTSVSSNIAD

Target ORF information:

RefSeq Version	XM_011517623.2
Organism	Homo sapiens(human)
Definition	Homo sapiens gamma-glutamyl hydrolase (GGH), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011517623.2

ORF Insert Sequence:

ATGGCCAGTC CGGGCTGCCT GCTGTGCGTG CTGGGCCTGC TACTCTGCGG GGCGGCGAGC 
CTCGAGCTGT CTAGACCCCA CGGCGACACC GCCAAGAAGC CCATCATCGG AATATTAATG 
CAAAAATGCC GTAATAAAGT CATGAAAAAC TATGGAAGAT ACTATATTGC TGCGTCCTAT 
GTAAAGTACT TGGAGTCTGC AGGTGCGAGA GTTGTACCAG TAAGGCTGGA TCTTACAGAG 
AAAGACTATG AAATACTTTT CAAATCTATT AATGGAATCC TTTTCCCTGG AGGAAGTGTT 
GACCTCAGAC GCTCAGATTA TGCTAAAGTG GCCAAAATAT TTTATAACTT GTCCATACAG 
AGTTTTGATG ATGGAGACTA TTTTCCTGTG TGGGGCACAT GCCTTGGATT TGAAGAGCTT 
TCACTGCTGA TTAGTGGAGA GTGCTTATTA ACTGCCACAG ATACTGTTGA CGTGGCAATG 
CCGCTGAACT TCACTGGAGG TCAATTGCAC AGCAGAATGT TCCAGAATTT TCCTACTGAG 
TTGTTGCTGT CATTAGCAGT AGAACCTCTG ACTGCCAATT TCCATAAGTG GAGCCTCTCC 
GTGAAGAATT TTACAATGAA TGAAAAGTTA AAGAAGTTTT TCAATGTCTT AACTACAAAT 
ACAGATGGCA AGATTGAGTT TATTTCAACA ATGGAAGTTT TCCTGGGTAT TTTCCTGAAT 
GGGGTGGTGA AGAAGAAAAG TAAAAGAATA AAGGGGGCAA GGATGAAGAA AGAAATGAAG 
AAAATGACTT CTGTTTCTAG CAATATTGCA GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GGH ( NM_003878.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003869.1 Homo sapiens gamma-glutamyl hydrolase (GGH), mRNA.

Price & Availability↑

CloneID	OHu19141
Clone ID Related Accession (Same CDS sequence)	NM_003878.2 , NM_003878.3
Accession Version	NM_003878.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506787200000
Organism	Homo sapiens(human)
Product	gamma-glutamyl hydrolase precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC120042.3 and BC025025.1. This sequence is a reference standard in the RefSeqGene project. On Dec 2, 2008 this sequence version replaced NM_003878.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.419599.1, SRR1803613.242668.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCAGTC CGGGCTGCCT GCTGTGCGTG CTGGGCCTGC TACTCTGCGG GGCGGCGAGC 
CTCGAGCTGT CTAGACCCCA CGGCGACACC GCCAAGAAGC CCATCATCGG AATATTAATG 
CAAAAATGCC GTAATAAAGT CATGAAAAAC TATGGAAGAT ACTATATTGC TGCGTCCTAT 
GTAAAGTACT TGGAGTCTGC AGGTGCGAGA GTTGTACCAG TAAGGCTGGA TCTTACAGAG 
AAAGACTATG AAATACTTTT CAAATCTATT AATGGAATCC TTTTCCCTGG AGGAAGTGTT 
GACCTCAGAC GCTCAGATTA TGCTAAAGTG GCCAAAATAT TTTATAACTT GTCCATACAG 
AGTTTTGATG ATGGAGACTA TTTTCCTGTG TGGGGCACAT GCCTTGGATT TGAAGAGCTT 
TCACTGCTGA TTAGTGGAGA GTGCTTATTA ACTGCCACAG ATACTGTTGA CGTGGCAATG 
CCGCTGAACT TCACTGGAGG TCAATTGCAC AGCAGAATGT TCCAGAATTT TCCTACTGAG 
TTGTTGCTGT CATTAGCAGT AGAACCTCTG ACTGCCAATT TCCATAAGTG GAGCCTCTCC 
GTGAAGAATT TTACAATGAA TGAAAAGTTA AAGAAGTTTT TCAATGTCTT AACTACAAAT 
ACAGATGGCA AGATTGAGTT TATTTCAACA ATGGAAGGAT ATAAGTATCC AGTATATGGT 
GTCCAGTGGC ATCCAGAGAA AGCACCTTAT GAGTGGAAGA ATTTGGATGG CATTTCCCAT 
GCACCTAATG CTGTGAAAAC CGCATTTTAT TTAGCAGAGT TTTTTGTTAA TGAAGCTCGG 
AAAAACAACC ATCATTTTAA ATCTGAATCT GAAGAGGAGA AAGCATTGAT TTATCAGTTC 
AGTCCAATTT ATACTGGAAA TATTTCTTCA TTTCAGCAAT GTTACATATT TGATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003869.1
CDS	284..1240
Translation	MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCRNKVMKNYGRYYIAASYVKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRSDYAKVAKIFYNLSIQSFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTELLLSLAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTDGKIEFISTMEGYKYPVYGVQWHPEKAPYEWKNLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEEKALIYQFSPIYTGNISSFQQCYIFD

Target ORF information:

RefSeq Version	NM_003878.2
Organism	Homo sapiens(human)
Definition	Homo sapiens gamma-glutamyl hydrolase (GGH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003878.2

ORF Insert Sequence:

ATGGCCAGTC CGGGCTGCCT GCTGTGCGTG CTGGGCCTGC TACTCTGCGG GGCGGCGAGC 
CTCGAGCTGT CTAGACCCCA CGGCGACACC GCCAAGAAGC CCATCATCGG AATATTAATG 
CAAAAATGCC GTAATAAAGT CATGAAAAAC TATGGAAGAT ACTATATTGC TGCGTCCTAT 
GTAAAGTACT TGGAGTCTGC AGGTGCGAGA GTTGTACCAG TAAGGCTGGA TCTTACAGAG 
AAAGACTATG AAATACTTTT CAAATCTATT AATGGAATCC TTTTCCCTGG AGGAAGTGTT 
GACCTCAGAC GCTCAGATTA TGCTAAAGTG GCCAAAATAT TTTATAACTT GTCCATACAG 
AGTTTTGATG ATGGAGACTA TTTTCCTGTG TGGGGCACAT GCCTTGGATT TGAAGAGCTT 
TCACTGCTGA TTAGTGGAGA GTGCTTATTA ACTGCCACAG ATACTGTTGA CGTGGCAATG 
CCGCTGAACT TCACTGGAGG TCAATTGCAC AGCAGAATGT TCCAGAATTT TCCTACTGAG 
TTGTTGCTGT CATTAGCAGT AGAACCTCTG ACTGCCAATT TCCATAAGTG GAGCCTCTCC 
GTGAAGAATT TTACAATGAA TGAAAAGTTA AAGAAGTTTT TCAATGTCTT AACTACAAAT 
ACAGATGGCA AGATTGAGTT TATTTCAACA ATGGAAGGAT ATAAGTATCC AGTATATGGT 
GTCCAGTGGC ATCCAGAGAA AGCACCTTAT GAGTGGAAGA ATTTGGATGG CATTTCCCAT 
GCACCTAATG CTGTGAAAAC CGCATTTTAT TTAGCAGAGT TTTTTGTTAA TGAAGCTCGG 
AAAAACAACC ATCATTTTAA ATCTGAATCT GAAGAGGAGA AAGCATTGAT TTATCAGTTC 
AGTCCAATTT ATACTGGAAA TATTTCTTCA TTTCAGCAAT GTTACATATT TGATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GGH ( NM_003878.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003869.1 Homo sapiens gamma-glutamyl hydrolase (GGH), mRNA.

Price & Availability↑

CloneID	OHu19141
Clone ID Related Accession (Same CDS sequence)	NM_003878.2 , NM_003878.3
Accession Version	NM_003878.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1566316800000
Organism	Homo sapiens(human)
Product	gamma-glutamyl hydrolase precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC025025.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_003878.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC025025.1, SRR1163655.419599.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000260118.7/ ENSP00000260118.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCAGTC CGGGCTGCCT GCTGTGCGTG CTGGGCCTGC TACTCTGCGG GGCGGCGAGC 
CTCGAGCTGT CTAGACCCCA CGGCGACACC GCCAAGAAGC CCATCATCGG AATATTAATG 
CAAAAATGCC GTAATAAAGT CATGAAAAAC TATGGAAGAT ACTATATTGC TGCGTCCTAT 
GTAAAGTACT TGGAGTCTGC AGGTGCGAGA GTTGTACCAG TAAGGCTGGA TCTTACAGAG 
AAAGACTATG AAATACTTTT CAAATCTATT AATGGAATCC TTTTCCCTGG AGGAAGTGTT 
GACCTCAGAC GCTCAGATTA TGCTAAAGTG GCCAAAATAT TTTATAACTT GTCCATACAG 
AGTTTTGATG ATGGAGACTA TTTTCCTGTG TGGGGCACAT GCCTTGGATT TGAAGAGCTT 
TCACTGCTGA TTAGTGGAGA GTGCTTATTA ACTGCCACAG ATACTGTTGA CGTGGCAATG 
CCGCTGAACT TCACTGGAGG TCAATTGCAC AGCAGAATGT TCCAGAATTT TCCTACTGAG 
TTGTTGCTGT CATTAGCAGT AGAACCTCTG ACTGCCAATT TCCATAAGTG GAGCCTCTCC 
GTGAAGAATT TTACAATGAA TGAAAAGTTA AAGAAGTTTT TCAATGTCTT AACTACAAAT 
ACAGATGGCA AGATTGAGTT TATTTCAACA ATGGAAGGAT ATAAGTATCC AGTATATGGT 
GTCCAGTGGC ATCCAGAGAA AGCACCTTAT GAGTGGAAGA ATTTGGATGG CATTTCCCAT 
GCACCTAATG CTGTGAAAAC CGCATTTTAT TTAGCAGAGT TTTTTGTTAA TGAAGCTCGG 
AAAAACAACC ATCATTTTAA ATCTGAATCT GAAGAGGAGA AAGCATTGAT TTATCAGTTC 
AGTCCAATTT ATACTGGAAA TATTTCTTCA TTTCAGCAAT GTTACATATT TGATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003869.1
CDS	39..995
Translation	MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCRNKVMKNYGRYYIAASYVKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRSDYAKVAKIFYNLSIQSFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTELLLSLAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTDGKIEFISTMEGYKYPVYGVQWHPEKAPYEWKNLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEEKALIYQFSPIYTGNISSFQQCYIFD

Target ORF information:

RefSeq Version	NM_003878.3
Organism	Homo sapiens(human)
Definition	Homo sapiens gamma-glutamyl hydrolase (GGH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003878.3

ORF Insert Sequence:

ATGGCCAGTC CGGGCTGCCT GCTGTGCGTG CTGGGCCTGC TACTCTGCGG GGCGGCGAGC 
CTCGAGCTGT CTAGACCCCA CGGCGACACC GCCAAGAAGC CCATCATCGG AATATTAATG 
CAAAAATGCC GTAATAAAGT CATGAAAAAC TATGGAAGAT ACTATATTGC TGCGTCCTAT 
GTAAAGTACT TGGAGTCTGC AGGTGCGAGA GTTGTACCAG TAAGGCTGGA TCTTACAGAG 
AAAGACTATG AAATACTTTT CAAATCTATT AATGGAATCC TTTTCCCTGG AGGAAGTGTT 
GACCTCAGAC GCTCAGATTA TGCTAAAGTG GCCAAAATAT TTTATAACTT GTCCATACAG 
AGTTTTGATG ATGGAGACTA TTTTCCTGTG TGGGGCACAT GCCTTGGATT TGAAGAGCTT 
TCACTGCTGA TTAGTGGAGA GTGCTTATTA ACTGCCACAG ATACTGTTGA CGTGGCAATG 
CCGCTGAACT TCACTGGAGG TCAATTGCAC AGCAGAATGT TCCAGAATTT TCCTACTGAG 
TTGTTGCTGT CATTAGCAGT AGAACCTCTG ACTGCCAATT TCCATAAGTG GAGCCTCTCC 
GTGAAGAATT TTACAATGAA TGAAAAGTTA AAGAAGTTTT TCAATGTCTT AACTACAAAT 
ACAGATGGCA AGATTGAGTT TATTTCAACA ATGGAAGGAT ATAAGTATCC AGTATATGGT 
GTCCAGTGGC ATCCAGAGAA AGCACCTTAT GAGTGGAAGA ATTTGGATGG CATTTCCCAT 
GCACCTAATG CTGTGAAAAC CGCATTTTAT TTAGCAGAGT TTTTTGTTAA TGAAGCTCGG 
AAAAACAACC ATCATTTTAA ATCTGAATCT GAAGAGGAGA AAGCATTGAT TTATCAGTTC 
AGTCCAATTT ATACTGGAAA TATTTCTTCA TTTCAGCAAT GTTACATATT TGATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Do SNPs in folate pharmacokinetic pathway alter levels of intracellular methotrexate polyglutamates and affect response? A prospective study in Indian patients.
Clinical rheumatology37(12)3221-3228(2018 Dec)
Sandhu A,Ahmad S,Kaur J,Bhatnagar A,Dhawan V,Dhir V

High-Level γ-Glutamyl-Hydrolase (GGH) Expression is Linked to Poor Prognosis in ERG Negative Prostate Cancer.
International journal of molecular sciences18(2)(2017 Jan)
Melling N,Rashed M,Schroeder C,Hube-Magg C,Kluth M,Lang D,Simon R,Möller-Koop C,Steurer S,Sauter G,Jacobsen F,Büscheck F,Wittmer C,Clauditz T,Krech T,Tsourlakis MC,Minner S,Huland H,Graefen M,Budäus L,Thederan I,Salomon G,Schlomm T,Wilczak W

Methylation level of CpG islands in GGH gene promoter in pediatric acute leukemia.
PloS one12(3)e0173472(2017)
Li Y,Liu S,Wang H,Mai H,Yuan X,Li C,Chen X,Wen F

Tumor-related gene expression levels in thymic carcinoma and Type B3 thymoma.
Journal of cardiothoracic surgery11(1)85(2016 May)
Karube Y,Kobayashi S,Maeda S,Sado T,Ishihama H,Chida M

Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis.
International journal of molecular medicine37(2)319-28(2016 Feb)
Shimamoto Y,Nukatsuka M,Takechi T,Fukushima M

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GGH cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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