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MAPK

MAPK [mitogen-activated protein (MAP) kinases] is a serine/Threonine kinase that is activated by a number of signaling pathways (e.g.: G-protein-linked-receptor and receptor Tyrosine kinases), and is directly phosphorylated by another kinase, MAP-kinase-kinase (MAPKK). The MAPKK is activated by a MAP-kinase-kinase-kinase (MAPKKK), which is thought to be activated by the binding of activated Ras.The MAPK also has an unusual feature in that full activation requires Phosphorylation at both a Threonine and a Tyrosine. This might insure that this kinase is kept in an inactive state, unless specifically activated by MAPKK.Also known as: extracellular-signal-regulated kinases (ERKs).


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