USP17L8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	USP17L8
Entrez Gene ID	392188
Full Name	ubiquitin specific peptidase 17-like family member 8
Synonyms	USP17L10
General protein information	Preferred Names ubiquitin specific peptidase 17-like family member 8 Names inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8 ubiquitin specific peptidase 17-like 8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p23.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001256872.1	NP_001243801.1	inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8

Pathways from BioSystems

Homologies

Homo sapiens (human)	USP17L4	NP_001243803.1
Homo sapiens (human)	USP17L1P	NP_001243802.1
Homo sapiens (human)	USP17L3	NP_001243800.1
Macaca mulatta (Rhesus monkey)	USP17L2	XP_001084204.1
Homo sapiens (human)	USP17L8	NP_001243801.1
Homo sapiens (human)	USP17L2	NP_958804.2

Gene Ontology
Bibliography

Related articles in PubMed

Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.
Ramakrishna S, Suresh B, Lee EJ, Lee HJ, Ahn WS, Baek KH
The Journal of biological chemistry286(12)10505-14(2011 Mar)

The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.
de la Vega M, Kelvin AA, Dunican DJ, McFarlane C, Burrows JF, Jaworski J, Stevenson NJ, Dib K, Rappoport JZ, Scott CJ, Long A, Johnston JA
Nature communications2259(2011 Mar)

Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.
Ramakrishna S, Suresh B, Kang IC, Baek KH
Hybridoma (2005)29(4)311-9(2010 Aug)

The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.
McFarlane C, Kelvin AA, de la Vega M, Govender U, Scott CJ, Burrows JF, Johnston JA
Cancer research70(8)3329-39(2010 Apr)

The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.
Burrows JF, Scott CJ, Johnston JA
BMC genomics11250(2010 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following USP17L8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the USP17L8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu00182	NM_001256872.1 Latest version!	Homo sapiens ubiquitin specific peptidase 17 like family member 8 (USP17L8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

USP17L8 ( NM_001256872.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243801.1 Homo sapiens ubiquitin specific peptidase 17 like family member 8 (USP17L8), mRNA.

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CloneID	OHu00182
Clone ID Related Accession (Same CDS sequence)	NM_001256872.1
Accession Version	NM_001256872.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1593bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1561737600000
Organism	Homo sapiens(human)
Product	inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8
Comment	Comment: INFERRED REFSEQ: This record is predicted by genome sequence analysis and is not yet supported by experimental evidence. The reference sequence was derived from AC130365.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. CCDS Note: This CCDS representation lacks full-length human transcript support. Its representation is therefore inferred, but it is supported by paralogous transcripts. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology MANE Ensembl match :: ENST00000527080.1/ ENSP00000485306.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGAGGACG ACTCACTCTA CTTGGGAGGT GAGTGGCAGT TCAACCACTT TTCAAAACTC 
ACATCTCCTC GGCCAGATGC AGCTTTTGCT GAAATCCAGC GGACTTCTCT CCCTGAGAAG 
TCACCACTCT CATCTGAGAC CCGTGTCGAC CTCTGTGATG ATTTGGCTCC TGTGGCAAGA 
CAGCTTGCTC CCAGGGAGAA GCTTCCTCTG AGTAGCAGGA GACCTGCTGC TGTGGGGGCT 
GGTCTCCAGA ATATGGGAAA TACCTGCTAC TTGAATGCTT CCCTGCAGTG CCTGACATAC 
ACACCGCCCC TTGCCAACTA CATGCTGTCC CGGGAGCACT CTCAAACATG TCAGCGTCCC 
AAGTGCTGCA TGCTCTGTAC TATGCAAGCT CACATCACAT GGGCCCTCCA CAGTCCTGGC 
CATGTCATCC AGCCCTCACA GGCATTGGCT GCTGGCTTCC ATAGAGGCAA GCAGGAAGAT 
GCCCATGAAT TTCTCATGTT CACTGTGGAT GCCATGAAAA AGGCATGCCT TCCCGGCCAC 
AAGCAGGTAG ATCATCACTC TAAGGACACC ACCCTCATCC ACCAAATATT TGGAGGCTGC 
TGGAGATCTC AAATCAAGTG TCTCCACTGC CACGGGATTT CAGACACTTT TGACCCTTAC 
CTGGACATCG CCCTGGATAT CCAGGCAGCT CAGAGTGTCA AGCAAGCTTT GGAACAGTTG 
GTGAAGCCCG AAGAACTCAA TGGAGAGAAT GCCTATCCTT GCGGTCTTTG TCTCCAGAGG 
GCGCCGGCCT CCAACACGTT AACTTTACAC ACTTCTGCCA AGGTCCTCAT CCTTGTCTTG 
AAGAGATTCT GCGATGTCAC AGGCAACAAA CTTGCCAAGA ATGTGCAATA TCCTGAGTGC 
CTTGACATGC AGCCATACAT GTCTCAGCAG AACACAGGAC CTCTTGTCTA TGTCCTCTAT 
GCTGTGCTGG TCCACGCTGG GTGGAGTTGT CACAACGGAT ATTACTTCTC TTATGTCAAA 
GCTCAAGAAG GCCAGTGGTA TAAAATGGAT GATGCCGAGG TCACTGCCTG TAGCATCACT 
TCTGTCCTGA GTCAACAGGC CTATGTCCTC TTTTACATCC AGAAGAGTGA ATGGGAAAGA 
CACAGTGAGA GTGTGTCAAG AGGCAGGGAA CCAAGAGCCC TTGGCGCTGA AGACACAGAC 
AGGCCAGCAA CGCAAGGAGA GCTCAAGAGA GACCACCCTT GCCTCCAGGT ACCCGAGTTG 
GACGAGCACT TGGTGGAAAG AGCCACTGAG GAAAGCACCT TAGACCACTG GAAATTCCCC 
CAAGAGCAAA ACAAAATGAA GCCTGAGTTC AACGTCAGAA AAGTTGAAGG TACCCTGCCT 
CCCAACGTAC TTGTGATTCA TCAATCAAAA TACAAGTGTG GGATGAAAAA CCACCATCCT 
GAACAGCAAA GCTCCCTGCT AAACCTCTCT TCGATGAACT CGACAGATCA GGAGTCCATG 
AACACTGGCA CACTCGCTTC TCTGCAAGGG AGGACCAGGA GATCCAAAGG GAAGAACAAA 
CACAGCAAGA GATCTCTGCT TGTGTGCCAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243801.1
CDS	1..1593
Translation	MEDDSLYLGGEWQFNHFSKLTSPRPDAAFAEIQRTSLPEKSPLSSETRVDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQNMGNTCYLNASLQCLTYTPPLANYMLSREHSQTCQRPKCCMLCTMQAHITWALHSPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGCWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVKQALEQLVKPEELNGENAYPCGLCLQRAPASNTLTLHTSAKVLILVLKRFCDVTGNKLAKNVQYPECLDMQPYMSQQNTGPLVYVLYAVLVHAGWSCHNGYYFSYVKAQEGQWYKMDDAEVTACSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRPATQGELKRDHPCLQVPELDEHLVERATEESTLDHWKFPQEQNKMKPEFNVRKVEGTLPPNVLVIHQSKYKCGMKNHHPEQQSSLLNLSSMNSTDQESMNTGTLASLQGRTRRSKGKNKHSKRSLLVCQ

Target ORF information:

RefSeq Version	NM_001256872.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquitin specific peptidase 17 like family member 8 (USP17L8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256872.1

ORF Insert Sequence:

ATGGAGGACG ACTCACTCTA CTTGGGAGGT GAGTGGCAGT TCAACCACTT TTCAAAACTC 
ACATCTCCTC GGCCAGATGC AGCTTTTGCT GAAATCCAGC GGACTTCTCT CCCTGAGAAG 
TCACCACTCT CATCTGAGAC CCGTGTCGAC CTCTGTGATG ATTTGGCTCC TGTGGCAAGA 
CAGCTTGCTC CCAGGGAGAA GCTTCCTCTG AGTAGCAGGA GACCTGCTGC TGTGGGGGCT 
GGTCTCCAGA ATATGGGAAA TACCTGCTAC TTGAATGCTT CCCTGCAGTG CCTGACATAC 
ACACCGCCCC TTGCCAACTA CATGCTGTCC CGGGAGCACT CTCAAACATG TCAGCGTCCC 
AAGTGCTGCA TGCTCTGTAC TATGCAAGCT CACATCACAT GGGCCCTCCA CAGTCCTGGC 
CATGTCATCC AGCCCTCACA GGCATTGGCT GCTGGCTTCC ATAGAGGCAA GCAGGAAGAT 
GCCCATGAAT TTCTCATGTT CACTGTGGAT GCCATGAAAA AGGCATGCCT TCCCGGCCAC 
AAGCAGGTAG ATCATCACTC TAAGGACACC ACCCTCATCC ACCAAATATT TGGAGGCTGC 
TGGAGATCTC AAATCAAGTG TCTCCACTGC CACGGGATTT CAGACACTTT TGACCCTTAC 
CTGGACATCG CCCTGGATAT CCAGGCAGCT CAGAGTGTCA AGCAAGCTTT GGAACAGTTG 
GTGAAGCCCG AAGAACTCAA TGGAGAGAAT GCCTATCCTT GCGGTCTTTG TCTCCAGAGG 
GCGCCGGCCT CCAACACGTT AACTTTACAC ACTTCTGCCA AGGTCCTCAT CCTTGTCTTG 
AAGAGATTCT GCGATGTCAC AGGCAACAAA CTTGCCAAGA ATGTGCAATA TCCTGAGTGC 
CTTGACATGC AGCCATACAT GTCTCAGCAG AACACAGGAC CTCTTGTCTA TGTCCTCTAT 
GCTGTGCTGG TCCACGCTGG GTGGAGTTGT CACAACGGAT ATTACTTCTC TTATGTCAAA 
GCTCAAGAAG GCCAGTGGTA TAAAATGGAT GATGCCGAGG TCACTGCCTG TAGCATCACT 
TCTGTCCTGA GTCAACAGGC CTATGTCCTC TTTTACATCC AGAAGAGTGA ATGGGAAAGA 
CACAGTGAGA GTGTGTCAAG AGGCAGGGAA CCAAGAGCCC TTGGCGCTGA AGACACAGAC 
AGGCCAGCAA CGCAAGGAGA GCTCAAGAGA GACCACCCTT GCCTCCAGGT ACCCGAGTTG 
GACGAGCACT TGGTGGAAAG AGCCACTGAG GAAAGCACCT TAGACCACTG GAAATTCCCC 
CAAGAGCAAA ACAAAATGAA GCCTGAGTTC AACGTCAGAA AAGTTGAAGG TACCCTGCCT 
CCCAACGTAC TTGTGATTCA TCAATCAAAA TACAAGTGTG GGATGAAAAA CCACCATCCT 
GAACAGCAAA GCTCCCTGCT AAACCTCTCT TCGATGAACT CGACAGATCA GGAGTCCATG 
AACACTGGCA CACTCGCTTC TCTGCAAGGG AGGACCAGGA GATCCAAAGG GAAGAACAAA 
CACAGCAAGA GATCTCTGCT TGTGTGCCAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.
The Journal of biological chemistry286(12)10505-14(2011 Mar)
Ramakrishna S,Suresh B,Lee EJ,Lee HJ,Ahn WS,Baek KH

The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.
Nature communications2259(2011 Mar)
de la Vega M,Kelvin AA,Dunican DJ,McFarlane C,Burrows JF,Jaworski J,Stevenson NJ,Dib K,Rappoport JZ,Scott CJ,Long A,Johnston JA

Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.
Hybridoma (2005)29(4)311-9(2010 Aug)
Ramakrishna S,Suresh B,Kang IC,Baek KH

The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.
Cancer research70(8)3329-39(2010 Apr)
McFarlane C,Kelvin AA,de la Vega M,Govender U,Scott CJ,Burrows JF,Johnston JA

The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.
BMC genomics11250(2010 Apr)
Burrows JF,Scott CJ,Johnston JA