ELK1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ELK1
Entrez Gene ID	2002
Full Name	ELK1, ETS transcription factor
General protein information	Preferred Names ELK1, ETS transcription factor Names ETS domain-containing protein Elk-1 ELK1, member of ETS oncogene family ETS-like gene 1 tyrosine kinase (ELK1) oncogene
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp11.23
Summary	This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012].
Disorder MIM:	311040

mRNA and Protein(s)

mRNA	Protein	Name
NM_001257168.1	NP_001244097.1	ETS domain-containing protein Elk-1 isoform b
NM_001114123.2	NP_001107595.1	ETS domain-containing protein Elk-1 isoform a
NM_005229.4	NP_005220.2	ETS domain-containing protein Elk-1 isoform a
XM_017029339.1	XP_016884828.1	ETS domain-containing protein Elk-1 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ELK1	XP_548979.4
Bos taurus (cattle)	ELK1	NP_001178165.1
Rattus norvegicus (Norway rat)	Elk1	NP_001101529.1
Homo sapiens (human)	ELK1	NP_005220.2
Mus musculus (house mouse)	Elk1	NP_031948.4
Xenopus tropicalis (tropical clawed frog)	LOC100497609	XP_004919804.1
Macaca mulatta (Rhesus monkey)	ELK1	XP_002806284.1

Gene Ontology
Bibliography

Related articles in PubMed

Myeloid Zinc Finger 1 (MZF1) Maintains the Mesenchymal Phenotype by Down-regulating IGF1R/p38 MAPK/ERα Signaling Pathway in High-level MZF1-expressing TNBC cells.
Yue CH, Liu JY, Chi CS, Hu CW, Tan KT, Huang FM, Pan YR, Lin KI, Lee CJ
Anticancer research39(8)4149-4164(2019 Aug)

De-ubiquitination of ELK-1 by USP17 potentiates mitogenic gene expression and cell proliferation.
Ducker C, Chow LKY, Saxton J, Handwerger J, McGregor A, Strahl T, Layfield R, Shaw PE
Nucleic acids research47(9)4495-4508(2019 05)

Alternative splicing within the elk-1 5' untranslated region serves to modulate initiation events downstream of the highly conserved upstream open reading frame 2.
Rahim G, Araud T, Jaquier-Gubler P, Curran J
Molecular and cellular biology32(9)1745-56(2012 May)

Alternatively spliced isoforms of the human elk-1 mRNA within the 5' UTR: implications for ELK-1 expression.
Araud T, Genolet R, Jaquier-Gubler P, Curran J
Nucleic acids research35(14)4649-63(2007)

Complexities in ETS-domain transcription factor function and regulation: lessons from the TCF (ternary complex factor) subfamily. The Colworth Medal Lecture.
Sharrocks AD
Biochemical Society transactions30(2)1-9(2002 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ELK1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ELK1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14032	NM_001114123.2 Latest version!	Homo sapiens ETS transcription factor ELK1 (ELK1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu14032	NM_005229.4 Latest version!	Homo sapiens ETS transcription factor ELK1 (ELK1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu14042	NM_001257168.1 Latest version!	Homo sapiens ETS transcription factor ELK1 (ELK1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu14032	XM_017029339.1 Latest version!	Homo sapiens ELK1, ETS transcription factor (ELK1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ELK1 ( NM_001114123.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001107595.1 Homo sapiens ETS transcription factor ELK1 (ELK1), transcript variant 1, mRNA.

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CloneID	OHu14032
Clone ID Related Accession (Same CDS sequence)	NM_001114123.2 , NM_005229.4 , XM_017029339.1
Accession Version	NM_001114123.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1287bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1574611200000
Organism	Homo sapiens(human)
Product	ETS domain-containing protein Elk-1 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB852603.1, M25269.1, BC056150.1 and BQ448492.1. This sequence is a reference standard in the RefSeqGene project. On or before Aug 31, 2013 this sequence version replaced XM_005272594.1, NM_001114123.1. Transcript Variant: This variant (1, also known as 5'UTR long or 5'UTRL) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode isoform a. Delayed translational reinitiation from an alternative downstream start codon, AUG sElk-1, can also result in a shorter isoform (sELK-1), as described in PMID:22354998. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.169652.1, SRR1803616.179725.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein regulatory uORF :: PMID: 22354998 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGACCCAT CTGTGACGCT GTGGCAGTTT CTGCTGCAGC TGCTGAGAGA GCAAGGCAAT 
GGCCACATCA TCTCCTGGAC TTCACGGGAT GGTGGTGAAT TCAAGCTGGT GGATGCAGAG 
GAGGTGGCCC GGCTGTGGGG GCTACGCAAG AACAAGACCA ACATGAATTA CGACAAGCTC 
AGCCGGGCCT TGCGGTACTA CTATGACAAG AACATCATCC GCAAGGTGAG CGGCCAGAAG 
TTCGTCTACA AGTTTGTGTC CTACCCTGAG GTCGCAGGGT GCTCCACTGA GGACTGCCCG 
CCCCAGCCAG AGGTGTCTGT TACCTCCACC ATGCCAAATG TGGCCCCTGC TGCTATACAT 
GCCGCCCCAG GGGACACTGT CTCTGGAAAG CCAGGCACAC CCAAGGGTGC AGGAATGGCA 
GGCCCAGGCG GTTTGGCACG CAGCAGCCGG AACGAGTACA TGCGCTCGGG CCTCTATTCC 
ACCTTCACCA TCCAGTCTCT GCAGCCGCAG CCACCCCCTC ATCCTCGGCC TGCTGTGGTG 
CTCCCCAGTG CAGCTCCTGC AGGGGCAGCA GCGCCCCCCT CGGGGAGCAG GAGCACCAGT 
CCAAGCCCCT TGGAGGCCTG TCTGGAGGCT GAAGAGGCCG GCTTGCCTCT GCAGGTCATC 
CTGACCCCGC CCGAGGCCCC AAACCTGAAA TCGGAAGAGC TTAATGTGGA GCCGGGTTTG 
GGCCGGGCTT TGCCCCCAGA AGTGAAAGTA GAAGGGCCCA AGGAAGAGTT GGAAGTTGCG 
GGGGAGAGAG GGTTTGTGCC AGAAACCACC AAGGCCGAGC CAGAAGTCCC TCCACAGGAG 
GGCGTGCCAG CCCGGCTGCC CGCGGTTGTT ATGGACACCG CAGGGCAGGC GGGCGGCCAT 
GCGGCTTCCA GCCCTGAGAT CTCCCAGCCG CAGAAGGGCC GGAAGCCCCG GGACCTAGAG 
CTTCCACTCA GCCCGAGCCT GCTAGGTGGG CCGGGACCCG AACGGACCCC AGGATCGGGA 
AGTGGCTCCG GCCTCCAGGC TCCGGGGCCG GCGCTGACCC CATCCCTGCT TCCTACGCAT 
ACATTGACCC CGGTGCTGCT GACACCCAGC TCGCTGCCTC CTAGCATTCA CTTCTGGAGC 
ACCCTGAGTC CCATTGCGCC CCGTAGCCCG GCCAAGCTCT CCTTCCAGTT TCCATCCAGT 
GGCAGCGCCC AGGTGCACAT CCCTTCTATC AGCGTGGATG GCCTCTCGAC CCCCGTGGTG 
CTCTCCCCAG GGCCCCAGAA GCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001107595.1
CDS	323..1609
Translation	MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSTMPNVAPAAIHAAPGDTVSGKPGTPKGAGMAGPGGLARSSRNEYMRSGLYSTFTIQSLQPQPPPHPRPAVVLPSAAPAGAAAPPSGSRSTSPSPLEACLEAEEAGLPLQVILTPPEAPNLKSEELNVEPGLGRALPPEVKVEGPKEELEVAGERGFVPETTKAEPEVPPQEGVPARLPAVVMDTAGQAGGHAASSPEISQPQKGRKPRDLELPLSPSLLGGPGPERTPGSGSGSGLQAPGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP

Target ORF information:

RefSeq Version	NM_001114123.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ETS transcription factor ELK1 (ELK1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001114123.2

ORF Insert Sequence:

ATGGACCCAT CTGTGACGCT GTGGCAGTTT CTGCTGCAGC TGCTGAGAGA GCAAGGCAAT 
GGCCACATCA TCTCCTGGAC TTCACGGGAT GGTGGTGAAT TCAAGCTGGT GGATGCAGAG 
GAGGTGGCCC GGCTGTGGGG GCTACGCAAG AACAAGACCA ACATGAATTA CGACAAGCTC 
AGCCGGGCCT TGCGGTACTA CTATGACAAG AACATCATCC GCAAGGTGAG CGGCCAGAAG 
TTCGTCTACA AGTTTGTGTC CTACCCTGAG GTCGCAGGGT GCTCCACTGA GGACTGCCCG 
CCCCAGCCAG AGGTGTCTGT TACCTCCACC ATGCCAAATG TGGCCCCTGC TGCTATACAT 
GCCGCCCCAG GGGACACTGT CTCTGGAAAG CCAGGCACAC CCAAGGGTGC AGGAATGGCA 
GGCCCAGGCG GTTTGGCACG CAGCAGCCGG AACGAGTACA TGCGCTCGGG CCTCTATTCC 
ACCTTCACCA TCCAGTCTCT GCAGCCGCAG CCACCCCCTC ATCCTCGGCC TGCTGTGGTG 
CTCCCCAGTG CAGCTCCTGC AGGGGCAGCA GCGCCCCCCT CGGGGAGCAG GAGCACCAGT 
CCAAGCCCCT TGGAGGCCTG TCTGGAGGCT GAAGAGGCCG GCTTGCCTCT GCAGGTCATC 
CTGACCCCGC CCGAGGCCCC AAACCTGAAA TCGGAAGAGC TTAATGTGGA GCCGGGTTTG 
GGCCGGGCTT TGCCCCCAGA AGTGAAAGTA GAAGGGCCCA AGGAAGAGTT GGAAGTTGCG 
GGGGAGAGAG GGTTTGTGCC AGAAACCACC AAGGCCGAGC CAGAAGTCCC TCCACAGGAG 
GGCGTGCCAG CCCGGCTGCC CGCGGTTGTT ATGGACACCG CAGGGCAGGC GGGCGGCCAT 
GCGGCTTCCA GCCCTGAGAT CTCCCAGCCG CAGAAGGGCC GGAAGCCCCG GGACCTAGAG 
CTTCCACTCA GCCCGAGCCT GCTAGGTGGG CCGGGACCCG AACGGACCCC AGGATCGGGA 
AGTGGCTCCG GCCTCCAGGC TCCGGGGCCG GCGCTGACCC CATCCCTGCT TCCTACGCAT 
ACATTGACCC CGGTGCTGCT GACACCCAGC TCGCTGCCTC CTAGCATTCA CTTCTGGAGC 
ACCCTGAGTC CCATTGCGCC CCGTAGCCCG GCCAAGCTCT CCTTCCAGTT TCCATCCAGT 
GGCAGCGCCC AGGTGCACAT CCCTTCTATC AGCGTGGATG GCCTCTCGAC CCCCGTGGTG 
CTCTCCCCAG GGCCCCAGAA GCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ELK1 ( NM_005229.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005220.2 Homo sapiens ETS transcription factor ELK1 (ELK1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu14032
Clone ID Related Accession (Same CDS sequence)	NM_001114123.2 , NM_005229.4 , XM_017029339.1
Accession Version	NM_005229.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1287bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1574611200000
Organism	Homo sapiens(human)
Product	ETS domain-containing protein Elk-1 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB852603.1, BC048296.1, BC056150.1 and BQ448492.1. On Mar 15, 2012 this sequence version replaced NM_005229.3. Transcript Variant: This variant (2, also known as 5'UTR short or 5'UTRS) lacks an alternate exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode isoform a. Delayed translational reinitiation from an alternative downstream start codon, AUG sElk-1, can also result in a shorter isoform (sELK-1), as described in PMID:22354998. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.250842.1, SRR1803613.183098.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## regulatory uORF :: PMID: 22354998 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGACCCAT CTGTGACGCT GTGGCAGTTT CTGCTGCAGC TGCTGAGAGA GCAAGGCAAT 
GGCCACATCA TCTCCTGGAC TTCACGGGAT GGTGGTGAAT TCAAGCTGGT GGATGCAGAG 
GAGGTGGCCC GGCTGTGGGG GCTACGCAAG AACAAGACCA ACATGAATTA CGACAAGCTC 
AGCCGGGCCT TGCGGTACTA CTATGACAAG AACATCATCC GCAAGGTGAG CGGCCAGAAG 
TTCGTCTACA AGTTTGTGTC CTACCCTGAG GTCGCAGGGT GCTCCACTGA GGACTGCCCG 
CCCCAGCCAG AGGTGTCTGT TACCTCCACC ATGCCAAATG TGGCCCCTGC TGCTATACAT 
GCCGCCCCAG GGGACACTGT CTCTGGAAAG CCAGGCACAC CCAAGGGTGC AGGAATGGCA 
GGCCCAGGCG GTTTGGCACG CAGCAGCCGG AACGAGTACA TGCGCTCGGG CCTCTATTCC 
ACCTTCACCA TCCAGTCTCT GCAGCCGCAG CCACCCCCTC ATCCTCGGCC TGCTGTGGTG 
CTCCCCAGTG CAGCTCCTGC AGGGGCAGCA GCGCCCCCCT CGGGGAGCAG GAGCACCAGT 
CCAAGCCCCT TGGAGGCCTG TCTGGAGGCT GAAGAGGCCG GCTTGCCTCT GCAGGTCATC 
CTGACCCCGC CCGAGGCCCC AAACCTGAAA TCGGAAGAGC TTAATGTGGA GCCGGGTTTG 
GGCCGGGCTT TGCCCCCAGA AGTGAAAGTA GAAGGGCCCA AGGAAGAGTT GGAAGTTGCG 
GGGGAGAGAG GGTTTGTGCC AGAAACCACC AAGGCCGAGC CAGAAGTCCC TCCACAGGAG 
GGCGTGCCAG CCCGGCTGCC CGCGGTTGTT ATGGACACCG CAGGGCAGGC GGGCGGCCAT 
GCGGCTTCCA GCCCTGAGAT CTCCCAGCCG CAGAAGGGCC GGAAGCCCCG GGACCTAGAG 
CTTCCACTCA GCCCGAGCCT GCTAGGTGGG CCGGGACCCG AACGGACCCC AGGATCGGGA 
AGTGGCTCCG GCCTCCAGGC TCCGGGGCCG GCGCTGACCC CATCCCTGCT TCCTACGCAT 
ACATTGACCC CGGTGCTGCT GACACCCAGC TCGCTGCCTC CTAGCATTCA CTTCTGGAGC 
ACCCTGAGTC CCATTGCGCC CCGTAGCCCG GCCAAGCTCT CCTTCCAGTT TCCATCCAGT 
GGCAGCGCCC AGGTGCACAT CCCTTCTATC AGCGTGGATG GCCTCTCGAC CCCCGTGGTG 
CTCTCCCCAG GGCCCCAGAA GCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005220.2
CDS	217..1503
Translation	MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSTMPNVAPAAIHAAPGDTVSGKPGTPKGAGMAGPGGLARSSRNEYMRSGLYSTFTIQSLQPQPPPHPRPAVVLPSAAPAGAAAPPSGSRSTSPSPLEACLEAEEAGLPLQVILTPPEAPNLKSEELNVEPGLGRALPPEVKVEGPKEELEVAGERGFVPETTKAEPEVPPQEGVPARLPAVVMDTAGQAGGHAASSPEISQPQKGRKPRDLELPLSPSLLGGPGPERTPGSGSGSGLQAPGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP

Target ORF information:

RefSeq Version	NM_005229.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ETS transcription factor ELK1 (ELK1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005229.4

ORF Insert Sequence:

ATGGACCCAT CTGTGACGCT GTGGCAGTTT CTGCTGCAGC TGCTGAGAGA GCAAGGCAAT 
GGCCACATCA TCTCCTGGAC TTCACGGGAT GGTGGTGAAT TCAAGCTGGT GGATGCAGAG 
GAGGTGGCCC GGCTGTGGGG GCTACGCAAG AACAAGACCA ACATGAATTA CGACAAGCTC 
AGCCGGGCCT TGCGGTACTA CTATGACAAG AACATCATCC GCAAGGTGAG CGGCCAGAAG 
TTCGTCTACA AGTTTGTGTC CTACCCTGAG GTCGCAGGGT GCTCCACTGA GGACTGCCCG 
CCCCAGCCAG AGGTGTCTGT TACCTCCACC ATGCCAAATG TGGCCCCTGC TGCTATACAT 
GCCGCCCCAG GGGACACTGT CTCTGGAAAG CCAGGCACAC CCAAGGGTGC AGGAATGGCA 
GGCCCAGGCG GTTTGGCACG CAGCAGCCGG AACGAGTACA TGCGCTCGGG CCTCTATTCC 
ACCTTCACCA TCCAGTCTCT GCAGCCGCAG CCACCCCCTC ATCCTCGGCC TGCTGTGGTG 
CTCCCCAGTG CAGCTCCTGC AGGGGCAGCA GCGCCCCCCT CGGGGAGCAG GAGCACCAGT 
CCAAGCCCCT TGGAGGCCTG TCTGGAGGCT GAAGAGGCCG GCTTGCCTCT GCAGGTCATC 
CTGACCCCGC CCGAGGCCCC AAACCTGAAA TCGGAAGAGC TTAATGTGGA GCCGGGTTTG 
GGCCGGGCTT TGCCCCCAGA AGTGAAAGTA GAAGGGCCCA AGGAAGAGTT GGAAGTTGCG 
GGGGAGAGAG GGTTTGTGCC AGAAACCACC AAGGCCGAGC CAGAAGTCCC TCCACAGGAG 
GGCGTGCCAG CCCGGCTGCC CGCGGTTGTT ATGGACACCG CAGGGCAGGC GGGCGGCCAT 
GCGGCTTCCA GCCCTGAGAT CTCCCAGCCG CAGAAGGGCC GGAAGCCCCG GGACCTAGAG 
CTTCCACTCA GCCCGAGCCT GCTAGGTGGG CCGGGACCCG AACGGACCCC AGGATCGGGA 
AGTGGCTCCG GCCTCCAGGC TCCGGGGCCG GCGCTGACCC CATCCCTGCT TCCTACGCAT 
ACATTGACCC CGGTGCTGCT GACACCCAGC TCGCTGCCTC CTAGCATTCA CTTCTGGAGC 
ACCCTGAGTC CCATTGCGCC CCGTAGCCCG GCCAAGCTCT CCTTCCAGTT TCCATCCAGT 
GGCAGCGCCC AGGTGCACAT CCCTTCTATC AGCGTGGATG GCCTCTCGAC CCCCGTGGTG 
CTCTCCCCAG GGCCCCAGAA GCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ELK1 ( NM_001257168.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001244097.1 Homo sapiens ETS transcription factor ELK1 (ELK1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu14042
Clone ID Related Accession (Same CDS sequence)	NM_001257168.1
Accession Version	NM_001257168.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 288bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1574611200000
Organism	Homo sapiens(human)
Product	ETS domain-containing protein Elk-1 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB852603.1, AF000672.1, BC056150.1 and BQ448492.1. Transcript Variant: This variant (3) uses two alternate splice sites and lacks an alternate exon which results in a frameshift in the central and 3' coding regions, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.192783.1, AF000672.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## regulatory uORF :: PMID: 22354998 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGACCCAT CTGTGACGCT GTGGCAGTTT CTGCTGCAGC TGCTGAGAGA GCAAGGCAAT 
GGCCACATCA TCTCCTGGAC TTCACGGGAT GGTGGTGAAT TCAAGCTGGT GGATGCAGAG 
GAGGTGGCCC GGCTGTGGGG GCTACGCAAG AACAAGACCA ACATGAATTA CGACAAGCTC 
AGCCGGGCCT TGCGGTACTA CTATGACAAG AACATCATCC GCAAGGTGAG CGGCCAGAAG 
TTCGTCTACA AGTTTGTGTC CTACCCTGAG TCCCATTGCG CCCCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001244097.1
CDS	323..610
Translation	MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPESHCAP

Target ORF information:

RefSeq Version	NM_001257168.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ETS transcription factor ELK1 (ELK1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001257168.1

ORF Insert Sequence:

ATGGACCCAT CTGTGACGCT GTGGCAGTTT CTGCTGCAGC TGCTGAGAGA GCAAGGCAAT 
GGCCACATCA TCTCCTGGAC TTCACGGGAT GGTGGTGAAT TCAAGCTGGT GGATGCAGAG 
GAGGTGGCCC GGCTGTGGGG GCTACGCAAG AACAAGACCA ACATGAATTA CGACAAGCTC 
AGCCGGGCCT TGCGGTACTA CTATGACAAG AACATCATCC GCAAGGTGAG CGGCCAGAAG 
TTCGTCTACA AGTTTGTGTC CTACCCTGAG TCCCATTGCG CCCCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ELK1 ( XM_017029339.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016884828.1 Homo sapiens ELK1, ETS transcription factor (ELK1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu14032
Clone ID Related Accession (Same CDS sequence)	NM_001114123.2 , NM_005229.4 , XM_017029339.1
Accession Version	XM_017029339.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1287bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1465056000000
Organism	Homo sapiens(human)
Product	ETS domain-containing protein Elk-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACCCAT CTGTGACGCT GTGGCAGTTT CTGCTGCAGC TGCTGAGAGA GCAAGGCAAT 
GGCCACATCA TCTCCTGGAC TTCACGGGAT GGTGGTGAAT TCAAGCTGGT GGATGCAGAG 
GAGGTGGCCC GGCTGTGGGG GCTACGCAAG AACAAGACCA ACATGAATTA CGACAAGCTC 
AGCCGGGCCT TGCGGTACTA CTATGACAAG AACATCATCC GCAAGGTGAG CGGCCAGAAG 
TTCGTCTACA AGTTTGTGTC CTACCCTGAG GTCGCAGGGT GCTCCACTGA GGACTGCCCG 
CCCCAGCCAG AGGTGTCTGT TACCTCCACC ATGCCAAATG TGGCCCCTGC TGCTATACAT 
GCCGCCCCAG GGGACACTGT CTCTGGAAAG CCAGGCACAC CCAAGGGTGC AGGAATGGCA 
GGCCCAGGCG GTTTGGCACG CAGCAGCCGG AACGAGTACA TGCGCTCGGG CCTCTATTCC 
ACCTTCACCA TCCAGTCTCT GCAGCCGCAG CCACCCCCTC ATCCTCGGCC TGCTGTGGTG 
CTCCCCAGTG CAGCTCCTGC AGGGGCAGCA GCGCCCCCCT CGGGGAGCAG GAGCACCAGT 
CCAAGCCCCT TGGAGGCCTG TCTGGAGGCT GAAGAGGCCG GCTTGCCTCT GCAGGTCATC 
CTGACCCCGC CCGAGGCCCC AAACCTGAAA TCGGAAGAGC TTAATGTGGA GCCGGGTTTG 
GGCCGGGCTT TGCCCCCAGA AGTGAAAGTA GAAGGGCCCA AGGAAGAGTT GGAAGTTGCG 
GGGGAGAGAG GGTTTGTGCC AGAAACCACC AAGGCCGAGC CAGAAGTCCC TCCACAGGAG 
GGCGTGCCAG CCCGGCTGCC CGCGGTTGTT ATGGACACCG CAGGGCAGGC GGGCGGCCAT 
GCGGCTTCCA GCCCTGAGAT CTCCCAGCCG CAGAAGGGCC GGAAGCCCCG GGACCTAGAG 
CTTCCACTCA GCCCGAGCCT GCTAGGTGGG CCGGGACCCG AACGGACCCC AGGATCGGGA 
AGTGGCTCCG GCCTCCAGGC TCCGGGGCCG GCGCTGACCC CATCCCTGCT TCCTACGCAT 
ACATTGACCC CGGTGCTGCT GACACCCAGC TCGCTGCCTC CTAGCATTCA CTTCTGGAGC 
ACCCTGAGTC CCATTGCGCC CCGTAGCCCG GCCAAGCTCT CCTTCCAGTT TCCATCCAGT 
GGCAGCGCCC AGGTGCACAT CCCTTCTATC AGCGTGGATG GCCTCTCGAC CCCCGTGGTG 
CTCTCCCCAG GGCCCCAGAA GCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016884828.1
CDS	38..1324
Translation	MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSTMPNVAPAAIHAAPGDTVSGKPGTPKGAGMAGPGGLARSSRNEYMRSGLYSTFTIQSLQPQPPPHPRPAVVLPSAAPAGAAAPPSGSRSTSPSPLEACLEAEEAGLPLQVILTPPEAPNLKSEELNVEPGLGRALPPEVKVEGPKEELEVAGERGFVPETTKAEPEVPPQEGVPARLPAVVMDTAGQAGGHAASSPEISQPQKGRKPRDLELPLSPSLLGGPGPERTPGSGSGSGLQAPGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP

Target ORF information:

RefSeq Version	XM_017029339.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ELK1, ETS transcription factor (ELK1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017029339.1

ORF Insert Sequence:

ATGGACCCAT CTGTGACGCT GTGGCAGTTT CTGCTGCAGC TGCTGAGAGA GCAAGGCAAT 
GGCCACATCA TCTCCTGGAC TTCACGGGAT GGTGGTGAAT TCAAGCTGGT GGATGCAGAG 
GAGGTGGCCC GGCTGTGGGG GCTACGCAAG AACAAGACCA ACATGAATTA CGACAAGCTC 
AGCCGGGCCT TGCGGTACTA CTATGACAAG AACATCATCC GCAAGGTGAG CGGCCAGAAG 
TTCGTCTACA AGTTTGTGTC CTACCCTGAG GTCGCAGGGT GCTCCACTGA GGACTGCCCG 
CCCCAGCCAG AGGTGTCTGT TACCTCCACC ATGCCAAATG TGGCCCCTGC TGCTATACAT 
GCCGCCCCAG GGGACACTGT CTCTGGAAAG CCAGGCACAC CCAAGGGTGC AGGAATGGCA 
GGCCCAGGCG GTTTGGCACG CAGCAGCCGG AACGAGTACA TGCGCTCGGG CCTCTATTCC 
ACCTTCACCA TCCAGTCTCT GCAGCCGCAG CCACCCCCTC ATCCTCGGCC TGCTGTGGTG 
CTCCCCAGTG CAGCTCCTGC AGGGGCAGCA GCGCCCCCCT CGGGGAGCAG GAGCACCAGT 
CCAAGCCCCT TGGAGGCCTG TCTGGAGGCT GAAGAGGCCG GCTTGCCTCT GCAGGTCATC 
CTGACCCCGC CCGAGGCCCC AAACCTGAAA TCGGAAGAGC TTAATGTGGA GCCGGGTTTG 
GGCCGGGCTT TGCCCCCAGA AGTGAAAGTA GAAGGGCCCA AGGAAGAGTT GGAAGTTGCG 
GGGGAGAGAG GGTTTGTGCC AGAAACCACC AAGGCCGAGC CAGAAGTCCC TCCACAGGAG 
GGCGTGCCAG CCCGGCTGCC CGCGGTTGTT ATGGACACCG CAGGGCAGGC GGGCGGCCAT 
GCGGCTTCCA GCCCTGAGAT CTCCCAGCCG CAGAAGGGCC GGAAGCCCCG GGACCTAGAG 
CTTCCACTCA GCCCGAGCCT GCTAGGTGGG CCGGGACCCG AACGGACCCC AGGATCGGGA 
AGTGGCTCCG GCCTCCAGGC TCCGGGGCCG GCGCTGACCC CATCCCTGCT TCCTACGCAT 
ACATTGACCC CGGTGCTGCT GACACCCAGC TCGCTGCCTC CTAGCATTCA CTTCTGGAGC 
ACCCTGAGTC CCATTGCGCC CCGTAGCCCG GCCAAGCTCT CCTTCCAGTT TCCATCCAGT 
GGCAGCGCCC AGGTGCACAT CCCTTCTATC AGCGTGGATG GCCTCTCGAC CCCCGTGGTG 
CTCTCCCCAG GGCCCCAGAA GCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Myeloid Zinc Finger 1 (MZF1) Maintains the Mesenchymal Phenotype by Down-regulating IGF1R/p38 MAPK/ERα Signaling Pathway in High-level MZF1-expressing TNBC cells.
Anticancer research39(8)4149-4164(2019 Aug)
Yue CH,Liu JY,Chi CS,Hu CW,Tan KT,Huang FM,Pan YR,Lin KI,Lee CJ

De-ubiquitination of ELK-1 by USP17 potentiates mitogenic gene expression and cell proliferation.
Nucleic acids research47(9)4495-4508(2019 05)
Ducker C,Chow LKY,Saxton J,Handwerger J,McGregor A,Strahl T,Layfield R,Shaw PE

Alternative splicing within the elk-1 5' untranslated region serves to modulate initiation events downstream of the highly conserved upstream open reading frame 2.
Molecular and cellular biology32(9)1745-56(2012 May)
Rahim G,Araud T,Jaquier-Gubler P,Curran J

Alternatively spliced isoforms of the human elk-1 mRNA within the 5' UTR: implications for ELK-1 expression.
Nucleic acids research35(14)4649-63(2007)
Araud T,Genolet R,Jaquier-Gubler P,Curran J

Complexities in ETS-domain transcription factor function and regulation: lessons from the TCF (ternary complex factor) subfamily. The Colworth Medal Lecture.
Biochemical Society transactions30(2)1-9(2002 Apr)
Sharrocks AD

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ELK1 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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