Cyclic Peptide Service

The -NH2 and -COOH groups on a peptide can form lactam through conjugation, resulting in a more stable cyclic conformation. Cyclosporine, Anidulafungin are these peptides. GenScript can provide various kinds of lactam peptides.

Disulfide cyclization is the most common peptide modification. FDA has approved many disulfide peptide drugs, such as Octreotide, Lanreotide and Linaclotide. GenScript can provide various complex disulfide cyclic peptides.

Click chemistry could link two units together through the formation of 1,2,3-triazole scaffold. This functional group has good biocompatibility. GenScript can provide conventional and copper-free click chemistry.

The conformational constraint of bicyclic peptides confers attractive drug-like properties, including the potential for high affinity to the target. GenScript has extensive experience in synthesizing bicyclic peptides with various center scaffolds.

Compared to the peptides with natural α helix, the α helix conformation of staple peptides is more stable and cell permeable. GenScript can provide various staple peptides, such as i,i+4 and i,i+7 staple peptides that are formed by RCM reaction.

Lactone peptides are abundant in nature and are an important source of drug discovery. Daptomycin, which has good efficiency on infections caused by Gram-negative organisms, is a natural lactone peptide. Genscript can provide various customized lactone peptides.