| Gene Symbol | SAP18 |
| Entrez Gene ID | 10284 |
| Full Name | Sin3A associated protein 18 |
| Synonyms | 2HOR0202,SAP18P |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]. |
| Disorder MIM: |
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SAP18 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following SAP18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SAP18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu107037 Clone ID Related Accession (Same CDS sequence) NM_001366643.1 Accession Version NM_001366643.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 507bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1565020800000 Organism Homo sapiens(human) Product histone deacetylase complex subunit SAP18 isoform 2 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL158032.32. On Oct 14, 2018 this sequence version replaced XM_011534868.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.12891.1, SRR1660805.225831.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
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301
361
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481ATGTACCGTC CAGCGAGTTG CAGATCTACA CTTGAGTCTT GCTCTGTCAT CCAGGCTGGA
GTGCAGTGGC GCGATCTCGG CTCACTGCAA CCTCTGCCTC CCAGGTATAA GCGATTCTCC
TGCCTCAGCC TCCTGAGTAG CTGGGATTAC AGGCGTGCAC CAAACTTCCT TTCATGCACA
CAATTACTTA AAATGATGTA TAAAATTGTA TTCCAGCTGT GTATAAGGAT GGATGCAACC
TTGAAAGAAC TGACAAGCTT AGTAAAAGAA GTCTACCCAG AAGCTAGAAA GAAGGGCACT
CACTTCAATT TTGCAATCGT TTTTACAGAT GTTAAAAGAC CTGGCTATCG AGTTAAGGAG
ATTGGCAGCA CCATGTCTGG CAGAAAGGGG ACTGATGATT CCATGACCCT GCAGTCGCAG
AAGTTCCAGA TAGGAGATTA CTTGGACATA GCAATTACCC CTCCAAATCG GGCACCACCT
CCTTCAGGGC GCATGAGACC ATATTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001353572.1 CDS 213..719 Translation 
Target ORF information:
RefSeq Version NM_001366643.1 Organism Homo sapiens(human) Definition Homo sapiens Sin3A associated protein 18 (SAP18), transcript variant 2, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_001366643.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481ATGTACCGTC CAGCGAGTTG CAGATCTACA CTTGAGTCTT GCTCTGTCAT CCAGGCTGGA
GTGCAGTGGC GCGATCTCGG CTCACTGCAA CCTCTGCCTC CCAGGTATAA GCGATTCTCC
TGCCTCAGCC TCCTGAGTAG CTGGGATTAC AGGCGTGCAC CAAACTTCCT TTCATGCACA
CAATTACTTA AAATGATGTA TAAAATTGTA TTCCAGCTGT GTATAAGGAT GGATGCAACC
TTGAAAGAAC TGACAAGCTT AGTAAAAGAA GTCTACCCAG AAGCTAGAAA GAAGGGCACT
CACTTCAATT TTGCAATCGT TTTTACAGAT GTTAAAAGAC CTGGCTATCG AGTTAAGGAG
ATTGGCAGCA CCATGTCTGG CAGAAAGGGG ACTGATGATT CCATGACCCT GCAGTCGCAG
AAGTTCCAGA TAGGAGATTA CTTGGACATA GCAATTACCC CTCCAAATCG GGCACCACCT
CCTTCAGGGC GCATGAGACC ATATTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu63842 Clone ID Related Accession (Same CDS sequence) XM_011534868.2 Accession Version XM_011534868.2 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 315bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1465056000000 Organism Homo sapiens(human) Product histone deacetylase complex subunit SAP18 isoform X1 Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011534868.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##
1
61
121
181
241
301ATGATGTATA AAATTGTATT CCAGCTGTGT ATAAGGATGG ATGCAACCTT GAAAGAACTG
ACAAGCTTAG TAAAAGAAGT CTACCCAGAA GCTAGAAAGA AGGGCACTCA CTTCAATTTT
GCAATCGTTT TTACAGATGT TAAAAGACCT GGCTATCGAG TTAAGGAGAT TGGCAGCACC
ATGTCTGGCA GAAAGGGGAC TGATGATTCC ATGACCCTGC AGTCGCAGAA GTTCCAGATA
GGAGATTACT TGGACATAGC AATTACCCCT CCAAATCGGG CACCACCTCC TTCAGGGCGC
ATGAGACCAT ATTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq XP_011533170.1 CDS 124..438 Translation
Target ORF information:
RefSeq Version XM_011534868.2 Organism Homo sapiens(human) Definition Homo sapiens Sin3A associated protein 18kDa (SAP18), transcript variant X1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK XM_011534868.2
ORF Insert Sequence:
1
61
121
181
241
301ATGATGTATA AAATTGTATT CCAGCTGTGT ATAAGGATGG ATGCAACCTT GAAAGAACTG
ACAAGCTTAG TAAAAGAAGT CTACCCAGAA GCTAGAAAGA AGGGCACTCA CTTCAATTTT
GCAATCGTTT TTACAGATGT TAAAAGACCT GGCTATCGAG TTAAGGAGAT TGGCAGCACC
ATGTCTGGCA GAAAGGGGAC TGATGATTCC ATGACCCTGC AGTCGCAGAA GTTCCAGATA
GGAGATTACT TGGACATAGC AATTACCCCT CCAAATCGGG CACCACCTCC TTCAGGGCGC
ATGAGACCAT ATTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu11719 Clone ID Related Accession (Same CDS sequence) NM_005870.4 Accession Version NM_005870.4 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 519bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1564761600000 Organism Homo sapiens(human) Product histone deacetylase complex subunit SAP18 isoform 1 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB171768.1, BC030836.1, AL158032.32 and BU618473.1. On Dec 3, 2008 this sequence version replaced NM_005870.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.155039.1, SRR1660807.125574.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481ATGCTCGCTG CAGGGGTCGG AGGTCAGGGC GAGCGTCTCG CAGGCCGTAG GAGGAAGATG
GCGGTGGAGT CGCGCGTTAC CCAGGAGGAA ATTAAGAAGG AGCCAGAGAA ACCGATCGAC
CGCGAGAAGA CATGCCCACT GTTGCTACGG GTCTTCACCA CCAATAACGG CCGCCACCAC
CGAATGGACG AGTTCTCCCG GGGAAATGTA CCGTCCAGCG AGTTGCAGAT CTACACTTGG
ATGGATGCAA CCTTGAAAGA ACTGACAAGC TTAGTAAAAG AAGTCTACCC AGAAGCTAGA
AAGAAGGGCA CTCACTTCAA TTTTGCAATC GTTTTTACAG ATGTTAAAAG ACCTGGCTAT
CGAGTTAAGG AGATTGGCAG CACCATGTCT GGCAGAAAGG GGACTGATGA TTCCATGACC
CTGCAGTCGC AGAAGTTCCA GATAGGAGAT TACTTGGACA TAGCAATTAC CCCTCCAAAT
CGGGCACCAC CTCCTTCAGG GCGCATGAGA CCATATTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_005861.2 CDS 40..558 Translation
Target ORF information:
RefSeq Version NM_005870.4 Organism Homo sapiens(human) Definition Homo sapiens Sin3A associated protein 18 (SAP18), transcript variant 1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_005870.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481ATGCTCGCTG CAGGGGTCGG AGGTCAGGGC GAGCGTCTCG CAGGCCGTAG GAGGAAGATG
GCGGTGGAGT CGCGCGTTAC CCAGGAGGAA ATTAAGAAGG AGCCAGAGAA ACCGATCGAC
CGCGAGAAGA CATGCCCACT GTTGCTACGG GTCTTCACCA CCAATAACGG CCGCCACCAC
CGAATGGACG AGTTCTCCCG GGGAAATGTA CCGTCCAGCG AGTTGCAGAT CTACACTTGG
ATGGATGCAA CCTTGAAAGA ACTGACAAGC TTAGTAAAAG AAGTCTACCC AGAAGCTAGA
AAGAAGGGCA CTCACTTCAA TTTTGCAATC GTTTTTACAG ATGTTAAAAG ACCTGGCTAT
CGAGTTAAGG AGATTGGCAG CACCATGTCT GGCAGAAAGG GGACTGATGA TTCCATGACC
CTGCAGTCGC AGAAGTTCCA GATAGGAGAT TACTTGGACA TAGCAATTAC CCCTCCAAAT
CGGGCACCAC CTCCTTCAGG GCGCATGAGA CCATATTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Sin3A-associated protein, 18 kDa, a novel binding partner of TRIB1, regulates MTTP expression.
Journal of lipid research56(6)1145-52(2015 Jun)
Makishima S,Boonvisut S,Ishizuka Y,Watanabe K,Nakayama K,Iwamoto S
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanhäusser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M
The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex.
Nature structural & molecular biology19(4)378-86(2012 Mar)
Murachelli AG,Ebert J,Basquin C,Le Hir H,Conti E
Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators.
Molecular and cellular biology32(5)954-67(2012 Mar)
Michelle L,Cloutier A,Toutant J,Shkreta L,Thibault P,Durand M,Garneau D,Gendron D,Lapointe E,Couture S,Le Hir H,Klinck R,Elela SA,Prinos P,Chabot B
Dynamic protein-protein interaction wiring of the human spliceosome.
Molecular cell45(4)567-80(2012 Feb)
Hegele A,Kamburov A,Grossmann A,Sourlis C,Wowro S,Weimann M,Will CL,Pena V,Lührmann R,Stelzl U
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