TGFB1 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	TGFB1
Entrez Gene ID	403998
Full Name	transforming growth factor beta 1
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001003309.1	NP_001003309.1	transforming growth factor beta-1 proprotein precursor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	tgfb1	XP_002939433.1
Homo sapiens (human)	TGFB1	NP_000651.3
Pan troglodytes (chimpanzee)	TGFB1	XP_512687.2
Danio rerio (zebrafish)	tgfb1a	NP_878293.1
Canis lupus familiaris (dog)	TGFB1	NP_001003309.1
Danio rerio (zebrafish)	LOC563884	XP_692338.3
Bos taurus (cattle)	TGFB1	NP_001159540.1
Mus musculus (house mouse)	Tgfb1	NP_035707.1
Rattus norvegicus (Norway rat)	Tgfb1	NP_067589.1

Gene Ontology
Bibliography

Related articles in PubMed

Febuxostat inhibits TGF‑β1‑induced epithelial‑mesenchymal transition via downregulation of USAG‑1 expression in Madin‑Darby canine kidney cells in vitro.
Lu L, Zhu J, Zhang Y, Wang Y, Zhang S, Xia A
Molecular medicine reports19(3)1694-1704(2019 Mar)

CD61 promotes the differentiation of canine ADMSCs into PGC-like cells through modulation of TGF-β signaling.
Fang J, Wei Y, Lv C, Peng S, Zhao S, Hua J
Scientific reports743851(2017 03)

Chronic obstructive sleep apnea accelerates pulmonary remodeling via TGF-β/miR-185/CoLA1 signaling in a canine model.
Ding X, Yu C, Liu Y, Yan S, Li W, Wang D, Sun L, Han Y, Li M, Zhang S, Yun F, Zhao H, Li Y
Oncotarget7(36)57545-57555(2016 Sep)

Apoptosis and abundance of Bcl-2 family and transforming growth factor β1 signaling proteins in canine myxomatous mitral valves.
Surachetpong S, Jiranantasak T, Rungsipipat A, Orton EC
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology15(3)171-80(2013 Sep)

Celastrol inhibits TGF-β1-induced epithelial-mesenchymal transition by inhibiting Snail and regulating E-cadherin expression.
Kang H, Lee M, Jang SW
Biochemical and biophysical research communications437(4)550-6(2013 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TGFB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TGFB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe00341	NM_001003309.1 Latest version!	Canis lupus familiaris transforming growth factor beta 1 (TGFB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TGFB1 ( NM_001003309.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001003309.1 Canis lupus familiaris transforming growth factor beta 1 (TGFB1), mRNA.

Price & Availability↑

CloneID	OCe00341
Clone ID Related Accession (Same CDS sequence)	NM_001003309.1
Accession Version	NM_001003309.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1173bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1568649600000
Organism	Canis lupus familiaris(dog)
Product	transforming growth factor beta-1 proprotein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L34956.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L34956.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END##

ATGCCGCCCT CCGGGCTGCG GCTGCTGCCG CTGCTGCTGC CGCTGCTGCG GCTACTAGTG 
CTGACGCCTG GCCGGCCGGC CGCCGGACTG TCCACCTGCA AGACCATCGA CATGGAACTG 
GTGAAGCGGA AGCGCATCGA GGCCATCCGC GGCCAGATCC TGTCCAAGCT GCGGCTCTCC 
AGCCCCCCGA GCCAGGGGGA GGTGCCGCCC GTGCCGCTGC CCGAGGCCGT GCTGGCCCTC 
TACAACAGCA CCCGCGACCG GGTGGCGGGG GAGAGCGCCG AGCCGGAGCC CGAGCCCGAG 
GCGGACTACT ACGCCAAGGA GGTCACCCGC GTGCTAATGG TGGAAAACAC CAACAAAATC 
TATGAGAAAG TCAAGAAAAG TCCGCACAGC ATATATATGC TCTTCAACAC ATCAGAGCTC 
CGAGAAGCAG TGCCTGAGCC CGTCTTGCTC TCCCGGGCAG AGTTGCGCCT GCTGAGGCTC 
AAGTTAAAAG CGGAGCAGCA TGTGGAGCTG TACCAGAAAT ATAGCAATGA TTCCTGGCGC 
TACCTCAGCA ACCGGCTGCT GGCGCCCAGC GACACGCCAG AATGGCTGTC CTTTGATGTC 
ACTGGAGTCG TGAGGCAGTG GCTGAGCCAT GGAGGGGAAG TCGAGGGCTT TCGCCTCAGT 
GCCCACTGTT CCTGTGACAG CAAAGATAAC ACACTGCAAG TAGACATTAA CGGGTTCAGT 
TCCAGCCGCC GAGGTGACCT GGCCACCATT CATGGCATGA ACCGACCCTT CCTGCTCCTC 
ATGGCCACCC CACTGGAGAG GGCCCAGCAC CTGCACAGCT CCCGGCAGCG CCGGGCCCTG 
GACACCAACT ACTGCTTCAG CTCCACGGAG AAGAACTGCT GCGTCCGGCA GCTCTACATT 
GACTTCCGCA AGGATCTGGG CTGGAAGTGG ATCCATGAGC CCAAGGGTTA CCACGCTAAC 
TTCTGCCTGG GGCCCTGCCC CTACATTTGG AGCCTGGACA CGCAGTACAG CAAGGTCCTG 
GCCCTGTACA ACCAGCACAA CCCGGGCGCG TCGGCGGCGC CGTGCTGCGT GCCGCAGGCG 
CTGGAGCCAC TGCCCATCGT GTACTACGTG GGCCGCAAGC CCAAGGTGGA GCAGCTGTCG 
AACATGATCG TGCGCTCCTG CAAGTGCAGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003309.1
CDS	58..1230
Translation	MPPSGLRLLPLLLPLLRLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLSSPPSQGEVPPVPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVENTNKIYEKVKKSPHSIYMLFNTSELREAVPEPVLLSRAELRLLRLKLKAEQHVELYQKYSNDSWRYLSNRLLAPSDTPEWLSFDVTGVVRQWLSHGGEVEGFRLSAHCSCDSKDNTLQVDINGFSSSRRGDLATIHGMNRPFLLLMATPLERAQHLHSSRQRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS

Target ORF information:

RefSeq Version	NM_001003309.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris transforming growth factor beta 1 (TGFB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003309.1

ORF Insert Sequence:

ATGCCGCCCT CCGGGCTGCG GCTGCTGCCG CTGCTGCTGC CGCTGCTGCG GCTACTAGTG 
CTGACGCCTG GCCGGCCGGC CGCCGGACTG TCCACCTGCA AGACCATCGA CATGGAACTG 
GTGAAGCGGA AGCGCATCGA GGCCATCCGC GGCCAGATCC TGTCCAAGCT GCGGCTCTCC 
AGCCCCCCGA GCCAGGGGGA GGTGCCGCCC GTGCCGCTGC CCGAGGCCGT GCTGGCCCTC 
TACAACAGCA CCCGCGACCG GGTGGCGGGG GAGAGCGCCG AGCCGGAGCC CGAGCCCGAG 
GCGGACTACT ACGCCAAGGA GGTCACCCGC GTGCTAATGG TGGAAAACAC CAACAAAATC 
TATGAGAAAG TCAAGAAAAG TCCGCACAGC ATATATATGC TCTTCAACAC ATCAGAGCTC 
CGAGAAGCAG TGCCTGAGCC CGTCTTGCTC TCCCGGGCAG AGTTGCGCCT GCTGAGGCTC 
AAGTTAAAAG CGGAGCAGCA TGTGGAGCTG TACCAGAAAT ATAGCAATGA TTCCTGGCGC 
TACCTCAGCA ACCGGCTGCT GGCGCCCAGC GACACGCCAG AATGGCTGTC CTTTGATGTC 
ACTGGAGTCG TGAGGCAGTG GCTGAGCCAT GGAGGGGAAG TCGAGGGCTT TCGCCTCAGT 
GCCCACTGTT CCTGTGACAG CAAAGATAAC ACACTGCAAG TAGACATTAA CGGGTTCAGT 
TCCAGCCGCC GAGGTGACCT GGCCACCATT CATGGCATGA ACCGACCCTT CCTGCTCCTC 
ATGGCCACCC CACTGGAGAG GGCCCAGCAC CTGCACAGCT CCCGGCAGCG CCGGGCCCTG 
GACACCAACT ACTGCTTCAG CTCCACGGAG AAGAACTGCT GCGTCCGGCA GCTCTACATT 
GACTTCCGCA AGGATCTGGG CTGGAAGTGG ATCCATGAGC CCAAGGGTTA CCACGCTAAC 
TTCTGCCTGG GGCCCTGCCC CTACATTTGG AGCCTGGACA CGCAGTACAG CAAGGTCCTG 
GCCCTGTACA ACCAGCACAA CCCGGGCGCG TCGGCGGCGC CGTGCTGCGT GCCGCAGGCG 
CTGGAGCCAC TGCCCATCGT GTACTACGTG GGCCGCAAGC CCAAGGTGGA GCAGCTGTCG 
AACATGATCG TGCGCTCCTG CAAGTGCAGC TGA