| Gene Symbol | CLIC4 |
| Entrez Gene ID | 25932 |
| Full Name | chloride intracellular channel 4 |
| Synonyms | CLIC4L,H1,MTCLIC,huH1,p64H1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
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CLIC4 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following CLIC4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLIC4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu22609 Clone ID Related Accession (Same CDS sequence) NM_013943.2 , NM_013943.3 Accession Version NM_013943.2 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 762bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1506787200000 Organism Homo sapiens(human) Product chloride intracellular channel protein 4 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB091421.1, DA904028.1, BC012444.1, AL662924.24, BQ929781.1 and BQ574968.1. On Oct 22, 2008 this sequence version replaced NM_013943.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.231796.1, SRR1660807.253380.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601
661
721ATGGCGTTGT CGATGCCGCT GAATGGGCTG AAGGAGGAGG ACAAAGAGCC CCTCATCGAG
CTCTTCGTCA AGGCTGGCAG TGATGGTGAA AGCATAGGAA ACTGCCCCTT TTCCCAGAGG
CTCTTCATGA TTCTTTGGCT CAAAGGAGTT GTATTTAGTG TGACGACTGT TGACCTGAAA
AGGAAGCCAG CAGACCTGCA GAACTTGGCT CCCGGGACCC ACCCACCATT TATAACTTTC
AACAGTGAAG TCAAAACGGA TGTAAATAAG ATTGAGGAAT TTCTTGAAGA AGTCTTATGC
CCTCCCAAGT ACTTAAAGCT TTCACCAAAA CACCCAGAAT CAAATACTGC TGGAATGGAC
ATCTTTGCCA AATTCTCTGC ATATATCAAG AATTCAAGGC CAGAGGCTAA TGAAGCACTG
GAGAGGGGTC TCCTGAAAAC CCTGCAGAAA CTGGATGAAT ATCTGAATTC TCCTCTCCCT
GATGAAATTG ATGAAAATAG TATGGAGGAC ATAAAGTTTT CTACACGTAA ATTTCTGGAT
GGCAATGAAA TGACATTAGC TGATTGCAAC CTGCTGCCCA AACTGCATAT TGTCAAGGTG
GTGGCCAAAA AATATCGCAA CTTTGATATT CCAAAAGAAA TGACTGGCAT CTGGAGATAC
CTAACTAATG CATACAGTAG GGACGAGTTC ACCAATACCT GTCCCAGTGA TAAGGAGGTT
GAAATAGCAT ATAGTGATGT AGCCAAAAGA CTCACCAAGT AAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_039234.1 CDS 286..1047 Translation 
Target ORF information:
RefSeq Version NM_013943.2 Organism Homo sapiens(human) Definition Homo sapiens chloride intracellular channel 4 (CLIC4), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_013943.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721ATGGCGTTGT CGATGCCGCT GAATGGGCTG AAGGAGGAGG ACAAAGAGCC CCTCATCGAG
CTCTTCGTCA AGGCTGGCAG TGATGGTGAA AGCATAGGAA ACTGCCCCTT TTCCCAGAGG
CTCTTCATGA TTCTTTGGCT CAAAGGAGTT GTATTTAGTG TGACGACTGT TGACCTGAAA
AGGAAGCCAG CAGACCTGCA GAACTTGGCT CCCGGGACCC ACCCACCATT TATAACTTTC
AACAGTGAAG TCAAAACGGA TGTAAATAAG ATTGAGGAAT TTCTTGAAGA AGTCTTATGC
CCTCCCAAGT ACTTAAAGCT TTCACCAAAA CACCCAGAAT CAAATACTGC TGGAATGGAC
ATCTTTGCCA AATTCTCTGC ATATATCAAG AATTCAAGGC CAGAGGCTAA TGAAGCACTG
GAGAGGGGTC TCCTGAAAAC CCTGCAGAAA CTGGATGAAT ATCTGAATTC TCCTCTCCCT
GATGAAATTG ATGAAAATAG TATGGAGGAC ATAAAGTTTT CTACACGTAA ATTTCTGGAT
GGCAATGAAA TGACATTAGC TGATTGCAAC CTGCTGCCCA AACTGCATAT TGTCAAGGTG
GTGGCCAAAA AATATCGCAA CTTTGATATT CCAAAAGAAA TGACTGGCAT CTGGAGATAC
CTAACTAATG CATACAGTAG GGACGAGTTC ACCAATACCT GTCCCAGTGA TAAGGAGGTT
GAAATAGCAT ATAGTGATGT AGCCAAAAGA CTCACCAAGT AAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu22609 Clone ID Related Accession (Same CDS sequence) NM_013943.2 , NM_013943.3 Accession Version NM_013943.3 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 762bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1572796800000 Organism Homo sapiens(human) Product chloride intracellular channel protein 4 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC012444.1, AL662924.24, BQ929781.1 and BQ574968.1. On Nov 22, 2018 this sequence version replaced NM_013943.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.62160.1, SRR1660807.56912.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000374379.9/ ENSP00000363500.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601
661
721ATGGCGTTGT CGATGCCGCT GAATGGGCTG AAGGAGGAGG ACAAAGAGCC CCTCATCGAG
CTCTTCGTCA AGGCTGGCAG TGATGGTGAA AGCATAGGAA ACTGCCCCTT TTCCCAGAGG
CTCTTCATGA TTCTTTGGCT CAAAGGAGTT GTATTTAGTG TGACGACTGT TGACCTGAAA
AGGAAGCCAG CAGACCTGCA GAACTTGGCT CCCGGGACCC ACCCACCATT TATAACTTTC
AACAGTGAAG TCAAAACGGA TGTAAATAAG ATTGAGGAAT TTCTTGAAGA AGTCTTATGC
CCTCCCAAGT ACTTAAAGCT TTCACCAAAA CACCCAGAAT CAAATACTGC TGGAATGGAC
ATCTTTGCCA AATTCTCTGC ATATATCAAG AATTCAAGGC CAGAGGCTAA TGAAGCACTG
GAGAGGGGTC TCCTGAAAAC CCTGCAGAAA CTGGATGAAT ATCTGAATTC TCCTCTCCCT
GATGAAATTG ATGAAAATAG TATGGAGGAC ATAAAGTTTT CTACACGTAA ATTTCTGGAT
GGCAATGAAA TGACATTAGC TGATTGCAAC CTGCTGCCCA AACTGCATAT TGTCAAGGTG
GTGGCCAAAA AATATCGCAA CTTTGATATT CCAAAAGAAA TGACTGGCAT CTGGAGATAC
CTAACTAATG CATACAGTAG GGACGAGTTC ACCAATACCT GTCCCAGTGA TAAGGAGGTT
GAAATAGCAT ATAGTGATGT AGCCAAAAGA CTCACCAAGT AAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_039234.1 CDS 108..869 Translation
Target ORF information:
RefSeq Version NM_013943.3 Organism Homo sapiens(human) Definition Homo sapiens chloride intracellular channel 4 (CLIC4), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_013943.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721ATGGCGTTGT CGATGCCGCT GAATGGGCTG AAGGAGGAGG ACAAAGAGCC CCTCATCGAG
CTCTTCGTCA AGGCTGGCAG TGATGGTGAA AGCATAGGAA ACTGCCCCTT TTCCCAGAGG
CTCTTCATGA TTCTTTGGCT CAAAGGAGTT GTATTTAGTG TGACGACTGT TGACCTGAAA
AGGAAGCCAG CAGACCTGCA GAACTTGGCT CCCGGGACCC ACCCACCATT TATAACTTTC
AACAGTGAAG TCAAAACGGA TGTAAATAAG ATTGAGGAAT TTCTTGAAGA AGTCTTATGC
CCTCCCAAGT ACTTAAAGCT TTCACCAAAA CACCCAGAAT CAAATACTGC TGGAATGGAC
ATCTTTGCCA AATTCTCTGC ATATATCAAG AATTCAAGGC CAGAGGCTAA TGAAGCACTG
GAGAGGGGTC TCCTGAAAAC CCTGCAGAAA CTGGATGAAT ATCTGAATTC TCCTCTCCCT
GATGAAATTG ATGAAAATAG TATGGAGGAC ATAAAGTTTT CTACACGTAA ATTTCTGGAT
GGCAATGAAA TGACATTAGC TGATTGCAAC CTGCTGCCCA AACTGCATAT TGTCAAGGTG
GTGGCCAAAA AATATCGCAA CTTTGATATT CCAAAAGAAA TGACTGGCAT CTGGAGATAC
CTAACTAATG CATACAGTAG GGACGAGTTC ACCAATACCT GTCCCAGTGA TAAGGAGGTT
GAAATAGCAT ATAGTGATGT AGCCAAAAGA CTCACCAAGT AAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Profilin binding couples chloride intracellular channel protein CLIC4 to RhoA-mDia2 signaling and filopodium formation.
The Journal of biological chemistry293(50)19161-19176(2018 12)
Argenzio E,Klarenbeek J,Kedziora KM,Nahidiazar L,Isogai T,Perrakis A,Jalink K,Moolenaar WH,Innocenti M
CLIC1 and CLIC4 complement CA125 as a diagnostic biomarker panel for all subtypes of epithelial ovarian cancer.
Scientific reports8(1)14725(2018 10)
Singha B,Harper SL,Goldman AR,Bitler BG,Aird KM,Borowsky ME,Cadungog MG,Liu Q,Zhang R,Jean S,Drapkin R,Speicher DW
A G-Quadruplex Structure in the Promoter Region of
International journal of molecular sciences19(9)(2018 Sep)
Huang MC,Chu IT,Wang ZF,Lin S,Chang TC,Chen CT
The cellular chloride channels CLIC1 and CLIC4 contribute to virus-mediated cell motility.
The Journal of biological chemistry293(12)4582-4590(2018 03)
Stakaitytė G,Nwogu N,Lippiat JD,Blair GE,Poterlowicz K,Boyne JR,Macdonald A,Mankouri J,Whitehouse A
Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW
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