RPL37 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RPL37
Entrez Gene ID	6167
Full Name	ribosomal protein L37
Synonyms	L37
General protein information	Preferred Names ribosomal protein L37 Names 60S ribosomal protein L37 60S ribosomal protein L37a G1.16 large ribosomal subunit protein eL37
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5p13.1
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37E family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C2C2-type zinc finger-like motif. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Disorder MIM:	604181

mRNA and Protein(s)

mRNA	Protein	Name
NM_000997.5	NP_000988.1	60S ribosomal protein L37
NM_000997.4	NP_000988.1	60S ribosomal protein L37

Pathways from BioSystems

Homologies

Schizosaccharomyces pombe (fission yeast)	rpl3702	NP_588350.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000952	XP_309142.3
Gallus gallus (chicken)	RPL37	NP_001116235.1
Saccharomyces cerevisiae (baker's yeast)	RPL37B	NP_010788.1
Kluyveromyces lactis	KLLA0C01870g	XP_452279.1
Oryza sativa (rice)	Os02g0111700	NP_001045655.1
Magnaporthe oryzae (rice blast fungus)	MGG_02620	XP_003721174.1
Caenorhabditis elegans (roundworm)	rpl-37	NP_497727.1
Rattus norvegicus (Norway rat)	LOC100360781	XP_002727823.2
Oryza sativa (rice)	Os02g0815001	NP_001173207.1
Pan troglodytes (chimpanzee)	RPL37	NP_001233400.1
Macaca mulatta (Rhesus monkey)	LOC695667	XP_001086649.1
Rattus norvegicus (Norway rat)	Rpl37	NP_112368.1
Drosophila melanogaster (fruit fly)	RpL37a	NP_001259561.1
Saccharomyces cerevisiae (baker's yeast)	RPL37A	NP_013286.1
Arabidopsis thaliana (thale cress)	AT3G16080	NP_566535.1
Arabidopsis thaliana (thale cress)	AT1G15250	NP_172977.1
Oryza sativa (rice)	Os08g0128500	NP_001060912.2
Neurospora crassa	NCU01966	XP_964330.1
Schizosaccharomyces pombe (fission yeast)	rpl3703	NP_001018221.1
Homo sapiens (human)	RPL37	NP_000988.1
Bos taurus (cattle)	RPL37	NP_001071600.1
Caenorhabditis elegans (roundworm)	W01D2.1	NP_497072.1
Canis lupus familiaris (dog)	RPL37	NP_001239158.1
Rattus norvegicus (Norway rat)	LOC100360841	XP_002730083.1
Eremothecium gossypii	AGOS_AFR688C	NP_986236.1
Mus musculus (house mouse)	Rpl37	NP_080345.1
Danio rerio (zebrafish)	rpl37	NP_001002069.1
Arabidopsis thaliana (thale cress)	AT1G52300	NP_175640.1
Xenopus tropicalis (tropical clawed frog)	rpl37	NP_001107325.1

Gene Ontology
Bibliography

Related articles in PubMed

Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network.
Daftuar L, Zhu Y, Jacq X, Prives C
PloS one8(7)e68667(2013)

Depletion of ribosomal protein L37 occurs in response to DNA damage and activates p53 through the L11/MDM2 pathway.
Llanos S, Serrano M
Cell cycle (Georgetown, Tex.)9(19)4005-12(2010 Oct)

CK2 is responsible for phosphorylation of human La protein serine-366 and can modulate rpL37 5'-terminal oligopyrimidine mRNA metabolism.
Schwartz EI, Intine RV, Maraia RJ
Molecular and cellular biology24(21)9580-91(2004 Nov)

The molecular mechanics of eukaryotic translation.
Kapp LD, Lorsch JR
Annual review of biochemistry73657-704(2004)

Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control.
Mazumder B, Sampath P, Seshadri V, Maitra RK, DiCorleto PE, Fox PL
Cell115(2)187-98(2003 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following RPL37 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPL37 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02557	NM_000997.5 Latest version!	Homo sapiens ribosomal protein L37 (RPL37), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu02557	NM_000997.4	Homo sapiens ribosomal protein L37 (RPL37), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RPL37 ( NM_000997.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000988.1 Homo sapiens ribosomal protein L37 (RPL37), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02557
Clone ID Related Accession (Same CDS sequence)	NM_000997.5 , NM_000997.4
Accession Version	NM_000997.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569427200000
Organism	Homo sapiens(human)
Product	60S ribosomal protein L37
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from AC008810.8. On or before Nov 30, 2018 this sequence version replaced NR_037665.1, NM_000997.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.490308.1, SRR3476690.779581.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000274242.10/ ENSP00000274242.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACGAAGG GAACGTCATC GTTTGGAAAG CGTCGCAATA AGACGCACAC GTTGTGCCGC 
CGCTGTGGCT CTAAGGCCTA CCACCTTCAG AAGTCGACCT GTGGCAAATG TGGCTACCCT 
GCCAAGCGCA AGAGAAAGTA TAACTGGAGT GCCAAGGCTA AAAGACGAAA TACCACCGGA 
ACTGGTCGAA TGAGGCACCT AAAAATTGTA TACCGCAGAT TCAGGCATGG ATTCCGTGAA 
GGAACAACAC CTAAACCCAA GAGGGCAGCT GTTGCAGCAT CCAGTTCATC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000988.1
CDS	38..331
Translation	MTKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSAKAKRRNTTGTGRMRHLKIVYRRFRHGFREGTTPKPKRAAVAASSSS

Target ORF information:

RefSeq Version	NM_000997.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein L37 (RPL37), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000997.5

ORF Insert Sequence:

ATGACGAAGG GAACGTCATC GTTTGGAAAG CGTCGCAATA AGACGCACAC GTTGTGCCGC 
CGCTGTGGCT CTAAGGCCTA CCACCTTCAG AAGTCGACCT GTGGCAAATG TGGCTACCCT 
GCCAAGCGCA AGAGAAAGTA TAACTGGAGT GCCAAGGCTA AAAGACGAAA TACCACCGGA 
ACTGGTCGAA TGAGGCACCT AAAAATTGTA TACCGCAGAT TCAGGCATGG ATTCCGTGAA 
GGAACAACAC CTAAACCCAA GAGGGCAGCT GTTGCAGCAT CCAGTTCATC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPL37 ( NM_000997.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000988.1 Homo sapiens ribosomal protein L37 (RPL37), mRNA.

Price & Availability↑

CloneID	OHu02557
Clone ID Related Accession (Same CDS sequence)	NM_000997.5 , NM_000997.4
Accession Version	NM_000997.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506787200000
Organism	Homo sapiens(human)
Product	60S ribosomal protein L37
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BU954721.1, L11567.1 and BC067790.1. On or before Dec 18, 2010 this sequence version replaced XR_108574.1, XR_113736.1, XR_112729.1, NM_000997.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC067790.1, SRR1660807.157891.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGACGAAGG GAACGTCATC GTTTGGAAAG CGTCGCAATA AGACGCACAC GTTGTGCCGC 
CGCTGTGGCT CTAAGGCCTA CCACCTTCAG AAGTCGACCT GTGGCAAATG TGGCTACCCT 
GCCAAGCGCA AGAGAAAGTA TAACTGGAGT GCCAAGGCTA AAAGACGAAA TACCACCGGA 
ACTGGTCGAA TGAGGCACCT AAAAATTGTA TACCGCAGAT TCAGGCATGG ATTCCGTGAA 
GGAACAACAC CTAAACCCAA GAGGGCAGCT GTTGCAGCAT CCAGTTCATC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000988.1
CDS	101..394
Translation	MTKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSAKAKRRNTTGTGRMRHLKIVYRRFRHGFREGTTPKPKRAAVAASSSS

Target ORF information:

RefSeq Version	NM_000997.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein L37 (RPL37), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000997.4

ORF Insert Sequence:

ATGACGAAGG GAACGTCATC GTTTGGAAAG CGTCGCAATA AGACGCACAC GTTGTGCCGC 
CGCTGTGGCT CTAAGGCCTA CCACCTTCAG AAGTCGACCT GTGGCAAATG TGGCTACCCT 
GCCAAGCGCA AGAGAAAGTA TAACTGGAGT GCCAAGGCTA AAAGACGAAA TACCACCGGA 
ACTGGTCGAA TGAGGCACCT AAAAATTGTA TACCGCAGAT TCAGGCATGG ATTCCGTGAA 
GGAACAACAC CTAAACCCAA GAGGGCAGCT GTTGCAGCAT CCAGTTCATC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network.
PloS one8(7)e68667(2013)
Daftuar L,Zhu Y,Jacq X,Prives C

Depletion of ribosomal protein L37 occurs in response to DNA damage and activates p53 through the L11/MDM2 pathway.
Cell cycle (Georgetown, Tex.)9(19)4005-12(2010 Oct)
Llanos S,Serrano M

CK2 is responsible for phosphorylation of human La protein serine-366 and can modulate rpL37 5'-terminal oligopyrimidine mRNA metabolism.
Molecular and cellular biology24(21)9580-91(2004 Nov)
Schwartz EI,Intine RV,Maraia RJ

The molecular mechanics of eukaryotic translation.
Annual review of biochemistry73657-704(2004)
Kapp LD,Lorsch JR

Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control.
Cell115(2)187-98(2003 Oct)
Mazumder B,Sampath P,Seshadri V,Maitra RK,DiCorleto PE,Fox PL